1 |
DRG1 | parental protein | 43 | 0.099 | 2058.690 | MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase TGS (PF02824, IPR004095): TGS domain MMR_HSR1_Xtn (PF16897, IPR031662): C-terminal region of MMR_HSR1 domain |
2 |
INTS4 | parental protein | 29 | 0.202 | 1051.893 | Adaptin_N (PF01602, IPR002553): Adaptin N terminal region HEAT (PF02985, IPR000357): HEAT repeat Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats |
3 |
ABL1 | oncoprotein | 8 | 0.476 | 11.184 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding SH3_1 (PF00018, IPR001452, SM00326): SH3 domain FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2 |
4 |
ASUN | interactor | 10 | 0.533 | 45.250 | DUF2151 (PF10221, IPR019355): Cell cycle and development regulator |
5 |
BARD1 | suppressor | 5 | 0.500 | 4.102 | BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies) zf-RING_6 (PF14835): zf-RING of BARD1-type protein BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain |
6 |
BRCA1 | suppressor | 9 | 0.179 | 94.567 | BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT |
7 |
C7orf26 | interactor | 7 | 0.762 | 5.950 | DUF4507 (PF14964, IPR027844): Domain of unknown function (DUF4507) |
8 |
CAND1 | interactor | 12 | 0.345 | 114.164 | Adaptin_N (PF01602, IPR002553): Adaptin N terminal region DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) HEAT (PF02985, IPR000357): HEAT repeat TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20) RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II |
9 |
CAND2 | interactor | 2 | 1.000 | 0 | Adaptin_N (PF01602, IPR002553): Adaptin N terminal region RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20) HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat CAF1A (PF12253, IPR022043): Chromatin assembly factor 1 subunit A MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal TFCD_C (PF12612, IPR022577): Tubulin folding cofactor D C terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats |
10 |
CAPNS1 | interactor | 4 | 0.833 | 0.222 | EF-hand_1 (PF00036, IPR002048, SM00054): EF hand EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_8 (PF13833, IPR002048): EF-hand domain pair |
11 |
CCDC8 | interactor | 8 | 0.429 | 34.713 | Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal PNMA (PF14893, IPR026523): PNMA |
12 |
CDC5L | interactor | 15 | 0.396 | 137.462 | OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain |
13 |
CLDN1 | suppressor | 1 | 0 | 0 | PMP22_Claudin (PF00822, IPR004031): PMP-22/EMP/MP20/Claudin family DUF4131 (PF13567, IPR025405): Domain of unknown function (DUF4131) |
14 |
COIL | interactor | 4 | 0.667 | 1.400 | CDC45 (PF02724, IPR003874): CDC45-like protein Macoilin (PF09726, IPR019130): Transmembrane protein Coilin_N (PF15862, IPR031722): Coilin N-terminus |
15 |
CPSF3L | interactor | 12 | 0.833 | 5.767 | RMMBL (PF07521, IPR011108): Zn-dependent metallo-hydrolase RNA specificity domain Beta-Casp (PF10996, IPR022712, SM01027): Beta-Casp domain Lactamase_B_3 (PF13483): Beta-lactamase superfamily domain Lactamase_B_6 (PF16661, IPR001279): Metallo-beta-lactamase superfamily domain |
16 |
CUL7 | protein found in more fusions | 8 | 0.571 | 8.801 | ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7 |
17 |
FAF2 | interactor | 5 | 0.333 | 19.091 | DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682) UBX (PF00789, IPR001012, SM00166): UBX domain Thioredoxin_7 (PF13899): Thioredoxin-like UBA_4 (PF14555): UBA-like domain |
18 |
FAM98A | interactor | 3 | 0.667 | 5.190 | DUF2465 (PF10239, IPR018797): Protein of unknown function (DUF2465) |
19 |
FEN1 | oncoprotein | 7 | 0.429 | 28.625 | 5_3_exonuc (PF01367, IPR020045, SM00475): 5'-3' exonuclease, C-terminal SAM fold XPG_I (PF00867, IPR006086, SM00484): XPG I-region XPG_N (PF00752, IPR006085, SM00485): XPG N-terminal domain |
20 |
FN1 | oncoprotein | 11 | 0.309 | 50.651 | fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) |
21 |
GRB2 | oncoprotein | 9 | 0.357 | 41.557 | SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093) |
22 |
HAO1 | interactor | 1 | 0 | 0 | FMN_dh (PF01070, IPR000262): FMN-dependent dehydrogenase |
23 |
HDGF | interactor | 9 | 0.333 | 150.230 | PWWP (PF00855, IPR000313, SM00293): PWWP domain |
24 |
HECW2 | interactor | 5 | 0.333 | 117.891 | C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57 RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2 |
25 |
