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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)72
The number (and %) of the onco-proteins14 (19.44 %)
The number (and %) of the tumor suppressors10 (13.89 %)
Total number of binary PPIs (saturation %)304 (11.89 %)
The number (and %) of affected PPIs72 (23.68 %)
The number of possible different fusions9
PPI diameter4
PPI radius2
The average degree of PPI7.722
Assortativity coefficient-0.2844
The network average Clustering coefficient0.466
The number (and %) of a zero Clustering coefficients11 (15.28 %)
The number (and %) of a zero Betweenness Centrality18 (25.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: DRG1,INTS4 All fusions
Proteins found in more fusions SSX2IP (see 1 fusions); HLA-B (see 4 fusions); STAU1 (see 2 fusions); SFN (see 1 fusions); CUL7 (see 2 fusions); SRPK2 (see 1 fusions); GRB2 (see 1 fusions); SNW1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DRG1parental protein430.0992058.690MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
TGS (PF02824, IPR004095): TGS domain
MMR_HSR1_Xtn (PF16897, IPR031662): C-terminal region of MMR_HSR1 domain
2 INTS4parental protein290.2021051.893Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
HEAT (PF02985, IPR000357): HEAT repeat
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
3 ABL1oncoprotein80.47611.184Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
4 ASUNinteractor100.53345.250DUF2151 (PF10221, IPR019355): Cell cycle and development regulator
5 BARD1suppressor50.5004.102BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
zf-RING_6 (PF14835): zf-RING of BARD1-type protein
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
6 BRCA1suppressor90.17994.567BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
7 C7orf26interactor70.7625.950DUF4507 (PF14964, IPR027844): Domain of unknown function (DUF4507)
8 CAND1interactor120.345114.164Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
9 CAND2interactor21.0000Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
CAF1A (PF12253, IPR022043): Chromatin assembly factor 1 subunit A
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
TFCD_C (PF12612, IPR022577): Tubulin folding cofactor D C terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
10 CAPNS1interactor40.8330.222EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
11 CCDC8interactor80.42934.713Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
12 CDC5Linteractor150.396137.462OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
13 CLDN1suppressor100PMP22_Claudin (PF00822, IPR004031): PMP-22/EMP/MP20/Claudin family
DUF4131 (PF13567, IPR025405): Domain of unknown function (DUF4131)
14 COILinteractor40.6671.400CDC45 (PF02724, IPR003874): CDC45-like protein
Macoilin (PF09726, IPR019130): Transmembrane protein
Coilin_N (PF15862, IPR031722): Coilin N-terminus
15 CPSF3Linteractor120.8335.767RMMBL (PF07521, IPR011108): Zn-dependent metallo-hydrolase RNA specificity domain
Beta-Casp (PF10996, IPR022712, SM01027): Beta-Casp domain
Lactamase_B_3 (PF13483): Beta-lactamase superfamily domain
Lactamase_B_6 (PF16661, IPR001279): Metallo-beta-lactamase superfamily domain
16 CUL7protein found in more fusions80.5718.801ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
17 FAF2interactor50.33319.091DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
UBX (PF00789, IPR001012, SM00166): UBX domain
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
18 FAM98Ainteractor30.6675.190DUF2465 (PF10239, IPR018797): Protein of unknown function (DUF2465)
19 FEN1oncoprotein70.42928.6255_3_exonuc (PF01367, IPR020045, SM00475): 5'-3' exonuclease, C-terminal SAM fold
XPG_I (PF00867, IPR006086, SM00484): XPG I-region
XPG_N (PF00752, IPR006085, SM00485): XPG N-terminal domain
20 FN1oncoprotein110.30950.651fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
21 GRB2oncoprotein90.35741.557SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
22 HAO1interactor100FMN_dh (PF01070, IPR000262): FMN-dependent dehydrogenase
23 HDGFinteractor90.333150.230PWWP (PF00855, IPR000313, SM00293): PWWP domain
24 HECW2interactor50.333117.891C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
25 HGSinteractor50.30062.651FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
PIEZO (PF15917, IPR031805): Piezo
26 HLA-Boncoprotein40.6670.667MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
27 IFRD2oncoprotein100IFRD (PF05004, IPR007701): Interferon-related developmental regulator (IFRD)
IFRD_C (PF04836, IPR006921): Interferon-related protein conserved region
28 INTS1interactor200.426214.623DUF3677 (PF12432, IPR022145): Protein of unknown function (DUF3677)
29 INTS10interactor110.72716.395NA
30 INTS3interactor170.50789.134SKA1 (PF07160, IPR009829): Spindle and kinetochore-associated protein 1
Fn_bind (PF02986, IPR004237): Fibronectin binding repeat
Ints3 (PF10189, IPR019333): Integrator complex subunit 3
31 INTS4P2interactor100NA
32 INTS5interactor170.544103.518INTS5_N (PF14837, IPR029445): Integrator complex subunit 5 N-terminus
INTS5_C (PF14838, IPR029444): Integrator complex subunit 5 C-terminus
33 INTS6suppressor160.62550.930VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
INT_SG_DDX_CT_C (PF15300, IPR029307): INTS6/SAGE1/DDX26B/CT45 C-terminus
DUF4596 (PF15363, IPR027907): Domain of unknown function (DUF4596)
34 INTS9interactor120.8335.767Beta-Casp (PF10996, IPR022712, SM01027): Beta-Casp domain
Lactamase_B_6 (PF16661, IPR001279): Metallo-beta-lactamase superfamily domain
35 ISLRinteractor2011.050I-set (PF07679, IPR013098): Immunoglobulin I-set domain
LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
36 ITGA4interactor120.43685.072FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
