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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)149
The number (and %) of the onco-proteins44 (29.53 %)
The number (and %) of the tumor suppressors20 (13.42 %)
Total number of binary PPIs (saturation %)1045 (9.48 %)
The number (and %) of affected PPIs149 (14.26 %)
The number of possible different fusions29
PPI diameter4
PPI radius2
The average degree of PPI13.289
Assortativity coefficient-0.3005
The network average Clustering coefficient0.481
The number (and %) of a zero Clustering coefficients6 (4.03 %)
The number (and %) of a zero Betweenness Centrality12 (8.05 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: TAB2,ATP6V0D1 All fusions
Proteins found in more fusions STAU1 (see 2 fusions); NPM1 (see 1 fusions); BECN1 (see 1 fusions); YWHAZ (see 5 fusions); HDAC5 (see 1 fusions); IKBKB (see 2 fusions); UBC (see 7 fusions); ZBTB16 (see 4 fusions); RPA1 (see 1 fusions); TAB2 (see 1 fusions); TRAF6 (see 1 fusions); APP (see 5 fusions); TNF (see 1 fusions); ATP1A1/VDAC3 (see 2 fusions); HSP90AA1 (see 6 fusions); RPL5 (see 1 fusions); ATXN1 (see 3 fusions); NFKB1 (see 2 fusions); MAPK14 (see 1 fusions); MALT1 (see 1 fusions); RIPK1 (see 1 fusions); MCM2 (see 1 fusions); NLK (see 4 fusions); MAP3K7 (see 7 fusions); TGM2 (see 3 fusions); ATP5A1 (see 1 fusions); TBL1X (see 2 fusions); VIM (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TAB2parental protein830.1085687.475CUE (PF02845, IPR003892, SM00546): CUE domain
DivIC (PF04977, IPR007060): Septum formation initiator
Mnd1 (PF03962, IPR005647): Mnd1 family
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
2 ATP6V0D1parental protein660.1503439.584vATP-synt_AC39 (PF01992, IPR002843): ATP synthase (C/AC39) subunit
3 APPprotein found in more fusions290.188757.823APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 ARoncoprotein130.47023.050Androgen_recep (PF02166, IPR001103): Androgen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
5 ARRB2interactor150.314179.585Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
6 ATG13oncoprotein40.6671.328ATG13 (PF10033, IPR018731): Autophagy-related protein 13
7 ATG5interactor30.6670.333APG5 (PF04106, IPR007239): Autophagy protein Apg5
8 ATP1A1protein found in more fusions230.399222.634Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
Tetraspannin (PF00335, IPR018499): Tetraspanin family
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
9 ATP1A2interactor50.9000.196Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
Sigma70_r4 (PF04545, IPR007630): Sigma-70, region 4
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
10 ATP1A3interactor70.61917.131Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
11 ATP1B3interactor120.60611.791Na_K-ATPase (PF00287, IPR000402): Sodium / potassium ATPase beta chain
12 ATP5A1protein found in more fusions270.449244.568ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_C (PF00306, IPR000793): ATP synthase alpha/beta chain, C terminal domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
13 ATP5Binteractor230.399201.419AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
NACHT (PF05729): NACHT domain
14 ATP5C1interactor240.489169.484ATP-synt (PF00231, IPR000131): ATP synthase
ACT_4 (PF13291, IPR002912): ACT domain
15 ATP5Dinteractor100.9560.404ATP-synt_DE_N (PF02823, IPR020546): ATP synthase, Delta/Epsilon chain, beta-sandwich domain
16 ATP5F1interactor190.53261.003Mt_ATP-synt_B (PF05405, IPR008688): Mitochondrial ATP synthase B chain precursor (ATP-synt_B)
DUF2105 (PF09878, IPR019212): Predicted membrane protein (DUF2105)
17 ATP5POinteractor200.51193.013OSCP (PF00213, IPR000711): ATP synthase delta (OSCP) subunit
18 ATP6AP2interactor80.52451.103Phosphodiest (PF01663, IPR002591): Type I phosphodiesterase / nucleotide pyrophosphatase
Renin_r (PF07850, IPR012493): Renin receptor-like protein
19 ATP6V0A1interactor130.33375.282V_ATPase_I (PF01496, IPR002490): V-type ATPase 116kDa subunit family
20 ATP6V1Ainteractor250.320264.269ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
ATP-synt_ab_Xtn (PF16886, IPR031686): ATPsynthase alpha/beta subunit N-term extension
21 ATP6V1B1interactor80.6794.935ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