HGS | interactor | 5 | 0.300 | 62.651 | FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif VHS (PF00790, IPR002014, SM00288): VHS domain EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate PIEZO (PF15917, IPR031805): Piezo |
26 |
HLA-B | oncoprotein | 4 | 0.667 | 0.667 | MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2 MHC_I_C (PF06623, IPR010579): MHC_I C-terminus C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain |
27 |
IFRD2 | oncoprotein | 1 | 0 | 0 | IFRD (PF05004, IPR007701): Interferon-related developmental regulator (IFRD) IFRD_C (PF04836, IPR006921): Interferon-related protein conserved region |
28 |
INTS1 | interactor | 20 | 0.426 | 214.623 | DUF3677 (PF12432, IPR022145): Protein of unknown function (DUF3677) |
29 |
INTS10 | interactor | 11 | 0.727 | 16.395 | NA |
30 |
INTS3 | interactor | 17 | 0.507 | 89.134 | SKA1 (PF07160, IPR009829): Spindle and kinetochore-associated protein 1 Fn_bind (PF02986, IPR004237): Fibronectin binding repeat Ints3 (PF10189, IPR019333): Integrator complex subunit 3 |
31 |
INTS4P2 | interactor | 1 | 0 | 0 | NA |
32 |
INTS5 | interactor | 17 | 0.544 | 103.518 | INTS5_N (PF14837, IPR029445): Integrator complex subunit 5 N-terminus INTS5_C (PF14838, IPR029444): Integrator complex subunit 5 C-terminus |
33 |
INTS6 | suppressor | 16 | 0.625 | 50.930 | VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain INT_SG_DDX_CT_C (PF15300, IPR029307): INTS6/SAGE1/DDX26B/CT45 C-terminus DUF4596 (PF15363, IPR027907): Domain of unknown function (DUF4596) |
34 |
INTS9 | interactor | 12 | 0.833 | 5.767 | Beta-Casp (PF10996, IPR022712, SM01027): Beta-Casp domain Lactamase_B_6 (PF16661, IPR001279): Metallo-beta-lactamase superfamily domain |
35 |
ISLR | interactor | 2 | 0 | 11.050 | I-set (PF07679, IPR013098): Immunoglobulin I-set domain LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain |
36 |
ITGA4 | interactor | 12 | 0.436 | 85.072 | FG-GAP (PF01839, IPR013517): FG-GAP repeat Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region Integrin_alpha2 (PF08441, IPR013649): Integrin alpha |
37 |
KIF23 | interactor | 2 | 1.000 | 0 | DUF730 (PF05325, IPR007989): Protein of unknown function (DUF730) Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding MKLP1_Arf_bdg (PF16540, IPR032384): Arf6-interacting domain of mitotic kinesin-like protein 1 |
38 |
LOC554223 | interactor | 1 | 0 | 0 | NA |
39 |
LRRC41 | interactor | 3 | 0.667 | 5.237 | LRR_6 (PF13516, IPR001611): Leucine Rich repeat |
40 |
MAST3 | interactor | 1 | 0 | 0 | DUF1908 (PF08926, IPR015022): Domain of unknown function (DUF1908) PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) Pkinase (PF00069, IPR000719): Protein kinase domain ACTL7A_N (PF16840, IPR031769): Actin-like protein 7A N-terminus |
41 |
NAA15 | interactor | 7 | 0.333 | 48.089 | NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1 ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat |
42 |
NTMT1 | interactor | 1 | 0 | 0 | Methyltransf_PK (PF05891, IPR008576): AdoMet dependent proline di-methyltransferase |
43 |
NTRK1 | oncoprotein | 26 | 0.223 | 788.503 | I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain |
44 |
PAXIP1 | interactor | 6 | 0.467 | 11.463 | BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase SURF6 (PF04935, IPR007019): Surfeit locus protein 6 DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052) CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance PTCB-BRCT (PF12738, IPR001357): twin BRCT domain BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT (PF16759, IPR031916): DNA ligase 3 BRCT domain RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain |
45 |
PHC2 | interactor | 5 | 0.500 | 5.169 | SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit zf-CGNR (PF11706, IPR021005): CGNR zinc finger DUF4692 (PF15763, IPR031517): Domain of unknown function (DUF4692) PHC2_SAM_assoc (PF16616): Unstructured region on Polyhomeotic-like protein 1 and 2 |
46 |
PHKG2 | interactor | 2 | 1.000 | 0 | APH (PF01636, IPR002575): Phosphotransferase enzyme family Pkinase (PF00069, IPR000719): Protein kinase domain |
47 |
PPP2CA | suppressor | 15 | 0.429 | 161.485 | Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain |
48 |
PPP2CB | suppressor | 10 | 0.822 | 18.473 | Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain |
49 |
PPP2R1A | oncoprotein | 18 | 0.431 | 178.946 | TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain HEAT (PF02985, IPR000357): HEAT repeat HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat HEAT_2 (PF13646): HEAT repeats |
50 |
