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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)166
The number (and %) of the onco-proteins41 (24.70 %)
The number (and %) of the tumor suppressors21 (12.65 %)
Total number of binary PPIs (saturation %)1882 (13.74 %)
The number (and %) of affected PPIs166 (8.82 %)
The number of possible different fusions36
PPI diameter3
PPI radius2
The average degree of PPI21.988
Assortativity coefficient-0.1306
The network average Clustering coefficient0.447
The number (and %) of a zero Clustering coefficients2 (1.20 %)
The number (and %) of a zero Betweenness Centrality7 (4.22 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ATP5A1,TM9SF2 All fusions
Proteins found in more fusions SMAD4 (see 3 fusions); STAU1 (see 2 fusions); OPA3 (see 2 fusions); NPM1 (see 1 fusions); CUL7 (see 2 fusions); CUL1 (see 3 fusions); CUL3 (see 1 fusions); PARK2 (see 1 fusions); MDH2 (see 1 fusions); IMMT (see 4 fusions); YWHAZ (see 5 fusions); SKI (see 1 fusions); HDAC5 (see 1 fusions); FN1/YWHAG (see 1 fusions); PARP1 (see 1 fusions); UBC (see 7 fusions); TP53 (see 3 fusions); PTBP1 (see 1 fusions); ILK (see 2 fusions); APP (see 5 fusions); ABCC1 (see 1 fusions); YWHAG (see 1 fusions); HSP90AA1 (see 6 fusions); HUWE1 (see 4 fusions); PABPC1 (see 3 fusions); HSP90AB1 (see 3 fusions); SERBP1 (see 1 fusions); ATP5A1/HUWE1 (see 2 fusions); ERBB3 (see 2 fusions); SH3KBP1 (see 1 fusions); EGFR (see 2 fusions); MCM2 (see 1 fusions); CSNK2A1 (see 2 fusions); ATP5A1 (see 1 fusions); MATR3 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ATP5A1parental protein1580.12811010.979ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_C (PF00306, IPR000793): ATP synthase alpha/beta chain, C terminal domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
2 TM9SF2parental protein80.10746.903FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
EMP70 (PF02990, IPR004240): Endomembrane protein 70
3 ABCC1oncoprotein100.44448.381ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
ABC_ATPase (PF09818, IPR019195): Predicted ATPase of the ABC class
DUF2304 (PF10066, IPR019277): Uncharacterized conserved protein (DUF2304)
DUF4131 (PF13567, IPR025405): Domain of unknown function (DUF4131)
4 ACKR3oncoprotein51.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
5 ACOT7interactor31.00004HBT (PF03061, IPR006683): Thioesterase superfamily
NINJA_B (PF16136, IPR032310): Putative nuclear localisation signal
6 ADRB2interactor230.32071.6717tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
7 AFG3L2interactor150.43822.679AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
FtsH_ext (PF06480, IPR011546): FtsH Extracellular
Peptidase_M41 (PF01434, IPR000642): Peptidase family M41
TniB (PF05621, IPR008868): Bacterial TniB protein
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
8 APPprotein found in more fusions430.203429.107APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
9 ARRB1interactor210.51020.794Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
10 ATL3interactor40.5002.350GBP (PF02263, IPR015894): Guanylate-binding protein, N-terminal domain
GBP_C (PF02841, IPR003191): Guanylate-binding protein, C-terminal domain
11 ATP1B3interactor110.45531.750Na_K-ATPase (PF00287, IPR000402): Sodium / potassium ATPase beta chain
12 ATP5Binteractor630.225862.967AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
NACHT (PF05729): NACHT domain
13 ATP5C1interactor410.324207.870ATP-synt (PF00231, IPR000131): ATP synthase
ACT_4 (PF13291, IPR002912): ACT domain
14 ATP5Dinteractor190.55635.086ATP-synt_DE_N (PF02823, IPR020546): ATP synthase, Delta/Epsilon chain, beta-sandwich domain
15 ATP5F1interactor320.349173.146Mt_ATP-synt_B (PF05405, IPR008688): Mitochondrial ATP synthase B chain precursor (ATP-synt_B)
DUF2105 (PF09878, IPR019212): Predicted membrane protein (DUF2105)
16 ATP5F1Einteractor80.50010.589ATP-synt_Eps (PF04627, IPR006721): Mitochondrial ATP synthase epsilon chain
17 ATP5Hinteractor200.41149.842Mt_ATP-synt_D (PF05873, IPR008689): ATP synthase D chain, mitochondrial (ATP5H)
18 ATP5Iinteractor180.52332.500ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
19 ATP5Jinteractor120.40923.968ATP-synt_F6 (PF05511, IPR008387): Mitochondrial ATP synthase coupling factor 6
20 ATP5J2interactor80.5714.857WRW (PF10206, IPR019344): Mitochondrial F1F0-ATP synthase, subunit f
21 ATP5MGinteractor220.38557.026ATP-synt_G (PF04718, IPR006808): Mitochondrial ATP synthase g subunit