DUF3533 (PF12051, IPR022703): Protein of unknown function (DUF3533)
22 ATP6V1B2interactor190.392124.149ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
DUF2481 (PF10654, IPR018916): Protein of unknown function (DUF2481)
23 ATP6V1Dinteractor90.6679.336ATP-synt_D (PF01813, IPR002699): ATP synthase subunit D
24 ATP6V1Hinteractor110.47369.027V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H
V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H
25 ATXN1protein found in more fusions120.073383.592AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
Spt20 (PF12090, IPR021950): Spt20 family
ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
26 BECN1suppressor80.4769.961APG6 (PF04111, IPR007243): Autophagy protein Apg6
Ima1_N (PF09779, IPR018617): Ima1 N-terminal domain
BH3 (PF15285, IPR029318): Beclin-1 BH3 domain, Bcl-2-interacting
27 BNIP3P6interactor100NA
28 BST2oncoprotein50.30053.903DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
29 CARD8oncoprotein50.7001.786CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
FIIND (PF13553, IPR025307): Function to find
30 CARNMT1interactor40.6670.738N2227 (PF07942, IPR012901): N2227-like protein
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
31 CDK1oncoprotein90.28646.245Pkinase (PF00069, IPR000719): Protein kinase domain
32 CHMP4Binteractor140.372161.151Snf7 (PF03357, IPR005024): Snf7
33 CHUKsuppressor220.414110.410Pkinase (PF00069, IPR000719): Protein kinase domain
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
34 CLTConcoprotein290.241700.009Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
Clathrin_H_link (PF13838): Clathrin-H-link
35 CNTROBinteractor40.50060.854DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
FadA (PF09403, IPR018543): Adhesion protein FadA
Flavodoxin_5 (PF12724, IPR026816): Flavodoxin domain
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
36 CSinteractor31.0000Citrate_synt (PF00285, IPR002020): Citrate synthase, C-terminal domain
37 CST9Linteractor100Cystatin (PF00031, IPR000010, SM00043): Cystatin domain
38 DBN1oncoprotein90.33372.711Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
39 EDARADDinteractor60.8000.743Death (PF00531, IPR000488, SM00005): Death domain
SCO1-SenC (PF02630, IPR003782): SCO1/SenC
40 EIF3Aoncoprotein60.6008.100DUF1003 (PF06210, IPR010406): Protein of unknown function (DUF1003)
Ly49 (PF08391, IPR013600): Ly49-like protein, N-terminal region
PCI (PF01399, IPR000717, SM00088): PCI domain
AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
41 EIF3Binteractor80.46413.201eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
PD40 (PF07676, IPR011659): WD40-like Beta Propeller Repeat
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PGBA_C (PF15437, IPR032737): Plasminogen-binding protein pgbA C-terminal
PALB2_WD40 (PF16756, IPR031920): Partner and localizer of BRCA2 WD40 domain
Methyltr_RsmF_N (PF17125, IPR031341): N-terminal domain of 16S rRNA methyltransferase RsmF
42 ERBB4suppressor50.5002.932Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
DUF3951 (PF13131, IPR025028): Protein of unknown function (DUF3951)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
43 ERC1oncoprotein70.33383.633RBD-FIP (PF09457, IPR019018): FIP domain
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
Cast (PF10174, IPR019323): RIM-binding protein of the cytomatrix active zone
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
44 ESR1suppressor330.222769.675Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
45 F2Rinteractor31.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
DUF412 (PF04217, IPR007334): Protein of unknown function, DUF412
46 FN1oncoprotein320.242731.091fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
47 FOSL1oncoprotein30.3337.373bZIP_1 (PF00170, IPR004827): bZIP transcription factor
48 GNB2interactor80.32149.788WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
CALM_bind (PF16025): Calcium-dependent calmodulin binding
WD40_like (PF17005, IPR031544): WD40-like domain
49 GOLT1Binteractor220.377167.443Got1 (PF04178, IPR007305): Got1/Sft2-like family
50 GTF2Iinteractor80.32154.052GTF2I (PF02946, IPR004212): GTF2I-like repeat
51 HDAC1suppressor190.294156.120FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
