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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)104
The number (and %) of the onco-proteins29 (27.88 %)
The number (and %) of the tumor suppressors17 (16.35 %)
Total number of binary PPIs (saturation %)694 (12.96 %)
The number (and %) of affected PPIs102 (14.70 %)
The number of possible different fusions18
PPI diameter2
PPI radiusinf
The average degree of PPI12.577
Assortativity coefficient-0.2605
The network average Clustering coefficient0.628
The number (and %) of a zero Clustering coefficients9 (8.65 %)
The number (and %) of a zero Betweenness Centrality34 (32.69 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: COPS2,CSMD2 All fusions
Proteins found in more fusions GRK5 (see 4 fusions); VDR (see 2 fusions); CUL4A (see 4 fusions); NPM1 (see 1 fusions); CUL1 (see 3 fusions); CUL3 (see 1 fusions); NAP1L1 (see 3 fusions); CREBBP (see 6 fusions); KDM1A (see 2 fusions); CSNK2A1 (see 1 fusions); COPS5 (see 1 fusions); EP300 (see 1 fusions); DDB1 (see 2 fusions); PSMC5 (see 2 fusions); THRA (see 3 fusions); TP53 (see 3 fusions); IBTK (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 COPS2parental protein1020.1076407.301YozE_SAM_like (PF06855, IPR023089): YozE SAM-like fold
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
DUF2087 (PF09860, IPR018656): Uncharacterized protein conserved in bacteria (DUF2087)
PCI (PF01399, IPR000717, SM00088): PCI domain
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
2 CSMD2interactor000CUB (PF00431, IPR000859, SM00042): CUB domain
Hep_core_N (PF08290, IPR013195): Hepatitis core protein, putative zinc finger
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
HRM (PF02793, IPR001879, SM00008): Hormone receptor domain
3 ABCA1oncoprotein21.0000ABC_tran (PF00005, IPR003439): ABC transporter
ABC2_membrane_3 (PF12698): ABC-2 family transporter protein
AAA_21 (PF13304, IPR003959): AAA domain, putative AbiEii toxin, Type IV TA system
DUF4162 (PF13732, IPR025302): Domain of unknown function (DUF4162)
4 ANAPC1suppressor41.0000PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
ANAPC1 (PF12859, IPR024990): Anaphase-promoting complex subunit 1
5 ANAPC4interactor51.0000ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
ANAPC4 (PF12896, IPR024790): Anaphase-promoting complex, cyclosome, subunit 4
6 APPBP2interactor50.7002.333TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
7 ARoncoprotein160.29555.094Androgen_recep (PF02166, IPR001103): Androgen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
8 BTBD1interactor91.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
PHR (PF08005, IPR012983): PHR domain
9 BTBD2interactor90.8890.682BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
PHR (PF08005, IPR012983): PHR domain
10 CDC16interactor60.6006.000Dynein_light (PF01221, IPR001372): Dynein light chain type 1
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
SRP_TPR_like (PF17004, IPR031545): Putative TPR-like repeat
11 CEP170P1interactor31.0000NA
12 COPS3interactor390.422163.464RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
PCI (PF01399, IPR000717, SM00088): PCI domain
13 COPS4interactor400.408171.703DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
PCI (PF01399, IPR000717, SM00088): PCI domain
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
14 COPS5protein found in more fusions500.319384.568JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
15 COPS6interactor430.390222.052DUF320 (PF03777, IPR005528): Small secreted domain (DUF320)
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
16 COPS7Ainteractor340.49991.193PCI (PF01399, IPR000717, SM00088): PCI domain
17 COPS7Binteractor260.67126.535PCI (PF01399, IPR000717, SM00088): PCI domain
18 COPS8interactor290.63839.774CSN8_PSD8_EIF3K (PF10075): CSN8/PSMD8/EIF3K family
19 COPS9interactor140.9670.327MYEOV2 (PF15004, IPR029391): Myeloma-overexpressed-like
20 CPSF1interactor70.7145.167CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
HPS3_N (PF14761, IPR029437): Hermansky-Pudlak syndrome 3
21 CREBBPsuppressor160.41932.402Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
22 CSNK2A1oncoprotein150.38531.271Pkinase (PF00069, IPR000719): Protein kinase domain
23 CUL1suppressor290.49786.332Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
24 CUL2suppressor260.49284.343Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
25 CUL3protein found in more fusions320.482120.677Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
26 CUL4Aprotein found in more fusions330.502104.916Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
27 CUL4Boncoprotein300.54974.733Cullin (PF00888, IPR001373, SM00182): Cullin family
EBP50_C (PF09007, IPR015098): EBP50, C-terminal
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain
MDFI (PF15316, IPR026134): MyoD family inhibitor
28 CUL5suppressor290.58449.758Cullin (PF00888, IPR001373, SM00182): Cullin family
GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
29 DCAF11interactor140.9231.136WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
30 DCAF4interactor81.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
DUF4221 (PF13970, IPR025316): Domain of unknown function (DUF4221)
31 DCAF4L2interactor31.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
32 DCAF6interactor80.5714.067Herpes_pp85 (PF04637, IPR006731): Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
DUF3408 (PF11888, IPR021823): Protein of unknown function (DUF3408)
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
ATAD4 (PF15321, IPR028237): ATPase family AAA domain containing 4
