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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins TMEM87A, FCMR (from a repository: Thu Jul 9 11:45:13 2020)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)16
The number (and %) of the onco-proteins3 (18.75 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)17 (14.17 %)
The number (and %) of affected PPIs14 (82.35 %)
The number of possible different fusions1
PPI diameter2
PPI radiusinf
The average degree of PPI2.000
Assortativity coefficient-0.0281
The network average Clustering coefficient0.169
The number (and %) of a zero Clustering coefficients12 (75.00 %)
The number (and %) of a zero Betweenness Centrality13 (81.25 %)


List of the fusions

PPI for parental proteins: TMEM87A,FCMR All fusions
Proteins found in more fusions

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 TMEM87Aparental protein110.036105.000Lung_7-TM_R (PF06814, IPR009637): Lung seven transmembrane receptor
SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6
2 FCMRparental protein306.000V-set (PF07686, IPR013106): Immunoglobulin V-set domain
CReP_N (PF10472, IPR019512): eIF2-alpha phosphatase phosphorylation constitutive repressor
3 AGPSinteractor100FAD-oxidase_C (PF02913, IPR004113): FAD linked oxidases, C-terminal domain
FAD_binding_4 (PF01565, IPR006094): FAD binding domain
4 ANKRD2interactor100Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
5 BTNL8interactor100I-set (PF07679, IPR013098): Immunoglobulin I-set domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
Ig_3 (PF13927): Immunoglobulin domain
6 ERGIC3oncoprotein100COPIIcoated_ERV (PF07970, IPR012936): Endoplasmic reticulum vesicle transporter
ERGIC_N (PF13850): Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)
7 GLRA2interactor100Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
8 HOXD9interactor100Hox9_act (PF04617, IPR006711): Hox9 activation region
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
9 HTR3Cinteractor100Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
10 LPAR1oncoprotein1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
11 SPCS2interactor30.6671.000SPC25 (PF06703, IPR009582): Microsomal signal peptidase 25 kDa subunit (SPC25)
12 TMEM17interactor100Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
13 TMEM216interactor21.0000Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
14 TSPAN5interactor21.0000Tetraspannin (PF00335, IPR018499): Tetraspanin family
15 USP7oncoprotein200MATH (PF00917, IPR002083, SM00061): MATH domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7
USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal
16 ZNHIT3interactor100FGGY_C (PF02782, IPR018485): FGGY family of carbohydrate kinases, C-terminal domain
zf-HIT (PF04438, IPR007529): HIT zinc finger

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