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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins NARS, NRXN3 (from a repository: Mon Aug 19 15:32:44 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)64
The number (and %) of the onco-proteins18 (28.12 %)
The number (and %) of the tumor suppressors6 (9.38 %)
Total number of binary PPIs (saturation %)270 (13.39 %)
The number (and %) of affected PPIs62 (22.96 %)
The number of possible different fusions9
PPI diameter5
PPI radius3
The average degree of PPI7.844
Assortativity coefficient-0.2105
The network average Clustering coefficient0.445
The number (and %) of a zero Clustering coefficients16 (25.00 %)
The number (and %) of a zero Betweenness Centrality21 (32.81 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: NARS1,NRXN3 All fusions
Proteins found in more fusions SF1 (see 1 fusions); MCM2 (see 1 fusions); PLOD2 (see 1 fusions); ATXN1 (see 3 fusions); SAMHD1 (see 1 fusions); UBC (see 7 fusions); MYC (see 2 fusions); HNRNPL (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 NARSparental protein550.1202204.045tRNA-synt_2 (PF00152, IPR004364): tRNA synthetases class II (D, K and N)
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
2 NRXN3parental protein70600.667EGF (PF00008, IPR000742, SM00181): EGF-like domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
Syndecan (PF01034, IPR027789): Syndecan domain
3 AARSinteractor70.6672.548DHHA1 (PF02272, IPR003156): DHHA1 domain
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
tRNA-synt_2c (PF01411, IPR018164): tRNA synthetases class II (A)
tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain
4 ABL1oncoprotein70.5338.638Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
5 AFDNoncoprotein40.167215.906DIL (PF01843, IPR018444, SM01132): DIL domain
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
FHA (PF00498, IPR000253, SM00240): FHA domain
MAP7 (PF05672, IPR008604): MAP7 (E-MAP-115) family
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
Pap_E4 (PF02711, IPR003861): E4 protein
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
ARGLU (PF15346): Arginine and glutamate-rich 1
6 ATXN1protein found in more fusions41.0000AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
Spt20 (PF12090, IPR021950): Spt20 family
ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
7 C1QBPinteractor100.62240.978MAM33 (PF02330, IPR003428): Mitochondrial glycoprotein
DUF3053 (PF11254, IPR021413): Protein of unknown function (DUF3053)
8 CEP128interactor60.5337.522DUF1129 (PF06570, IPR009214): Protein of unknown function (DUF1129)
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
SpoOE-like (PF09388, IPR018540): Spo0E like sporulation regulatory protein
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
TraF_2 (PF13729, IPR032811): F plasmid transfer operon, TraF, protein
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
HAUS6_N (PF14661, IPR028163): HAUS augmin-like complex subunit 6 N-terminus
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
9 CEP170interactor60.46711.305FHA (PF00498, IPR000253, SM00240): FHA domain
DUF4254 (PF14063, IPR025350): Protein of unknown function (DUF4254)
CEP170_C (PF15308, IPR029300): CEP170 C-terminus
10 CIRBPoncoprotein60.4677.452RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
11 CUL2suppressor110.52712.457Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
12 DDX19Binteractor40.5003.000DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
13 DUSP19interactor100DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
14 EIF4Binteractor100.8611.405RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF3774 (PF12609, IPR022251): Wound-induced protein
PROL5-SMR (PF15621, IPR026288): Proline-rich submaxillary gland androgen-regulated family
15 EPRSinteractor90.7503.193GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain
HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
ProRS-C_1 (PF09180, IPR016061, SM00946): Prolyl-tRNA synthetase, C-terminal
tRNA-synt_1c (PF00749, IPR020058): tRNA synthetases class I (E and Q), catalytic domain
tRNA-synt_1c_C (PF03950, IPR020059): tRNA synthetases class I (E and Q), anti-codon binding domain
tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
16 FAM213Binteractor100AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
AhpC-TSA_2 (PF13911, IPR032801): AhpC/TSA antioxidant enzyme
17 FN1oncoprotein180.320186.713fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
18 GANABsuppressor120.54555.944Glyco_hydro_31 (PF01055, IPR000322): Glycosyl hydrolases family 31
Gal_mutarotas_2 (PF13802, IPR025887): Galactose mutarotase-like
DUF5110 (PF17137): Domain of unknown function (DUF5110)
19 GARSinteractor130.37242.525HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
20 GPR183interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
21 GRB10oncoprotein21.0000BPS (PF08947, IPR015042): BPS (Between PH and SH2)
PH (PF00169, IPR001849, SM00233): PH domain
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
Argos (PF11581, IPR021633): Antagonist of EGFR signalling, Argos
22 HDAC2suppressor50.50022.968Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
23 HNRNPLprotein found in more fusions70.8000.967RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Dscam_C (PF12355, IPR021012): Down syndrome cell adhesion molecule C terminal
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
24 HSPB2interactor31.0000Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
25 IARSinteractor120.57612.964Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA
tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V)
26 JUPsuppressor120.62112.242Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
27 KARSinteractor110.54518.222tRNA-synt_2 (PF00152, IPR004364): tRNA synthetases class II (D, K and N)
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
28 KIAA1217interactor100AIP3 (PF03915, IPR022782, SM00806): Actin interacting protein 3
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
MRI (PF15325, IPR028278): Modulator of retrovirus infection
29 KLHL20interactor200BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
30 LARSinteractor100.6447.693Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA
tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V)
31 LILRA3interactor100DUF11 (PF01345, IPR001434): Domain of unknown function DUF11
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase (PF00069, IPR000719): Protein kinase domain
PPAK (PF02818, IPR004168): PPAK motif
Titin_Z (PF09042, IPR015129): Titin Z
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_3 (PF13927): Immunoglobulin domain
32 LRRC42interactor100LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
33 LSM1interactor100LSM (PF01423, IPR001163): LSM domain
34 MCM2oncoprotein150.47320.464AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
35 MYConcoprotein100.361462.961HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
36 NLGN1interactor100COesterase (PF00135, IPR002018): Carboxylesterase family
Sarcoglycan_2 (PF05510, IPR008908): Sarcoglycan alpha/epsilon
37 NLGN2interactor100COesterase (PF00135, IPR002018): Carboxylesterase family
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
38 NLGN3interactor100COesterase (PF00135, IPR002018): Carboxylesterase family
Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
39 NPHP1interactor60.6003.167SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
FAM176 (PF14851): FAM176 family
Speriolin_N (PF15058, IPR029385): Speriolin N terminus
DUF4746 (PF15928, IPR031827): Domain of unknown function (DUF4746)
40 NTRK1oncoprotein330.232532.945I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
41 NUP50interactor31.0000NUP50 (PF08911, IPR015007): NUP50 (Nucleoporin 50 kDa)
Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain
42 OSBPinteractor90.8332.169Oxysterol_BP (PF01237, IPR000648): Oxysterol-binding protein
PH (PF00169, IPR001849, SM00233): PH domain
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
betaPIX_CC (PF16523, IPR032409): betaPIX coiled coil
HlyD_D23 (PF16576, IPR032317): Barrel-sandwich domain of CusB or HlyD membrane-fusion
43 PAPOLAinteractor30.6670.500PAP_central (PF04928, IPR007012): Poly(A) polymerase central domain
PAP_RNA-bind (PF04926, IPR007010): Poly(A) polymerase predicted RNA binding domain