RPAP2 | interactor | 5 | 0.300 | 41.070 | NAD_Gly3P_dh_N (PF01210, IPR011128): NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus RPAP2_Rtr1 (PF04181, IPR007308): Rtr1/RPAP2 family SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein |
51 |
RPL10 | suppressor | 10 | 0.422 | 21.944 | Ribosomal_L16 (PF00252, IPR016180): Ribosomal protein L16p/L10e |
52 |
RWDD1 | interactor | 2 | 1.000 | 0 | RWD (PF05773, IPR006575, SM00591): RWD domain Folliculin (PF11704, IPR021713): Vesicle coat protein involved in Golgi to plasma membrane transport DFRP_C (PF16543, IPR032378): DRG Family Regulatory Proteins, Tma46 |
53 |
SFN | suppressor | 6 | 0.600 | 14.297 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
54 |
SHFM1 | interactor | 9 | 0.444 | 79.266 | CLLAC (PF15675, IPR031379): CLLAC-motif containing domain |
55 |
SKIL | suppressor | 5 | 0.500 | 7.521 | c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain DUF489 (PF04356, IPR007451): Protein of unknown function (DUF489) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family DUF2115 (PF09888, IPR019215): Uncharacterized protein conserved in archaea (DUF2115) |
56 |
SLAMF1 | interactor | 3 | 1.000 | 0 | ig (PF00047, IPR013151, SM00409): Immunoglobulin domain SLAM (PF06214, IPR010407): Signaling lymphocytic activation molecule (SLAM) protein |
57 |
SNW1 | protein found in more fusions | 13 | 0.379 | 117.821 | SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term SIR4_SID (PF16991, IPR031556): Sir4 SID domain |
58 |
SRPK2 | oncoprotein | 7 | 0.400 | 73.804 | DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387) Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator Pkinase (PF00069, IPR000719): Protein kinase domain S-antigen (PF05756, IPR008825): S-antigen protein DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) |
59 |
SSX2IP | protein found in more fusions | 5 | 0.500 | 3.767 | ZapB (PF06005, IPR009252): Cell division protein ZapB ERM (PF00769, IPR011259): Ezrin/radixin/moesin family Surfac_D-trimer (PF09006, IPR015097): Lung surfactant protein D coiled-coil trimerisation ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding YqzH (PF14164, IPR025546): YqzH-like protein |
60 |
STAU1 | protein found in more fusions | 12 | 0.509 | 21.215 | dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif Staufen_C (PF16482, IPR032478): Staufen C-terminal domain |
61 |
STK16 | interactor | 3 | 1.000 | 0 | Pkinase (PF00069, IPR000719): Protein kinase domain |
62 |
TAL1 | oncoprotein | 2 | 0 | 0 | HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain SelK_SelG (PF10961, IPR024491): Selenoprotein SelK_SelG |
63 |
TGOLN2 | interactor | 3 | 1.000 | 0 | MSA_2 (PF00985, IPR001136): Merozoite Surface Antigen 2 (MSA-2) family UCR_TM (PF02921, IPR004192): Ubiquinol cytochrome reductase transmembrane region SbcCD_C (PF13558): Putative exonuclease SbcCD, C subunit TUTF7_u4 (PF16631): Unstructured region 4 on terminal uridylyltransferase 7 |
64 |
UBE2I | interactor | 7 | 0.267 | 55.136 | UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme |
65 |
USHBP1 | interactor | 3 | 1.000 | 0 | DASH_Dam1 (PF08653, IPR013962): DASH complex subunit Dam1 HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper SlyX (PF04102, IPR007236): SlyX MCC-bdg_PDZ (PF10506, IPR019536): PDZ domain of MCC-2 bdg protein for Usher syndrome YlqD (PF11068, IPR021297): YlqD protein DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404) CAGE1 (PF15066, IPR029381): Cancer-associated gene protein 1 family TEX13 (PF15186, IPR028193): Testis-expressed sequence 13 protein family |
66 |
VCAM1 | interactor | 9 | 0.389 | 33.837 | C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain |
67 |
VSIG4 | interactor | 1 | 0 | 0 | EMP70 (PF02990, IPR004240): Endomembrane protein 70 V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain |
68 |
VWA9 | interactor | 11 | 0.764 | 12.608 | VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain |
69 |
WWOX | suppressor | 3 | 0.667 | 2.816 | adh_short (PF00106, IPR002198): short chain dehydrogenase WW (PF00397, IPR001202, SM00456): WW domain |
70 |
XPO1 | interactor | 15 | 0.200 | 150.029 | CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region |
71 |
ZC3H15 | interactor | 5 | 0.700 | 14.297 | zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus (PF16131, IPR032297): Torus domain DFRP_C (PF16543, IPR032378): DRG Family Regulatory Proteins, Tma46 |
72 |
ZMIZ2 | interactor | 1 | 0 | 0 | zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger |