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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ITM2B, HOMER1 (from a repository: Sun Jul 28 08:36:22 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)60
The number (and %) of the onco-proteins11 (18.33 %)
The number (and %) of the tumor suppressors5 (8.33 %)
Total number of binary PPIs (saturation %)102 (5.76 %)
The number (and %) of affected PPIs58 (56.86 %)
The number of possible different fusions6
PPI diameter5
PPI radius3
The average degree of PPI2.800
Assortativity coefficient-0.6032
The network average Clustering coefficient0.272
The number (and %) of a zero Clustering coefficients36 (60.00 %)
The number (and %) of a zero Betweenness Centrality41 (68.33 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ITM2B,HOMER1 All fusions
Proteins found in more fusions RYR2 (see 2 fusions); GRAMD2B (see 4 fusions); PARK2 (see 1 fusions); TPM1 (see 2 fusions); ACTB (see 7 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ITM2Bparental protein300.0072434.667BRICHOS (PF04089, IPR007084, SM01039): BRICHOS domain
SpoVG (PF04026, IPR007170): SpoVG
2 HOMER1parental protein280.0501982.933WH1 (PF00568, IPR000697, SM00461): WH1 domain
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
3 ABI3interactor31.0000Abi_HHR (PF07815, IPR012849): Abl-interactor HHR
Drf_FH1 (PF06346, IPR009408): Formin Homology Region 1
SH3_9 (PF14604, IPR001452): Variant SH3 domain
4 ACTBoncoprotein50.500384.400Actin (PF00022, IPR004000, SM00268): Actin
5 AGAP2oncoprotein100ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
PH (PF00169, IPR001849, SM00233): PH domain
Ras (PF00071, IPR001806, SM00173): Ras family
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
6 AIMP1suppressor100DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
PRP1_N (PF06424, IPR010491): PRP1 splicing factor, N-terminal
tRNA_bind (PF01588, IPR002547): Putative tRNA binding domain
7 AMIGO1interactor200I-set (PF07679, IPR013098): Immunoglobulin I-set domain
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
8 ATF6Binteractor200bZIP_1 (PF00170, IPR004827): bZIP transcription factor
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
9 B4GALNT1interactor200Glycos_transf_2 (PF00535, IPR001173): Glycosyl transferase family 2
GspH (PF12019, IPR022346): Type II transport protein GspH
10 BCL2oncoprotein40883.200Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
11 BTN2A2interactor21.0000C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
Phage_holin_3_6 (PF07332, IPR009937): Putative Actinobacterial Holin-X, holin superfamily III
IncA (PF04156, IPR007285): IncA protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
12 C19orf57interactor200DUF4671 (PF15710, IPR031441): Domain of unknown function (DUF4671)
13 C1orf116interactor100SARG (PF15385): Specifically androgen-regulated gene protein
14 CACNA2D1interactor100dCache_1 (PF02743, IPR004010): Cache domain
VGCC_alpha2 (PF08473, IPR013680): Neuronal voltage-dependent calcium channel alpha 2acd
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
VWA_N (PF08399, IPR013608): VWA N-terminal
VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
15 CCDC155interactor100CorA (PF01544, IPR002523): CorA-like Mg2+ transporter protein
EF-hand_9 (PF14658): EF-hand domain
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
16 CHST12interactor100Sulfotransfer_2 (PF03567, IPR005331): Sulfotransferase family
17 CREB3interactor31.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
18 CSPP1interactor30.6671.000Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region
DUF1168 (PF06658, IPR009548): Protein of unknown function (DUF1168)
IncA (PF04156, IPR007285): IncA protein
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term
DUF4578 (PF15147, IPR028106): Domain of unknown function (DUF4578)
CCDC66 (PF15236): Coiled-coil domain-containing protein 66
