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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PIGL, SETD5 (from a repository: Fri Jul 26 13:02:08 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)13
The number (and %) of the onco-proteins3 (23.08 %)
The number (and %) of the tumor suppressors1 (7.69 %)
Total number of binary PPIs (saturation %)23 (29.49 %)
The number (and %) of affected PPIs11 (47.83 %)
The number of possible different fusions3
PPI diameter2
PPI radiusinf
The average degree of PPI2.308
Assortativity coefficient-0.1657
The network average Clustering coefficient0.315
The number (and %) of a zero Clustering coefficients7 (53.85 %)
The number (and %) of a zero Betweenness Centrality9 (69.23 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SETD5,PIGL All fusions
Proteins found in more fusions CEP70 (see 1 fusions); MEIS2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SETD5parental protein100.08979.000FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
SET (PF00856, IPR001214, SM00317): SET domain
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
DUF3807 (PF12720, IPR024526): Protein of unknown function (DUF3807)
2 PIGLparental protein100PIG-L (PF02585, IPR003737): GlcNAc-PI de-N-acetylase
3 CCDC85Binteractor30.6671.000CCDC85 (PF10226, IPR019359): CCDC85 family
4 CEP70protein found in more fusions31.0000IncA (PF04156, IPR007285): IncA protein
Mog1 (PF04603, IPR007681): Ran-interacting Mog1 protein
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
Colicin-DNase (PF12639, IPR024622): DNase/tRNase domain of colicin-like bacteriocin
5 DPPA2interactor200SAP (PF02037, IPR003034, SM00513): SAP domain
DCR (PF14047, IPR025891): Dppa2/4 conserved region
Dppa2_A (PF14049, IPR025892): Dppa2/4 conserved region in higher vertebrates
6 KRT40interactor21.0000Filament (PF00038, IPR001664): Intermediate filament protein
UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
7 LDOC1oncoprotein40.6671.000DUF4939 (PF16297, IPR032549): Domain of unknown function (DUF4939)
8 MEIS2protein found in more fusions200Homeobox_KN (PF05920, IPR008422): Homeobox KN domain
Meis_PKNOX_N (PF16493, IPR032453): N-terminal of Homeobox Meis and PKNOX1
9 MTUS2suppressor200DUF496 (PF04363, IPR007458): Protein of unknown function (DUF496)
RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
FAM184 (PF15665): Family with sequence similarity 184, A and B
10 NXF1interactor40.6671.000NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
11 PRMT2interactor100PRMT5 (PF05185, IPR025799): PRMT5 arginine-N-methyltransferase
SH3_9 (PF14604, IPR001452): Variant SH3 domain
12 SKAP1interactor200PH (PF00169, IPR001849, SM00233): PH domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
13 TRAF2interactor200MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)

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