Macoilin (PF09726, IPR019130): Transmembrane protein
44 PIP5K1Aoncoprotein100PIP5K (PF01504, IPR002498): Phosphatidylinositol-4-phosphate 5-Kinase
45 PLOD2protein found in more fusions110.5567.4262OG-FeII_Oxy (PF03171, IPR005123): 2OG-Fe(II) oxygenase superfamily
Anp1 (PF03452, IPR005109): Anp1
Glycos_transf_2 (PF00535, IPR001173): Glycosyl transferase family 2
46 PRMT3interactor90.8062.119PrmA (PF06325, IPR010456): Ribosomal protein L11 methyltransferase (PrmA)
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
47 PRPS1oncoprotein31.0000Pribosyltran (PF00156, IPR000836): Phosphoribosyl transferase domain
Pribosyltran_N (PF13793, IPR029099): N-terminal domain of ribose phosphate pyrophosphokinase
Pribosyl_synth (PF14572, IPR005946): Phosphoribosyl synthetase-associated domain
48 PUS1interactor100PseudoU_synth_1 (PF01416, IPR020097): tRNA pseudouridine synthase
49 RABIFinteractor100Mss4 (PF04421, IPR007515): Mss4 protein
DNA_RNApol_7kD (PF03604, IPR006591, SM00659): DNA directed RNA polymerase, 7 kDa subunit
50 RARSinteractor100.60048.757Arg_tRNA_synt_N (PF03485, IPR005148, SM01016): Arginyl tRNA synthetase N terminal domain
DALR_1 (PF05746, IPR008909, SM00836): DALR anticodon binding domain
DivIC (PF04977, IPR007060): Septum formation initiator
tRNA-synt_1d (PF00750, IPR015945): tRNA synthetases class I (R)
Mto2_bdg (PF12808, IPR024545): Micro-tubular organiser Mto1 C-term Mto2-binding region
51 RPL24interactor90.5566.538MAS20 (PF02064, IPR002056): MAS20 protein import receptor
Ribosomal_L24e (PF01246, IPR000988): Ribosomal protein L24e
52 SAMHD1protein found in more fusions170.55024.226HD (PF01966, IPR006674): HD domain
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
53 SCLT1oncoprotein40.6672.000DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
SlyX (PF04102, IPR007236): SlyX
XhlA (PF10779, IPR019715): Haemolysin XhlA
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
Imm7 (PF15585, IPR028965): Immunity protein 7
CCCAP (PF15964, IPR031887): Centrosomal colon cancer autoantigen protein family
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
54 SEC23Ainteractor120.54512.851Gelsolin (PF00626, IPR007123): Gelsolin repeat
Sec23_BS (PF08033, IPR012990): Sec23/Sec24 beta-sandwich domain
Sec23_helical (PF04815, IPR006900): Sec23/Sec24 helical domain
Sec23_trunk (PF04811, IPR006896): Sec23/Sec24 trunk domain
zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
55 SERPINB5suppressor21.0000Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
56 SF1protein found in more fusions140.46232.866UPF0181 (PF03701, IPR005371): Uncharacterised protein family (UPF0181)
zf-CCHC (PF00098, IPR001878): Zinc knuckle
KH_1 (PF00013, IPR004088, SM00322): KH domain
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
PRIMA1 (PF16101): Proline-rich membrane anchor 1
SF1-HH (PF16275, IPR032570): Splicing factor 1 helix-hairpin domain
57 SIRT7interactor120.28878.736DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
58 SUV39H2interactor100Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
Pre-SET (PF05033, IPR007728): Pre-SET motif
SET (PF00856, IPR001214, SM00317): SET domain
Tox-GHH (PF15636, IPR028916): GHH signature containing HNH/Endo VII superfamily nuclease toxin
59 TRMT1interactor100.51111.219TRM (PF02005, IPR002905): N2,N2-dimethylguanosine tRNA methyltransferase
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
60 UBCprotein found in more fusions120.47320.541ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
61 UBE2Sinteractor40.6670.286ALF (PF03752, IPR005506): Short repeats of unknown function
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
62 XPO7interactor130.51331.635IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Rep_fac_C (PF08542, IPR013748): Replication factor C C-terminal domain
63 XRCC5suppressor190.444108.881Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain
Ku_PK_bind (PF08785, IPR014893): Ku C terminal domain like
64 XRCC6oncoprotein140.53858.360Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain
SAP (PF02037, IPR003034, SM00513): SAP domain

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