Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	62
The number (and %) of the onco-proteins	13 (20.97 %)
The number (and %) of the tumor suppressors	7 (11.29 %)
Total number of binary PPIs (saturation %)	205 (10.84 %)
The number (and %) of affected PPIs	60 (29.27 %)
The number of possible different fusions	12
PPI diameter	2
PPI radius	inf
The average degree of PPI	5.710
Assortativity coefficient	-0.3501
The network average Clustering coefficient	0.542
The number (and %) of a zero Clustering coefficients	7 (11.29 %)
The number (and %) of a zero Betweenness Centrality	17 (27.42 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: RNA45SN2,EIF4E2	All fusions
Proteins found in more fusions	AMOTL2 (see 1 fusions); ARIH1 (see 4 fusions); KRT19 (see 1 fusions); TRAF6 (see 1 fusions); HUWE1 (see 4 fusions); APP (see 5 fusions); AES (see 3 fusions); MAGED1 (see 1 fusions); MIPOL1 (see 1 fusions); TMCC2 (see 3 fusions); TP53 (see 3 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	RNA45SN2	interactor	0	0	0	NA
2	EIF4E2	parental protein	60	0.066	2914.133	IF4E (PF01652, IPR001040): Eukaryotic initiation factor 4E
3	ADAMTSL4	interactor	6	0.867	0.800	ADAM_spacer1 (PF05986, IPR010294): ADAM-TS Spacer 1 PLAC (PF08686, IPR010909, SM00022): PLAC (protease and lacunin) domain TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain Zn_ribbon_17 (PF17120): Zinc-ribbon, C4HC2 type
4	AES	protein found in more fusions	15	0.209	64.167	TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain
5	AMOTL2	protein found in more fusions	13	0.242	43.167	HOOK (PF05622, IPR008636): HOOK protein SlyX (PF04102, IPR007236): SlyX Angiomotin_C (PF12240, IPR024646): Angiomotin C terminal Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
6	APP	protein found in more fusions	8	0.333	13.667	APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP) BUD22 (PF09073, IPR015158): BUD22 IncA (PF04156, IPR007285): IncA protein Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
7	ARIH1	protein found in more fusions	4	0.667	0.667	CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain Med14 (PF08638, IPR013947): Mediator complex subunit MED14 zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
8	CARD9	interactor	11	0.311	25.000	CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper IncA (PF04156, IPR007285): IncA protein NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
9	CDR2	interactor	4	1.000	0	DivIC (PF04977, IPR007060): Septum formation initiator SlyX (PF04102, IPR007236): SlyX Striatin (PF08232, IPR013258): Striatin family BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2 zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452) DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
10	DIS3L	interactor	4	0.833	0.667	RNB (PF00773, SM00955): RNB domain Rrp44_CSD1 (PF17216): Rrp44-like cold shock domain Rrp44_S1 (PF17215): S1 domain
11	EIF3F	suppressor	3	0.667	0.667	JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
12	EIF4EBP3	interactor	1	0	0	eIF_4EBP (PF05456, IPR008606): Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
13	EIF4ENIF1	interactor	4	0.500	2.067	EIF4E-T (PF10477, IPR018862): Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E DUF4718 (PF15842, IPR031695): Domain of unknown function (DUF4718)
14	FAM58A	interactor	1	0	0	Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
15	FBXO25	suppressor	2	1.000	0	Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
16	FBXW11	interactor	11	0.333	24.833	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain F-box-like (PF12937, IPR001810): F-box-like
17	FERMT3	interactor	2	1.000	0	FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain
18	GIGYF1	interactor	3	0.667	0.500	GYF (PF02213, IPR003169, SM00444): GYF domain RNase_H2-Ydr279 (PF09468, IPR019024): Ydr279p protein family (RNase H2 complex component) PRTase_3 (PF15610, IPR028944): PRTase ComF-like VIR_N (PF15912, IPR031801): Virilizer, N-terminal
