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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SPTLC2, SMIM20 (from a repository: Fri Jul 26 03:35:59 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)16
The number (and %) of the onco-proteins2 (12.50 %)
The number (and %) of the tumor suppressors2 (12.50 %)
Total number of binary PPIs (saturation %)23 (19.17 %)
The number (and %) of affected PPIs14 (60.87 %)
The number of possible different fusions2
PPI diameter4
PPI radius2
The average degree of PPI2.500
Assortativity coefficient-0.5021
The network average Clustering coefficient0.233
The number (and %) of a zero Clustering coefficients9 (56.25 %)
The number (and %) of a zero Betweenness Centrality10 (62.50 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SMIM20,SPTLC2 All fusions
Proteins found in more fusions BCL6 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SMIM20parental protein40.3335.000DUF4538 (PF15061, IPR027917): Domain of unknown function (DUF4538)
2 SPTLC2parental protein100.022168.000Aminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II
3 BCL6oncoprotein200BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
DZR (PF12773, IPR025874): Double zinc ribbon
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
4 DDX46interactor207.333CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
CdAMP_rec (PF06153, IPR010375): Cyclic-di-AMP receptor
DDRGK (PF09756, IPR019153, SM01128): DDRGK domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
FAM176 (PF14851): FAM176 family
5 EVA1Cinteractor100Gal_Lectin (PF02140, IPR000922): Galactose binding lectin domain
FAM176 (PF14851): FAM176 family
6 FAM189A2interactor100CD20 (PF04103, IPR007237): CD20-like family
7 HERC2interactor200ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
MIB_HERC2 (PF06701, IPR010606): Mib_herc2
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
8 NOTCH3suppressor21.0000Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
9 NRG1interactor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Neuregulin (PF02158, IPR002154): Neuregulin family
10 NTRK1oncoprotein60.200102.000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
11 P2RX4interactor100P2X_receptor (PF00864, IPR001429): ATP P2X receptor
12 SF3B2interactor40.50030.333DUF382 (PF04037, IPR007180): Domain of unknown function (DUF382)
PAPA-1 (PF04795, IPR006880): PAPA-1-like conserved region
PSP (PF04046, IPR006568, SM00581): PSP
SAP (PF02037, IPR003034, SM00513): SAP domain
Usp (PF00582, IPR006016): Universal stress protein family
Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
Vma12 (PF11712, IPR021013): Endoplasmic reticulum-based factor for assembly of V-ATPase
FAM176 (PF14851): FAM176 family
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
13 SF3B5interactor21.0000SF3b10 (PF07189, IPR009846): Splicing factor 3B subunit 10 (SF3b10)
14 SPINT2suppressor100Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
15 SRSF9interactor30.6677.333RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
16 WBP1interactor100WBP-1 (PF11669, IPR021684): WW domain-binding protein 1

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