22 ATP5POinteractor430.260347.843OSCP (PF00213, IPR000711): ATP synthase delta (OSCP) subunit
23 ATP6V0D1interactor200.56341.221vATP-synt_AC39 (PF01992, IPR002843): ATP synthase (C/AC39) subunit
24 ATP6V1Ainteractor150.54313.597ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
ATP-synt_ab_Xtn (PF16886, IPR031686): ATPsynthase alpha/beta subunit N-term extension
25 ATP6V1B2interactor160.39228.897ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
DUF2481 (PF10654, IPR018916): Protein of unknown function (DUF2481)
26 ATPAF2interactor40.5002.368ATP12 (PF07542, IPR011419): ATP12 chaperone protein
Ribosomal_L14e (PF01929, IPR002784): Ribosomal protein L14
27 BASP1suppressor50.8000.289BASP1 (PF05466, IPR008408): Brain acid soluble protein 1 (BASP1 protein)
28 BCKDHAinteractor30.6670.133E1_dh (PF00676, IPR001017): Dehydrogenase E1 component
29 BLKoncoprotein150.51424.671Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
30 BTKsuppressor90.5363.571BTK (PF00779, IPR001562, SM00107): BTK motif
PH (PF00169, IPR001849, SM00233): PH domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
31 C1QBPinteractor330.288171.867MAM33 (PF02330, IPR003428): Mitochondrial glycoprotein
DUF3053 (PF11254, IPR021413): Protein of unknown function (DUF3053)
32 C7orf55-LUC7L2interactor100LUC7 (PF03194, IPR004882): LUC7 N_terminus
Paramyxo_ncap (PF00973, IPR002021): Paramyxovirus nucleocapsid protein
Methyltransf_32 (PF13679, IPR025714): Methyltransferase domain
33 CA9interactor40.6670.550Carb_anhydrase (PF00194, IPR001148, SM01057): Eukaryotic-type carbonic anhydrase
Octapeptide (PF03373, IPR005038): Octapeptide repeat
DUF4730 (PF15873, IPR031742): Domain of unknown function (DUF4730)
34 CAND1interactor460.422176.443Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
35 CCDC8interactor420.341154.706Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
36 CD4suppressor120.4367.750ATP1G1_PLM_MAT8 (PF02038, IPR000272): ATP1G1/PLM/MAT8 family
C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
CD4-extracel (PF09191, IPR015274): CD4, extracellular
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Tcell_CD4_C (PF12104, IPR021963): T cell CD4 receptor C terminal region
37 CD81interactor150.39614.184Tetraspannin (PF00335, IPR018499): Tetraspanin family
38 CDK2suppressor410.350171.035Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
39 CHCHD2interactor170.16766.661CHCH (PF06747, IPR010625): CHCH domain
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
40 CLPXinteractor100.5114.601AAA_2 (PF07724, IPR013093): AAA domain (Cdc48 subfamily)
ClpB_D2-small (PF10431, IPR019489, SM01086): C-terminal, D2-small domain, of ClpB protein
Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain
Sigma54_activ_2 (PF14532, IPR002078): Sigma-54 interaction domain
41 CRY1interactor190.45112.429DNA_photolyase (PF00875, IPR006050): DNA photolyase
FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
42 CSNK2A1oncoprotein240.49435.280Pkinase (PF00069, IPR000719): Protein kinase domain
43 CUL1suppressor410.432107.261Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
44 CUL3protein found in more fusions510.344241.576Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
45 CUL5suppressor270.52434.748Cullin (PF00888, IPR001373, SM00182): Cullin family
GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
46 CUL7protein found in more fusions440.328184.327ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
47 CYC1interactor190.43348.391Cytochrom_C1 (PF02167, IPR002326): Cytochrome C1 family
48 DDAH1interactor40.5001.225Amidinotransf (PF02274, IPR003198): Amidinotransferase
49 ECH1interactor90.3069.031ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
50 EGFRoncoprotein400.283214.218Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
51 EIF4A1interactor270.44239.320DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
52 ERBB3oncoprotein100.5565.382Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
53 ERGoncoprotein80.6791.644Ets (PF00178, IPR000418, SM00413): Ets-domain
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
54 ESRRBsuppressor120.5454.930zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
55 ETFAinteractor100.42216.921ETF (PF01012, IPR014730, SM00893): Electron transfer flavoprotein domain
ETF_alpha (PF00766, IPR014731): Electron transfer flavoprotein FAD-binding domain
56 FAM134Ainteractor50.8000.646INSIG (PF07281, IPR025929): Insulin-induced protein (INSIG)
Reticulon (PF02453, IPR003388): Reticulon
57 FBXO25suppressor160.45019.094Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
