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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)94
The number (and %) of the onco-proteins15 (15.96 %)
The number (and %) of the tumor suppressors3 (3.19 %)
Total number of binary PPIs (saturation %)256 (5.86 %)
The number (and %) of affected PPIs92 (35.94 %)
The number of possible different fusions9
PPI diameter2
PPI radiusinf
The average degree of PPI5.128
Assortativity coefficient-0.4569
The network average Clustering coefficient0.497
The number (and %) of a zero Clustering coefficients27 (28.72 %)
The number (and %) of a zero Betweenness Centrality51 (54.26 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CLN3,PIGL All fusions
Proteins found in more fusions PRKDC (see 2 fusions); TFRC (see 1 fusions); FKBP8 (see 1 fusions); IMMT (see 4 fusions); CKAP4 (see 5 fusions); MEIS2 (see 1 fusions); KCNIP3 (see 2 fusions); SLC25A11 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CLN3parental protein910.0367309.764CLN3 (PF02487, IPR003492): CLN3 protein
2 PIGLparental protein100PIG-L (PF02585, IPR003737): GlcNAc-PI de-N-acetylase
3 ABCD3interactor100ABC_membrane_2 (PF06472, IPR010509): ABC transporter transmembrane region 2
ABC_tran (PF00005, IPR003439): ABC transporter
4 ADGRL2oncoprotein1007tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family)
Gal_Lectin (PF02140, IPR000922): Galactose binding lectin domain
GPS (PF01825, IPR000203, SM00303): GPCR proteolysis site, GPS, motif
Latrophilin (PF02354, IPR003334): Latrophilin Cytoplasmic C-terminal region
OLF (PF02191, IPR003112, SM00284): Olfactomedin-like domain
zf-C2HCIx2C (PF10782, IPR019718): Zinc-finger
HRM (PF02793, IPR001879, SM00008): Hormone receptor domain
GAIN (PF16489, IPR032471): GPCR-Autoproteolysis INducing (GAIN) domain
5 AFG3L2interactor80.8571.069AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
FtsH_ext (PF06480, IPR011546): FtsH Extracellular
Peptidase_M41 (PF01434, IPR000642): Peptidase family M41
TniB (PF05621, IPR008868): Bacterial TniB protein
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
6 ARF3interactor21.0000Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
7 ARF4interactor21.0000Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
8 ARF5interactor31.0000Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
9 ARMC6interactor50.4006.000Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Mis14 (PF08641, IPR013950): Kinetochore protein Mis14 like
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
10 ATG7interactor100ThiF (PF00899, IPR000594): ThiF family
ATG7_N (PF16420, IPR032197): Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
11 ATP1A1interactor140.53827.431Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
Tetraspannin (PF00335, IPR018499): Tetraspanin family
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
12 ATP2A2interactor40.6671.667Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
HAD (PF12710): haloacid dehalogenase-like hydrolase
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
13 ATP5MGinteractor90.50012.619ATP-synt_G (PF04718, IPR006808): Mitochondrial ATP synthase g subunit
14 AUP1interactor40.6672.000CUE (PF02845, IPR003892, SM00546): CUE domain
15 B3GALT2interactor100Galactosyl_T (PF01762, IPR002659): Galactosyltransferase
16 C19orf70interactor40.5002.667QIL1 (PF15884, IPR026769): Protein QIL1
17 CALUinteractor21.0000EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
18 CAND1interactor100.33320.833Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
19 CCDC47interactor40.5002.333DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
STAC2_u1 (PF16664): Unstructured on SH3 and cysteine-rich domain-containing protein 2
20 CDS2interactor100CTP_transf_1 (PF01148, IPR000374): Cytidylyltransferase family
21 CKAP4protein found in more fusions31.0000DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
FPP (PF05911, IPR008587): Filament-like plant protein, long coiled-coil
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
22 COX15interactor21.0000COX15-CtaA (PF02628, IPR003780): Cytochrome oxidase assembly protein
Peptidase_S3 (PF00944, IPR000930): Alphavirus core protein
23 CPT1Ainteractor100Carn_acyltransf (PF00755, IPR000542): Choline/Carnitine o-acyltransferase
CPT_N (PF16484, IPR032476): Carnitine O-palmitoyltransferase N-terminus
24 CSE1Loncoprotein50.4005.667CAS_CSE1 (PF03378, IPR005043): CAS/CSE protein, C-terminus
Cse1 (PF08506, IPR013713): Cse1
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
25 CYC1interactor120.50024.157Cytochrom_C1 (PF02167, IPR002326): Cytochrome C1 family
26 DBHinteractor100Cu2_monoox_C (PF03712, IPR024548): Copper type II ascorbate-dependent monooxygenase, C-terminal domain
