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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CD33, RNA45S4 (from a repository: Thu Jul 25 14:28:46 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)12
The number (and %) of the onco-proteins0 (0.00 %)
The number (and %) of the tumor suppressors3 (25.00 %)
Total number of binary PPIs (saturation %)14 (21.21 %)
The number (and %) of affected PPIs10 (71.43 %)
The number of possible different fusions2
PPI diameter2
PPI radiusinf
The average degree of PPI2.000
Assortativity coefficient-0.7016
The network average Clustering coefficient0.226
The number (and %) of a zero Clustering coefficients8 (66.67 %)
The number (and %) of a zero Betweenness Centrality10 (83.33 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CD33,RNA45S4 All fusions
Proteins found in more fusions PTPN11 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CD33parental protein100.04485.000DUF998 (PF06197, IPR009339): Protein of unknown function (DUF998)
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
2 RNA45S4interactor000NA
3 CBLsuppressor40.6671.000Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1
Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain
Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
4 COMMD3interactor100COMM_domain (PF07258): COMM domain
5 HERC3interactor100RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
6 KRT31interactor100Filament (PF00038, IPR001664): Intermediate filament protein
7 KRT40interactor100Filament (PF00038, IPR001664): Intermediate filament protein
UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
8 PEX19interactor100Pex19 (PF04614, IPR006708): Pex19 protein family
Rod-binding (PF10135, IPR019301): Rod binding protein
9 PTPN11suppressor31.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
10 PTPN6suppressor21.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
PolyA_pol_arg_C (PF12626, IPR025866): Polymerase A arginine-rich C-terminus
11 SAAL1interactor100NA
12 SLC39A11interactor100Zip (PF02535, IPR003689): ZIP Zinc transporter

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