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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SCARB1, BRI3BP (from a repository: Sun Aug 25 03:14:12 2019)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)35
The number (and %) of the onco-proteins2 (5.71 %)
The number (and %) of the tumor suppressors5 (14.29 %)
Total number of binary PPIs (saturation %)58 (9.75 %)
The number (and %) of affected PPIs33 (56.90 %)
The number of possible different fusions3
PPI diameter5
PPI radius3
The average degree of PPI2.857
Assortativity coefficient-0.3985
The network average Clustering coefficient0.251
The number (and %) of a zero Clustering coefficients22 (62.86 %)
The number (and %) of a zero Betweenness Centrality22 (62.86 %)


List of the fusions

PPI for parental proteins: BRI3BP,SCARB1 All fusions
Proteins found in more fusions CUL1 (see 3 fusions); HLA-C (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 BRI3BPparental protein150672.833HemY_N (PF07219, IPR010817): HemY protein N-terminus
BRI3BP (PF14965): Negative regulator of p53/TP53
CLZ (PF16526, IPR032406): C-terminal leucine zipper domain of cyclic nucleotide-gated channels
2 SCARB1parental protein180.052532.917CD36 (PF01130, IPR002159): CD36 family
3 AMFRoncoprotein200CUE (PF02845, IPR003892, SM00546): CUE domain
UbiA (PF01040, IPR000537): UbiA prenyltransferase family
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
4 APOA1interactor31.0000ApoA-II (PF04711, IPR006801): Apolipoprotein A-II (ApoA-II)
Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain
Gp-FAR-1 (PF05823, IPR008632): Nematode fatty acid retinoid binding protein (Gp-FAR-1)
5 APOA2interactor21.0000ApoA-II (PF04711, IPR006801): Apolipoprotein A-II (ApoA-II)
6 ATP1B3interactor30.66728.821Na_K-ATPase (PF00287, IPR000402): Sodium / potassium ATPase beta chain
7 BTNL8interactor2028.821I-set (PF07679, IPR013098): Immunoglobulin I-set domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
Ig_3 (PF13927): Immunoglobulin domain
8 CAND1interactor31.0000Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
9 CUL1suppressor50.33384.917Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
10 DLK1suppressor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
11 ESR1suppressor3078.000Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
12 FBXO6interactor70.286127.571FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
13 GDE1interactor100GDPD (PF03009, IPR004129): Glycerophosphoryl diester phosphodiesterase family
14 HLA-Cprotein found in more fusions50.66729.988Marek_A (PF02124, IPR001038): Marek's disease glycoprotein A
MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
15 HLA-DPA1interactor100MHC_II_alpha (PF00993, IPR001003, SM00920): Class II histocompatibility antigen, alpha domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
C1-set_C (PF16196, IPR032431): C1-set C-terminal domain
16 HLA-DRAinteractor2028.821MHC_II_alpha (PF00993, IPR001003, SM00920): Class II histocompatibility antigen, alpha domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
C1-set_C (PF16196, IPR032431): C1-set C-terminal domain
17 HTR3Cinteractor100Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
18 KRTAP10-9interactor31.0000Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
19 KRTAP5-9interactor21.0000Ery_res_leader2 (PF08057, IPR012559): Erythromycin resistance leader peptide
20 LCA5interactor100IncA (PF04156, IPR007285): IncA protein
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
Tantalus (PF15386, IPR028149): Drosophila Tantalus-like
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
21 NAAAinteractor30.66728.821CBAH (PF02275, IPR003199): Linear amide C-N hydrolases, choloylglycine hydrolase family
NAAA-beta (PF15508, IPR029130): beta subunit of N-acylethanolamine-hydrolyzing acid amidase
22 P2RY12interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
23 PDZK1interactor100PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DUF4265 (PF14085, IPR025361): Domain of unknown function (DUF4265)
24 PON2interactor21.0000Arylesterase (PF01731, IPR002640): Arylesterase
25 PTH1Rinteractor1007tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family)
HRM (PF02793, IPR001879, SM00008): Hormone receptor domain
26 PTPRKsuppressor2028.821fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu
Protocadherin (PF08374, IPR013585): Protocadherin
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
27 RNF2interactor200zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
28 TCTN1interactor100DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
29 TCTN2interactor80.107391.667DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
30 TCTN3interactor2052.000DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
31 TMEM17interactor100Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
32 TMEM216interactor100Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
33 TSPAN5interactor100Tetraspannin (PF00335, IPR018499): Tetraspanin family
34 TUSC5suppressor100CD225 (PF04505, IPR007593): Interferon-induced transmembrane protein
35 ZACNinteractor100Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region

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