19	GIGYF2	interactor	9	0.361	18.833	DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) GYF (PF02213, IPR003169, SM00444): GYF domain Macoilin (PF09726, IPR019130): Transmembrane protein Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3 DUF3801 (PF12687, IPR024234): Protein of unknown function (DUF3801) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term AAA_23 (PF13476): AAA domain ARGLU (PF15346): Arginine and glutamate-rich 1 PRTase_3 (PF15610, IPR028944): PRTase ComF-like Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
20	HOMEZ	interactor	2	1.000	0	Homeobox_KN (PF05920, IPR008422): Homeobox KN domain Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein Homeobox (PF00046, IPR001356, SM00389): Homeobox domain Homez (PF11569, IPR024578): Homeodomain leucine-zipper encoding, Homez WRNPLPNID (PF15017): Putative WW-binding domain and destruction box PRIMA1 (PF16101): Proline-rich membrane anchor 1
21	HUWE1	oncoprotein	10	0.389	18.700	BUD22 (PF09073, IPR015158): BUD22 DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908) DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Mucin (PF01456, IPR000458): Mucin-like glycoprotein Nop14 (PF04147, IPR007276): Nop14-like family PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32 RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain WWE (PF02825, IPR004170, SM00678): WWE domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54 U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
22	KRT13	interactor	4	0.667	0.667	Filament (PF00038, IPR001664): Intermediate filament protein FliD_N (PF02465, IPR003481): Flagellar hook-associated protein 2 N-terminus Keratin_2_head (PF16208, IPR032444): Keratin type II head
23	KRT19	suppressor	6	0.500	3.500	Filament (PF00038, IPR001664): Intermediate filament protein
24	KRT20	interactor	9	0.429	12.333	Duffy_binding (PF05424, IPR008602): Duffy binding domain Filament (PF00038, IPR001664): Intermediate filament protein
25	KRT31	interactor	5	0.600	1.667	Filament (PF00038, IPR001664): Intermediate filament protein
26	KRT40	interactor	5	0.600	1.833	Filament (PF00038, IPR001664): Intermediate filament protein UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
27	KRTAP10-5	interactor	8	0.524	7.967	Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
28	KRTAP10-8	interactor	9	0.679	4.800	Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein PMG (PF05287, IPR007951): PMG protein Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
29	KRTAP10-9	interactor	10	0.556	11.467	Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
30	KRTAP4-12	interactor	8	0.810	1.600	Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
31	LZTS2	suppressor	3	0.667	0.667	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal DUF1127 (PF06568, IPR009506): Domain of unknown function (DUF1127) Fez1 (PF06818): Fez1 ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding DUF4250 (PF14056, IPR025346): Domain of unknown function (DUF4250)
32	MAGED1	protein found in more fusions	3	1.000	0	MAGE (PF01454, IPR002190): MAGE family
33	MAPRE3	interactor	1	0	0	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain EB1 (PF03271, IPR004953): EB1-like C-terminal motif
34	MDFI	interactor	6	0.400	5.667	MDFI (PF15316, IPR026134): MyoD family inhibitor
35	MIPOL1	protein found in more fusions	2	0	0	Bac_globin (PF01152, IPR001486): Bacterial-like globin CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding DUF1003 (PF06210, IPR010406): Protein of unknown function (DUF1003) ZapB (PF06005, IPR009252): Cell division protein ZapB DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Rho_Binding (PF08912, IPR015008): Rho Binding IL17R_fnIII_D2 (PF16578): Interleukin 17 receptor D
36	MYOG	interactor	3	0.667	1.000	Basic (PF01586, IPR002546, SM00520): Myogenic Basic domain HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
37	NECAB2	interactor	4	0.667	0.333	ABM (PF03992, IPR007138): Antibiotic biosynthesis monooxygenase EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
38	NOTCH2NL	interactor	8	0.571	7.133	EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
39	PRDM14	interactor	1	0	0	Desulfoferrod_N (PF06397, IPR004462): Desulfoferrodoxin, N-terminal domain SET (PF00856, IPR001214, SM00317): SET domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger
40	REL	oncoprotein	3	0.667	1.000	RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
