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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MTX2, SLC16A4 (from a repository: Wed Dec 11 18:18:24 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)29
The number (and %) of the onco-proteins4 (13.79 %)
The number (and %) of the tumor suppressors2 (6.90 %)
Total number of binary PPIs (saturation %)72 (17.73 %)
The number (and %) of affected PPIs27 (37.50 %)
The number of possible different fusions2
PPI diameter5
PPI radius3
The average degree of PPI4.552
Assortativity coefficient-0.4088
The network average Clustering coefficient0.422
The number (and %) of a zero Clustering coefficients8 (27.59 %)
The number (and %) of a zero Betweenness Centrality10 (34.48 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SLC16A4,MTX2 All fusions
Proteins found in more fusions IMMT (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SLC16A4parental protein2054.000MFS_1 (PF07690, IPR011701): Major Facilitator Superfamily
2 MTX2parental protein250.117535.886Tom37 (PF10568, IPR019564): Outer mitochondrial membrane transport complex protein
GST_C_6 (PF17171): Glutathione S-transferase, C-terminal domain
3 APOOLinteractor70.6672.400ApoO (PF09769, IPR019166): Apolipoprotein O
4 BSGinteractor100Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
5 C19orf70interactor70.5246.400QIL1 (PF15884, IPR026769): Protein QIL1
6 CCDC155interactor100CorA (PF01544, IPR002523): CorA-like Mg2+ transporter protein
EF-hand_9 (PF14658): EF-hand domain
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
7 CD244interactor21.0000Receptor_2B4 (PF11465, IPR024303): Natural killer cell receptor 2B4
WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
8 CEP120interactor100C2 (PF00168, IPR000008, SM00239): C2 domain
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
DUF3668 (PF12416, IPR022136): Cep120 protein
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
9 CHCHD3interactor70.52410.148DUF737 (PF05300, IPR007964): Protein of unknown function (DUF737)
eIF3g (PF12353, IPR024675): Eukaryotic translation initiation factor 3 subunit G
10 CHCHD6interactor40.6672.500CHCH (PF06747, IPR010625): CHCH domain
DUF737 (PF05300, IPR007964): Protein of unknown function (DUF737)
11 EIF2B4interactor100IF-2B (PF01008, IPR000649): Initiation factor 2 subunit family
Mpp10 (PF04006, IPR007151): Mpp10 protein
12 ELAVL1oncoprotein60.100108.333RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
13 HNRNPRinteractor21.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
14 IMMTprotein found in more fusions100.27832.162Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
15 KRASoncoprotein40.33323.629Ras (PF00071, IPR001806, SM00173): Ras family
16 MINOS1interactor50.5003.733DUF543 (PF04418, IPR007512): Domain of unknown function (DUF543)
17 MMGT1interactor80.39361.424MMgT (PF10270, IPR018937): Membrane magnesium transporter
18 MOV10interactor30.6671.000AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
19 NDUFA4interactor60.5002.733B12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
20 PHBsuppressor60.5338.905Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4290 (PF14123, IPR025632): Domain of unknown function (DUF4290)
21 PHB2interactor41.0000DUF2605 (PF10792, IPR019728): Protein of unknown function (DUF2605)
Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
22 PPP1CAsuppressor100Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
23 SAMM50interactor60.6672.400Bac_surface_Ag (PF01103, IPR000184): Surface antigen
POTRA (PF07244, IPR010827): Surface antigen variable number repeat
24 SLC25A3interactor40.5002.400Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
25 TADA2Ainteractor100SWIRM (PF04433, IPR007526): SWIRM domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
26 TPD52oncoprotein40.6671.000TPD52 (PF04201, IPR007327): Tumour protein D52 family
27 TRAK2interactor2020.771ZapB (PF06005, IPR009252): Cell division protein ZapB
HAP1_N (PF04849, IPR006933): HAP1 N-terminal conserved region
Milton (PF12448, IPR022154): Kinesin associated protein
28 VDAC2interactor60.60036.176Porin_3 (PF01459, IPR027246): Eukaryotic porin
29 YWHAQinteractor21.000014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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