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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins TTC19, TM9SF2 (from a repository: Mon Aug 19 01:48:27 2019)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)35
The number (and %) of the onco-proteins7 (20.00 %)
The number (and %) of the tumor suppressors1 (2.86 %)
Total number of binary PPIs (saturation %)47 (7.90 %)
The number (and %) of affected PPIs33 (70.21 %)
The number of possible different fusions5
PPI diameter2
PPI radiusinf
The average degree of PPI2.229
Assortativity coefficient-0.5508
The network average Clustering coefficient0.237
The number (and %) of a zero Clustering coefficients24 (68.57 %)
The number (and %) of a zero Betweenness Centrality31 (88.57 %)


List of the fusions

PPI for parental proteins: TTC19,TM9SF2 All fusions
Proteins found in more fusions L3MBTL3 (see 1 fusions); ATXN1 (see 3 fusions); UBA1 (see 2 fusions); SMAD4 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 TTC19parental protein250.010593.000ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
2 TM9SF2parental protein80.10747.000FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
EMP70 (PF02990, IPR004240): Endomembrane protein 70
3 ATP1B3interactor100Na_K-ATPase (PF00287, IPR000402): Sodium / potassium ATPase beta chain
4 ATXN1protein found in more fusions40.6671.000AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
Spt20 (PF12090, IPR021950): Spt20 family
ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
5 BPHLinteractor100Abhydrolase_1 (PF00561, IPR000073): alpha/beta hydrolase fold
6 C2orf48interactor100NA
7 CCDC33interactor21.0000C2 (PF00168, IPR000008, SM00239): C2 domain
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
SlyX (PF04102, IPR007236): SlyX
8 CCDC36interactor100DUF4700 (PF15771, IPR031529): Domain of unknown function (DUF4700)
9 CHMP4Ainteractor200Snf7 (PF03357, IPR005024): Snf7
10 CMPK1oncoprotein100ADK (PF00406, IPR000850): Adenylate kinase
Cytidylate_kin (PF02224, IPR011994): Cytidylate kinase
11 EIF4ENIF1interactor21.0000EIF4E-T (PF10477, IPR018862): Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
DUF4718 (PF15842, IPR031695): Domain of unknown function (DUF4718)
12 ELMO1oncoprotein100ELMO_CED12 (PF04727, IPR006816): ELMO/CED-12 family
FERM_N (PF09379, IPR018979): FERM N-terminal domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
Imm42 (PF15593, IPR028958): Immunity protein 42
PH_12 (PF16457, IPR001849): Pleckstrin homology domain
13 FAM64Ainteractor100DUF1466 (PF07326, IPR009932): Protein of unknown function (DUF1466)
14 GPANK1interactor100G-patch (PF01585, IPR000467, SM00443): G-patch domain
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
zf-DBF (PF07535, IPR006572, SM00586): DBF zinc finger
Ank_4 (PF13637): Ankyrin repeats (many copies)
15 GUK1interactor100Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
16 HPS6interactor100HPS6 (PF15702, IPR017218): Hermansky-Pudlak syndrome 6 protein
17 KIAA1456interactor100Methyltransf_11 (PF08241, IPR013216): Methyltransferase domain
Methyltransf_23 (PF13489): Methyltransferase domain
18 L3MBTL3protein found in more fusions200CDC45 (PF02724, IPR003874): CDC45-like protein
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
Glyco_hydro_2_N (PF02837, IPR006104): Glycosyl hydrolases family 2, sugar binding domain
MBT (PF02820, IPR004092, SM00561): mbt repeat
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
zf-C2HC (PF01530, IPR002515, SM00343): Zinc finger, C2HC type
Calci_bind_CcbP (PF11535, IPR020994): Calcium binding
Apelin (PF15360, IPR026155): APJ endogenous ligand
19 MMGT1interactor21.0000MMgT (PF10270, IPR018937): Membrane magnesium transporter
20 MYBPHLinteractor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
21 NAB2oncoprotein31.0000NCD1 (PF04904, IPR006988): NAB conserved region 1 (NCD1)
NCD2 (PF04905, IPR006989): NAB conserved region 2 (NCD2)
22 PAK5interactor200PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
23 RELoncoprotein21.0000RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
24 RHODinteractor100Ras (PF00071, IPR001806, SM00173): Ras family
25 RPN2interactor21.0000Ribophorin_II (PF05817, IPR008814): Oligosaccharyltransferase subunit Ribophorin II
26 RTBDNinteractor100Folate_rec (PF03024, IPR018143): Folate receptor family
Serglycin (PF04360, IPR007455): Serglycin
27 SLC25A3interactor100Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
28 SMAD4suppressor200MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
29 SMC6interactor200SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
30 SPRED1interactor100SMC_ScpA (PF02616, IPR003768): Segregation and condensation protein ScpA
Sprouty (PF05210, IPR007875): Sprouty protein (Spry)
WH1 (PF00568, IPR000697, SM00461): WH1 domain
31 SRSF7interactor100RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TP2 (PF01254, IPR000678): Nuclear transition protein 2
zf-CCHC (PF00098, IPR001878): Zinc knuckle
32 TCTN3interactor40.5003.000DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
33 UBA1protein found in more fusions200ThiF (PF00899, IPR000594): ThiF family
E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain
UBA_e1_thiolCys (PF10585, IPR019572): Ubiquitin-activating enzyme active site
34 UNC93B1interactor21.0000UNC-93 (PF05978, IPR010291): Ion channel regulatory protein UNC-93
Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup
DUF4131 (PF13567, IPR025405): Domain of unknown function (DUF4131)
35 UPF3Binteractor100HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
POPLD (PF08170, IPR012590): POPLD (NUC188) domain
Smg4_UPF3 (PF03467, IPR005120): Smg-4/UPF3 family
TAF4 (PF05236, IPR007900): Transcription initiation factor TFIID component TAF4 family
DUF2098 (PF09871, IPR019209): Uncharacterized protein conserved in archaea (DUF2098)
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
DUF3464 (PF11947, IPR021855): Protein of unknown function (DUF3464)

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