MRI (PF15325, IPR028278): Modulator of retrovirus infection
WD40_like (PF17005, IPR031544): WD40-like domain
33 DCAF8interactor111.0000DUF1635 (PF07795, IPR012862): Protein of unknown function (DUF1635)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
DUF4661 (PF15576, IPR029073): Domain of unknown function (DUF4661)
34 DCUN1D1interactor210.7959.954Cullin_binding (PF03556, IPR005176): Cullin binding
UBA_4 (PF14555): UBA-like domain
35 DDA1interactor170.8386.423DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase
36 DDB1protein found in more fusions310.53379.102CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
37 DDB2suppressor210.67433.074WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
38 EHBP1L1interactor100CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
NT-C2 (PF10358, IPR019448): N-terminal C2 in EEIG1 and EHBP1 proteins
DUF3585 (PF12130, IPR022735): Protein of unknown function (DUF3585)
39 EIF3Eoncoprotein41.0000eIF3_N (PF09440, IPR019010): eIF3 subunit 6 N terminal domain
PCI (PF01399, IPR000717, SM00088): PCI domain
HD_assoc (PF13286, IPR026875): Phosphohydrolase-associated domain
SPESP1 (PF15754, IPR026743): Sperm equatorial segment protein 1
40 EP300oncoprotein230.290101.540Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
41 EPB41L1interactor51.00004_1_CTD (PF05902, IPR008379): 4.1 protein C-terminal domain (CTD)
42 ERCC3oncoprotein60.5335.233ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit
DUF2748 (PF10871, IPR020183): Protein of unknown function (DUF2748)
Helicase_C_3 (PF13625, IPR032830): Helicase conserved C-terminal domain
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
ERCC3_RAD25_C (PF16203, IPR032438): ERCC3/RAD25/XPB C-terminal helicase
43 ERCC8oncoprotein180.75220.026WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
DUF4859 (PF16151, IPR032339): Domain of unknown function (DUF4859)
44 FBXO17interactor81.0000FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
45 FBXO6interactor170.53734.553FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
46 FBXO7interactor50.9000.333Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
PI31_Prot_N (PF11566, IPR021625): PI31 proteasome regulator N-terminal
F-box-like (PF12937, IPR001810): F-box-like
47 FBXW4oncoprotein101.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
F-box-like (PF12937, IPR001810): F-box-like
F-box_4 (PF15966, IPR001810): F-box
48 FEM1Binteractor91.0000Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
49 GAPVD1interactor100RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
VPS9 (PF02204, IPR003123, SM00167): Vacuolar sorting protein 9 (VPS9) domain
50 GFERinteractor51.0000Evr1_Alr (PF04777, IPR017905): Erv1 / Alr family
Meiotic_rec114 (PF03525, IPR004354): Meiotic recombination protein rec114
51 GPS1interactor320.468116.740RPN7 (PF10602, IPR019585): 26S proteasome subunit RPN7
PCI (PF01399, IPR000717, SM00088): PCI domain
52 GRK5protein found in more fusions110.57814.152Pkinase (PF00069, IPR000719): Protein kinase domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
53 GTF2H2interactor40.6671.067C1_4 (PF07975, IPR004595, SM01047): TFIIH C1-like domain
Prim_Zn_Ribbon (PF08273, IPR013237, SM00778): Zinc-binding domain of primase-helicase
Ssl1 (PF04056, IPR007198): Ssl1-like
zf-HIT (PF04438, IPR007529): HIT zinc finger
UPF0547 (PF10571, IPR018886): Uncharacterised protein family UPF0547
zf-C2H2_4 (PF13894): C2H2-type zinc finger
54 HIST1H3Ainteractor100.5566.656Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
55 HIST1H4Ainteractor120.54514.829CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
56 IBTKprotein found in more fusions70.6002.733BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
Ank_5 (PF13857): Ankyrin repeats (many copies)
57 ING1suppressor50.8000.508PHD (PF00628, IPR019787, SM00249): PHD-finger
NPR3 (PF03666, IPR005365): Nitrogen Permease regulator of amino acid transport activity 3
ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding
zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta
58 ING2suppressor40.8330.222PHD (PF00628, IPR019787, SM00249): PHD-finger
S1FA (PF04689, IPR006779): DNA binding protein S1FA
ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding
zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
59 IP6K1interactor41.0000IPK (PF03770, IPR005522): Inositol polyphosphate kinase
SIN1 (PF05422, IPR008828): Stress-activated map kinase interacting protein 1 (SIN1)
60 IRF5suppressor130.56114.580IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
61 IRF8suppressor61.0000IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
62 IRS2oncoprotein100CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
PH (PF00169, IPR001849, SM00233): PH domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
PRIMA1 (PF16101): Proline-rich membrane anchor 1
63 JUNoncoprotein110.51110.337bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
64 KDM1Aprotein found in more fusions110.37821.022Amino_oxidase (PF01593, IPR002937): Flavin containing amine oxidoreductase
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
SWIRM (PF04433, IPR007526): SWIRM domain
DUF4298 (PF14131, IPR025384): Domain of unknown function (DUF4298)
65 KLHDC3interactor51.0000Kelch_2 (PF07646, IPR011498): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_4 (PF13418): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
Kelch_6 (PF13964): Kelch motif
66 KLHL13interactor71.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
67 KRASoncoprotein110.42223.800Ras (PF00071, IPR001806, SM00173): Ras family
68 LRR1interactor140.81313.028LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
