Find Fusion Network

Fusion ID:
Protein names:

Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ZFAND4, RNF40 (from a repository: Mon Apr 22 06:05:16 2019)

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Force Directed
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)65
The number (and %) of the onco-proteins18 (27.69 %)
The number (and %) of the tumor suppressors6 (9.23 %)
Total number of binary PPIs (saturation %)222 (10.67 %)
The number (and %) of affected PPIs64 (28.83 %)
The number of possible different fusions12
PPI diameter4
PPI radius2
The average degree of PPI5.877
Assortativity coefficient-0.2849
The network average Clustering coefficient0.495
The number (and %) of a zero Clustering coefficients13 (20.00 %)
The number (and %) of a zero Betweenness Centrality21 (32.31 %)


List of the fusions

PPI for parental proteins: RNF40,ZFAND4 All fusions
Proteins found in more fusions AMOTL2 (see 1 fusions); EWSR1 (see 2 fusions); RNF40 (see 2 fusions); ESR1/SEPT2 (see 1 fusions); UBE2L6 (see 2 fusions); UBE2E1 (see 3 fusions); ZNF451 (see 1 fusions); HSP90AA1 (see 5 fusions); SNAP29 (see 1 fusions); WAC (see 3 fusions); CDK9 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 RNF40parental protein630.0673053.538BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
DUF745 (PF05335, IPR007999): Protein of unknown function (DUF745)
ZapB (PF06005, IPR009252): Cell division protein ZapB
EzrA (PF06160, IPR010379): Septation ring formation regulator, EzrA
FlgN (PF05130, IPR007809): FlgN protein
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
SpoIIE (PF07228, IPR001932): Stage II sporulation protein E (SpoIIE)
T5orf172 (PF10544, IPR018306, SM00974): T5orf172 domain
XhlA (PF10779, IPR019715): Haemolysin XhlA
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
zf-RING_6 (PF14835): zf-RING of BARD1-type protein
2 ZFAND4parental protein100zf-AN1 (PF01428, IPR000058, SM00154): AN1-like Zinc finger
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
3 AMOTL2protein found in more fusions31.0000HOOK (PF05622, IPR008636): HOOK protein
SlyX (PF04102, IPR007236): SlyX
Angiomotin_C (PF12240, IPR024646): Angiomotin C terminal
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
4 ARoncoprotein80.5249.652Androgen_recep (PF02166, IPR001103): Androgen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
5 ATMsuppressor60.8001.167FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair
ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5
6 BORCS6interactor100DUF2365 (PF10157, IPR019314): Uncharacterized conserved protein (DUF2365)
7 CCDC146interactor100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
DUF745 (PF05335, IPR007999): Protein of unknown function (DUF745)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Med21 (PF11221, IPR021384): Subunit 21 of Mediator complex
Kinetocho_Slk19 (PF12709, IPR024312): Central kinetochore-associated
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
8 CDC73suppressor80.5369.238CDC73_C (PF05179, IPR007852): RNA pol II accessory factor, Cdc73 family, C-terminal
CDC73_N (PF16050, IPR032041): Paf1 complex subunit CDC73 N-terminal
9 CDK9protein found in more fusions170.32562.352Pkinase (PF00069, IPR000719): Protein kinase domain
10 CIAPIN1interactor50.6671.067CIAPIN1 (PF05093, IPR007785): Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis
Methyltransf_11 (PF08241, IPR013216): Methyltransferase domain
Methyltransf_31 (PF13847, IPR025714): Methyltransferase domain
11 CMTR1interactor31.0000FtsJ (PF01728, IPR002877): FtsJ-like methyltransferase
G-patch (PF01585, IPR000467, SM00443): G-patch domain
mRNA_cap_enzyme (PF01331, IPR001339): mRNA capping enzyme, catalytic domain
WW (PF00397, IPR001202, SM00456): WW domain
12 DSN1interactor40.6670.686MIS13 (PF08202, IPR013218): Mis12-Mtw1 protein family
13 ESR1suppressor70.33314.700Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
14 EWSR1oncoprotein100.27822.167RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
15 FCGR3Ainteractor100Ig_2 (PF13895, IPR007110): Immunoglobulin domain
