Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins ITM2B, HOMER1 (from a repository: Sun Jul 28 08:36:22 2019)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 60 The number (and %) of the onco-proteins 11 (18.33 %) The number (and %) of the tumor suppressors 5 (8.33 %) Total number of binary PPIs (saturation %) 102 (5.76 %) The number (and %) of affected PPIs 58 (56.86 %) The number of possible different fusions 6 PPI diameter 5 PPI radius 3 The average degree of PPI 2.800 Assortativity coefficient -0.6032 The network average Clustering coefficient 0.272 The number (and %) of a zero Clustering coefficients 36 (60.00 %) The number (and %) of a zero Betweenness Centrality 41 (68.33 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: ITM2B,HOMER1	All fusions
Proteins found in more fusions	RYR2 (see 2 fusions); GRAMD2B (see 4 fusions); PARK2 (see 1 fusions); TPM1 (see 2 fusions); ACTB (see 7 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	ITM2B	parental protein	30	0.007	2434.667	BRICHOS (PF04089, IPR007084, SM01039): BRICHOS domain SpoVG (PF04026, IPR007170): SpoVG
2	HOMER1	parental protein	28	0.050	1982.933	WH1 (PF00568, IPR000697, SM00461): WH1 domain TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
3	ABI3	interactor	3	1.000	0	Abi_HHR (PF07815, IPR012849): Abl-interactor HHR Drf_FH1 (PF06346, IPR009408): Formin Homology Region 1 SH3_9 (PF14604, IPR001452): Variant SH3 domain
4	ACTB	oncoprotein	5	0.500	384.400	Actin (PF00022, IPR004000, SM00268): Actin
5	AGAP2	oncoprotein	1	0	0	ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf PH (PF00169, IPR001849, SM00233): PH domain Ras (PF00071, IPR001806, SM00173): Ras family Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
6	AIMP1	suppressor	1	0	0	DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region PRP1_N (PF06424, IPR010491): PRP1 splicing factor, N-terminal tRNA_bind (PF01588, IPR002547): Putative tRNA binding domain
7	AMIGO1	interactor	2	0	0	I-set (PF07679, IPR013098): Immunoglobulin I-set domain LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat
8	ATF6B	interactor	2	0	0	bZIP_1 (PF00170, IPR004827): bZIP transcription factor NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
9	B4GALNT1	interactor	2	0	0	Glycos_transf_2 (PF00535, IPR001173): Glycosyl transferase family 2 GspH (PF12019, IPR022346): Type II transport protein GspH
10	BCL2	oncoprotein	4	0	883.200	Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
11	BTN2A2	interactor	2	1.000	0	C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain Phage_holin_3_6 (PF07332, IPR009937): Putative Actinobacterial Holin-X, holin superfamily III IncA (PF04156, IPR007285): IncA protein SPRY (PF00622, IPR003877, SM00449): SPRY domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
12	C19orf57	interactor	2	0	0	DUF4671 (PF15710, IPR031441): Domain of unknown function (DUF4671)
13	C1orf116	interactor	1	0	0	SARG (PF15385): Specifically androgen-regulated gene protein
14	CACNA2D1	interactor	1	0	0	dCache_1 (PF02743, IPR004010): Cache domain VGCC_alpha2 (PF08473, IPR013680): Neuronal voltage-dependent calcium channel alpha 2acd VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain VWA_N (PF08399, IPR013608): VWA N-terminal VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
15	CCDC155	interactor	1	0	0	CorA (PF01544, IPR002523): CorA-like Mg2+ transporter protein EF-hand_9 (PF14658): EF-hand domain KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
16	CHST12	interactor	1	0	0	Sulfotransfer_2 (PF03567, IPR005331): Sulfotransferase family
17	CREB3	interactor	3	1.000	0	bZIP_1 (PF00170, IPR004827): bZIP transcription factor GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
18	CSPP1	interactor	3	0.667	1.000	Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region DUF1168 (PF06658, IPR009548): Protein of unknown function (DUF1168) IncA (PF04156, IPR007285): IncA protein OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term DUF4578 (PF15147, IPR028106): Domain of unknown function (DUF4578) CCDC66 (PF15236): Coiled-coil domain-containing protein 66
19	DBN1	oncoprotein	3	0.667	1.000	Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