37 KIF23interactor21.0000DUF730 (PF05325, IPR007989): Protein of unknown function (DUF730)
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
MKLP1_Arf_bdg (PF16540, IPR032384): Arf6-interacting domain of mitotic kinesin-like protein 1
38 LOC554223interactor100NA
39 LRRC41interactor30.6675.237LRR_6 (PF13516, IPR001611): Leucine Rich repeat
40 MAST3interactor100DUF1908 (PF08926, IPR015022): Domain of unknown function (DUF1908)
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Pkinase (PF00069, IPR000719): Protein kinase domain
ACTL7A_N (PF16840, IPR031769): Actin-like protein 7A N-terminus
41 NAA15interactor70.33348.089NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
42 NTMT1interactor100Methyltransf_PK (PF05891, IPR008576): AdoMet dependent proline di-methyltransferase
43 NTRK1oncoprotein260.223788.503I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
44 PAXIP1interactor60.46711.463BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase
SURF6 (PF04935, IPR007019): Surfeit locus protein 6
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
LIG3_BRCT (PF16759, IPR031916): DNA ligase 3 BRCT domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
45 PHC2interactor50.5005.169SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
zf-CGNR (PF11706, IPR021005): CGNR zinc finger
DUF4692 (PF15763, IPR031517): Domain of unknown function (DUF4692)
PHC2_SAM_assoc (PF16616): Unstructured region on Polyhomeotic-like protein 1 and 2
46 PHKG2interactor21.0000APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
47 PPP2CAsuppressor150.429161.485Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
48 PPP2CBsuppressor100.82218.473Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
49 PPP2R1Aoncoprotein180.431178.946TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
HEAT (PF02985, IPR000357): HEAT repeat
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
50 RPAP2interactor50.30041.070NAD_Gly3P_dh_N (PF01210, IPR011128): NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
RPAP2_Rtr1 (PF04181, IPR007308): Rtr1/RPAP2 family
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
51 RPL10suppressor100.42221.944Ribosomal_L16 (PF00252, IPR016180): Ribosomal protein L16p/L10e
52 RWDD1interactor21.0000RWD (PF05773, IPR006575, SM00591): RWD domain
Folliculin (PF11704, IPR021713): Vesicle coat protein involved in Golgi to plasma membrane transport
DFRP_C (PF16543, IPR032378): DRG Family Regulatory Proteins, Tma46
53 SFNsuppressor60.60014.29714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
54 SHFM1interactor90.44479.266CLLAC (PF15675, IPR031379): CLLAC-motif containing domain
55 SKILsuppressor50.5007.521c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain
DUF489 (PF04356, IPR007451): Protein of unknown function (DUF489)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family
DUF2115 (PF09888, IPR019215): Uncharacterized protein conserved in archaea (DUF2115)
56 SLAMF1interactor31.0000ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
SLAM (PF06214, IPR010407): Signaling lymphocytic activation molecule (SLAM) protein
57 SNW1protein found in more fusions130.379117.821SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
58 SRPK2oncoprotein70.40073.804DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
59 SSX2IPprotein found in more fusions50.5003.767ZapB (PF06005, IPR009252): Cell division protein ZapB
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Surfac_D-trimer (PF09006, IPR015097): Lung surfactant protein D coiled-coil trimerisation
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
YqzH (PF14164, IPR025546): YqzH-like protein
60 STAU1protein found in more fusions120.50921.215dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
61 STK16interactor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
62 TAL1oncoprotein200HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
SelK_SelG (PF10961, IPR024491): Selenoprotein SelK_SelG
63 TGOLN2interactor31.0000MSA_2 (PF00985, IPR001136): Merozoite Surface Antigen 2 (MSA-2) family
UCR_TM (PF02921, IPR004192): Ubiquinol cytochrome reductase transmembrane region
SbcCD_C (PF13558): Putative exonuclease SbcCD, C subunit
TUTF7_u4 (PF16631): Unstructured region 4 on terminal uridylyltransferase 7
64 UBE2Iinteractor70.26755.136UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
65 USHBP1interactor31.0000DASH_Dam1 (PF08653, IPR013962): DASH complex subunit Dam1
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
SlyX (PF04102, IPR007236): SlyX
MCC-bdg_PDZ (PF10506, IPR019536): PDZ domain of MCC-2 bdg protein for Usher syndrome
YlqD (PF11068, IPR021297): YlqD protein
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
CAGE1 (PF15066, IPR029381): Cancer-associated gene protein 1 family
TEX13 (PF15186, IPR028193): Testis-expressed sequence 13 protein family
66 VCAM1interactor90.38933.837C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
67 VSIG4interactor100EMP70 (PF02990, IPR004240): Endomembrane protein 70
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
68 VWA9interactor110.76412.608VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
69 WWOXsuppressor30.6672.816adh_short (PF00106, IPR002198): short chain dehydrogenase
WW (PF00397, IPR001202, SM00456): WW domain
70 XPO1interactor150.200150.029CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
71 ZC3H15interactor50.70014.297zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
Torus (PF16131, IPR032297): Torus domain
DFRP_C (PF16543, IPR032378): DRG Family Regulatory Proteins, Tma46
72 ZMIZ2interactor100zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger

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