41	SPAG5	interactor	2	1.000	0	CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) DUF1307 (PF06998, IPR009736): Protein of unknown function (DUF1307) DUF1515 (PF07439, IPR010889): Protein of unknown function (DUF1515) DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein DUF3573 (PF12097, IPR021956): Protein of unknown function (DUF3573) DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) DUF4266 (PF14086, IPR025362): Domain of unknown function (DUF4266) BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
42	SPERT	interactor	2	0	0	ZapB (PF06005, IPR009252): Cell division protein ZapB DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407) Chibby (PF14645, IPR028118): Chibby family JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
43	SPRY2	suppressor	8	0.667	5.467	KAR9 (PF08580, IPR013889): Yeast cortical protein KAR9 Sprouty (PF05210, IPR007875): Sprouty protein (Spry)
44	TADA2A	interactor	2	1.000	0	SWIRM (PF04433, IPR007526): SWIRM domain Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
45	TCF4	suppressor	4	0.500	2.667	CDC45 (PF02724, IPR003874): CDC45-like protein HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
46	TMCC2	protein found in more fusions	6	0.500	4.333	Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
47	TP53	suppressor	9	0.393	15.467	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
48	TRAF6	protein found in more fusions	5	0.500	2.667	SlyX (PF04102, IPR007236): SlyX zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
49	TRIM27	oncoprotein	6	0.500	3.500	IncA (PF04156, IPR007285): IncA protein SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger PRY (PF13765, IPR006574, SM00589): SPRY-associated domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
50	TRIM54	interactor	5	0.500	2.333	DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349) zf-HIT (PF04438, IPR007529): HIT zinc finger zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
51	TUBGCP3	interactor	4	0.667	0.800	Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family
52	UBE2L3	interactor	5	0.500	2.333	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
53	UBXN11	interactor	3	0.667	0.500	DivIC (PF04977, IPR007060): Septum formation initiator SEP (PF08059, IPR012989, SM00553): SEP domain UBX (PF00789, IPR001012, SM00166): UBX domain DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) TRPM_tetra (PF16519, IPR032415): Tetramerisation domain of TRPM
54	USHBP1	interactor	9	0.286	15.000	DASH_Dam1 (PF08653, IPR013962): DASH complex subunit Dam1 HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper SlyX (PF04102, IPR007236): SlyX MCC-bdg_PDZ (PF10506, IPR019536): PDZ domain of MCC-2 bdg protein for Usher syndrome YlqD (PF11068, IPR021297): YlqD protein DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404) CAGE1 (PF15066, IPR029381): Cancer-associated gene protein 1 family TEX13 (PF15186, IPR028193): Testis-expressed sequence 13 protein family
55	USP4	oncoprotein	5	0.500	2.667	UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase DUSP (PF06337, IPR006615, SM00695): DUSP domain Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain
56	USP54	interactor	3	1.000	0	UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
57	WDR83	interactor	2	1.000	0	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
58	XPO1	interactor	12	0.227	46.567	CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
59	YWHAB	interactor	7	0.429	9.133	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein Virulence_fact (PF13769, IPR025989): Virulence factor
60	YWHAE	oncoprotein	6	0.667	2.400	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
61	ZBTB9	interactor	3	0.667	0.667	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-C2HC_2 (PF13913): zinc-finger of a C2HC-type PRIMA1 (PF16101): Proline-rich membrane anchor 1
62	ZNF598	interactor	3	1.000	0	Arc_trans_TRASH (PF08394, IPR013603): Archaeal TRASH domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-C2H2_4 (PF13894): C2H2-type zinc finger

B a c k t o T o p ⇑

Fusion ID: Protein names:	9470 109864279
Level of PPIs:	or Upload text file:	Update repository

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List of active interactors