20	DCBLD2	interactor	1	0	0	CUB (PF00431, IPR000859, SM00042): CUB domain LCCL (PF03815, IPR004043, SM00603): LCCL domain Syndecan (PF01034, IPR027789): Syndecan domain F5_F8_type_C (PF00754, IPR000421, SM00231): F5/8 type C domain
21	EEF1A2	oncoprotein	3	1.000	0	GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
22	FAM234B	interactor	1	0	0	FG-GAP (PF01839, IPR013517): FG-GAP repeat PQQ (PF01011, IPR002372, SM00564): PQQ enzyme repeat PQQ_2 (PF13360, IPR002372): PQQ-like domain VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
23	FBXO28	interactor	1	0	0	Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit F-box (PF00646, IPR001810, SM00256): F-box domain FAM76 (PF16046, IPR032017): FAM76 protein
24	GLG1	interactor	1	0	0	BAT2_N (PF07001, IPR009738): BAT2 N-terminus Cys_rich_FGFR (PF00839, IPR001893): Cysteine rich repeat
25	GRAMD2B	protein found in more fusions	2	0	0	GRAM (PF02893, IPR004182, SM00568): GRAM domain 7TM_GPCR_Srd (PF10317, IPR019421): Serpentine type 7TM GPCR chemoreceptor Srd
26	GRM1	interactor	3	1.000	0	7tm_3 (PF00003, IPR017978): 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region NCD3G (PF07562, IPR011500): Nine Cysteines Domain of family 3 GPCR DUF2318 (PF10080, IPR018758): Predicted membrane protein (DUF2318) GluR_Homer-bdg (PF10606, IPR019588): Homer-binding domain of metabotropic glutamate receptor
27	GRM5	interactor	1	0	0	7tm_3 (PF00003, IPR017978): 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region NCD3G (PF07562, IPR011500): Nine Cysteines Domain of family 3 GPCR GluR_Homer-bdg (PF10606, IPR019588): Homer-binding domain of metabotropic glutamate receptor
28	HLA-A	oncoprotein	2	1.000	0	DUF202 (PF02656, IPR003807): Domain of unknown function (DUF202) MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2 MHC_I_C (PF06623, IPR010579): MHC_I C-terminus C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
29	HOMER2	suppressor	4	0.500	2.667	MerR-DNA-bind (PF09278, IPR015358): MerR, DNA binding WH1 (PF00568, IPR000697, SM00461): WH1 domain Macoilin (PF09726, IPR019130): Transmembrane protein
30	HOMER3	interactor	8	0.333	13.667	COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2 MerR-DNA-bind (PF09278, IPR015358): MerR, DNA binding WH1 (PF00568, IPR000697, SM00461): WH1 domain bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
31	HS6ST1	interactor	1	0	0	Sulfotransfer_2 (PF03567, IPR005331): Sulfotransferase family
32	IFT57	interactor	3	0.667	0.667	IFT57 (PF10498, IPR019530): Intra-flagellar transport protein 57
33	KIF18A	interactor	1	0	0	Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain DUF4005 (PF13178, IPR025064): Protein of unknown function (DUF4005)
34	KIF5C	interactor	2	0	355.400	DivIC (PF04977, IPR007060): Septum formation initiator DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1 Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate DUF4226 (PF10774, IPR019710): Domain of unknown function (DUF4226) PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
35	LRFN3	interactor	1	0	0	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat
36	MED4	interactor	3	0.667	12.867	Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
37	MR1	interactor	1	0	0	MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
38	NAALADL2	interactor	1	0	0	Peptidase_M28 (PF04389, IPR007484): Peptidase family M28 TFR_dimer (PF04253, IPR007365): Transferrin receptor-like dimerisation domain DUF4731 (PF15875, IPR031744): Domain of unknown function (DUF4731)
39	PARK2	suppressor	6	0.400	429.267	IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
40	PGAP1	interactor	1	0	0	PGAP1 (PF07819, IPR012908): PGAP1-like protein ChlI (PF13541): Subunit ChlI of Mg-chelatase
41	POU5F1	oncoprotein	2	0	0	Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
42	RYK	oncoprotein	1	0	0	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase WIF (PF02019, IPR003306, SM00469): WIF domain
