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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)54
The number (and %) of the onco-proteins11 (20.37 %)
The number (and %) of the tumor suppressors1 (1.85 %)
Total number of binary PPIs (saturation %)134 (9.36 %)
The number (and %) of affected PPIs52 (38.81 %)
The number of possible different fusions5
PPI diameter5
PPI radius3
The average degree of PPI4.296
Assortativity coefficient-0.4444
The network average Clustering coefficient0.241
The number (and %) of a zero Clustering coefficients26 (48.15 %)
The number (and %) of a zero Betweenness Centrality23 (42.59 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ITM2B,ZNF207 All fusions
Proteins found in more fusions ERBB3 (see 2 fusions); KPNB1 (see 2 fusions); EWSR1 (see 1 fusions); UBR5 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ITM2Bparental protein300.0071750.964BRICHOS (PF04089, IPR007084, SM01039): BRICHOS domain
SpoVG (PF04026, IPR007170): SpoVG
2 ZNF207parental protein220.173543.216MCPVI (PF02993, IPR004243): Minor capsid protein VI
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
zf-FCS (PF06467, IPR010507): MYM-type Zinc finger with FCS sequence motif
zf-C2H2_4 (PF13894): C2H2-type zinc finger
3 ABCE1interactor90.42997.593ABC_tran (PF00005, IPR003439): ABC transporter
Fer4 (PF00037, IPR001450): 4Fe-4S binding domain
RLI (PF04068, IPR007209): Possible Fer4-like domain in RNase L inhibitor, RLI
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain
AAA_29 (PF13555): P-loop containing region of AAA domain
4 AMIGO1interactor200I-set (PF07679, IPR013098): Immunoglobulin I-set domain
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
5 ATF6Binteractor4068.034bZIP_1 (PF00170, IPR004827): bZIP transcription factor
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
6 B4GALNT1interactor200Glycos_transf_2 (PF00535, IPR001173): Glycosyl transferase family 2
GspH (PF12019, IPR022346): Type II transport protein GspH
7 BCL2oncoprotein200Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
8 BTN2A2interactor21.0000C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
Phage_holin_3_6 (PF07332, IPR009937): Putative Actinobacterial Holin-X, holin superfamily III
IncA (PF04156, IPR007285): IncA protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
9 BUB3interactor80.42940.561WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
10 CACNA2D1interactor30.33395.203dCache_1 (PF02743, IPR004010): Cache domain
VGCC_alpha2 (PF08473, IPR013680): Neuronal voltage-dependent calcium channel alpha 2acd
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
VWA_N (PF08399, IPR013608): VWA N-terminal
VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
11 CCDC155interactor100CorA (PF01544, IPR002523): CorA-like Mg2+ transporter protein
EF-hand_9 (PF14658): EF-hand domain
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
12 CHST12interactor100Sulfotransfer_2 (PF03567, IPR005331): Sulfotransferase family
13 CREB3interactor50.16780.398bZIP_1 (PF00170, IPR004827): bZIP transcription factor
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
14 DCBLD2interactor100CUB (PF00431, IPR000859, SM00042): CUB domain
LCCL (PF03815, IPR004043, SM00603): LCCL domain
Syndecan (PF01034, IPR027789): Syndecan domain
F5_F8_type_C (PF00754, IPR000421, SM00231): F5/8 type C domain
15 ERBB3oncoprotein4025.384Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
16 EWSR1oncoprotein70.60017.189RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
17 FAM234Binteractor100FG-GAP (PF01839, IPR013517): FG-GAP repeat
PQQ (PF01011, IPR002372, SM00564): PQQ enzyme repeat
PQQ_2 (PF13360, IPR002372): PQQ-like domain
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
18 GLG1interactor2066.249BAT2_N (PF07001, IPR009738): BAT2 N-terminus
Cys_rich_FGFR (PF00839, IPR001893): Cysteine rich repeat
19 HECW2interactor40.6671.000C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
20 HLA-Aoncoprotein40.167105.343DUF202 (PF02656, IPR003807): Domain of unknown function (DUF202)
MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
21 HNRNPMinteractor70.47614.849RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNP_M (PF11532, IPR024666): Heterogeneous nuclear ribonucleoprotein M
Collagen_mid (PF15984, IPR031929): Bacterial collagen, middle region
22 HNRNPUL1interactor60.50013.139Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Rox3 (PF08633, IPR013942): Rox3 mediator complex subunit
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
23 HS6ST1interactor100Sulfotransfer_2 (PF03567, IPR005331): Sulfotransferase family
24 KIF18Ainteractor100Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF4005 (PF13178, IPR025064): Protein of unknown function (DUF4005)