19 DBN1oncoprotein30.6671.000Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
20 DCBLD2interactor100CUB (PF00431, IPR000859, SM00042): CUB domain
LCCL (PF03815, IPR004043, SM00603): LCCL domain
Syndecan (PF01034, IPR027789): Syndecan domain
F5_F8_type_C (PF00754, IPR000421, SM00231): F5/8 type C domain
21 EEF1A2oncoprotein31.0000GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
22 FAM234Binteractor100FG-GAP (PF01839, IPR013517): FG-GAP repeat
PQQ (PF01011, IPR002372, SM00564): PQQ enzyme repeat
PQQ_2 (PF13360, IPR002372): PQQ-like domain
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
23 FBXO28interactor100Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
F-box (PF00646, IPR001810, SM00256): F-box domain
FAM76 (PF16046, IPR032017): FAM76 protein
24 GLG1interactor100BAT2_N (PF07001, IPR009738): BAT2 N-terminus
Cys_rich_FGFR (PF00839, IPR001893): Cysteine rich repeat
25 GRAMD2Bprotein found in more fusions200GRAM (PF02893, IPR004182, SM00568): GRAM domain
7TM_GPCR_Srd (PF10317, IPR019421): Serpentine type 7TM GPCR chemoreceptor Srd
26 GRM1interactor31.00007tm_3 (PF00003, IPR017978): 7 transmembrane sweet-taste receptor of 3 GCPR
ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region
NCD3G (PF07562, IPR011500): Nine Cysteines Domain of family 3 GPCR
DUF2318 (PF10080, IPR018758): Predicted membrane protein (DUF2318)
GluR_Homer-bdg (PF10606, IPR019588): Homer-binding domain of metabotropic glutamate receptor
27 GRM5interactor1007tm_3 (PF00003, IPR017978): 7 transmembrane sweet-taste receptor of 3 GCPR
ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region
NCD3G (PF07562, IPR011500): Nine Cysteines Domain of family 3 GPCR
GluR_Homer-bdg (PF10606, IPR019588): Homer-binding domain of metabotropic glutamate receptor
28 HLA-Aoncoprotein21.0000DUF202 (PF02656, IPR003807): Domain of unknown function (DUF202)
MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
29 HOMER2suppressor40.5002.667MerR-DNA-bind (PF09278, IPR015358): MerR, DNA binding
WH1 (PF00568, IPR000697, SM00461): WH1 domain
Macoilin (PF09726, IPR019130): Transmembrane protein
30 HOMER3interactor80.33313.667COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2
MerR-DNA-bind (PF09278, IPR015358): MerR, DNA binding
WH1 (PF00568, IPR000697, SM00461): WH1 domain
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
31 HS6ST1interactor100Sulfotransfer_2 (PF03567, IPR005331): Sulfotransferase family
32 IFT57interactor30.6670.667IFT57 (PF10498, IPR019530): Intra-flagellar transport protein 57
33 KIF18Ainteractor100Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF4005 (PF13178, IPR025064): Protein of unknown function (DUF4005)
34 KIF5Cinteractor20355.400DivIC (PF04977, IPR007060): Septum formation initiator
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
DUF4226 (PF10774, IPR019710): Domain of unknown function (DUF4226)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
35 LRFN3interactor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
36 MED4interactor30.66712.867Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
37 MR1interactor100MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
38 NAALADL2interactor100Peptidase_M28 (PF04389, IPR007484): Peptidase family M28
TFR_dimer (PF04253, IPR007365): Transferrin receptor-like dimerisation domain
DUF4731 (PF15875, IPR031744): Domain of unknown function (DUF4731)
39 PARK2suppressor60.400429.267IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
40 PGAP1interactor100PGAP1 (PF07819, IPR012908): PGAP1-like protein
ChlI (PF13541): Subunit ChlI of Mg-chelatase
41 POU5F1oncoprotein200Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
42 RYKoncoprotein100Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
WIF (PF02019, IPR003306, SM00469): WIF domain
43 RYR1interactor40.5002.667CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
Ins145_P3_rec (PF08709, IPR014821): Inositol 1,4,5-trisphosphate/ryanodine receptor
