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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PLG, UAP1L1 (from a repository: Mon May 1 05:34:15 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)42
The number (and %) of the onco-proteins15 (35.71 %)
The number (and %) of the tumor suppressors7 (16.67 %)
Total number of binary PPIs (saturation %)88 (10.22 %)
The number (and %) of affected PPIs40 (45.45 %)
The number of possible different fusions9
PPI diameter5
PPI radius3
The average degree of PPI3.571
Assortativity coefficient-0.4159
The network average Clustering coefficient0.395
The number (and %) of a zero Clustering coefficients17 (40.48 %)
The number (and %) of a zero Betweenness Centrality26 (61.90 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PLG,UAP1L1 All fusions
Proteins found in more fusions HSPB1 (see 4 fusions); PRDX4 (see 1 fusions); MAPK14 (see 1 fusions); EP300 (see 1 fusions); ACTB (see 3 fusions); SMAD4 (see 2 fusions); SMAD3 (see 3 fusions); SUZ12 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PLGparental protein340.0551284.533Kringle (PF00051, IPR000001): Kringle domain
PAN_1 (PF00024, IPR003014): PAN domain
Trypsin (PF00089, IPR001254, SM00020): Trypsin
2 UAP1L1parental protein60.133270.000UDPGP (PF01704, IPR002618): UTP--glucose-1-phosphate uridylyltransferase
3 ACTBoncoprotein50.6671.333Actin (PF00022, IPR004000, SM00268): Actin
4 AFMIDinteractor21.0000Abhydrolase_3 (PF07859, IPR013094): alpha/beta hydrolase fold
Esterase (PF00756, IPR000801): Putative esterase
5 C7interactor100MACPF (PF01823, IPR020864, SM00457): MAC/Perforin domain
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
6 CHGAoncoprotein100Granin (PF01271, IPR001990): Granin (chromogranin or secretogranin)
PP1_bind (PF15276, IPR029334): Protein phosphatase 1 binding
7 CPB2interactor21.0000Peptidase_M14 (PF00246, IPR000834, SM00631): Zinc carboxypeptidase
Propep_M14 (PF02244, IPR003146): Carboxypeptidase activation peptide
8 CYFIP2interactor21.0000DUF1394 (PF07159, IPR009828): Protein of unknown function (DUF1394)
FragX_IP (PF05994, IPR008081): Cytoplasmic Fragile-X interacting family
zf-CW (PF07496, IPR011124): CW-type Zinc Finger
9 ENO1oncoprotein40.333223.367Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
10 EP300oncoprotein70.66713.300Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
11 F10interactor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
Gla (PF00594, IPR000294, SM00069): Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
Trypsin (PF00089, IPR001254, SM00020): Trypsin
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
12 F3interactor100Interfer-bind (PF09294, IPR015373): Interferon-alpha/beta receptor, fibronectin type III
Tissue_fac (PF01108, IPR003961): Tissue factor
TMEM154 (PF15102, IPR028064): TMEM154 protein family
13 FN1oncoprotein110.20073.767fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
14 HMGB1oncoprotein30.6670.500HMG_box_2 (PF09011, IPR009071): HMG-box domain
NOA36 (PF06524, IPR010531): NOA36 protein
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
15 HSPA1Ainteractor50.6003.167HSP70 (PF00012, IPR013126): Hsp70 protein
16 HSPB1oncoprotein31.0000HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
17 HSPD1suppressor40.6674.467Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
18 IGFBP3suppressor21.0000IGFBP (PF00219, IPR000867, SM00121): Insulin-like growth factor binding protein
Thyroglobulin_1 (PF00086, IPR000716, SM00211): Thyroglobulin type-1 repeat
19 KNG1interactor100Bradykinin (PF06753, IPR009608): Bradykinin
Chorion_2 (PF03964, IPR005649): Chorion family 2
Cystatin (PF00031, IPR000010, SM00043): Cystatin domain
20 LAMA1interactor100Laminin_B (PF00052, IPR000034): Laminin B (Domain IV)
Laminin_G_1 (PF00054, IPR001791): Laminin G domain
Laminin_I (PF06008, IPR009254): Laminin Domain I
Laminin_II (PF06009, IPR010307): Laminin Domain II
Sec34 (PF04136, IPR007265): Sec34-like family
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
Laminin_N (PF00055, IPR008211, SM00136): Laminin N-terminal (Domain VI)
