Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins COPS2, ALG5 (from a repository: Sun Jul 28 09:24:01 2019)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 110 The number (and %) of the onco-proteins 29 (26.36 %) The number (and %) of the tumor suppressors 18 (16.36 %) Total number of binary PPIs (saturation %) 702 (11.71 %) The number (and %) of affected PPIs 108 (15.38 %) The number of possible different fusions 18 PPI diameter 5 PPI radius 3 The average degree of PPI 12.018 Assortativity coefficient -0.2426 The network average Clustering coefficient 0.593 The number (and %) of a zero Clustering coefficients 15 (13.64 %) The number (and %) of a zero Betweenness Centrality 38 (34.55 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: ALG5,COPS2	All fusions
Proteins found in more fusions	GRK5 (see 2 fusions); VDR (see 2 fusions); CUL4A (see 4 fusions); NPM1 (see 1 fusions); CUL1 (see 3 fusions); CUL3 (see 1 fusions); NAP1L1 (see 4 fusions); CREBBP (see 6 fusions); KDM1A (see 3 fusions); CSNK2A1 (see 2 fusions); COPS5 (see 1 fusions); EP300 (see 1 fusions); DDB1 (see 4 fusions); PSMC5 (see 2 fusions); THRA (see 3 fusions); TP53 (see 3 fusions); IBTK (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	ALG5	parental protein	6	0	1060.000	Glycos_transf_2 (PF00535, IPR001173): Glycosyl transferase family 2 DUF2749 (PF10907, IPR024475): Protein of unknown function (DUF2749)
2	COPS2	parental protein	102	0.107	7193.356	YozE_SAM_like (PF06855, IPR023089): YozE SAM-like fold TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat DUF2087 (PF09860, IPR018656): Uncharacterized protein conserved in bacteria (DUF2087) PCI (PF01399, IPR000717, SM00088): PCI domain TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
3	ABCA1	oncoprotein	2	1.000	0	ABC_tran (PF00005, IPR003439): ABC transporter ABC2_membrane_3 (PF12698): ABC-2 family transporter protein AAA_21 (PF13304, IPR003959): AAA domain, putative AbiEii toxin, Type IV TA system DUF4162 (PF13732, IPR025302): Domain of unknown function (DUF4162)
4	ANAPC1	suppressor	4	1.000	0	PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat ANAPC1 (PF12859, IPR024990): Anaphase-promoting complex subunit 1
5	ANAPC4	interactor	5	1.000	0	ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain ANAPC4 (PF12896, IPR024790): Anaphase-promoting complex, cyclosome, subunit 4
6	APPBP2	interactor	5	0.700	2.333	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_17 (PF13431): Tetratricopeptide repeat
7	AR	oncoprotein	16	0.295	95.282	Androgen_recep (PF02166, IPR001103): Androgen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
8	BTBD1	interactor	9	1.000	0	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain PHR (PF08005, IPR012983): PHR domain
9	BTBD2	interactor	9	0.889	0.682	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal PHR (PF08005, IPR012983): PHR domain
10	CACNG4	interactor	1	0	0	PMP22_Claudin (PF00822, IPR004031): PMP-22/EMP/MP20/Claudin family
11	CD1B	interactor	1	0	0	C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain MLANA (PF14991, IPR029242): Protein melan-A MHC_I_3 (PF16497, IPR011161): MHC-I family domain
12	CDC16	interactor	6	0.600	6.000	Dynein_light (PF01221, IPR001372): Dynein light chain type 1 TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 (PF13424): Tetratricopeptide repeat TPR_17 (PF13431): Tetratricopeptide repeat TPR_16 (PF13432): Tetratricopeptide repeat SRP_TPR_like (PF17004, IPR031545): Putative TPR-like repeat
13	CEP170P1	interactor	3	1.000	0	NA
14	COPS3	interactor	39	0.422	163.464	RasGEF (PF00617, IPR001895, SM00147): RasGEF domain TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat PCI (PF01399, IPR000717, SM00088): PCI domain
15	COPS4	interactor	40	0.408	171.703	DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) PCI (PF01399, IPR000717, SM00088): PCI domain TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_14 (PF13428): Tetratricopeptide repeat
16	COPS5	protein found in more fusions	50	0.319	384.568	JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
17	COPS6	interactor	43	0.390	222.052	DUF320 (PF03777, IPR005528): Small secreted domain (DUF320) JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
18	COPS7A	interactor	34	0.499	91.193	PCI (PF01399, IPR000717, SM00088): PCI domain
19	COPS7B	interactor	26	0.671	26.535	PCI (PF01399, IPR000717, SM00088): PCI domain
20	COPS8	interactor	29	0.638	39.774	CSN8_PSD8_EIF3K (PF10075): CSN8/PSMD8/EIF3K family
21	COPS9	interactor	14	0.967	0.327	MYEOV2 (PF15004, IPR029391): Myeloma-overexpressed-like
22	CPSF1	interactor	7	0.714	5.167	CPSF_A (PF03178, IPR004871): CPSF A subunit region MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term HPS3_N (PF14761, IPR029437): Hermansky-Pudlak syndrome 3