Ion_trans (PF00520, IPR005821): Ion transport protein
Mak16 (PF04874, IPR006958): Mak16 protein C-terminal region
MIR (PF02815, IPR016093, SM00472): MIR domain
Na_trans_assoc (PF06512, IPR010526): Sodium ion transport-associated
RIH_assoc (PF08454, IPR013662): RyR and IP3R Homology associated
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
RYDR_ITPR (PF01365, IPR000699): RIH domain
RyR (PF02026, IPR003032): RyR domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
Urb2 (PF10441, IPR018849): Urb2/Npa2 family
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
44 RYR2protein found in more fusions31.0000Ins145_P3_rec (PF08709, IPR014821): Inositol 1,4,5-trisphosphate/ryanodine receptor
Ion_trans (PF00520, IPR005821): Ion transport protein
MIR (PF02815, IPR016093, SM00472): MIR domain
RIH_assoc (PF08454, IPR013662): RyR and IP3R Homology associated
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
RYDR_ITPR (PF01365, IPR000699): RIH domain
RyR (PF02026, IPR003032): RyR domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
SRP72 (PF08492, IPR013699): SRP72 RNA-binding domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
YjfB_motility (PF14070, IPR025906): Putative motility protein
45 SEMA4Finteractor100CbiM (PF01891, IPR002751): Cobalt uptake substrate-specific transmembrane region
CcmD (PF04995, IPR007078): Heme exporter protein D (CcmD)
PSI (PF01437, IPR002165, SM00423): Plexin repeat
Sema (PF01403, IPR001627, SM00630): Sema domain
46 SEMA6Ainteractor21.0000PSI (PF01437, IPR002165, SM00423): Plexin repeat
Sema (PF01403, IPR001627, SM00630): Sema domain
47 SPTBN4interactor100Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region
ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Laminin_II (PF06009, IPR010307): Laminin Domain II
Spectrin (PF00435, IPR002017): Spectrin repeat
PH_9 (PF15410): Pleckstrin homology domain
48 SYNE4interactor20360.067KASH (PF10541, IPR012315): Nuclear envelope localisation domain
49 TGFBR3suppressor100Delta_lysin (PF05372, IPR008034): Delta lysin family
Zona_pellucida (PF00100, IPR001507, SM00241): Zona pellucida-like domain
50 TMEM17interactor30.6671.000Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
51 TMEM219interactor100TMEM219 (PF14940): Transmembrane 219
TMEM52 (PF14979): Transmembrane 52
52 TMEM59Linteractor100BSMAP (PF12280, IPR022065): Brain specific membrane anchored protein
53 TP53BP2suppressor30.333394.267ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Erp_C (PF06780, IPR009618): Erp protein C-terminus
SlyX (PF04102, IPR007236): SlyX
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
54 TPM1protein found in more fusions40.66712.867Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
55 TRAF5interactor200Sina (PF03145, IPR018121): Seven in absentia protein family
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
HMMR_N (PF15905, IPR031787): Hyaluronan mediated motility receptor N-terminal
Spc29 (PF17082, IPR031392): Spindle Pole Component 29
56 TRPC1interactor50.6672.000Ion_trans (PF00520, IPR005821): Ion transport protein
TRP_2 (PF08344, IPR013555): Transient receptor ion channel II
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
57 TRPC2interactor200NA
58 TRPC5interactor31.0000Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Gp-FAR-1 (PF05823, IPR008632): Nematode fatty acid retinoid binding protein (Gp-FAR-1)
Ion_trans (PF00520, IPR005821): Ion transport protein
TRP_2 (PF08344, IPR013555): Transient receptor ion channel II
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
59 UBR1interactor100ATPase_2 (PF01637, IPR011579): ATPase domain predominantly from Archaea
ClpS (PF02617, IPR003769): ATP-dependent Clp protease adaptor protein ClpS
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
60 UNKinteractor20387.400MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain

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