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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins EBAG9, EFS (from a repository: Sat Jul 20 14:10:49 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)25
The number (and %) of the onco-proteins8 (32.00 %)
The number (and %) of the tumor suppressors4 (16.00 %)
Total number of binary PPIs (saturation %)50 (16.67 %)
The number (and %) of affected PPIs23 (46.00 %)
The number of possible different fusions6
PPI diameter4
PPI radius3
The average degree of PPI3.280
Assortativity coefficient-0.4126
The network average Clustering coefficient0.253
The number (and %) of a zero Clustering coefficients13 (52.00 %)
The number (and %) of a zero Betweenness Centrality11 (44.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: EFS,EBAG9 All fusions
Proteins found in more fusions APP (see 5 fusions); NEDD4 (see 1 fusions); SORBS2 (see 4 fusions); FYN (see 1 fusions); UBC (see 7 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 EFSparental protein200.063443.348DUF3513 (PF12026, IPR021901): Domain of unknown function (DUF3513)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
2 EBAG9parental protein3011.700DUF3395 (PF11875, IPR024586): Domain of unknown function (DUF3395)
3 ABI2suppressor200Abi_HHR (PF07815, IPR012849): Abl-interactor HHR
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
SH3_9 (PF14604, IPR001452): Variant SH3 domain
TMEM171 (PF15471, IPR029173): Transmembrane protein family 171
ATP-synt_ab_Xtn (PF16886, IPR031686): ATPsynthase alpha/beta subunit N-term extension
4 APPprotein found in more fusions50.33329.155APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 BCAR1oncoprotein60.4679.767Serine_rich (PF08824, IPR014928): Serine rich protein interaction domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF3513 (PF12026, IPR021901): Domain of unknown function (DUF3513)
Caskin1-CID (PF16600): Caskin1 CASK-interaction domain
6 BLKoncoprotein100Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
7 CRKoncoprotein40.6671.667SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
8 FYNoncoprotein50.66715.852Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
9 LYSTinteractor100Beach (PF02138, IPR000409, SM01026): Beige/BEACH domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
PH_BEACH (PF14844, IPR023362): PH domain associated with Beige/BEACH
DUF4800 (PF16057): Domain of unknown function (DUF4800)
10 NEDD4suppressor50.16729.607Rota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
11 NLGN3interactor100COesterase (PF00135, IPR002018): Carboxylesterase family
Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
12 NPAS2suppressor100HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
DehI (PF10778, IPR019714): Halocarboxylic acid dehydrogenase DehI
PAS_11 (PF14598): PAS domain
13 NUP155interactor3060.238Nucleoporin_C (PF03177, IPR007187): Non-repetitive/WGA-negative nucleoporin C-terminal
Nucleoporin_N (PF08801, IPR014908): Nup133 N terminal like
14 OSTF1interactor30.6671.900SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
15 PTPN12suppressor40.5004.619Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
PTPlike_phytase (PF14566): Inositol hexakisphosphate
ER-remodelling (PF14755, IPR032786): Intracellular membrane remodeller
16 SH2D3Cinteractor21.0000RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
17 SORBS2oncoprotein31.0000Sorb (PF02208, IPR003127, SM00459): Sorbin homologous domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
18 SORBS3interactor200Sorb (PF02208, IPR003127, SM00459): Sorbin homologous domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
19 SRConcoprotein70.46724.919Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
20 TMEM17interactor205.269Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
21 TMEM216interactor3017.157Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
22 TRAPPC6Ainteractor200TRAPP (PF04051, IPR007194): Transport protein particle (TRAPP) component
23 TSSK1Binteractor100Pkinase (PF00069, IPR000719): Protein kinase domain
24 UBCprotein found in more fusions40.33314.802ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
25 ZNF417interactor100A2L_zn_ribbon (PF08792, IPR014900): A2L zinc ribbon domain
C1_4 (PF07975, IPR004595, SM01047): TFIIH C1-like domain
KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger

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