16 GTF2H5interactor100Tfb5 (PF06331, IPR009400): Transcription factor TFIIH complex subunit Tfb5
17 HIST2H2BEinteractor70.7143.233Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
18 HSP90AA1oncoprotein130.33330.619HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
19 HSPA5oncoprotein90.42912.619HSP70 (PF00012, IPR013126): Hsp70 protein
20 IER2oncoprotein100IER (PF05760, IPR008653): Immediate early response protein (IER)
MAGI_u1 (PF16663): Unstructured region on MAGI
21 IL36Ainteractor21.0000IL1 (PF00340, IPR000975, SM00125): Interleukin-1 / 18
22 ITSN1interactor200C2 (PF00168, IPR000008, SM00239): C2 domain
VIT1 (PF01988, IPR008217): VIT family
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
FmdE (PF02663, IPR003814): FmdE, Molybdenum formylmethanofuran dehydrogenase operon
GSH_synthase (PF03199, IPR004887): Eukaryotic glutathione synthase
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748)
INTAP (PF16617): Intersectin and clathrin adaptor AP2 binding region
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
23 IWS1interactor30.6671.000DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
24 KLC3interactor40.6670.667TPR_4 (PF07721, IPR011717): Tetratricopeptide repeat
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
TPR_12 (PF13424): Tetratricopeptide repeat
25 KRASoncoprotein70.40014.333Ras (PF00071, IPR001806, SM00173): Ras family
26 MBIPinteractor40.6670.667DUF1192 (PF06698, IPR009579): Protein of unknown function (DUF1192)
27 MORC1interactor100FliJ (PF02050, IPR012823): Flagellar FliJ protein
p25-alpha (PF05517, IPR008907): p25-alpha
zf-CW (PF07496, IPR011124): CW-type Zinc Finger
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
28 MSL1interactor70.7143.967Herpes_UL6 (PF01763, IPR002660): Herpesvirus UL6 like
KLRAQ (PF10205, IPR019343): Predicted coiled-coil domain-containing protein
PEHE (PF15275, IPR029332): PEHE domain
MSL1_dimer (PF16801, IPR031840): Dimerisation domain of Male-specific-Lethal 1
29 MSL2interactor60.9330.400MSL2-CXC (PF16682, IPR032049): CXC domain of E3 ubiquitin-protein ligase MSL2
zf-RING_10 (PF16685, IPR032043): zinc RING finger of MSL2
30 NCBP1interactor31.0000MIF4G (PF02854, IPR003890, SM00543): MIF4G domain
MIF4G_like (PF09088, IPR015172): MIF4G like
MIF4G_like_2 (PF09090, IPR015174): MIF4G like
SlyX (PF04102, IPR007236): SlyX
31 NOTCH1suppressor40.6670.667Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
32 NTRK1oncoprotein180.22188.519I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
33 NXF1interactor120.23648.700NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
34 OIP5interactor30.6671.000Yippee-Mis18 (PF03226, IPR004910): Yippee zinc-binding/DNA-binding /Mis18, centromere assembly
35 PAF1oncoprotein90.55610.786Paf1 (PF03985, IPR007133): Paf1
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
36 PLCG1oncoprotein40.5001.833C2 (PF00168, IPR000008, SM00239): C2 domain
PH (PF00169, IPR001849, SM00233): PH domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
PH_12 (PF16457, IPR001849): Pleckstrin homology domain
37 PLEKHO2interactor21.0000PH (PF00169, IPR001849, SM00233): PH domain
38 RB1suppressor60.46710.952RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
Rb_C (PF08934, IPR015030): Rb C-terminal domain
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
DUF4592 (PF15262, IPR028030): Domain of unknown function (DUF4592)
39 RNF20interactor270.163244.752Allexi_40kDa (PF05549, IPR008398): Allexivirus 40kDa protein
Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
DUF1690 (PF07956, IPR012471): Protein of Unknown function (DUF1690)
HrpB7 (PF09486, IPR013392): Bacterial type III secretion protein (HrpB7)
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
Sox_N (PF12444, IPR022151): Sox developmental protein N terminal
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
40 SEPT2oncoprotein40.6671.000FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
Septin (PF00735, IPR000038): Septin
41 SFR1interactor100Mei5 (PF10376, IPR018468): Double-strand recombination repair protein
42 SIRT6suppressor31.0000SIR2 (PF02146, IPR003000): Sir2 family
