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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins TMEM59, CLN8 (from a repository: Wed Mar 8 22:08:26 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)41
The number (and %) of the onco-proteins8 (19.51 %)
The number (and %) of the tumor suppressors4 (9.76 %)
Total number of binary PPIs (saturation %)79 (9.63 %)
The number (and %) of affected PPIs39 (49.37 %)
The number of possible different fusions5
PPI diameter5
PPI radius3
The average degree of PPI3.415
Assortativity coefficient-0.5522
The network average Clustering coefficient0.219
The number (and %) of a zero Clustering coefficients23 (56.10 %)
The number (and %) of a zero Betweenness Centrality19 (46.34 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CLN8,TMEM59 All fusions
Proteins found in more fusions CUL7 (see 2 fusions); PLP2 (see 2 fusions); UBC (see 1 fusions); RTN4 (see 11 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CLN8parental protein300.0181140.062TRAM_LAG1_CLN8 (PF03798, IPR006634): TLC domain
2 TMEM59parental protein90.167183.240BSMAP (PF12280, IPR022065): Brain specific membrane anchored protein
3 ARL6IP5suppressor21.0000PRA1 (PF03208, IPR004895): PRA1 family protein
RBD-FIP (PF09457, IPR019018): FIP domain
4 ATG16L1interactor40.3338.239ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
DUF2332 (PF10094, IPR011200): Uncharacterized protein conserved in bacteria (DUF2332)
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
5 BNIP3oncoprotein50.50053.372BNIP3 (PF06553, IPR010548): BNIP3
6 BNIP3Lsuppressor50.6672.422BNIP3 (PF06553, IPR010548): BNIP3
7 C14orf1interactor100Erg28 (PF03694, IPR005352): Erg28 like protein
8 CD9oncoprotein2014.760Tetraspannin (PF00335, IPR018499): Tetraspanin family
9 CUL7protein found in more fusions60.10044.341ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
10 CYB5Binteractor2014.760Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
MIP (PF00230, IPR000425): Major intrinsic protein
11 ELAVL1oncoprotein150.066255.504RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
12 GABARAPL2interactor40.33329.566Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
13 GPM6Binteractor2014.760PspB (PF06667, IPR009554): Phage shock protein B
Myelin_PLP (PF01275, IPR001614, SM00002): Myelin proteolipid protein (PLP or lipophilin)
14 IL20RBinteractor100Interfer-bind (PF09294, IPR015373): Interferon-alpha/beta receptor, fibronectin type III
Tissue_fac (PF01108, IPR003961): Tissue factor
15 MTX1interactor100Tom37 (PF10568, IPR019564): Outer mitochondrial membrane transport complex protein
GST_C_6 (PF17171): Glutathione S-transferase, C-terminal domain
16 NDRG2suppressor100Ndr (PF03096, IPR004142): Ndr family
17 NTRK1oncoprotein70.13371.206I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
18 PDE3Binteractor100CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
DUF1129 (PF06570, IPR009214): Protein of unknown function (DUF1129)
PDEase_I (PF00233, IPR002073): 3'5'-cyclic nucleotide phosphodiesterase
19 PDIA6interactor3033.560FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
20 PLP1interactor21.0000Myelin_PLP (PF01275, IPR001614, SM00002): Myelin proteolipid protein (PLP or lipophilin)
21 PLP2protein found in more fusions200MARVEL (PF01284, IPR008253): Membrane-associating domain
22 PTPRNinteractor21.0000Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
Receptor_IA-2 (PF11548, IPR021613): Protein-tyrosine phosphatase receptor IA-2
RESP18 (PF14948, IPR029403): RESP18 domain
23 RRP15interactor2018.063Rrp15p (PF07890, IPR012459): Rrp15p
24 RTN4suppressor50.50023.905CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
Reticulon (PF02453, IPR003388): Reticulon
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
25 RYKoncoprotein30.3338.239Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
WIF (PF02019, IPR003306, SM00469): WIF domain
26 SELENOKinteractor100SelK_SelG (PF10961, IPR024491): Selenoprotein SelK_SelG
27 SPCS2interactor100SPC25 (PF06703, IPR009582): Microsomal signal peptidase 25 kDa subunit (SPC25)
28 STX8interactor100CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
SNARE (PF05739, IPR000727, SM00397): SNARE domain
HD_assoc (PF13286, IPR026875): Phosphohydrolase-associated domain
29 TMEM107interactor100TMEM107 (PF14995, IPR029248): Transmembrane protein
30 TMEM11interactor31.0000Mito_morph_reg (PF14972, IPR026120): Mitochondrial morphogenesis regulator
31 TMEM128interactor100NA
32 TMEM134interactor2014.760CD99L2 (PF12301, IPR022078): CD99 antigen like protein 2
33 TMEM147interactor100DUF2053 (PF09767, IPR019164): Predicted membrane protein (DUF2053)
34 TMEM14Ainteractor2014.760Tmemb_14 (PF03647, IPR005349): Transmembrane proteins 14C
35 TMEM30Ainteractor30.33329.050CDC50 (PF03381, IPR005045): LEM3 (ligand-effect modulator 3) family / CDC50 family
36 TUBB4Ainteractor100Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
37 TYW1interactor21.0000Flavodoxin_1 (PF00258, IPR008254): Flavodoxin
Radical_SAM (PF04055, IPR007197): Radical SAM superfamily
Wyosine_form (PF08608, IPR013917): Wyosine base formation
38 UBCprotein found in more fusions60126.129ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
39 VAPAinteractor40.50016.544DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
40 YIPF6interactor2014.760Yip1 (PF04893, IPR006977): Yip1 domain
41 ZUFSPinteractor100zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Peptidase_C78 (PF07910, IPR012462): Peptidase family C78
zf-C2H2_4 (PF13894): C2H2-type zinc finger

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