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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)64
The number (and %) of the onco-proteins14 (21.88 %)
The number (and %) of the tumor suppressors7 (10.94 %)
Total number of binary PPIs (saturation %)221 (10.96 %)
The number (and %) of affected PPIs62 (28.05 %)
The number of possible different fusions13
PPI diameter4
PPI radius2
The average degree of PPI5.969
Assortativity coefficient-0.3546
The network average Clustering coefficient0.508
The number (and %) of a zero Clustering coefficients6 (9.38 %)
The number (and %) of a zero Betweenness Centrality15 (23.44 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MEGF11,EIF4E2 All fusions
Proteins found in more fusions AMOTL2 (see 1 fusions); ARIH1 (see 4 fusions); KRT19 (see 1 fusions); ATN1 (see 1 fusions); TRAF6 (see 1 fusions); HUWE1 (see 2 fusions); EWSR1 (see 2 fusions); APP (see 4 fusions); AES (see 3 fusions); MAGED1 (see 1 fusions); TMCC2 (see 3 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MEGF11parental protein21.0000DSL (PF01414, IPR001774, SM00051): Delta serrate ligand
EGF_2 (PF07974, IPR013111): EGF-like domain
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
2 EIF4E2parental protein600.0663013.453IF4E (PF01652, IPR001040): Eukaryotic initiation factor 4E
3 ADAMTSL4interactor60.8670.800ADAM_spacer1 (PF05986, IPR010294): ADAM-TS Spacer 1
PLAC (PF08686, IPR010909, SM00022): PLAC (protease and lacunin) domain
TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
Zn_ribbon_17 (PF17120): Zinc-ribbon, C4HC2 type
4 AESprotein found in more fusions160.190116.917TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain
5 AMOTL2protein found in more fusions130.24244.161HOOK (PF05622, IPR008636): HOOK protein
SlyX (PF04102, IPR007236): SlyX
Angiomotin_C (PF12240, IPR024646): Angiomotin C terminal
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
6 APPprotein found in more fusions80.33313.667APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
7 ARIH1protein found in more fusions40.6670.667CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
Med14 (PF08638, IPR013947): Mediator complex subunit MED14
zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
8 ATN1protein found in more fusions110.067138.400Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
9 CARD9interactor110.31127.168CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
IncA (PF04156, IPR007285): IncA protein
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
10 CDR2interactor41.0000DivIC (PF04977, IPR007060): Septum formation initiator
SlyX (PF04102, IPR007236): SlyX
Striatin (PF08232, IPR013258): Striatin family
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
11 DIS3Linteractor40.8330.667RNB (PF00773, SM00955): RNB domain
Rrp44_CSD1 (PF17216): Rrp44-like cold shock domain
Rrp44_S1 (PF17215): S1 domain
12 EIF3Fsuppressor30.6670.667JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
13 EIF4EBP3interactor100eIF_4EBP (PF05456, IPR008606): Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
14 EIF4ENIF1interactor50.30037.856EIF4E-T (PF10477, IPR018862): Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
DUF4718 (PF15842, IPR031695): Domain of unknown function (DUF4718)
15 EWSR1oncoprotein60.20036.449RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
16 FAM58Ainteractor100Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
17 FBXO25suppressor21.0000Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
18 FBXW11interactor110.33328.256WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
19 FERMT3interactor21.0000FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
20 GIGYF1interactor40.33312.745GYF (PF02213, IPR003169, SM00444): GYF domain
RNase_H2-Ydr279 (PF09468, IPR019024): Ydr279p protein family (RNase H2 complex component)
PRTase_3 (PF15610, IPR028944): PRTase ComF-like
VIR_N (PF15912, IPR031801): Virilizer, N-terminal
21 GIGYF2interactor100.28955.608DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
GYF (PF02213, IPR003169, SM00444): GYF domain
Macoilin (PF09726, IPR019130): Transmembrane protein
Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3
DUF3801 (PF12687, IPR024234): Protein of unknown function (DUF3801)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
AAA_23 (PF13476): AAA domain
ARGLU (PF15346): Arginine and glutamate-rich 1
PRTase_3 (PF15610, IPR028944): PRTase ComF-like
Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
22 HOMEZinteractor21.0000Homeobox_KN (PF05920, IPR008422): Homeobox KN domain
Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
Homez (PF11569, IPR024578): Homeodomain leucine-zipper encoding, Homez
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
PRIMA1 (PF16101): Proline-rich membrane anchor 1
23 HUWE1oncoprotein100.38921.907BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
24 KRT13interactor40.6670.863Filament (PF00038, IPR001664): Intermediate filament protein
FliD_N (PF02465, IPR003481): Flagellar hook-associated protein 2 N-terminus
Keratin_2_head (PF16208, IPR032444): Keratin type II head
25 KRT19suppressor60.5004.483Filament (PF00038, IPR001664): Intermediate filament protein
26 KRT20interactor90.42912.333Duffy_binding (PF05424, IPR008602): Duffy binding domain
Filament (PF00038, IPR001664): Intermediate filament protein
27 KRT31interactor60.46721.296Filament (PF00038, IPR001664): Intermediate filament protein
28 KRT40interactor50.6002.030Filament (PF00038, IPR001664): Intermediate filament protein
UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
29 KRTAP10-5interactor80.5247.967Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