25 KPNB1protein found in more fusions80.238132.662Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H
CLASP_N (PF12348, IPR024395): CLASP N terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
HEAT_EZ (PF13513): HEAT-like repeat
26 LRFN3interactor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
27 MAP2K2interactor200Pkinase (PF00069, IPR000719): Protein kinase domain
CAMSAP_CC1 (PF17095, IPR031372): Spectrin-binding region of Ca2+-Calmodulin
28 MOV10interactor60.20089.921AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
29 MR1interactor100MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
30 NAALADL2interactor100Peptidase_M28 (PF04389, IPR007484): Peptidase family M28
TFR_dimer (PF04253, IPR007365): Transferrin receptor-like dimerisation domain
DUF4731 (PF15875, IPR031744): Domain of unknown function (DUF4731)
31 NTRK1oncoprotein170.192352.186I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
32 NXF1interactor90.179138.018NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
33 PGAP1interactor100PGAP1 (PF07819, IPR012908): PGAP1-like protein
ChlI (PF13541): Subunit ChlI of Mg-chelatase
34 POLR1Binteractor31.0000RNA_pol_Rpa2_4 (PF06883, IPR009674): RNA polymerase I, Rpa2 specific domain
RNA_pol_Rpb2_1 (PF04563, IPR007644): RNA polymerase beta subunit
RNA_pol_Rpb2_3 (PF04565, IPR007645): RNA polymerase Rpb2, domain 3
RNA_pol_Rpb2_6 (PF00562, IPR007120): RNA polymerase Rpb2, domain 6
RNA_pol_Rpb2_7 (PF04560, IPR007641): RNA polymerase Rpb2, domain 7
35 POU5F1oncoprotein60209.851Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
36 RNPS1interactor60.53314.252RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
Macoilin (PF09726, IPR019130): Transmembrane protein
37 RYKoncoprotein40101.677Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
WIF (PF02019, IPR003306, SM00469): WIF domain
38 SEMA4Finteractor100CbiM (PF01891, IPR002751): Cobalt uptake substrate-specific transmembrane region
CcmD (PF04995, IPR007078): Heme exporter protein D (CcmD)
PSI (PF01437, IPR002165, SM00423): Plexin repeat
Sema (PF01403, IPR001627, SM00630): Sema domain
39 SEMA6Ainteractor21.0000PSI (PF01437, IPR002165, SM00423): Plexin repeat
Sema (PF01403, IPR001627, SM00630): Sema domain
40 SF3A2interactor60.4676.667Cytadhesin_P30 (PF07271, IPR009896): Cytadhesin P30/P32
PRP4 (PF08799, IPR014906): pre-mRNA processing factor 4 (PRP4) like
Totivirus_coat (PF05518, IPR008871): Totivirus coat protein
zf-met (PF12874): Zinc-finger of C2H2 type
ARL6IP6 (PF15062, IPR029383): Haemopoietic lineage transmembrane helix
SF3A2 (PF16835, IPR031781): Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11)
41 SHMT2interactor50.30060.344SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
42 SYNE4interactor100KASH (PF10541, IPR012315): Nuclear envelope localisation domain
43 TGFBR3suppressor100Delta_lysin (PF05372, IPR008034): Delta lysin family
Zona_pellucida (PF00100, IPR001507, SM00241): Zona pellucida-like domain
44 TMEM17interactor50.300125.815Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
45 TMEM219interactor100TMEM219 (PF14940): Transmembrane 219
TMEM52 (PF14979): Transmembrane 52
46 TMEM59Linteractor100BSMAP (PF12280, IPR022065): Brain specific membrane anchored protein
47 TXNDC5interactor21.0000Thioredoxin (PF00085, IPR013766): Thioredoxin
48 UBR1interactor30109.548ATPase_2 (PF01637, IPR011579): ATPase domain predominantly from Archaea
ClpS (PF02617, IPR003769): ATP-dependent Clp protease adaptor protein ClpS
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
49 UBR5protein found in more fusions40.33319.250CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
SDA1 (PF05285, IPR007949): SDA1
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain
E3_UbLigase_EDD (PF11547, IPR024725): E3 ubiquitin ligase EDD
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
50 UNKinteractor2057.863MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain
51 USP7oncoprotein90.393102.659MATH (PF00917, IPR002083, SM00061): MATH domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7
USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal
52 WBP4interactor40.6671.167CDC45 (PF02724, IPR003874): CDC45-like protein
WW (PF00397, IPR001202, SM00456): WW domain
zf-U1 (PF06220, IPR013085, SM00451): U1 zinc finger
TMCO5 (PF14992, IPR026617): TMCO5 family
53 WDR77oncoprotein60.60035.295LT-IIB (PF06453, IPR010503): Type II heat-labile enterotoxin , B subunit (LT-IIB)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
54 ZC3H14interactor30.6675.704PWI (PF01480, IPR002483, SM00311): PWI domain
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger

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