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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins GPR37L1, PLXNB3 (from a repository: Mon Oct 14 18:59:26 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)8
The number (and %) of the onco-proteins1 (12.50 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)7 (25.00 %)
The number (and %) of affected PPIs6 (85.71 %)
The number of possible different fusions2
PPI diameter2
PPI radiusinf
The average degree of PPI1.500
Assortativity coefficient0
The network average Clustering coefficient0.000
The number (and %) of a zero Clustering coefficients8 (100.00 %)
The number (and %) of a zero Betweenness Centrality7 (87.50 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PLXNB3,GPR37L1 All fusions
Proteins found in more fusions CUL7 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PLXNB3parental protein6030.000Plexin_cytopl (PF08337, IPR013548): Plexin cytoplasmic RasGAP domain
PSI (PF01437, IPR002165, SM00423): Plexin repeat
Sema (PF01403, IPR001627, SM00630): Sema domain
Taeniidae_ag (PF05596, IPR008860): Taeniidae antigen
TIG (PF01833, IPR002909): IPT/TIG domain
2 GPR37L1interactor0007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
3 ARHGEF11interactor100CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
RGS-like (PF09128, IPR015212): Regulator of G protein signalling-like domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
4 BTBD3interactor100BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
PHR (PF08005, IPR012983): PHR domain
5 CUL7protein found in more fusions200ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
6 MAGI2interactor100PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
WW (PF00397, IPR001202, SM00456): WW domain
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
PDZ_2 (PF13180, IPR001478): PDZ domain
MAGI_u1 (PF16663): Unstructured region on MAGI
MAGI_u5 (PF16666): Unstructured region on MAGI
7 MAGI3interactor100PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
WW (PF00397, IPR001202, SM00456): WW domain
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
PDZ_2 (PF13180, IPR001478): PDZ domain
MAGI_u1 (PF16663): Unstructured region on MAGI
8 SPOCK2interactor100SPARC_Ca_bdg (PF10591, IPR019577): Secreted protein acidic and rich in cysteine Ca binding region
Kazal_2 (PF07648, IPR002350, SM00280): Kazal-type serine protease inhibitor domain
Thyroglobulin_1 (PF00086, IPR000716, SM00211): Thyroglobulin type-1 repeat

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