Cu2_monooxygen (PF01082, IPR000323): Copper type II ascorbate-dependent monooxygenase, N-terminal domain
DOMON (PF03351, IPR005018, SM00664): DOMON domain
27 DDOSTinteractor150.42942.121DDOST_48kD (PF03345, IPR005013): Oligosaccharyltransferase 48 kDa subunit beta
28 DDX20interactor31.0000DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
29 DPM1interactor100Glycos_transf_2 (PF00535, IPR001173): Glycosyl transferase family 2
30 ELAVL1oncoprotein190.163120.667RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
31 EMDinteractor50.5003.000LEM (PF03020, IPR003887, SM00540): LEM domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
32 ERLIN2interactor50.5004.333Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4346 (PF14251, IPR025595): Domain of unknown function (DUF4346)
33 ESYT2interactor100C2 (PF00168, IPR000008, SM00239): C2 domain
DUF3720 (PF12517, IPR022195): Protein of unknown function (DUF3720)
SMP_LBD (PF17047, IPR031468): Synaptotagmin-like mitochondrial-lipid-binding domain
34 FADS2interactor100Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
FA_desaturase (PF00487, IPR005804): Fatty acid desaturase
35 FANCIinteractor40.5003.000DUF3972 (PF13118, IPR025002): Protein of unknown function (DUF3972)
FANCI_S1-cap (PF14674, IPR029305): FANCI solenoid 1 cap
FANCI_S1 (PF14675, IPR029308): FANCI solenoid 1
FANCI_S2 (PF14676, IPR026171): FANCI solenoid 2
FANCI_S3 (PF14677, IPR029313): FANCI solenoid 3
FANCI_S4 (PF14678, IPR029314): FANCI solenoid 4
FANCI_HD1 (PF14679, IPR029310): FANCI helical domain 1
FANCI_HD2 (PF14680, IPR029312): FANCI helical domain 2
36 FAR1interactor100NAD_binding_4 (PF07993, IPR013120): Male sterility protein
Sterile (PF03015, IPR026055): Male sterility protein
37 FKBP8protein found in more fusions31.0000FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
38 GANABsuppressor21.0000Glyco_hydro_31 (PF01055, IPR000322): Glycosyl hydrolases family 31
Gal_mutarotas_2 (PF13802, IPR025887): Galactose mutarotase-like
DUF5110 (PF17137): Domain of unknown function (DUF5110)
39 GCN1interactor21.0000Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
CLASP_N (PF12348, IPR024395): CLASP N terminal
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
TFCD_C (PF12612, IPR022577): Tubulin folding cofactor D C terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
40 GEMIN4interactor31.0000NA
41 HACD3interactor40.5002.667PTPLA (PF04387, IPR007482): Protein tyrosine phosphatase-like protein, PTPLA
42 HSD17B12interactor90.8062.069adh_short (PF00106, IPR002198): short chain dehydrogenase
43 ILVBLinteractor50.7000.905TPP_enzyme_C (PF02775, IPR011766): Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
TPP_enzyme_N (PF02776, IPR012001): Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
44 IMMTprotein found in more fusions70.4008.333Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
45 IRAK1interactor100.25025.500Death (PF00531, IPR000488, SM00005): Death domain
Pkinase (PF00069, IPR000719): Protein kinase domain
46 KCNIP3protein found in more fusions200SPARC_Ca_bdg (PF10591, IPR019577): Secreted protein acidic and rich in cysteine Ca binding region
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
EF-hand_9 (PF14658): EF-hand domain
47 KIAA0368interactor40.6671.500HEAT (PF02985, IPR000357): HEAT repeat
IFRD (PF05004, IPR007701): Interferon-related developmental regulator (IFRD)
CLASP_N (PF12348, IPR024395): CLASP N terminal
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal
Ecm29 (PF13001, IPR024372): Proteasome stabiliser
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
48 LPGAT1interactor21.0000Acyltransferase (PF01553, IPR002123, SM00563): Acyltransferase
Acyltransf_C (PF16076, IPR032098): Acyltransferase C-terminus
49 MEIS2protein found in more fusions200Homeobox_KN (PF05920, IPR008422): Homeobox KN domain
Meis_PKNOX_N (PF16493, IPR032453): N-terminal of Homeobox Meis and PKNOX1
50 NPEPPSinteractor21.0000Peptidase_M1 (PF01433, IPR014782): Peptidase family M1
ERAP1_C (PF11838, IPR024571): ERAP1-like C-terminal domain
51 NUP205interactor21.0000Nup192 (PF11894, IPR021827): Nuclear pore complex scaffold, nucleoporins 186/192/205
52 NUP93oncoprotein30.6671.000Nic96 (PF04097, IPR007231): Nup93/Nic96
53 PHBsuppressor120.45525.129Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4290 (PF14123, IPR025632): Domain of unknown function (DUF4290)
54 PHGDHinteractor40.5001.8332-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
55 PRKDCprotein found in more fusions70.3338.833FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
NUC194 (PF08163, IPR012582): NUC194 domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
