Find Fusion Network

Enter

Fusion ID: Protein names:	9517 389203
Level of PPIs:	or Upload text file:	Update repository

Visible interactions:

all

affected

independent (normal)

nothing (blank)

Visualization interactions

Cytoscape Web for: parental proteins SPTLC2, SMIM20 (from a repository: Fri Jul 26 03:35:59 2019)

Examples	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
Layout Tree Circle Radial Force Directed Preset
Export graph PDF file SVG file SIF file XML file GraphML file

Statistics and Network structure information

Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	16
The number (and %) of the onco-proteins	2 (12.50 %)
The number (and %) of the tumor suppressors	2 (12.50 %)
Total number of binary PPIs (saturation %)	23 (19.17 %)
The number (and %) of affected PPIs	14 (60.87 %)
The number of possible different fusions	2
PPI diameter	4
PPI radius	2
The average degree of PPI	2.500
Assortativity coefficient	-0.5021
The network average Clustering coefficient	0.233
The number (and %) of a zero Clustering coefficients	9 (56.25 %)
The number (and %) of a zero Betweenness Centrality	10 (62.50 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: SMIM20,SPTLC2	All fusions
Proteins found in more fusions	BCL6 (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	SMIM20	parental protein	4	0.333	5.000	DUF4538 (PF15061, IPR027917): Domain of unknown function (DUF4538)
2	SPTLC2	parental protein	10	0.022	168.000	Aminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II
3	BCL6	oncoprotein	2	0	0	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding DZR (PF12773, IPR025874): Double zinc ribbon zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
4	DDX46	interactor	2	0	7.333	CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain DEAD (PF00270, IPR011545): DEAD/DEAH box helicase DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) CdAMP_rec (PF06153, IPR010375): Cyclic-di-AMP receptor DDRGK (PF09756, IPR019153, SM01128): DDRGK domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term FAM176 (PF14851): FAM176 family
5	EVA1C	interactor	1	0	0	Gal_Lectin (PF02140, IPR000922): Galactose binding lectin domain FAM176 (PF14851): FAM176 family
6	FAM189A2	interactor	1	0	0	CD20 (PF04103, IPR007237): CD20-like family
7	HERC2	interactor	2	0	0	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain MIB_HERC2 (PF06701, IPR010606): Mib_herc2 RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box) HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7 Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
8	NOTCH3	suppressor	2	1.000	0	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain NOD (PF06816, IPR010660): NOTCH protein NODP (PF07684, IPR011656): NOTCH protein Notch (PF00066, IPR000800, SM00004): LNR domain DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454) hEGF (PF12661, IPR013032): Human growth factor-like EGF cEGF (PF12662, IPR026823): Complement Clr-like EGF-like Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
9	NRG1	interactor	1	0	0	EGF (PF00008, IPR000742, SM00181): EGF-like domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain Neuregulin (PF02158, IPR002154): Neuregulin family
10	NTRK1	oncoprotein	6	0.200	102.000	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
11	P2RX4	interactor	1	0	0	P2X_receptor (PF00864, IPR001429): ATP P2X receptor
12	SF3B2	interactor	4	0.500	30.333	DUF382 (PF04037, IPR007180): Domain of unknown function (DUF382) PAPA-1 (PF04795, IPR006880): PAPA-1-like conserved region PSP (PF04046, IPR006568, SM00581): PSP SAP (PF02037, IPR003034, SM00513): SAP domain Usp (PF00582, IPR006016): Universal stress protein family Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19 Vma12 (PF11712, IPR021013): Endoplasmic reticulum-based factor for assembly of V-ATPase FAM176 (PF14851): FAM176 family WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
13	SF3B5	interactor	2	1.000	0	SF3b10 (PF07189, IPR009846): Splicing factor 3B subunit 10 (SF3b10)
14	SPINT2	suppressor	1	0	0	Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
15	SRSF9	interactor	3	0.667	7.333	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
16	WBP1	interactor	1	0	0	WBP-1 (PF11669, IPR021684): WW domain-binding protein 1

B a c k t o T o p ⇑