52 HDAC3suppressor180.309150.713Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
53 HDAC5protein found in more fusions350.2101043.934Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NOA36 (PF06524, IPR010531): NOA36 protein
Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
54 HSP90AA1oncoprotein320.247587.401HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
55 IKBKBprotein found in more fusions170.49286.122FliT (PF05400, IPR008622): Flagellar protein FliT
Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain
Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
56 IKBKGinteractor240.403117.273CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
57 IRAK1interactor130.45585.184Death (PF00531, IPR000488, SM00005): Death domain
Pkinase (PF00069, IPR000719): Protein kinase domain
58 LIG4interactor100APG17 (PF04108, IPR007240): Autophagy protein Apg17
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
DNA_ligase_A_C (PF04679, IPR012309): ATP dependent DNA ligase C terminal region
DNA_ligase_A_M (PF01068, IPR012310): ATP dependent DNA ligase domain
DNA_ligase_A_N (PF04675, IPR012308): DNA ligase N terminus
DNA_ligase_IV (PF11411, IPR021536): DNA ligase IV
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
59 LITAFsuppressor205.377zf-LITAF-like (PF10601, IPR006629, SM00714): LITAF-like zinc ribbon domain
DUF3824 (PF12868, IPR024436): Domain of unknwon function (DUF3824)
60 MALT1oncoprotein80.7621.658Peptidase_C14 (PF00656, IPR011600): Caspase domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
61 MAP3K7oncoprotein390.208761.024Mnd1 (PF03962, IPR005647): Mnd1 family
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
62 MAP3K8suppressor80.6793.223Pkinase (PF00069, IPR000719): Protein kinase domain
IML1 (PF12257, IPR027244): Vacuolar membrane-associated protein Iml1
63 MAPK14oncoprotein110.33396.524Pkinase (PF00069, IPR000719): Protein kinase domain
64 MBD3interactor51.0000DUF2201_N (PF13203, IPR025154): Putative metallopeptidase domain
65 MCAMinteractor21.0000C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
DUF4366 (PF14283, IPR025376): Domain of unknown function (DUF4366)
66 MCM2oncoprotein360.261911.273AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
67 MTCH1interactor140.59315.852YdjM (PF04307, IPR007404): LexA-binding, inner membrane-associated putative hydrolase
Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
68 MTCH2interactor190.55674.299Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
69 NCOR1oncoprotein160.400101.065BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal
Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein
Hid1 (PF12722): High-temperature-induced dauer-formation protein
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
RBR (PF17208): RNA binding Region
70 NDUFA2interactor120.364118.640L51_S25_CI-B8 (PF05047, IPR007741, SM00916): Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
71 NDUFB7interactor80.5005.476DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
NDUF_B7 (PF05676, IPR008698): NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7)
OrfB_IS605 (PF01385, IPR001959): Probable transposase
72 NDUFB8interactor120.45521.912NDUF_B8 (PF05821, IPR008699): NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8)
73 NDUFS1interactor180.40574.656NADH_dhqG_C (PF09326, IPR015405): NADH-ubiquinone oxidoreductase subunit G, C-terminal
Fer4 (PF00037, IPR001450): 4Fe-4S binding domain
Molybdopterin (PF00384, IPR006656): Molybdopterin oxidoreductase
NADH-G_4Fe-4S_3 (PF10588, IPR019574, SM00929): NADH-ubiquinone oxidoreductase-G iron-sulfur binding region
Fer2_4 (PF13510): 2Fe-2S iron-sulfur cluster binding domain
74 NDUFS4interactor190.46268.279ETC_C1_NDUFA4 (PF04800, IPR006885): ETC complex I subunit conserved region
75 NDUFV1interactor110.6736.096Complex1_51K (PF01512, IPR011538): Respiratory-chain NADH dehydrogenase 51 Kd subunit
NADH_4Fe-4S (PF10589, IPR019575, SM00928): NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
SLBB (PF10531, IPR019554): SLBB domain
76 NFKB1suppressor110.48915.300Death (PF00531, IPR000488, SM00005): Death domain
GHMP_kinases_C (PF08544, IPR013750): GHMP kinases C terminal
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
77 NLKprotein found in more fusions40.3337.850Pkinase (PF00069, IPR000719): Protein kinase domain
