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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SEPT9, LARGE1 (from a repository: Sun Jul 21 05:04:56 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)57
The number (and %) of the onco-proteins16 (28.07 %)
The number (and %) of the tumor suppressors7 (12.28 %)
Total number of binary PPIs (saturation %)239 (14.97 %)
The number (and %) of affected PPIs55 (23.01 %)
The number of possible different fusions12
PPI diameter4
PPI radius3
The average degree of PPI7.649
Assortativity coefficient-0.2166
The network average Clustering coefficient0.556
The number (and %) of a zero Clustering coefficients6 (10.53 %)
The number (and %) of a zero Betweenness Centrality11 (19.30 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SEPTIN9,LARGE1 All fusions
Proteins found in more fusions HNRNPD (see 1 fusions); APP (see 5 fusions); TPM3 (see 3 fusions); COPA (see 1 fusions); MSH2 (see 1 fusions); SH3KBP1 (see 1 fusions); NEDD4 (see 1 fusions); NCL (see 4 fusions); NTRK1/TPM3 (see 2 fusions); U2AF2 (see 2 fusions); SNW1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SEPT9parental protein530.1172088.111Septin (PF00735, IPR000038): Septin
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
2 LARGE1parental protein204.000Glyco_transf_8 (PF01501, IPR002495): Glycosyl transferase family 8
Glyco_transf_49 (PF13896): Glycosyl-transferase for dystroglycan
3 ANLNoncoprotein100.44417.856Anillin (PF08174, IPR012966): Cell division protein anillin
PH (PF00169, IPR001849, SM00233): PH domain
Anillin_N (PF16018, IPR031970): Anillin N-terminus
4 APPprotein found in more fusions100.25023.619APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 CDC42EP4interactor70.7622.833PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
BORG_CEP (PF14957, IPR029273): Cdc42 effector
6 CDC5Linteractor140.60315.826OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
7 CFTRsuppressor80.38110.400ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
8 COPAprotein found in more fusions100.50014.408Coatomer_WDAD (PF04053, IPR006692): Coatomer WD associated region
COPI_C (PF06957, IPR010714): Coatomer (COPI) alpha subunit C-terminus
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
9 DDA1interactor21.0000DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase
10 EEDsuppressor90.7502.740WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
11 FERMT2interactor50.5003.000FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
12 FLNBoncoprotein50.5002.022CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
PapC_N (PF13954, IPR025885): PapC N-terminal domain
13 FN1oncoprotein120.24241.879fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
14 HAUS1interactor31.0000THP2 (PF09432, IPR018557): Tho complex subunit THP2
XhlA (PF10779, IPR019715): Haemolysin XhlA
DUF3496 (PF12001, IPR021885): Domain of unknown function (DUF3496)
15 HIF1Asuppressor21.0000Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein
HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1
16 HNRNPDoncoprotein110.6228.146CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Keratin_2_head (PF16208, IPR032444): Keratin type II head
17 HSPA5oncoprotein160.533196.635HSP70 (PF00012, IPR013126): Hsp70 protein
18 HSPD1suppressor120.56120.058Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
19 IKBKGinteractor31.0000CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
20 JPT1interactor100JUPITER (PF17054): Microtubule-Associated protein Jupiter
21 MSH2suppressor60.9000.250MutS_I (PF01624, IPR007695): MutS domain I
MutS_II (PF05188, IPR007860): MutS domain II
MutS_V (PF00488, IPR000432, SM00534): MutS domain V
MutS_III (PF05192, IPR007696, SM00533): MutS domain III
AAA_27 (PF13514): AAA domain
22 NCLprotein found in more fusions80.6671.872DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
Myc_N (PF01056, IPR012682): Myc amino-terminal region
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
YL1 (PF05764, IPR008895): YL1 nuclear protein
Limkain-b1 (PF11608, IPR024582): Limkain b1
23 NDUFV2interactor50.4005.0002Fe-2S_thioredx (PF01257, IPR002023): Thioredoxin-like [2Fe-2S] ferredoxin
24 NEDD4suppressor40.6670.500Rota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
25 NTRK1oncoprotein200.298104.522I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