21 LAMA3interactor100Laminin_B (PF00052, IPR000034): Laminin B (Domain IV)
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
Laminin_I (PF06008, IPR009254): Laminin Domain I
Laminin_II (PF06009, IPR010307): Laminin Domain II
PPE (PF00823, IPR000030): PPE family
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
Laminin_N (PF00055, IPR008211, SM00136): Laminin N-terminal (Domain VI)
Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
TSNAXIP1_N (PF15739, IPR032755): Translin-associated factor X-interacting N-terminus
22 MAPK14oncoprotein60.400241.300Pkinase (PF00069, IPR000719): Protein kinase domain
23 OATinteractor100Aminotran_3 (PF00202, IPR005814): Aminotransferase class-III
24 PAPPAinteractor21.0000Peptidase_M43 (PF05572, IPR008754): Pregnancy-associated plasma protein-A
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
Notch (PF00066, IPR000800, SM00004): LNR domain
Laminin_G_3 (PF13385): Concanavalin A-like lectin/glucanases superfamily
DUF4215 (PF13948, IPR011936): Domain of unknown function (DUF4215)
25 PCBD1interactor40.66736.000Pterin_4a (PF01329, IPR001533): Pterin 4 alpha carbinolamine dehydratase
26 PRDX4protein found in more fusions31.0000AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
27 RAB11Boncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
28 RAP2Aoncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
29 RBBP6oncoprotein100DUF936 (PF06075, IPR010341): Plant protein of unknown function (DUF936)
DWNN (PF08783, IPR014891): DWNN domain
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
U-box (PF04564, IPR003613, SM00504): U-box domain
SBF2 (PF12335, IPR022096): Myotubularin protein
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
zf-CCHC_2 (PF13696, IPR025829): Zinc knuckle
AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term
CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106
PRIMA1 (PF16101): Proline-rich membrane anchor 1
30 RELAoncoprotein100.38941.600DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
31 RNF2interactor41.0000zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
32 S100A10oncoprotein200S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
33 SDHBsuppressor100Fer2_3 (PF13085, IPR025192): 2Fe-2S iron-sulfur cluster binding domain
Fer4_8 (PF13183, IPR017896): 4Fe-4S dicluster domain
Fer4_17 (PF13534): 4Fe-4S dicluster domain
34 SERPINE1interactor200Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
35 SERPINF2interactor21.0000Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
36 SMAD3oncoprotein70.6005.167MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
37 SMAD4suppressor70.5335.833MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
38 SPARCsuppressor100FOLN (PF09289, IPR015369, SM00274): Follistatin/Osteonectin-like EGF domain
Kazal_1 (PF00050, IPR002350): Kazal-type serine protease inhibitor domain
SPARC_Ca_bdg (PF10591, IPR019577): Secreted protein acidic and rich in cysteine Ca binding region
39 SUZ12suppressor50.8330.667DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070)
VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
40 THBS1suppressor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
TSP_3 (PF02412, IPR003367): Thrombospondin type 3 repeat
TSP_C (PF05735, IPR008859): Thrombospondin C-terminal region
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
EndIII_4Fe-2S (PF10576, IPR003651): Iron-sulfur binding domain of endonuclease III
TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EGF_3 (PF12947, IPR024731): EGF domain
Laminin_G_3 (PF13385): Concanavalin A-like lectin/glucanases superfamily
41 WDR1interactor40.167421.000eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
PQQ (PF01011, IPR002372, SM00564): PQQ enzyme repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
42 YTHDC1interactor100DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
YTH (PF04146, IPR007275): YT521-B-like domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
TFB6 (PF17110, IPR031349): Subunit 11 of the general transcription factor TFIIH

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