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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins COL4A3, NEURL1 (from a repository: Sun Aug 18 15:02:39 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)13
The number (and %) of the onco-proteins4 (30.77 %)
The number (and %) of the tumor suppressors1 (7.69 %)
Total number of binary PPIs (saturation %)24 (30.77 %)
The number (and %) of affected PPIs11 (45.83 %)
The number of possible different fusions4
PPI diameter5
PPI radius3
The average degree of PPI2.615
Assortativity coefficient-0.1355
The network average Clustering coefficient0.344
The number (and %) of a zero Clustering coefficients7 (53.85 %)
The number (and %) of a zero Betweenness Centrality6 (46.15 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: COL4A3,NEURL1 All fusions
Proteins found in more fusions VHL (see 1 fusions); UBE2H (see 4 fusions); UBE2N (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 COL4A3parental protein4046.667C4 (PF01413, IPR001442, SM00111): C-terminal tandem repeated domain in type 4 procollagen
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
DUF1860 (PF08949, IPR015044): Domain of unknown function (DUF1860)
2 NEURL1parental protein70.14361.333Neuralized (PF07177, IPR006573, SM00588): Neuralized
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
3 APBB1interactor31.0000PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
WW (PF00397, IPR001202, SM00456): WW domain
RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31
PID_2 (PF14719, IPR006020): Phosphotyrosine interaction domain (PTB/PID)
4 ARFIP2interactor3018.000Arfaptin (PF06456, IPR010504, SM01015): Arfaptin-like domain
5 ELAVL1oncoprotein50.33326.667RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
6 JAG1oncoprotein21.0000DSL (PF01414, IPR001774, SM00051): Delta serrate ligand
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
MNNL (PF07657, IPR011651): N terminus of Notch ligand
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
MAP17 (PF15807, IPR031627): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
7 MFAP2interactor100MAGP (PF05507, IPR008673): Microfibril-associated glycoprotein (MAGP)
ShK (PF01549, IPR003582, SM00254): ShK domain-like
8 MOV10interactor2012.667AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
9 SHMT2interactor100SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
10 UBE2D1interactor309.667UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
11 UBE2Hprotein found in more fusions31.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
Uteroglobin (PF01099, IPR016126, SM00096): Uteroglobin family
12 UBE2Nprotein found in more fusions31.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
13 VHLsuppressor4039.000Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): VHL beta domain
VHL_C (PF17211): VHL box domain

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