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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MRFAP1, MT-ND6 (from a repository: Mon Apr 17 14:36:18 2017)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)25
The number (and %) of the onco-proteins4 (16.00 %)
The number (and %) of the tumor suppressors2 (8.00 %)
Total number of binary PPIs (saturation %)48 (16.00 %)
The number (and %) of affected PPIs23 (47.92 %)
The number of possible different fusions4
PPI diameter2
PPI radiusinf
The average degree of PPI3.280
Assortativity coefficient-0.5434
The network average Clustering coefficient0.435
The number (and %) of a zero Clustering coefficients11 (44.00 %)
The number (and %) of a zero Betweenness Centrality18 (72.00 %)


List of the fusions

Proteins found in more fusions ZDHHC17 (see 2 fusions); NDUFS3 (see 1 fusions); HTT (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 MRFAP1parental protein180.078269.167MRFAP1 (PF15155, IPR029254): MORF4 family-associated protein1
2 MT-ND6parental protein50.6008.000CD20 (PF04103, IPR007237): CD20-like family
Oxidored_q3 (PF00499, IPR001457): NADH-ubiquinone/plastoquinone oxidoreductase chain 6
3 ACAD9interactor41.0000Acyl-CoA_dh_1 (PF00441, IPR009075): Acyl-CoA dehydrogenase, C-terminal domain
Acyl-CoA_dh_M (PF02770, IPR006091): Acyl-CoA dehydrogenase, middle domain
Acyl-CoA_dh_N (PF02771, IPR013786): Acyl-CoA dehydrogenase, N-terminal domain
4 C14orf93interactor100DUF4616 (PF15394, IPR028101): Domain of unknown function (DUF4616)
5 C3orf62interactor30.6670.500DUF4712 (PF15830, IPR031670): Domain of unknown function (DUF4712)
6 C8orf33interactor100DUF4615 (PF15393, IPR029274): Domain of unknown function (DUF4615)
7 DCDC2suppressor100DCX (PF03607, IPR003533, SM00537): Doublecortin
Na_trans_assoc (PF06512, IPR010526): Sodium ion transport-associated
8 GOLGA8Finteractor100T3SS_needle_E (PF08988, IPR012671): Type III secretion system, cytoplasmic E component of needle
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FlxA (PF14282, IPR025577): FlxA-like protein
GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
9 GOLGA8Ginteractor100T3SS_needle_E (PF08988, IPR012671): Type III secretion system, cytoplasmic E component of needle
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FlxA (PF14282, IPR025577): FlxA-like protein
GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
10 HTTprotein found in more fusions41.0000HEAT (PF02985, IPR000357): HEAT repeat
SPX (PF03105, IPR004331): SPX domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
DUF3652 (PF12372, IPR024613): Huntingtin protein region
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
11 MAP1LC3Binteractor100Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
12 MED4interactor100Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
13 MORF4L1interactor60.7001.833MRG (PF05712, IPR026541): MRG
Fmp27_WPPW (PF10359, IPR019449): RNA pol II promoter Fmp27 protein domain
Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
14 MORF4L2interactor50.7001.833MRG (PF05712, IPR026541): MRG
15 MRFAP1L1interactor70.4677.333MRFAP1 (PF15155, IPR029254): MORF4 family-associated protein1
16 MRGBPinteractor31.0000Eaf7 (PF07904, IPR012423): Chromatin modification-related protein EAF7
17 NDUFAF3interactor41.0000DUF498 (PF04430, IPR007523): Protein of unknown function (DUF498/DUF598)
18 NDUFS3protein found in more fusions51.0000Complex1_30kDa (PF00329, IPR001268): Respiratory-chain NADH dehydrogenase, 30 Kd subunit
19 NDUFS5interactor41.0000Ndufs5 (PF10200, IPR019342): NADH:ubiquinone oxidoreductase, NDUFS5-15kDa
20 PAM16interactor200Pam16 (PF03656): Pam16
21 RB1suppressor40.6671.333RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
Rb_C (PF08934, IPR015030): Rb C-terminal domain
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
DUF4592 (PF15262, IPR028030): Domain of unknown function (DUF4592)
22 SUV39H2interactor100Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
Pre-SET (PF05033, IPR007728): Pre-SET motif
SET (PF00856, IPR001214, SM00317): SET domain
Tox-GHH (PF15636, IPR028916): GHH signature containing HNH/Endo VII superfamily nuclease toxin
23 TK1oncoprotein200TK (PF00265, IPR001267, SM00203): Thymidine kinase
24 YME1L1interactor100AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Peptidase_M41 (PF01434, IPR000642): Peptidase family M41
25 ZDHHC17protein found in more fusions41.0000zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
Ank_4 (PF13637): Ankyrin repeats (many copies)

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