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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ITGA1, NRXN1 (from a repository: Sun Feb 12 13:36:48 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)23
The number (and %) of the onco-proteins4 (17.39 %)
The number (and %) of the tumor suppressors3 (13.04 %)
Total number of binary PPIs (saturation %)31 (12.25 %)
The number (and %) of affected PPIs21 (67.74 %)
The number of possible different fusions3
PPI diameter2
PPI radiusinf
The average degree of PPI2.261
Assortativity coefficient-0.7075
The network average Clustering coefficient0.200
The number (and %) of a zero Clustering coefficients17 (73.91 %)
The number (and %) of a zero Betweenness Centrality20 (86.96 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions LIMK1 (see 1 fusions); LGALS3 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 NRXN1parental protein10090.000EGF (PF00008, IPR000742, SM00181): EGF-like domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
Syndecan (PF01034, IPR027789): Syndecan domain
2 ITGA1parental protein110.09195.000FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
FG-GAP_2 (PF14312, IPR013517): FG-GAP repeat
LYRIC (PF15686, IPR031402): Lysine-rich CEACAM1 co-isolated protein family
3 AFDNoncoprotein100DIL (PF01843, IPR018444, SM01132): DIL domain
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
FHA (PF00498, IPR000253, SM00240): FHA domain
MAP7 (PF05672, IPR008604): MAP7 (E-MAP-115) family
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
Pap_E4 (PF02711, IPR003861): E4 protein
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
ARGLU (PF15346): Arginine and glutamate-rich 1
4 ATP13A2interactor100E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase (PF00702, IPR023214): haloacid dehalogenase-like hydrolase
MARVEL (PF01284, IPR008253): Membrane-associating domain
P5-ATPase (PF12409, IPR006544): P5-type ATPase cation transporter
5 AUP1interactor100CUE (PF02845, IPR003892, SM00546): CUE domain
6 BIN1suppressor200BAR (PF03114, IPR004148, SM00721): BAR domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
7 ITGB1suppressor50.5005.000EGF_2 (PF07974, IPR013111): EGF-like domain
Integrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain
Integrin_B_tail (PF07965, IPR012896): Integrin beta tail domain
Integrin_beta (PF00362, IPR002369, SM00187): Integrin, beta chain
PSI_integrin (PF17205): Integrin plexin domain
8 LAMA1interactor31.0000Laminin_B (PF00052, IPR000034): Laminin B (Domain IV)
Laminin_G_1 (PF00054, IPR001791): Laminin G domain
Laminin_I (PF06008, IPR009254): Laminin Domain I
Laminin_II (PF06009, IPR010307): Laminin Domain II
Sec34 (PF04136, IPR007265): Sec34-like family
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
Laminin_N (PF00055, IPR008211, SM00136): Laminin N-terminal (Domain VI)
9 LGALS3oncoprotein41.0000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
10 LGALS8interactor21.0000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
11 LIMK1oncoprotein200LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
12 MACF1oncoprotein100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
CTV_P33 (PF07184, IPR010803): Citrus tristeza virus P33 protein
DnaI_N (PF07319, IPR009928): Primosomal protein DnaI N-terminus
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF19 (PF01579, IPR002542): Domain of unknown function (DUF19)
FliJ (PF02050, IPR012823): Flagellar FliJ protein
GAS2 (PF02187, IPR003108, SM00243): Growth-Arrest-Specific Protein 2 Domain
Laminin_II (PF06009, IPR010307): Laminin Domain II
Peptidase_S49 (PF01343, IPR002142): Peptidase family S49
Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Spectrin (PF00435, IPR002017): Spectrin repeat
SYF2 (PF08231, IPR013260): SYF2 splicing factor
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Plectin (PF00681, IPR001101, SM00250): Plectin repeat
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
DUF3813 (PF12758, IPR024217): Protein of unknown function (DUF3813)
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
TEX12 (PF15219, IPR029193): Testis-expressed 12
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
13 MATN1interactor100VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
Matrilin_ccoil (PF10393, IPR019466): Trimeric coiled-coil oligomerisation domain of matrilin
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
14 MYO16interactor100CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
NYAP_N (PF15439): Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
NYAP_C (PF15452, IPR029353): Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
PRIMA1 (PF16101): Proline-rich membrane anchor 1
15 NLGN1interactor100COesterase (PF00135, IPR002018): Carboxylesterase family
Sarcoglycan_2 (PF05510, IPR008908): Sarcoglycan alpha/epsilon
16 NLGN2interactor100COesterase (PF00135, IPR002018): Carboxylesterase family
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
17 NLGN3interactor100COesterase (PF00135, IPR002018): Carboxylesterase family
Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
18 PDZD2interactor100PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
19 SHARPINinteractor200DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518)
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Sharpin_PH (PF16764, IPR031912): Sharpin PH domain
20 SIPA1L1interactor100PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Rap_GAP (PF02145, IPR000331): Rap/ran-GAP
SPAR_C (PF11881, IPR021818): C-terminal domain of SPAR protein
DUF4164 (PF13747, IPR025310): Domain of unknown function (DUF4164)
IQCJ-SCHIP1 (PF15157, IPR029362): Fusion protein IQCJ-SCHIP1 with IQ-like motif
21 SLF2interactor100FAM178 (PF14816, IPR026161): Family of unknown function, FAM178
MRI (PF15325, IPR028278): Modulator of retrovirus infection
22 SYT13suppressor200C2 (PF00168, IPR000008, SM00239): C2 domain
23 TLN1interactor21.0000DUF1013 (PF06242, IPR010421): Protein of unknown function (DUF1013)
DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
Talin_middle (PF09141, IPR015224): Talin, middle domain
VBS (PF08913, IPR015009): Vinculin Binding Site
CoatB (PF10389, IPR008020): Bacteriophage coat protein B
LOH1CR12 (PF10158, IPR018780): Tumour suppressor protein
I_LWEQ (PF01608, IPR002558, SM00307): I/LWEQ domain
TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair
FERM_f0 (PF16511, IPR032425): N-terminal or F0 domain of Talin-head FERM

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