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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)68
The number (and %) of the onco-proteins6 (8.82 %)
The number (and %) of the tumor suppressors1 (1.47 %)
Total number of binary PPIs (saturation %)212 (9.31 %)
The number (and %) of affected PPIs67 (31.60 %)
The number of possible different fusions6
PPI diameter5
PPI radius3
The average degree of PPI5.912
Assortativity coefficient-0.4030
The network average Clustering coefficient0.496
The number (and %) of a zero Clustering coefficients17 (25.00 %)
The number (and %) of a zero Betweenness Centrality25 (36.76 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: H6PD,PEX14 All fusions
Proteins found in more fusions IMPDH2 (see 2 fusions); AP2M1 (see 3 fusions); KIF11 (see 1 fusions); PEX14 (see 1 fusions); PEX10 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 H6PDparental protein30135.499G6PD_C (PF02781, IPR022675): Glucose-6-phosphate dehydrogenase, C-terminal domain
G6PD_N (PF00479, IPR022674): Glucose-6-phosphate dehydrogenase, NAD binding domain
Glucosamine_iso (PF01182, IPR006148): Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase
2 PEX14parental protein640.0563555.819HemX (PF04375, IPR007470): HemX, putative uroporphyrinogen-III C-methyltransferase
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
3 ABCD3interactor50.5005.717ABC_membrane_2 (PF06472, IPR010509): ABC transporter transmembrane region 2
ABC_tran (PF00005, IPR003439): ABC transporter
4 AGPSinteractor40.6672.000FAD-oxidase_C (PF02913, IPR004113): FAD linked oxidases, C-terminal domain
FAD_binding_4 (PF01565, IPR006094): FAD binding domain
5 ANTXR1interactor60.26749.908Ant_C (PF05586, IPR008399): Anthrax receptor C-terminus region
Anth_Ig (PF05587, IPR008400): Anthrax receptor extracellular domain
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
6 AP2M1protein found in more fusions90.50013.596Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family
Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
7 ARHGEF2oncoprotein30.3339.904IncA (PF04156, IPR007285): IncA protein
PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
8 ATAD1interactor21.0000AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
PhoH (PF02562, IPR003714): PhoH-like protein
DUF3240 (PF11582, IPR021634): Protein of unknown function (DUF3240)
AAA_18 (PF13238): AAA domain
9 CCT2interactor140.58241.237Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
10 CCT3interactor110.85510.664Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
11 CCT4interactor100.9338.931Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
12 CCT5interactor100.9338.931Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
13 CCT6Ainteractor110.85510.664Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
14 CCT7interactor120.74216.998Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
15 CCT8interactor100.84410.461Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
16 CNOT1interactor100Not1 (PF04054, IPR007196): CCR4-Not complex component, Not1
DUF3439 (PF11921, IPR024592): Domain of unknown function (DUF3439)
DUF3819 (PF12842, IPR024557): Domain of unknown function (DUF3819)
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
CNOT1_CAF1_bind (PF16415, IPR032191): CCR4-NOT transcription complex subunit 1 CAF1-binding domain
CNOT1_TTP_bind (PF16417, IPR032193): CCR4-NOT transcription complex subunit 1 TTP binding domain
CNOT1_HEAT (PF16418, IPR032194): CCR4-NOT transcription complex subunit 1 HEAT repeat
17 CNPinteractor100CNPase (PF05881, IPR008431): 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase)
NB-ARC (PF00931, IPR002182): NB-ARC domain
AAA_33 (PF13671): AAA domain
18 DCTN1interactor70.4009.328Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
FlgN (PF05130, IPR007809): FlgN protein
HOOK (PF05622, IPR008636): HOOK protein
SlyX (PF04102, IPR007236): SlyX
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
DUF2443 (PF10398, IPR019469): Protein of unknown function (DUF2443)
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
Dynactin (PF12455, IPR022157): Dynein associated protein
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
19 DHRS4interactor31.0000adh_short_C2 (PF13561): Enoyl-(Acyl carrier protein) reductase
