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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)33
The number (and %) of the onco-proteins13 (39.39 %)
The number (and %) of the tumor suppressors3 (9.09 %)
Total number of binary PPIs (saturation %)102 (19.32 %)
The number (and %) of affected PPIs31 (30.39 %)
The number of possible different fusions8
PPI diameter2
PPI radiusinf
The average degree of PPI5.273
Assortativity coefficient-0.1106
The network average Clustering coefficient0.512
The number (and %) of a zero Clustering coefficients5 (15.15 %)
The number (and %) of a zero Betweenness Centrality11 (33.33 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CLASP2,ORAI3 All fusions
Proteins found in more fusions NIN (see 1 fusions); CSNK2A1 (see 2 fusions); MAPRE1 (see 1 fusions); DCTN1 (see 2 fusions); SRPK2 (see 1 fusions); GRB2 (see 1 fusions); MARK2 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CLASP2parental protein310.120657.833HEAT (PF02985, IPR000357): HEAT repeat
TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair
CLASP_N (PF12348, IPR024395): CLASP N terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal
HEAT_EZ (PF13513): HEAT-like repeat
2 ORAI3interactor000Orai-1 (PF07856, IPR012446): Mediator of CRAC channel activity
3 AKT1oncoprotein70.4674.800PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
4 ASB3interactor100Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
SOCS_box (PF07525, IPR001496): SOCS box
5 CENPEinteractor40.6671.000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
VIT1 (PF01988, IPR008217): VIT family
DUF1515 (PF07439, IPR010889): Protein of unknown function (DUF1515)
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
ZapB (PF06005, IPR009252): Cell division protein ZapB
Fez1 (PF06818): Fez1
FUSC (PF04632, IPR006726): Fusaric acid resistance protein family
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
IncA (PF04156, IPR007285): IncA protein
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pepsin-I3 (PF06394, IPR010480): Pepsin inhibitor-3-like repeated domain
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
SlyX (PF04102, IPR007236): SlyX
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
TrbI_Ftype (PF09677, IPR014115): Type-F conjugative transfer system protein (TrbI_Ftype)
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
AAA_13 (PF13166, IPR026866): AAA domain
DUF4023 (PF13215, IPR025097): Protein of unknown function (DUF4023)
HAUS6_N (PF14661, IPR028163): HAUS augmin-like complex subunit 6 N-terminus
UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449
HMMR_N (PF15905, IPR031787): Hyaluronan mediated motility receptor N-terminal
T3SSipB (PF16535, IPR032391): Type III cell invasion protein SipB
6 CENPJinteractor50.5002.833DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like
DUF1795 (PF08786, IPR014894): Domain of unknown function (DUF1795)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Rota_VP2 (PF05087, IPR007779): Rotavirus VP2 protein
Tcp10_C (PF07202, IPR009852): T-complex protein 10 C-terminus
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
AAA_23 (PF13476): AAA domain
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
7 CLIP2interactor21.0000APG6 (PF04111, IPR007243): Autophagy protein Apg6
CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
CorA (PF01544, IPR002523): CorA-like Mg2+ transporter protein
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
ZapB (PF06005, IPR009252): Cell division protein ZapB
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Fez1 (PF06818): Fez1
Sas10 (PF09368, IPR018972): Sas10 C-terminal domain
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
Caskin1-CID (PF16600): Caskin1 CASK-interaction domain
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
8 CSNK2A1oncoprotein70.5333.467Pkinase (PF00069, IPR000719): Protein kinase domain
9 DCTN1protein found in more fusions110.31124.867Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
FlgN (PF05130, IPR007809): FlgN protein
HOOK (PF05622, IPR008636): HOOK protein
SlyX (PF04102, IPR007236): SlyX
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
DUF2443 (PF10398, IPR019469): Protein of unknown function (DUF2443)
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
Dynactin (PF12455, IPR022157): Dynein associated protein
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
10 FAM43Ainteractor21.0000PID_2 (PF14719, IPR006020): Phosphotyrosine interaction domain (PTB/PID)
11 FEZ1interactor31.0000FEZ (PF07763, IPR011680): FEZ-like protein
DUF5102 (PF17104, IPR031355): Domain of unknown function (DUF5102)
12 FEZ2interactor21.0000FEZ (PF07763, IPR011680): FEZ-like protein
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
DUF5102 (PF17104, IPR031355): Domain of unknown function (DUF5102)
13 GOPConcoprotein40.6670.333DUF903 (PF06004, IPR010305): Bacterial protein of unknown function (DUF903)
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
DUF3209 (PF11483, IPR021577): Protein of unknown function (DUF3209)
14 GRB2oncoprotein60.8000.900SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
15 GSK3Bsuppressor60.4004.833Pkinase (PF00069, IPR000719): Protein kinase domain
16 LXNsuppressor100Latexin (PF06907, IPR009684): Latexin
17 LYPD3oncoprotein100DUF753 (PF05444, IPR008472): Protein of unknown function (DUF753)
UPAR_LY6 (PF00021, IPR001526): u-PAR/Ly-6 domain
18 MAPRE1oncoprotein60.6003.500CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EB1 (PF03271, IPR004953): EB1-like C-terminal motif
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
19 MARK2protein found in more fusions70.7331.800DUF702 (PF05142, IPR007818): Domain of unknown function (DUF702)
KA1 (PF02149, IPR001772): Kinase associated domain 1
Pkinase (PF00069, IPR000719): Protein kinase domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
20 MOV10interactor70.33310.167AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
21 MPGinteractor100Pur_DNA_glyco (PF02245, IPR003180): Methylpurine-DNA glycosylase (MPG)
22 NINoncoprotein50.5002.667BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
bZIP_1 (PF00170, IPR004827): bZIP transcription factor
DivIC (PF04977, IPR007060): Septum formation initiator
DivIVA (PF05103, IPR007793): DivIVA protein
DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
ZapB (PF06005, IPR009252): Cell division protein ZapB
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
Rho_Binding (PF08912, IPR015008): Rho Binding
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
DUF2205 (PF10224, IPR019357): Predicted coiled-coil protein (DUF2205)
Kinetocho_Slk19 (PF12709, IPR024312): Central kinetochore-associated
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
FlxA (PF14282, IPR025577): FlxA-like protein
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
DUF4665 (PF15679, IPR031389): Domain of unknown function (DUF4665)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
23 NTRK1oncoprotein130.37930.700I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
24 NXF1interactor100.25020.000NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
25 PAN2interactor21.0000RNase_T (PF00929, IPR013520): Exonuclease
UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase
WD40_like (PF17005, IPR031544): WD40-like domain
26 RAD21oncoprotein21.0000Rad21_Rec8 (PF04824, IPR006909): Conserved region of Rad21 / Rec8 like protein
Rad21_Rec8_N (PF04825, IPR006910): N terminus of Rad21 / Rec8 like protein
FAM176 (PF14851): FAM176 family
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
27 SMURF1interactor40.6670.500C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
28 SMYD2interactor40.5002.000Complex1_LYR (PF05347, IPR008011): Complex 1 protein (LYR family)
SET (PF00856, IPR001214, SM00317): SET domain
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
29 SRPK2oncoprotein70.4676.233DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
30 TP53BP1suppressor30.6670.33353-BP1_Tudor (PF09038, IPR015125): Tumour suppressor p53-binding protein-1 Tudor
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
DUF4772 (PF15997, IPR031940): Domain of unknown function (DUF4772)
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
31 XPO1interactor70.4298.800CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
32 YWHABinteractor80.5367.63314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
33 YWHAEoncoprotein100.37822.80014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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