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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)53
The number (and %) of the onco-proteins12 (22.64 %)
The number (and %) of the tumor suppressors7 (13.21 %)
Total number of binary PPIs (saturation %)116 (8.42 %)
The number (and %) of affected PPIs51 (43.97 %)
The number of possible different fusions7
PPI diameter5
PPI radius3
The average degree of PPI3.774
Assortativity coefficient-0.3453
The network average Clustering coefficient0.378
The number (and %) of a zero Clustering coefficients23 (43.40 %)
The number (and %) of a zero Betweenness Centrality32 (60.38 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ATG5,CACNA2D1 All fusions
Proteins found in more fusions IMPDH2 (see 1 fusions); VCP (see 4 fusions); TKT (see 5 fusions); BCL2L1 (see 1 fusions); TAB2 (see 1 fusions); HTT (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ATG5parental protein290.0891157.644APG5 (PF04106, IPR007239): Autophagy protein Apg5
2 CACNA2D1parental protein220.0131250.433dCache_1 (PF02743, IPR004010): Cache domain
VGCC_alpha2 (PF08473, IPR013680): Neuronal voltage-dependent calcium channel alpha 2acd
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
VWA_N (PF08399, IPR013608): VWA N-terminal
VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
3 ABCE1interactor40.333160.403ABC_tran (PF00005, IPR003439): ABC transporter
Fer4 (PF00037, IPR001450): 4Fe-4S binding domain
RLI (PF04068, IPR007209): Possible Fer4-like domain in RNase L inhibitor, RLI
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain
AAA_29 (PF13555): P-loop containing region of AAA domain
4 ATG12interactor100.33384.229APG12 (PF04110, IPR007242): Ubiquitin-like autophagy protein Apg12
5 ATG16L1interactor110.42272.414ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
DUF2332 (PF10094, IPR011200): Uncharacterized protein conserved in bacteria (DUF2332)
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
6 ATG3interactor70.57121.493Autophagy_C (PF10381, IPR019461): Autophagocytosis associated protein C-terminal
Autophagy_N (PF03986, IPR007134): Autophagocytosis associated protein (Atg3), N-terminal domain
Autophagy_act_C (PF03987, IPR007135): Autophagocytosis associated protein, active-site domain
7 BCL10suppressor41.0000CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
8 BCL2L1oncoprotein200Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
9 BTNL8interactor100I-set (PF07679, IPR013098): Immunoglobulin I-set domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
Ig_3 (PF13927): Immunoglobulin domain
10 CAPN1interactor100Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
11 CAPN2interactor21.0000Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
12 CAV1suppressor40.333102.077Caveolin (PF01146, IPR001612): Caveolin
13 CCDC8interactor80.190477.829Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
14 CCHCR1interactor200HCR (PF07111, IPR009800): Alpha helical coiled-coil rod protein (HCR)
15 CNOT2interactor30188.994NOT2_3_5 (PF04153, IPR007282): NOT2 / NOT3 / NOT5 family
16 DNAAF2interactor100Glyco_hydro_57 (PF03065, IPR004300): Glycosyl hydrolase family 57
PIH1 (PF08190, IPR012981): pre-RNA processing PIH1/Nop17
17 ELAVL1oncoprotein100.250317.177RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
18 ERLIN2interactor2063.681Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4346 (PF14251, IPR025595): Domain of unknown function (DUF4346)
19 EXOC4oncoprotein21.0000DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
Sec8_exocyst (PF04048, IPR007191): Sec8 exocyst complex component specific domain
Vps51 (PF08700): Vps51/Vps67
20 FADDsuppressor21.0000Death (PF00531, IPR000488, SM00005): Death domain
DED (PF01335, IPR001875, SM00031): Death effector domain
Hpt (PF01627, IPR008207, SM00073): Hpt domain
21 GLT8D2interactor100Glyco_transf_8 (PF01501, IPR002495): Glycosyl transferase family 8
22 HNRNPUinteractor21.0000CDC45 (PF02724, IPR003874): CDC45-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
23 HTTprotein found in more fusions31.0000HEAT (PF02985, IPR000357): HEAT repeat
SPX (PF03105, IPR004331): SPX domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
DUF3652 (PF12372, IPR024613): Huntingtin protein region
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
24 IMPDH2protein found in more fusions200IMPDH (PF00478, IPR001093): IMP dehydrogenase / GMP reductase domain