69 MAP3K10interactor200Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
DUF3552 (PF12072, IPR022711): Domain of unknown function (DUF3552)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
70 MED23interactor60.6673.167Med23 (PF11573, IPR021629): Mediator complex subunit 23
71 MED4interactor60.4008.167Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
72 NAP1L1protein found in more fusions110.6673.729NAP (PF00956, IPR002164): Nucleosome assembly protein (NAP)
RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
73 NCOR1oncoprotein150.41935.610BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal
Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein
Hid1 (PF12722): High-temperature-induced dauer-formation protein
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
RBR (PF17208): RNA binding Region
74 NEDD8interactor250.67430.306ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
75 NFKBIAoncoprotein70.5244.122Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
76 NIF3L1interactor200NIF3 (PF01784, IPR002678): NIF3 (NGG1p interacting factor 3)
77 NPM1suppressor210.41657.680Nucleoplasmin (PF03066): Nucleoplasmin
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
78 NR0B1interactor21.0000zf-C4_ClpX (PF06689, IPR010603, SM00994): ClpX C4-type zinc finger
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
NR_Repeat (PF14046, IPR025900): Nuclear receptor repeat
79 NR2F1oncoprotein21.0000zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
80 NUCKS1interactor100FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
XRCC4 (PF06632, IPR010585): DNA double-strand break repair and V(D)J recombination protein XRCC4
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
CCSAP (PF15748, IPR029774): Centriole, cilia and spindle-associated
81 PFKFB2interactor1006PF2K (PF01591, IPR013079): 6-phosphofructo-2-kinase
His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1)
82 PMPCAinteractor100Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
83 PRAMEinteractor40.6671.000LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
84 PRKD1oncoprotein70.5333.167PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
85 PSMA6interactor100.51114.767Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
86 PSMC1interactor90.50011.455AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
DivIC (PF04977, IPR007060): Septum formation initiator
DUF815 (PF05673, IPR008533): Protein of unknown function (DUF815)
Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
87 PSMC3interactor100.5569.902AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
DUF3713 (PF12506, IPR022186): Protein of unknown function (DUF3713)
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
88 PSMC5protein found in more fusions150.34145.489AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Laminin_II (PF06009, IPR010307): Laminin Domain II
RILP (PF11461, IPR021563): Rab interacting lysosomal protein
AAA_16 (PF13191): AAA ATPase domain
89 PSMD5interactor51.0000Proteasom_PSMB (PF10508, IPR019538): Proteasome non-ATPase 26S subunit
90 RAB5Concoprotein21.0000Ras (PF00071, IPR001806, SM00173): Ras family
91 RFWD2suppressor230.68821.426Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
IncA (PF04156, IPR007285): IncA protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
WD40_like (PF17005, IPR031544): WD40-like domain
92 SENP8interactor60.8670.216Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain
93 SEPHS1interactor31.0000AIRS (PF00586, IPR000728): AIR synthase related protein, N-terminal domain
AIRS_C (PF02769, IPR010918): AIR synthase related protein, C-terminal domain
94 SEPT2oncoprotein30.6670.333FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
Septin (PF00735, IPR000038): Septin
95 SIN3Aoncoprotein130.37226.727Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor
PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat
Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
96 SIN3Binteractor41.0000Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor
PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat
Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
97 SLAIN2interactor30.6670.500bZIP_1 (PF00170, IPR004827): bZIP transcription factor
SLAIN (PF15301, IPR026179): SLAIN motif-containing family
98 THRAsuppressor60.5003.786C1_2 (PF03107, IPR004146): C1 domain
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
99 THRBsuppressor50.8330.400zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
100 TP53suppressor300.259208.246DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
101 TRIP11oncoprotein30.6671.000ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DUF1529 (PF07485, IPR011094): Domain of Unknown Function (DUF1259)
DUF1690 (PF07956, IPR012471): Protein of Unknown function (DUF1690)
DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349)
ZapB (PF06005, IPR009252): Cell division protein ZapB
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
DUF3138 (PF11336, IPR021485): Protein of unknown function (DUF3138)
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
102 UIMC1suppressor21.0000Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
103 VDRsuppressor100.6118.400zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
104 WRAP73interactor60.7002.667eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
IKI3 (PF04762, IPR006849): IKI3 family
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
DUF2555 (PF10742, IPR019678): Protein of unknown function (DUF2555)
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain

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