20 DNM1Linteractor200Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
AAA_16 (PF13191): AAA ATPase domain
21 DNM2interactor40.50010.904Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
PH (PF00169, IPR001849, SM00233): PH domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
22 DYNC1H1interactor31.0000AAA_5 (PF07728, IPR011704): AAA domain (dynein-related subfamily)
DHC_N1 (PF08385, IPR013594): Dynein heavy chain, N-terminal region 1
DHC_N2 (PF08393, IPR013602): Dynein heavy chain, N-terminal region 2
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
Dynein_heavy (PF03028, IPR004273): Dynein heavy chain and region D6 of dynein motor
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
AAA_6 (PF12774): Hydrolytic ATP binding site of dynein motor region D1
AAA_7 (PF12775): P-loop containing dynein motor region D3
MT (PF12777, IPR024743): Microtubule-binding stalk of dynein motor
AAA_8 (PF12780, IPR024317): P-loop containing dynein motor region D4
AAA_9 (PF12781): ATP-binding dynein motor region D5
23 DYNC1I2interactor31.0000Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
Dynein_IC2 (PF11540, IPR025956): Cytoplasmic dynein 1 intermediate chain 2
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
DUF4329 (PF14220, IPR025479): Domain of unknown function (DUF4329)
24 DYNC2H1interactor100AAA_5 (PF07728, IPR011704): AAA domain (dynein-related subfamily)
DHC_N1 (PF08385, IPR013594): Dynein heavy chain, N-terminal region 1
DHC_N2 (PF08393, IPR013602): Dynein heavy chain, N-terminal region 2
DUF1366 (PF07104, IPR009796): Protein of unknown function (DUF1366)
DUF258 (PF03193, IPR004881): Protein of unknown function, DUF258
Dynein_heavy (PF03028, IPR004273): Dynein heavy chain and region D6 of dynein motor
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
Laminin_II (PF06009, IPR010307): Laminin Domain II
AAA_6 (PF12774): Hydrolytic ATP binding site of dynein motor region D1
AAA_7 (PF12775): P-loop containing dynein motor region D3
MT (PF12777, IPR024743): Microtubule-binding stalk of dynein motor
AAA_8 (PF12780, IPR024317): P-loop containing dynein motor region D4
AAA_9 (PF12781): ATP-binding dynein motor region D5
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
25 ELAVL3interactor100RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
26 FAR1interactor100NAD_binding_4 (PF07993, IPR013120): Male sterility protein
Sterile (PF03015, IPR026055): Male sterility protein
27 FBXO6interactor220.169376.056FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
28 GNPATinteractor31.0000Acyltransferase (PF01553, IPR002123, SM00563): Acyltransferase
29 HSD17B4interactor21.0000adh_short (PF00106, IPR002198): short chain dehydrogenase
MaoC_dehydratas (PF01575, IPR002539): MaoC like domain
SCP2 (PF02036, IPR003033): SCP-2 sterol transfer family
MaoC_dehydrat_N (PF13452): N-terminal half of MaoC dehydratase
30 IMPDH2protein found in more fusions307.461IMPDH (PF00478, IPR001093): IMP dehydrogenase / GMP reductase domain
31 IQGAP1interactor40.5002.739CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DUF87 (PF01935, IPR002789): Domain of unknown function DUF87
IDEAL (PF08858, IPR014957, SM00914): IDEAL domain
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
RasGAP_C (PF03836, IPR000593): RasGAP C-terminus
WW (PF00397, IPR001202, SM00456): WW domain
32 IQGAP2suppressor100CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
RasGAP_C (PF03836, IPR000593): RasGAP C-terminus
WW (PF00397, IPR001202, SM00456): WW domain
33 KIF11protein found in more fusions40.3339.904Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2
DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
Gag_p17 (PF00540, IPR000071): gag gene protein p17 (matrix protein)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF3510 (PF12022, IPR024603): Domain of unknown function (DUF3510)
Microtub_bind (PF13931, IPR025901): Kinesin-associated microtubule-binding
34 LRPPRCinteractor207.461DED (PF01335, IPR001875, SM00031): Death effector domain
MA3 (PF02847, IPR003891, SM00544): MA3 domain
PPR (PF01535, IPR002885): PPR repeat
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
ApoB100_C (PF12491, IPR022176): Apolipoprotein B100 C terminal
PPR_2 (PF13041, IPR002885): PPR repeat family
PPR_3 (PF13812, IPR002885): Pentatricopeptide repeat domain
TPR_19 (PF14559): Tetratricopeptide repeat