25 ISLRinteractor100I-set (PF07679, IPR013098): Immunoglobulin I-set domain
LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
26 ITM2Binteractor100BRICHOS (PF04089, IPR007084, SM01039): BRICHOS domain
SpoVG (PF04026, IPR007170): SpoVG
27 KEAP1oncoprotein40.6676.219BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
28 LMAN2interactor21.0000Lectin_leg-like (PF03388, IPR005052): Legume-like lectin family
Tad (PF13400, IPR028087): Putative Flp pilus-assembly TadE/G-like
29 MAP1LC3Binteractor40.6671.333Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
30 MAP1LC3Cinteractor50.7003.773Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
31 MEOX2interactor100Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
32 MYH7Binteractor100Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
YkuI_C (PF10388, IPR018842): EAL-domain associated signalling protein domain
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
33 NDUFS4interactor100ETC_C1_NDUFA4 (PF04800, IPR006885): ETC complex I subunit conserved region
34 PON2interactor100Arylesterase (PF01731, IPR002640): Arylesterase
35 PTCH1suppressor2080.477Patched (PF02460, IPR003392): Patched family
36 PTPRKsuppressor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu
Protocadherin (PF08374, IPR013585): Protocadherin
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
37 RAB11Aoncoprotein2063.681Ras (PF00071, IPR001806, SM00173): Ras family
38 RB1CC1suppressor40.50096.754Arc_PepC_II (PF06847, IPR009655): Archaeal Peptidase A24 C-terminus Type II
DHC (PF09626, IPR018588): Dihaem cytochrome c
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
ATG11 (PF10377, IPR019460): Autophagy-related protein 11
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Jag_N (PF14804, IPR032782): Jag N-terminus
NPBW (PF15180, IPR013297): Neuropeptides B and W
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
Goodbye (PF17109, IPR031350): fungal STAND N-terminal Goodbye domain
39 SIRT1suppressor31.0000DUF592 (PF04574, IPR007654): Protein of unknown function (DUF592)
SIR2 (PF02146, IPR003000): Sir2 family
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
40 STT3Binteractor100STT3 (PF02516, IPR003674): Oligosaccharyl transferase STT3 subunit
41 SUSD4interactor100Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
42 TAB2oncoprotein40.66711.328CUE (PF02845, IPR003892, SM00546): CUE domain
DivIC (PF04977, IPR007060): Septum formation initiator
Mnd1 (PF03962, IPR005647): Mnd1 family
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
43 TAB3oncoprotein31.0000CUE (PF02845, IPR003892, SM00546): CUE domain
Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
44 TAZinteractor100Acyltransferase (PF01553, IPR002123, SM00563): Acyltransferase
45 TECPR1interactor31.0000DUF1768 (PF08719, IPR012816): Domain of unknown function (DUF1768)
Pex24p (PF06398, IPR010482): Integral peroxisomal membrane peroxin
PH (PF00169, IPR001849, SM00233): PH domain
Hyd_WA (PF06462, IPR006624, SM00706): Propeller
46 TEKT4interactor100Tektin (PF03148, IPR000435): Tektin family
47 TKTprotein found in more fusions31.0000Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain
Transketolase_N (PF00456, IPR005474): Transketolase, thiamine diphosphate binding domain
48 TMEM185Ainteractor100Tmemb_185A (PF10269, IPR019396): Transmembrane Fragile-X-F protein
49 USP7oncoprotein31.0000MATH (PF00917, IPR002083, SM00061): MATH domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7
USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal
50 VCPprotein found in more fusions80.238188.765AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
51 WDFY3interactor40.8330.500Beach (PF02138, IPR000409, SM01026): Beige/BEACH domain
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Laminin_G_3 (PF13385): Concanavalin A-like lectin/glucanases superfamily
E3_UbLigase_R4 (PF13764, IPR025704): E3 ubiquitin-protein ligase UBR4
PH_BEACH (PF14844, IPR023362): PH domain associated with Beige/BEACH
DUF4704 (PF15787, IPR031570): Domain of unknown function (DUF4704)
DUF4800 (PF16057): Domain of unknown function (DUF4800)
52 WIPI2interactor31.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
53 XPO1interactor120.212540.793CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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