58 FBXO6interactor450.257267.369FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
59 FDX1interactor21.0000Fer2 (PF00111, IPR001041): 2Fe-2S iron-sulfur cluster binding domain
60 FLOT1interactor160.20873.444CrtC (PF07143, IPR010791): CrtC N-terminal lipocalin domain
Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
Flot (PF15975, IPR031905): Flotillin
61 FN1oncoprotein420.317288.546fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
62 FUSsuppressor360.50275.858Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Limkain-b1 (PF11608, IPR024582): Limkain b1
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
63 GLRX5interactor30.6670.373Glutaredoxin (PF00462, IPR002109): Glutaredoxin
64 GOLT1Binteractor200.321143.226Got1 (PF04178, IPR007305): Got1/Sft2-like family
65 HDAC5protein found in more fusions400.306142.613Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NOA36 (PF06524, IPR010531): NOA36 protein
Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
66 HNRNPA1interactor510.402204.269RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
67 HNRNPUinteractor530.311359.817CDC45 (PF02724, IPR003874): CDC45-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
68 HSD17B10interactor210.38170.387adh_short (PF00106, IPR002198): short chain dehydrogenase
69 HSP90AA1oncoprotein540.322313.541HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
70 HSP90AB1oncoprotein560.327356.714HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
71 HSPA1Ainteractor360.354112.444HSP70 (PF00012, IPR013126): Hsp70 protein
72 HSPA1Linteractor190.45031.186HSP70 (PF00012, IPR013126): Hsp70 protein
73 HSPA5oncoprotein570.329415.700HSP70 (PF00012, IPR013126): Hsp70 protein
74 HSPB2interactor31.0000Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
75 HUWE1oncoprotein420.355164.075BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
76 IDEinteractor60.4672.330Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
Peptidase_M16_M (PF16187, IPR032632): Middle or third domain of peptidase_M16
77 ILKsuppressor160.39030.480Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
78 IMMTprotein found in more fusions240.26998.254Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
79 IQCB1interactor100.31114.230DUF1765 (PF08578, IPR013887): Protein of unknown function (DUF1765)
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
Condensin2nSMC (PF12422, IPR024741): Condensin II non structural maintenance of chromosomes subunit
80 ISG15suppressor130.46267.689ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
81 LMAN1interactor150.40025.815Lectin_leg-like (PF03388, IPR005052): Legume-like lectin family
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
82 MAPK7oncoprotein120.6912.023Pkinase (PF00069, IPR000719): Protein kinase domain
Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor
83 MATR3protein found in more fusions260.47331.521DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-U1 (PF06220, IPR013085, SM00451): U1 zinc finger
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
FAM60A (PF15396, IPR026065): Protein Family FAM60A
84 MBOAT1interactor31.0000MBOAT (PF03062, IPR004299): MBOAT, membrane-bound O-acyltransferase family
CBP_BcsF (PF11120, IPR019995): Cellulose biosynthesis protein BcsF
DUF3329 (PF11808, IPR021766): Domain of unknown function (DUF3329)
85 MCM2oncoprotein560.354261.047AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
86 MCM5oncoprotein220.46330.998MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
87 MDH2protein found in more fusions150.4516.611Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
88 MLH1suppressor40.8330.200DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Mlh1_C (PF16413, IPR032189): DNA mismatch repair protein Mlh1 C-terminus
89 MMGT1interactor90.33332.005MMgT (PF10270, IPR018937): Membrane magnesium transporter
90 MOV10interactor310.286165.520AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
91 MRPL46interactor70.6195.382NUDIX (PF00293, IPR000086): NUDIX domain
MRP-L46 (PF11788, IPR021757): 39S mitochondrial ribosomal protein L46
92 MRPL58interactor310.215188.431RF-1 (PF00472, IPR000352): RF-1 domain
93 MTCH1interactor130.62818.361YdjM (PF04307, IPR007404): LexA-binding, inner membrane-associated putative hydrolase
Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
94 MTCH2interactor210.53345.467Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
95 MYH9suppressor300.40287.538IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