PPR_long (PF17177): Pentacotripeptide-repeat region of PROPR
35 MAP2K2interactor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
CAMSAP_CC1 (PF17095, IPR031372): Spectrin-binding region of Ca2+-Calmodulin
36 MED8interactor100Med8 (PF10232, IPR019364): Mediator of RNA polymerase II transcription complex subunit 8
37 MIER2interactor100ELM2 (PF01448, IPR000949): ELM2 domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
38 NEU2interactor21.0000BNR_2 (PF13088, IPR011040): BNR repeat-like domain
39 NUP35interactor100Nup35_RRM (PF05172, IPR007846): Nup53/35/40-type RNA recognition motif
40 PEX10protein found in more fusions60.7002.167Pex2_Pex12 (PF04757, IPR006845): Pex2 / Pex12 amino terminal region
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
41 PEX12interactor40.8330.500Pex2_Pex12 (PF04757, IPR006845): Pex2 / Pex12 amino terminal region
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
42 PEX13interactor50.6671.500Peroxin-13_N (PF04088, IPR007223): Peroxin 13, N-terminal region
SH3_9 (PF14604, IPR001452): Variant SH3 domain
43 PEX16interactor21.0000Pex16 (PF08610, IPR013919): Peroxisomal membrane protein (Pex16)
44 PEX19interactor70.38112.333Pex19 (PF04614, IPR006708): Pex19 protein family
Rod-binding (PF10135, IPR019301): Rod binding protein
45 PEX2interactor31.0000C1_2 (PF03107, IPR004146): C1 domain
Pex2_Pex12 (PF04757, IPR006845): Pex2 / Pex12 amino terminal region
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
46 PEX3interactor31.0000Peroxin-3 (PF04882, IPR006966): Peroxin-3
47 PEX5interactor130.20561.000TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
SHNi-TPR (PF10516, IPR019544): SHNi-TPR
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_15 (PF13429): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
48 PEX7interactor100.68916.537WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
49 PNPLA3interactor21.0000Patatin (PF01734, IPR002641): Patatin-like phospholipase
50 PRKCSHinteractor40.6673.279CDC45 (PF02724, IPR003874): CDC45-like protein
Ax_dynein_light (PF10211, IPR019347): Axonemal dynein light chain
PRKCSH-like (PF12999, IPR028146): Glucosidase II beta subunit-like
PRKCSH_1 (PF13015, IPR009011): Glucosidase II beta subunit-like protein
EF-hand_5 (PF13202, IPR002048): EF hand
51 SLC27A2interactor40.5003.000AMP-binding (PF00501, IPR000873): AMP-binding enzyme
AMP-binding_C (PF13193, IPR025110): AMP-binding enzyme C-terminal domain
52 SMARCC2interactor100GHMP_kinases_N (PF00288, IPR006204): GHMP kinases N terminal domain
SWIRM (PF04433, IPR007526): SWIRM domain
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1
SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal
SWIRM-assoc_3 (PF16498, IPR032448): SWIRM-associated domain at the C-terminal
53 TAZinteractor100Acyltransferase (PF01553, IPR002123, SM00563): Acyltransferase
54 TCP1interactor100.9338.931Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
55 TTC1interactor30.6670.867TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
56 TUBA1Aoncoprotein120.42473.067Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
57 TUBA4Ainteractor100.46739.471Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
58 TUBBinteractor90.58319.663Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
59 TUBB2Ainteractor80.6077.686Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
60 TUBB2Binteractor90.52822.648Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
61 TUBB3interactor80.46447.167Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
62 TUBB4Ainteractor40.33332.964Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
63 TUBB4Binteractor70.8101.900Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
64 TUBB6interactor50.7009.261Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
65 TUBB8interactor40.33324.905Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
66 TUBG2interactor207.461Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
67 VAPAinteractor50.30025.512DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
68 ZHX1interactor200Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
Homez (PF11569, IPR024578): Homeodomain leucine-zipper encoding, Homez
zf-C2H2_4 (PF13894): C2H2-type zinc finger
TerB_C (PF15615, IPR028932): TerB-C domain

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