23	CREBBP	suppressor	16	0.419	32.402	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain MAS20 (PF02064, IPR002056): MAS20 protein import receptor TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26 HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729) DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
24	CSNK2A1	oncoprotein	15	0.385	63.037	Pkinase (PF00069, IPR000719): Protein kinase domain
25	CUL1	suppressor	29	0.497	86.332	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
26	CUL2	suppressor	26	0.492	84.343	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
27	CUL3	protein found in more fusions	32	0.482	120.677	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
28	CUL4A	protein found in more fusions	33	0.502	104.916	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
29	CUL4B	oncoprotein	30	0.549	174.733	Cullin (PF00888, IPR001373, SM00182): Cullin family EBP50_C (PF09007, IPR015098): EBP50, C-terminal Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain MDFI (PF15316, IPR026134): MyoD family inhibitor
30	CUL5	suppressor	29	0.584	49.758	Cullin (PF00888, IPR001373, SM00182): Cullin family GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
31	DCAF11	interactor	14	0.923	1.136	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
32	DCAF4	interactor	8	1.000	0	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain DUF4221 (PF13970, IPR025316): Domain of unknown function (DUF4221)
33	DCAF4L2	interactor	3	1.000	0	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
34	DCAF6	interactor	8	0.571	4.067	Herpes_pp85 (PF04637, IPR006731): Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat DUF3408 (PF11888, IPR021823): Protein of unknown function (DUF3408) ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain ATAD4 (PF15321, IPR028237): ATPase family AAA domain containing 4 MRI (PF15325, IPR028278): Modulator of retrovirus infection WD40_like (PF17005, IPR031544): WD40-like domain
35	DCAF8	interactor	11	1.000	0	DUF1635 (PF07795, IPR012862): Protein of unknown function (DUF1635) WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain DUF4661 (PF15576, IPR029073): Domain of unknown function (DUF4661)
36	DCUN1D1	interactor	21	0.795	9.954	Cullin_binding (PF03556, IPR005176): Cullin binding UBA_4 (PF14555): UBA-like domain
37	DDA1	interactor	17	0.838	6.423	DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase
38	DDB1	protein found in more fusions	31	0.533	174.824	CPSF_A (PF03178, IPR004871): CPSF A subunit region MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
39	DDB2	suppressor	21	0.674	33.074	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
40	EDA	interactor	2	0	1236.000	Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies) TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
41	EHBP1L1	interactor	1	0	0	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain NT-C2 (PF10358, IPR019448): N-terminal C2 in EEIG1 and EHBP1 proteins DUF3585 (PF12130, IPR022735): Protein of unknown function (DUF3585)
42	EIF3E	oncoprotein	4	1.000	0	eIF3_N (PF09440, IPR019010): eIF3 subunit 6 N terminal domain PCI (PF01399, IPR000717, SM00088): PCI domain HD_assoc (PF13286, IPR026875): Phosphohydrolase-associated domain SPESP1 (PF15754, IPR026743): Sperm equatorial segment protein 1
43	EP300	oncoprotein	23	0.290	101.540	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
44	EPB41L1	interactor	5	1.000	0	4_1_CTD (PF05902, IPR008379): 4.1 protein C-terminal domain (CTD)
45	ERCC3	oncoprotein	6	0.533	5.233	ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit DUF2748 (PF10871, IPR020183): Protein of unknown function (DUF2748) Helicase_C_3 (PF13625, IPR032830): Helicase conserved C-terminal domain PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal ERCC3_RAD25_C (PF16203, IPR032438): ERCC3/RAD25/XPB C-terminal helicase
46	ERCC8	oncoprotein	18	0.752	20.026	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain DUF4859 (PF16151, IPR032339): Domain of unknown function (DUF4859)
47	FBXO17	interactor	8	1.000	0	FBA (PF04300, IPR007397): F-box associated region F-box-like (PF12937, IPR001810): F-box-like
48	FBXO6	interactor	17	0.537	34.553	FBA (PF04300, IPR007397): F-box associated region F-box-like (PF12937, IPR001810): F-box-like
49	FBXO7	interactor	5	0.900	0.333	Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A PI31_Prot_N (PF11566, IPR021625): PI31 proteasome regulator N-terminal F-box-like (PF12937, IPR001810): F-box-like
50	FBXW4	oncoprotein	10	1.000	0	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat F-box-like (PF12937, IPR001810): F-box-like F-box_4 (PF15966, IPR001810): F-box
51	FEM1B	interactor	9	1.000	0	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
52	GAPVD1	interactor	1	0	0	RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase VPS9 (PF02204, IPR003123, SM00167): Vacuolar sorting protein 9 (VPS9) domain