43	RYR1	interactor	4	0.500	2.667	CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510) DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840) Ins145_P3_rec (PF08709, IPR014821): Inositol 1,4,5-trisphosphate/ryanodine receptor Ion_trans (PF00520, IPR005821): Ion transport protein Mak16 (PF04874, IPR006958): Mak16 protein C-terminal region MIR (PF02815, IPR016093, SM00472): MIR domain Na_trans_assoc (PF06512, IPR010526): Sodium ion transport-associated RIH_assoc (PF08454, IPR013662): RyR and IP3R Homology associated RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 RYDR_ITPR (PF01365, IPR000699): RIH domain RyR (PF02026, IPR003032): RyR domain SPRY (PF00622, IPR003877, SM00449): SPRY domain Urb2 (PF10441, IPR018849): Urb2/Npa2 family DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391) Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
44	RYR2	protein found in more fusions	3	1.000	0	Ins145_P3_rec (PF08709, IPR014821): Inositol 1,4,5-trisphosphate/ryanodine receptor Ion_trans (PF00520, IPR005821): Ion transport protein MIR (PF02815, IPR016093, SM00472): MIR domain RIH_assoc (PF08454, IPR013662): RyR and IP3R Homology associated RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 RYDR_ITPR (PF01365, IPR000699): RIH domain RyR (PF02026, IPR003032): RyR domain SPRY (PF00622, IPR003877, SM00449): SPRY domain SRP72 (PF08492, IPR013699): SRP72 RNA-binding domain EF-hand_8 (PF13833, IPR002048): EF-hand domain pair YjfB_motility (PF14070, IPR025906): Putative motility protein
45	SEMA4F	interactor	1	0	0	CbiM (PF01891, IPR002751): Cobalt uptake substrate-specific transmembrane region CcmD (PF04995, IPR007078): Heme exporter protein D (CcmD) PSI (PF01437, IPR002165, SM00423): Plexin repeat Sema (PF01403, IPR001627, SM00630): Sema domain
46	SEMA6A	interactor	2	1.000	0	PSI (PF01437, IPR002165, SM00423): Plexin repeat Sema (PF01403, IPR001627, SM00630): Sema domain
47	SPTBN4	interactor	1	0	0	Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) Laminin_II (PF06009, IPR010307): Laminin Domain II Spectrin (PF00435, IPR002017): Spectrin repeat PH_9 (PF15410): Pleckstrin homology domain
48	SYNE4	interactor	2	0	360.067	KASH (PF10541, IPR012315): Nuclear envelope localisation domain
49	TGFBR3	suppressor	1	0	0	Delta_lysin (PF05372, IPR008034): Delta lysin family Zona_pellucida (PF00100, IPR001507, SM00241): Zona pellucida-like domain
50	TMEM17	interactor	3	0.667	1.000	Transmemb_17 (PF09799, IPR019184): Predicted membrane protein DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
51	TMEM219	interactor	1	0	0	TMEM219 (PF14940): Transmembrane 219 TMEM52 (PF14979): Transmembrane 52
52	TMEM59L	interactor	1	0	0	BSMAP (PF12280, IPR022065): Brain specific membrane anchored protein
53	TP53BP2	suppressor	3	0.333	394.267	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) Erp_C (PF06780, IPR009618): Erp protein C-terminus SlyX (PF04102, IPR007236): SlyX SH3_1 (PF00018, IPR001452, SM00326): SH3 domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
54	TPM1	protein found in more fusions	4	0.667	12.867	Tropomyosin (PF00261, IPR000533): Tropomyosin Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
55	TRAF5	interactor	2	0	0	Sina (PF03145, IPR018121): Seven in absentia protein family zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain HMMR_N (PF15905, IPR031787): Hyaluronan mediated motility receptor N-terminal Spc29 (PF17082, IPR031392): Spindle Pole Component 29
56	TRPC1	interactor	5	0.667	2.000	Ion_trans (PF00520, IPR005821): Ion transport protein TRP_2 (PF08344, IPR013555): Transient receptor ion channel II Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies)
57	TRPC2	interactor	2	0	0	NA
58	TRPC5	interactor	3	1.000	0	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat Gp-FAR-1 (PF05823, IPR008632): Nematode fatty acid retinoid binding protein (Gp-FAR-1) Ion_trans (PF00520, IPR005821): Ion transport protein TRP_2 (PF08344, IPR013555): Transient receptor ion channel II Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
59	UBR1	interactor	1	0	0	ATPase_2 (PF01637, IPR011579): ATPase domain predominantly from Archaea ClpS (PF02617, IPR003769): ATP-dependent Clp protease adaptor protein ClpS zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box) zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
60	UNK	interactor	2	0	387.400	MbeD_MobD (PF04899, IPR006983): MbeD/MobD like NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger Torus (PF16131, IPR032297): Torus domain

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