56 PTH1Rinteractor1007tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family)
HRM (PF02793, IPR001879, SM00008): Hormone receptor domain
57 RARS2interactor100DALR_1 (PF05746, IPR008909, SM00836): DALR anticodon binding domain
tRNA-synt_1d (PF00750, IPR015945): tRNA synthetases class I (R)
58 RCN2interactor40.6671.667EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
59 RIF1interactor100Rif1_N (PF12231, IPR022031): Rap1-interacting factor 1 N terminal
DUF4519 (PF15012, IPR027960): Domain of unknown function (DUF4519)
NICE-1 (PF15845, IPR031698): Cysteine-rich C-terminal 1 family
60 RPN1oncoprotein160.45041.431Ribophorin_I (PF04597, IPR007676): Ribophorin I
CtIP_N (PF10482, IPR019518): Tumour-suppressor protein CtIP N-terminal domain
61 RPN2interactor60.8002.000Ribophorin_II (PF05817, IPR008814): Oligosaccharyltransferase subunit Ribophorin II
62 SAMM50interactor30.6670.667Bac_surface_Ag (PF01103, IPR000184): Surface antigen
POTRA (PF07244, IPR010827): Surface antigen variable number repeat
63 SBDSoncoprotein100SBDS (PF01172, IPR019783): Shwachman-Bodian-Diamond syndrome (SBDS) protein
SBDS_C (PF09377, IPR018978): SBDS protein C-terminal domain
64 SCAMP3interactor40.8330.400SCAMP (PF04144, IPR007273): SCAMP family
65 SEC61A1interactor41.0000DUF1430 (PF07242, IPR006541): Protein of unknown function (DUF1430)
SecY (PF00344, IPR002208): SecY translocase
Plug_translocon (PF10559, IPR019561): Plug domain of Sec61p
66 SEC61A2interactor100SecY (PF00344, IPR002208): SecY translocase
Plug_translocon (PF10559, IPR019561): Plug domain of Sec61p
67 SFXN1interactor50.5004.333Mtc (PF03820, IPR004686): Tricarboxylate carrier
68 SFXN3interactor40.8330.667Mtc (PF03820, IPR004686): Tricarboxylate carrier
69 SFXN4interactor100Mtc (PF03820, IPR004686): Tricarboxylate carrier
70 SIGMAR1interactor100ERG2_Sigma1R (PF04622, IPR006716): ERG2 and Sigma1 receptor like protein
71 SLC25A1interactor21.0000Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
72 SLC25A10interactor21.0000Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
73 SLC25A11protein found in more fusions31.0000Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
74 SLC25A13interactor40.6671.333Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
75 SLC25A22interactor100Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
DUF4257 (PF14074, IPR025353): Protein of unknown function (DUF4257)
76 SLC25A3interactor120.50022.605Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
77 SLC25A4interactor21.0000Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
78 SLC25A5interactor70.5247.533Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
79 SLC25A6interactor21.0000Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
80 SLC35B2interactor100UAA (PF08449, IPR013657): UAA transporter family
81 SSR4interactor80.7503.650TRAP-delta (PF05404, IPR008855): Translocon-associated protein, delta subunit precursor (TRAP-delta)
OppC_N (PF12911, IPR025966): N-terminal TM domain of oligopeptide transport permease C
82 STRA6interactor100RBP_receptor (PF14752): Retinol binding protein receptor
83 TECRinteractor120.56116.240Steroid_dh (PF02544, IPR001104): 3-oxo-5-alpha-steroid 4-dehydrogenase
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
84 TELO2interactor30.6670.500Telomere_reg-2 (PF10193, IPR019337): Telomere length regulation protein
HEAT_2 (PF13646): HEAT repeats
85 TFRConcoprotein200PA (PF02225, IPR003137): PA domain
Peptidase_M28 (PF04389, IPR007484): Peptidase family M28
TFR_dimer (PF04253, IPR007365): Transferrin receptor-like dimerisation domain
DUF3855 (PF12967, IPR024482): Domain of Unknown Function with PDB structure (DUF3855)
86 TMEM33interactor100UPF0121 (PF03661, IPR005344): Uncharacterised protein family (UPF0121)
87 TMPOinteractor21.0000LEM (PF03020, IPR003887, SM00540): LEM domain
Thymopoietin (PF08198, IPR013146): Thymopoietin protein
LAP2alpha (PF11560, IPR021623): Lamina-associated polypeptide 2 alpha
88 TRIP13interactor31.0000AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
89 UNC45Ainteractor21.0000Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central
TPR_16 (PF13432): Tetratricopeptide repeat
HEAT_2 (PF13646): HEAT repeats
90 UQCRC2oncoprotein140.46235.805Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
91 VDAC2interactor150.35254.738Porin_3 (PF01459, IPR027246): Eukaryotic porin
92 XPO1interactor100.22231.333CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
93 XPO5suppressor100IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
94 XPOTinteractor21.0000DUF310 (PF03750, IPR010149): Protein of unknown function (DUF310)
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein

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