53	GFER	interactor	5	1.000	0	Evr1_Alr (PF04777, IPR017905): Erv1 / Alr family Meiotic_rec114 (PF03525, IPR004354): Meiotic recombination protein rec114
54	GPS1	interactor	32	0.468	116.740	RPN7 (PF10602, IPR019585): 26S proteasome subunit RPN7 PCI (PF01399, IPR000717, SM00088): PCI domain
55	GRK5	protein found in more fusions	11	0.578	36.219	Pkinase (PF00069, IPR000719): Protein kinase domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
56	GTF2H2	interactor	4	0.667	1.067	C1_4 (PF07975, IPR004595, SM01047): TFIIH C1-like domain Prim_Zn_Ribbon (PF08273, IPR013237, SM00778): Zinc-binding domain of primase-helicase Ssl1 (PF04056, IPR007198): Ssl1-like zf-HIT (PF04438, IPR007529): HIT zinc finger UPF0547 (PF10571, IPR018886): Uncharacterised protein family UPF0547 zf-C2H2_4 (PF13894): C2H2-type zinc finger
57	HIST1H3A	interactor	10	0.556	6.656	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
58	HIST1H4A	interactor	12	0.545	14.829	CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
59	IBTK	protein found in more fusions	7	0.600	2.733	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat Ank_5 (PF13857): Ankyrin repeats (many copies)
60	ING1	suppressor	5	0.800	4.063	PHD (PF00628, IPR019787, SM00249): PHD-finger NPR3 (PF03666, IPR005365): Nitrogen Permease regulator of amino acid transport activity 3 ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta
61	ING2	suppressor	4	0.833	1.778	PHD (PF00628, IPR019787, SM00249): PHD-finger S1FA (PF04689, IPR006779): DNA binding protein S1FA ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
62	IP6K1	interactor	4	1.000	0	IPK (PF03770, IPR005522): Inositol polyphosphate kinase SIN1 (PF05422, IPR008828): Stress-activated map kinase interacting protein 1 (SIN1)
63	IRF5	suppressor	13	0.561	38.569	IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
64	IRF8	suppressor	6	1.000	0	IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
65	IRS2	oncoprotein	1	0	0	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein PRIMA1 (PF16101): Proline-rich membrane anchor 1
66	JUN	oncoprotein	11	0.511	10.337	bZIP_1 (PF00170, IPR004827): bZIP transcription factor Jun (PF03957, IPR005643): Jun-like transcription factor
67	KDM1A	protein found in more fusions	11	0.378	48.244	Amino_oxidase (PF01593, IPR002937): Flavin containing amine oxidoreductase CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain SWIRM (PF04433, IPR007526): SWIRM domain DUF4298 (PF14131, IPR025384): Domain of unknown function (DUF4298)
68	KLHDC3	interactor	5	1.000	0	Kelch_2 (PF07646, IPR011498): Kelch motif Kelch_3 (PF13415): Galactose oxidase, central domain Kelch_4 (PF13418): Galactose oxidase, central domain Kelch_5 (PF13854): Kelch motif Kelch_6 (PF13964): Kelch motif
69	KLHL13	interactor	7	1.000	0	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif Kelch_3 (PF13415): Galactose oxidase, central domain
70	KRAS	oncoprotein	11	0.422	23.800	Ras (PF00071, IPR001806, SM00173): Ras family
71	LRR1	interactor	14	0.813	13.028	LRR_1 (PF00560, IPR001611): Leucine Rich Repeat LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat
72	MAP3K10	interactor	2	0	0	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase DUF3552 (PF12072, IPR022711): Domain of unknown function (DUF3552) SH3_9 (PF14604, IPR001452): Variant SH3 domain
73	MED23	interactor	6	0.667	3.167	Med23 (PF11573, IPR021629): Mediator complex subunit 23
74	MED4	interactor	6	0.400	8.167	Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
75	NAP1L1	protein found in more fusions	11	0.667	3.729	NAP (PF00956, IPR002164): Nucleosome assembly protein (NAP) RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31 PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
76	NCOR1	oncoprotein	15	0.419	74.166	BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp) MAS20 (PF02064, IPR002056): MAS20 protein import receptor Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein Hid1 (PF12722): High-temperature-induced dauer-formation protein Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834) RBR (PF17208): RNA binding Region
77	NEDD8	interactor	25	0.674	30.306	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
78	NFKBIA	oncoprotein	7	0.524	4.122	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
79	NIF3L1	interactor	2	0	0	NIF3 (PF01784, IPR002678): NIF3 (NGG1p interacting factor 3)
80	NPM1	suppressor	21	0.416	57.680	Nucleoplasmin (PF03066): Nucleoplasmin/nucleophosmin domain SDA1 (PF05285, IPR007949): SDA1 NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
81	NR0B1	interactor	2	1.000	0	zf-C4_ClpX (PF06689, IPR010603, SM00994): ClpX C4-type zinc finger Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor NR_Repeat (PF14046, IPR025900): Nuclear receptor repeat
82	NR2F1	oncoprotein	2	1.000	0	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