96 NCSTNinteractor80.39312.259Nicastrin (PF05450, IPR008710): Nicastrin
Ost4 (PF10215, IPR018943): Oligosaccaryltransferase
97 NDUFAB1interactor40.5002.667MinE (PF03776, IPR005527): Septum formation topological specificity factor MinE
PP-binding (PF00550, IPR009081): Phosphopantetheine attachment site
98 NDUFS4interactor130.7185.096ETC_C1_NDUFA4 (PF04800, IPR006885): ETC complex I subunit conserved region
99 NPM1suppressor560.374269.847Nucleoplasmin (PF03066): Nucleoplasmin/nucleophosmin domain
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
100 NRDCinteractor70.4673.283Cnd2 (PF05786, IPR022816): Condensin complex subunit 2
Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
Tom22 (PF04281, IPR005683): Mitochondrial import receptor subunit Tom22
Peptidase_M16_M (PF16187, IPR032632): Middle or third domain of peptidase_M16
101 NTRK1oncoprotein750.224993.520I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
102 NXF1interactor330.296283.565NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
103 OBSL1interactor350.38783.809BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
104 OPA3protein found in more fusions140.26930.618IL11 (PF07400, IPR020438): Interleukin 11
OPA3 (PF07047, IPR010754): Optic atrophy 3 protein (OPA3)
105 P4HBinteractor240.50237.666Glycos_trans_3N (PF02885, IPR017459): Glycosyl transferase family, helical bundle domain
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
106 PABPC1oncoprotein320.38570.244RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain
YflT (PF11181, IPR025889): Heat induced stress protein YflT
107 PAN2interactor210.42935.901RNase_T (PF00929, IPR013520): Exonuclease
UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase
WD40_like (PF17005, IPR031544): WD40-like domain
108 PARK2suppressor370.308144.023IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
109 PARP1suppressor200.36330.069BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
PADR1 (PF08063, IPR012982): PADR1 (NUC008) domain
PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
PARP_reg (PF02877, IPR004102): Poly(ADP-ribose) polymerase, regulatory domain
WGR (PF05406, IPR008893, SM00773): WGR domain
zf-PARP (PF00645, IPR001510): Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
110 PGK1interactor170.63211.687PGK (PF00162, IPR001576): Phosphoglycerate kinase
111 PMPCAinteractor40.8330.182Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
112 PMPCBinteractor60.5334.405Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
113 POLDIP2interactor110.36410.122DUF525 (PF04379, IPR007474): ApaG domain
YccV-like (PF08755, IPR011722, SM00992): Hemimethylated DNA-binding protein YccV like
114 POU5F1oncoprotein70.4004.138Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
115 PPT1interactor50.9000.222Palm_thioest (PF02089, IPR002472): Palmitoyl protein thioesterase
116 PSMD4interactor170.45619.816UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
117 PTBP1oncoprotein330.50845.962RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
118 PTENsuppressor190.31052.145DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
119 RER1interactor110.41823.511Rer1 (PF03248, IPR004932): Rer1 family
120 RNF146interactor60.6001.159WWE (PF02825, IPR004170, SM00678): WWE domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
121 RPL18interactor280.50533.854Ribosomal_L18 (PF17135): Ribosomal protein 60S L18 and 50S L18e
122 RPN1oncoprotein360.317184.915Ribophorin_I (PF04597, IPR007676): Ribophorin I
CtIP_N (PF10482, IPR019518): Tumour-suppressor protein CtIP N-terminal domain
123 RPN2interactor150.40087.088Ribophorin_II (PF05817, IPR008814): Oligosaccharyltransferase subunit Ribophorin II
124 RPS15Ainteractor190.53811.684Ribosomal_S8 (PF00410, IPR000630): Ribosomal protein S8
125 RPS3interactor410.405122.265KH_2 (PF07650, IPR004044): KH domain
Ribosomal_S3_C (PF00189, IPR001351): Ribosomal protein S3, C-terminal domain
126 RPS6KB2interactor180.49717.868Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
127 SERBP1protein found in more fusions240.46637.834HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
128 SFXN1interactor90.33310.761Mtc (PF03820, IPR004686): Tricarboxylate carrier
129 SH3KBP1protein found in more fusions100.3899.695Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein
SH3_9 (PF14604, IPR001452): Variant SH3 domain
130 SHBGoncoprotein31.0000Laminin_G_1 (PF00054, IPR001791): Laminin G domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