26 OBSL1interactor150.39636.048BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
27 PLAURoncoprotein2029.638Toxin_1 (PF00087, IPR003571): Snake toxin
UPAR_LY6 (PF00021, IPR001526): u-PAR/Ly-6 domain
28 RIDAinteractor31.0000Ribonuc_L-PSP (PF01042, IPR006175): Endoribonuclease L-PSP
29 SCO2interactor50.5004.667SCO1-SenC (PF02630, IPR003782): SCO1/SenC
30 SCP2interactor40.6671.333SCP2 (PF02036, IPR003033): SCP-2 sterol transfer family
Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
31 SEC22Binteractor80.28617.556Synaptobrevin (PF00957, IPR001388): Synaptobrevin
Longin (PF13774, IPR010908): Regulated-SNARE-like domain
32 SEPT1interactor80.7622.833Pet20 (PF08692, IPR014804): Mitochondrial protein Pet20
Septin (PF00735, IPR000038): Septin
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
33 SEPT11interactor120.43929.319Septin (PF00735, IPR000038): Septin
DUF3080 (PF11279, IPR021431): Protein of unknown function (DUF3080)
34 SEPT2oncoprotein170.44948.179FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
Septin (PF00735, IPR000038): Septin
35 SEPT3interactor80.9520.286Septin (PF00735, IPR000038): Septin
36 SEPT6oncoprotein130.50029.626Septin (PF00735, IPR000038): Septin
DUF2959 (PF11172, IPR021342): Protein of unknown function (DUF2959)
37 SEPT7interactor150.51431.915Fez1 (PF06818): Fez1
Septin (PF00735, IPR000038): Septin
38 SH3KBP1protein found in more fusions80.8101.633Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein
SH3_9 (PF14604, IPR001452): Variant SH3 domain
39 SNW1protein found in more fusions160.54331.220SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
40 SRRM2interactor140.53830.382cwf21 (PF08312, IPR013170, SM01115): cwf21 domain
DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
Pap_E4 (PF02711, IPR003861): E4 protein
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
CTD (PF12815, IPR024945, SM01104): Spt5 C-terminal nonapeptide repeat binding Spt4
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
41 STK11suppressor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
42 SUCLG1interactor30.6670.667CoA_binding (PF02629, IPR003781, SM00881): CoA binding domain
Ligase_CoA (PF00549, IPR005811): CoA-ligase
CoA_binding_2 (PF13380, IPR003781): CoA binding domain
43 SUCLG2interactor40.5002.167ATP-grasp_2 (PF08442, IPR013650): ATP-grasp domain
Ligase_CoA (PF00549, IPR005811): CoA-ligase
44 SVILinteractor40.5002.667Gelsolin (PF00626, IPR007123): Gelsolin repeat
VHP (PF02209, IPR003128, SM00153): Villin headpiece domain
DUF4695 (PF15766, IPR031521): Domain of unknown function (DUF4695)
45 TIMM44interactor40.6671.667Tim44 (PF04280, IPR007379, SM00978): Tim44-like domain
DUF4211 (PF13926, IPR025451): Domain of unknown function (DUF4211)
AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
RecG_N (PF17190): RecG N-terminal helical domain
46 TMED9interactor30.6670.500EMP24_GP25L (PF01105, IPR009038): emp24/gp25L/p24 family/GOLD
47 TMEM25interactor2080.362C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
DUF4674 (PF15719, IPR029779): Domain of unknown function (DUF4674)
48 TOR1AIP1interactor21.0000LAP1C (PF05609, IPR008662): Lamina-associated polypeptide 1C (LAP1C)
Pap_E4 (PF02711, IPR003861): E4 protein
49 TPM3oncoprotein60.4001.939Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
50 U2AF2protein found in more fusions140.6928.989RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495, IPR010519): Fruit fly transformer protein
51 UBXN6interactor30.6671.000PUB (PF09409, IPR018997): PUB domain
UBX (PF00789, IPR001012, SM00166): UBX domain
52 UQCRFS1interactor21.0000Rieske (PF00355, IPR017941): Rieske [2Fe-2S] domain
Ubiq-Cytc-red_N (PF09165, IPR015248): Ubiquinol-cytochrome c reductase 8 kDa, N-terminal
UCR_TM (PF02921, IPR004192): Ubiquinol cytochrome reductase transmembrane region
53 UQCRFS1P1interactor100NA
54 VAMP2interactor31.0000Synaptobrevin (PF00957, IPR001388): Synaptobrevin
PRIMA1 (PF16101): Proline-rich membrane anchor 1
55 VAPBinteractor50.5005.000ATP-synt_G (PF04718, IPR006808): Mitochondrial ATP synthase g subunit
ZapB (PF06005, IPR009252): Cell division protein ZapB
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
56 VMA21interactor20131.638VMA21 (PF09446, IPR019013): VMA21-like domain
57 XPO1interactor110.36423.094CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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