30 KRTAP10-8interactor90.6795.092Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
PMG (PF05287, IPR007951): PMG protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
31 KRTAP10-9interactor100.55611.759Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
32 KRTAP4-12interactor90.60727.517Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
33 LZTS2suppressor30.6670.667CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
DUF1127 (PF06568, IPR009506): Domain of unknown function (DUF1127)
Fez1 (PF06818): Fez1
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
DUF4250 (PF14056, IPR025346): Domain of unknown function (DUF4250)
34 MAGED1protein found in more fusions31.0000MAGE (PF01454, IPR002190): MAGE family
35 MAPRE3interactor100CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EB1 (PF03271, IPR004953): EB1-like C-terminal motif
36 MDFIinteractor80.23859.940MDFI (PF15316, IPR026134): MyoD family inhibitor
37 MIPOL1interactor200Bac_globin (PF01152, IPR001486): Bacterial-like globin
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
DUF1003 (PF06210, IPR010406): Protein of unknown function (DUF1003)
ZapB (PF06005, IPR009252): Cell division protein ZapB
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Rho_Binding (PF08912, IPR015008): Rho Binding
IL17R_fnIII_D2 (PF16578): Interleukin 17 receptor D
38 MYOGinteractor30.6671.000Basic (PF01586, IPR002546, SM00520): Myogenic Basic domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
39 NECAB2interactor40.6670.333ABM (PF03992, IPR007138): Antibiotic biosynthesis monooxygenase
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
40 NOTCH2NLinteractor80.5717.426EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
41 PRDM14interactor100Desulfoferrod_N (PF06397, IPR004462): Desulfoferrodoxin, N-terminal domain
SET (PF00856, IPR001214, SM00317): SET domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
42 RELoncoprotein30.6671.000RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
43 SPAG5interactor30.33310.824CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF1307 (PF06998, IPR009736): Protein of unknown function (DUF1307)
DUF1515 (PF07439, IPR010889): Protein of unknown function (DUF1515)
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
DUF3573 (PF12097, IPR021956): Protein of unknown function (DUF3573)
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
DUF4266 (PF14086, IPR025362): Domain of unknown function (DUF4266)
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
44 SPERTinteractor200ZapB (PF06005, IPR009252): Cell division protein ZapB
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Chibby (PF14645, IPR028118): Chibby family
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
45 SPRY2suppressor80.6676.552KAR9 (PF08580, IPR013889): Yeast cortical protein KAR9
Sprouty (PF05210, IPR007875): Sprouty protein (Spry)
46 TADA2Ainteractor21.0000SWIRM (PF04433, IPR007526): SWIRM domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
47 TCF4suppressor40.5002.667CDC45 (PF02724, IPR003874): CDC45-like protein
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
48 TMCC2protein found in more fusions60.5004.923Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
49 TP53suppressor100.30663.926DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
50 TRAF6protein found in more fusions50.5002.667SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
51 TRIM27oncoprotein60.5004.083IncA (PF04156, IPR007285): IncA protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
52 TRIM54interactor50.5002.333DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349)
zf-HIT (PF04438, IPR007529): HIT zinc finger
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
53 TUBGCP3interactor40.6670.800Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family
54 UBE2L3interactor50.5002.333UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
55 UBXN11interactor30.6670.500DivIC (PF04977, IPR007060): Septum formation initiator
SEP (PF08059, IPR012989, SM00553): SEP domain
UBX (PF00789, IPR001012, SM00166): UBX domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
TRPM_tetra (PF16519, IPR032415): Tetramerisation domain of TRPM
56 USHBP1interactor90.28615.988DASH_Dam1 (PF08653, IPR013962): DASH complex subunit Dam1
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
SlyX (PF04102, IPR007236): SlyX
MCC-bdg_PDZ (PF10506, IPR019536): PDZ domain of MCC-2 bdg protein for Usher syndrome
YlqD (PF11068, IPR021297): YlqD protein
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
CAGE1 (PF15066, IPR029381): Cancer-associated gene protein 1 family
TEX13 (PF15186, IPR028193): Testis-expressed sequence 13 protein family
57 USP4oncoprotein50.5002.667UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337, IPR006615, SM00695): DUSP domain
Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain
58 USP54interactor40.50013.240UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
59 WDR83interactor21.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
60 XPO1interactor120.22750.406CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
61 YWHABinteractor70.4299.44814-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
62 YWHAEoncoprotein60.6672.60014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
63 ZBTB9interactor30.6670.952BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2HC_2 (PF13913): zinc-finger of a C2HC-type
PRIMA1 (PF16101): Proline-rich membrane anchor 1
64 ZNF598interactor31.0000Arc_trans_TRASH (PF08394, IPR013603): Archaeal TRASH domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_4 (PF13894): C2H2-type zinc finger

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