131 SIRT3suppressor40.6670.299SIR2 (PF02146, IPR003000): Sir2 family
132 SKIoncoprotein130.40975.777c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain
Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family
SlyX (PF04102, IPR007236): SlyX
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
133 SLC25A3interactor330.244217.025Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
134 SLC33A1interactor60.26711.719Acatn (PF13000, IPR024371): Acetyl-coenzyme A transporter 1
135 SMAD4suppressor5010.606MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
136 SOX2oncoprotein80.4295.575HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOXp (PF12336, IPR022097): SOX transcription factor
137 SPRTNinteractor100.5117.174GreA_GreB (PF01272, IPR001437): Transcription elongation factor, GreA/GreB, C-term
SprT-like (PF10263, IPR006640, SM00731): SprT-like family
PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein
138 SRSF7interactor170.43468.622RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TP2 (PF01254, IPR000678): Nuclear transition protein 2
zf-CCHC (PF00098, IPR001878): Zinc knuckle
139 SSR4interactor210.51422.525TRAP-delta (PF05404, IPR008855): Translocon-associated protein, delta subunit precursor (TRAP-delta)
OppC_N (PF12911, IPR025966): N-terminal TM domain of oligopeptide transport permease C
140 STAU1protein found in more fusions340.424109.134dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
141 STOML2oncoprotein240.35991.300Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4769 (PF15992, IPR031934): Domain of unknown function (DUF4769)
Band_7_C (PF16200, IPR032435): C-terminal region of band_7
142 TARDBPinteractor310.53143.118RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
143 TCTN3interactor160.158115.856DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
144 TMEM63Binteractor140.39628.596RSN1_7TM (PF02714, IPR003864): Calcium-dependent channel, 7TM region, putative phosphate
Wzy_C (PF04932, IPR007016): O-Antigen ligase
DUF4006 (PF13179, IPR025065): Family of unknown function (DUF4006)
RSN1_TM (PF13967, IPR032880): Late exocytosis, associated with Golgi transport
PHM7_cyt (PF14703, IPR027815): Cytosolic domain of 10TM putative phosphate transporter
145 TP53suppressor360.402100.138DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
146 TP63suppressor70.8000.349Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
147 TSPOinteractor70.8570.499MASE2 (PF05230, IPR007894): MASE2 domain
TspO_MBR (PF03073, IPR004307): TspO/MBR family
148 TUBA1Cinteractor360.265219.359Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
149 UBCprotein found in more fusions490.333275.821ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
150 UBL4Ainteractor310.305101.186ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
151 UNC93B1interactor60.26716.307UNC-93 (PF05978, IPR010291): Ion channel regulatory protein UNC-93
Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup
DUF4131 (PF13567, IPR025405): Domain of unknown function (DUF4131)
152 UNKinteractor190.28747.959MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain
153 UQCRC2oncoprotein300.363119.753Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
154 USMG5interactor70.3336.740ATP_synth_reg (PF14960): ATP synthase regulation
155 VCAM1interactor320.34775.989C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
156 VDAC1interactor350.343201.512Porin_3 (PF01459, IPR027246): Eukaryotic porin
157 VDAC2interactor370.332229.221Porin_3 (PF01459, IPR027246): Eukaryotic porin
158 VDAC3interactor310.385127.547Porin_3 (PF01459, IPR027246): Eukaryotic porin
159 XRCC3oncoprotein40.5001.002Rad51 (PF08423, IPR013632): Rad51
RNA_pol_A_CTD (PF03118, IPR011260): Bacterial RNA polymerase, alpha chain C terminal domain
160 YIPF5interactor80.50045.158Yip1 (PF04893, IPR006977): Yip1 domain
161 YME1L1interactor90.3339.579AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Peptidase_M41 (PF01434, IPR000642): Peptidase family M41
162 YWHABinteractor240.51830.70914-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
163 YWHAEoncoprotein360.45673.82014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
164 YWHAGprotein found in more fusions240.51820.33514-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
165 YWHAQinteractor290.49837.43114-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
166 YWHAZprotein found in more fusions350.43173.64414-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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