83	NUCKS1	interactor	1	0	0	FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid) XRCC4 (PF06632, IPR010585): DNA double-strand break repair and V(D)J recombination protein XRCC4 PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal CCSAP (PF15748, IPR029774): Centriole, cilia and spindle-associated
84	PFKFB2	interactor	1	0	0	6PF2K (PF01591, IPR013079): 6-phosphofructo-2-kinase His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1)
85	PKD2	interactor	2	0	0	Ion_trans (PF00520, IPR005821): Ion transport protein PKD_channel (PF08016, IPR013122): Polycystin cation channel Tetraspannin (PF00335, IPR018499): Tetraspanin family EF-hand_1 (PF00036, IPR002048, SM00054): EF hand EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
86	PMPCA	interactor	1	0	0	Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16) Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
87	POMK	interactor	1	0	0	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
88	PRAME	interactor	4	0.667	1.000	LRR_1 (PF00560, IPR001611): Leucine Rich Repeat LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
89	PRKD1	oncoprotein	7	0.533	3.167	PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
90	PSMA6	interactor	10	0.511	14.767	Proteasome (PF00227, IPR001353): Proteasome subunit Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
91	PSMC1	interactor	9	0.500	11.455	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) DivIC (PF04977, IPR007060): Septum formation initiator DUF815 (PF05673, IPR008533): Protein of unknown function (DUF815) Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
92	PSMC3	interactor	10	0.556	9.902	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) DUF3713 (PF12506, IPR022186): Protein of unknown function (DUF3713) JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
93	PSMC5	protein found in more fusions	15	0.341	45.489	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) Laminin_II (PF06009, IPR010307): Laminin Domain II RILP (PF11461, IPR021563): Rab interacting lysosomal protein AAA_16 (PF13191): AAA ATPase domain
94	PSMD5	interactor	5	1.000	0	Proteasom_PSMB (PF10508, IPR019538): Proteasome non-ATPase 26S subunit
95	RAB5C	oncoprotein	2	1.000	0	Ras (PF00071, IPR001806, SM00173): Ras family
96	RFWD2	suppressor	23	0.688	21.426	Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein IncA (PF04156, IPR007285): IncA protein WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) WD40_like (PF17005, IPR031544): WD40-like domain
97	SENP8	interactor	6	0.867	0.216	Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain
98	SEPHS1	interactor	3	1.000	0	AIRS (PF00586, IPR000728): AIR synthase related protein, N-terminal domain AIRS_C (PF02769, IPR010918): AIR synthase related protein, C-terminal domain
99	SEPT2	oncoprotein	3	0.667	0.333	FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger Septin (PF00735, IPR000038): Septin
100	SIN3A	oncoprotein	14	0.319	1454.727	Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
101	SIN3B	interactor	4	1.000	0	Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
102	SLAIN2	interactor	3	0.667	0.500	bZIP_1 (PF00170, IPR004827): bZIP transcription factor SLAIN (PF15301, IPR026179): SLAIN motif-containing family
103	SPINT2	suppressor	1	0	0	Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
104	THRA	suppressor	6	0.500	3.786	C1_2 (PF03107, IPR004146): C1 domain zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
105	THRB	suppressor	5	0.833	0.400	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
106	TP53	suppressor	30	0.259	283.569	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
107	TRIP11	oncoprotein	3	0.667	1.000	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) DUF1529 (PF07485, IPR011094): Domain of Unknown Function (DUF1259) DUF1690 (PF07956, IPR012471): Protein of Unknown function (DUF1690) DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349) ZapB (PF06005, IPR009252): Cell division protein ZapB ERM (PF00769, IPR011259): Ezrin/radixin/moesin family NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5 bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper DUF3138 (PF11336, IPR021485): Protein of unknown function (DUF3138) ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407) Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
108	UIMC1	suppressor	2	1.000	0	Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
109	VDR	suppressor	10	0.611	8.400	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
110	WRAP73	interactor	6	0.700	2.667	eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A IKI3 (PF04762, IPR006849): IKI3 family WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat DUF2555 (PF10742, IPR019678): Protein of unknown function (DUF2555) ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain

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