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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins HSPA12B, MYLK3 (from a repository: Sun Aug 25 14:47:46 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)12
The number (and %) of the onco-proteins4 (33.33 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)14 (21.21 %)
The number (and %) of affected PPIs10 (71.43 %)
The number of possible different fusions4
PPI diameter2
PPI radiusinf
The average degree of PPI1.833
Assortativity coefficient-0.5164
The network average Clustering coefficient0.175
The number (and %) of a zero Clustering coefficients9 (75.00 %)
The number (and %) of a zero Betweenness Centrality10 (83.33 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: HSPA12B,MYLK3 All fusions
Proteins found in more fusions HSP90AA1 (see 2 fusions); MYC (see 1 fusions); MAPK14 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 HSPA12Bparental protein5020.000HSP70 (PF00012, IPR013126): Hsp70 protein
2 MYLK3parental protein50.10018.000APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
XhlA (PF10779, IPR019715): Haemolysin XhlA
3 ALBinteractor100Serum_albumin (PF00273, IPR014760, SM00103): Serum albumin family
4 BSGinteractor100Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
5 CBWD1interactor100cobW (PF02492, IPR003495): CobW/HypB/UreG, nucleotide-binding domain
CobW_C (PF07683, IPR011629, SM00833): Cobalamin synthesis protein cobW C-terminal domain
6 HSP90AA1oncoprotein31.0000HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
7 KRT31interactor100Filament (PF00038, IPR001664): Intermediate filament protein
8 KRT40interactor100Filament (PF00038, IPR001664): Intermediate filament protein
UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
9 MAPK12oncoprotein100Pkinase (PF00069, IPR000719): Protein kinase domain
Peripla_BP_5 (PF13433): Periplasmic binding protein domain
10 MAPK14oncoprotein200Pkinase (PF00069, IPR000719): Protein kinase domain
11 MYConcoprotein31.0000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
12 NOTCH2NLinteractor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like

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