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
78 NPM1suppressor270.342435.410Nucleoplasmin (PF03066): Nucleoplasmin/nucleophosmin domain
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
79 NR2C2suppressor110.48913.312Flagellin_N (PF00669, IPR001029): Bacterial flagellin N-terminal helical region
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
80 NSFinteractor40.6672.146AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
ATPase (PF06745, IPR014774): KaiC
AAA_19 (PF13245): AAA domain
81 NUMBLinteractor50.40011.118DUF1932 (PF09130, IPR015814): Domain of unknown function (DUF1932)
NumbF (PF06311, IPR010449): NUMB domain
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
DUF2722 (PF10846, IPR021216): Protein of unknown function (DUF2722)
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
82 PDLIM7interactor80.32163.106LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
83 PIAS3oncoprotein40.6672.040SAP (PF02037, IPR003034, SM00513): SAP domain
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
84 PPP2CBsuppressor40.6670.713Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
85 PPP6Cinteractor31.0000Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
86 PSMD3interactor60.26741.429Rpn3_C (PF08375, IPR013586): Proteasome regulatory subunit C-terminal
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
PCI (PF01399, IPR000717, SM00088): PCI domain
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
TSKS (PF15358, IPR028214): Testis-specific serine kinase substrate
87 PTPN1suppressor30.6670.200Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
88 RAB2Aoncoprotein130.47493.291Ras (PF00071, IPR001806, SM00173): Ras family
89 RAB5Concoprotein210.362132.523Ras (PF00071, IPR001806, SM00173): Ras family
90 RAB7Asuppressor180.32083.567Ras (PF00071, IPR001806, SM00173): Ras family
91 RBCK1interactor140.53829.082GAGA (PF09237, IPR015318): GAGA factor
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
92 RFPL4Binteractor40.6671.286SPRY (PF00622, IPR003877, SM00449): SPRY domain
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
93 RFWD3interactor70.42930.345OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
94 RIPK1protein found in more fusions170.50044.163Death (PF00531, IPR000488, SM00005): Death domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RHIM (PF12721, IPR025735): RIP homotypic interaction motif
95 RIPK2interactor120.7455.373CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
96 RNF4interactor110.37848.511Sgf11 (PF08209, IPR013246): Sgf11 (transcriptional regulation protein)
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-UDP (PF14569, IPR027934): Zinc-binding RING-finger
97 RPA1suppressor200.351149.617Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
98 RPA2oncoprotein170.404102.492RPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
99 RPA3interactor150.45162.069Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
100 RPL5suppressor140.62840.275Ribosomal_L18_c (PF14204, IPR025607): Ribosomal L18 C-terminal region
Ribosomal_L5e (PF17144): Ribosomal large subunit proteins 60S L5, and 50S L18
101 RPN1oncoprotein220.442182.691Ribophorin_I (PF04597, IPR007676): Ribophorin I
CtIP_N (PF10482, IPR019518): Tumour-suppressor protein CtIP N-terminal domain
102 RPS16interactor110.61834.549Ribosomal_S9 (PF00380, IPR000754): Ribosomal protein S9/S16
103 RPS2interactor130.48765.460Ribosomal_S5 (PF00333, IPR013810): Ribosomal protein S5, N-terminal domain
Ribosomal_S5_C (PF03719, IPR005324): Ribosomal protein S5, C-terminal domain
104 SERINC2interactor21.0000Serinc (PF03348, IPR005016): Serine incorporator (Serinc)
105 SIK1suppressor50.8000.778Pkinase (PF00069, IPR000719): Protein kinase domain
106 SIK3oncoprotein40.6670.778GET2 (PF08690, IPR028143): GET complex subunit GET2
Pkinase (PF00069, IPR000719): Protein kinase domain
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
107 SIN3Aoncoprotein110.50976.337Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor
PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat
Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
108 SLC19A3interactor100Folate_carrier (PF01770, IPR002666): Reduced folate carrier
NfeD (PF01957, IPR002810): NfeD-like C-terminal, partner-binding