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
43 SNAP29protein found in more fusions50.5002.400DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
V-SNARE_C (PF12352): Snare region anchored in the vesicle membrane C-terminus
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
44 SNX2interactor40.6671.667PX (PF00787, IPR001683, SM00312): PX domain
Sorting_nexin (PF03700, IPR005329): Sorting nexin, N-terminal domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
45 STX1Ainteractor40.6671.000Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
4HB_MCP_1 (PF12729, IPR024478): Four helix bundle sensory module for signal transduction
46 SUPT6Hinteractor40.5003.000Afi1 (PF07792, IPR012860): Docking domain of Afi1 for Arf3 in vesicle trafficking
S1 (PF00575, IPR003029, SM00316): S1 RNA binding domain
Tex_N (PF09371, IPR018974): Tex-like protein N-terminal domain
zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6
SH2_2 (PF14633, IPR000980): SH2 domain
HHH_7 (PF14635, IPR032706): Helix-hairpin-helix motif
YqgF (PF14639, IPR028231): Holliday-junction resolvase-like of SPT6
HTH_44 (PF14641, IPR028088): Helix-turn-helix DNA-binding domain of SPT6
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
DLD (PF14878, IPR027999): Death-like domain of SPT6
47 TALDO1interactor50.6003.167TAL_FSA (PF00923, IPR001585): Transaldolase/Fructose-6-phosphate aldolase
48 TERF1interactor70.7332.333TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
49 TERF2interactor90.46419.267Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
TERF2_RBM (PF16772, IPR031902): Telomeric repeat-binding factor 2 Rap1-binding motif
50 TFAP2Cinteractor20126.000TF_AP-2 (PF03299, IPR013854): Transcription factor AP-2
51 TRABDinteractor100TraB (PF01963, IPR002816): TraB family
52 TRIM51interactor100CCT_2 (PF09425, IPR018467): Divergent CCT motif
RRF (PF01765, IPR023584): Ribosome recycling factor
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
Tubulin_3 (PF14881, IPR029209): Tubulin domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
53 TXNDC5interactor40.8330.286Thioredoxin (PF00085, IPR013766): Thioredoxin
54 UBE2Ainteractor70.7332.667UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
55 UBE2Binteractor51.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
56 UBE2E1protein found in more fusions50.6675.000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
57 UBE2Iinteractor110.244269.667UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
58 UBE2L6protein found in more fusions200UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
59 UBE2Sinteractor40.6670.400ALF (PF03752, IPR005506): Short repeats of unknown function
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
60 USP15oncoprotein90.32113.900UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337, IPR006615, SM00695): DUSP domain
Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain
61 WACprotein found in more fusions80.4769.400DUF1319 (PF07028, IPR010746): Protein of unknown function (DUF1319)
MGC-24 (PF05283, IPR007947): Multi-glycosylated core protein 24 (MGC-24), sialomucin
WW (PF00397, IPR001202, SM00456): WW domain
MDFI (PF15316, IPR026134): MyoD family inhibitor
CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106
62 WDR61interactor40.6671.333WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
63 WNT4interactor21.0000MEF2_binding (PF09047, IPR015134): MEF2 binding
wnt (PF00110, IPR005817, SM00097): wnt family
64 XPNPEP1interactor50.6002.233Creatinase_N (PF01321, IPR000587): Creatinase/Prolidase N-terminal domain
Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
Peptidase_M24_C (PF16188, IPR032416): C-terminal region of peptidase_M24
Creatinase_N_2 (PF16189): Creatinase/Prolidase N-terminal domain
65 ZNF451protein found in more fusions41.0000zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
zf-met (PF12874): Zinc-finger of C2H2 type
zf-C2H2_4 (PF13894): C2H2-type zinc finger
Cys_rich_KTR (PF14205, IPR025957): Cysteine-rich KTR
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain

B a c k    t o    T o p ⇑