109 SLC25A4interactor40.6671.263Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
110 SLC25A5interactor130.50044.554Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
111 SLC25A6interactor50.30025.201Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
112 SMAD7interactor90.50012.844MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
113 SSR1interactor50.9000.286TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
114 STAU1protein found in more fusions260.283235.130dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
115 TAB1interactor290.227427.897PP2C (PF00481, IPR001932): Protein phosphatase 2C
116 TAB3oncoprotein180.36882.109CUE (PF02845, IPR003892, SM00546): CUE domain
Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
117 TANKsuppressor80.571100.721DUF3713 (PF12506, IPR022186): Protein of unknown function (DUF3713)
TBD (PF12845, IPR024581): TBD domain
118 TBL1Xprotein found in more fusions90.7862.467K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
LisH (PF08513, IPR013720, SM00667): LisH
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
LCE6A (PF15858, IPR031716): Late cornified envelope protein 6A family
119 TBL1XR1oncoprotein100.7566.006LisH (PF08513, IPR013720, SM00667): LisH
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
120 TGFBR1oncoprotein70.42983.087Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase (PF00069, IPR000719): Protein kinase domain
TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
121 TGM2protein found in more fusions60.9000.169Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain
Transglut_N (PF00868, IPR001102): Transglutaminase family
Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily
122 THOC2interactor60.6007.286Sec62 (PF03839, IPR004728): Translocation protein Sec62
Tho2 (PF11262, IPR021418): Transcription factor/nuclear export subunit protein 2
Thoc2 (PF11732, IPR021726): Transcription- and export-related complex subunit
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
THOC2_N (PF16134, IPR032302): THO complex subunit 2 N-terminus
123 TIRAPinteractor70.7331.675TIR_2 (PF13676, IPR000157): TIR domain
124 TLR3interactor40.8330.241LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
TIR (PF01582, IPR000157, SM00255): TIR domain
LRR_5 (PF13306, IPR026906): Leucine rich repeats (6 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
125 TMEM63Binteractor130.423100.997RSN1_7TM (PF02714, IPR003864): Calcium-dependent channel, 7TM region, putative phosphate
Wzy_C (PF04932, IPR007016): O-Antigen ligase
DUF4006 (PF13179, IPR025065): Family of unknown function (DUF4006)
RSN1_TM (PF13967, IPR032880): Late exocytosis, associated with Golgi transport
PHM7_cyt (PF14703, IPR027815): Cytosolic domain of 10TM putative phosphate transporter
126 TMPOinteractor80.28684.306LEM (PF03020, IPR003887, SM00540): LEM domain
Thymopoietin (PF08198, IPR013146): Thymopoietin protein
LAP2alpha (PF11560, IPR021623): Lamina-associated polypeptide 2 alpha
127 TNFoncoprotein110.7783.050TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
128 TNFRSF11Aoncoprotein41.0000Abi (PF02517, IPR003675): CAAX protease self-immunity
DAG1 (PF05454, IPR008465): Dystroglycan (Dystrophin-associated glycoprotein 1)
KIX (PF02172, IPR003101): KIX domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
129 TRAF2interactor220.376134.885MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
130 TRAF3IP1interactor40.8330.133MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
131 TRAF6protein found in more fusions360.203702.549SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
132 TRIM22interactor200SPRY (PF00622, IPR003877, SM00449): SPRY domain
YojJ (PF10372, IPR019457): Bacterial membrane-spanning protein N-terminus
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
UBZ_FAAP20 (PF15750, IPR031490): Ubiquitin-binding zinc-finger
CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour
133 TRIM38interactor60.6009.238DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
134 TRIM5interactor70.7331.008Baculo_IE-1 (PF05290, IPR007954): Baculovirus immediate-early protein (IE-0)
Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
135 UBCprotein found in more fusions330.2321228.276ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
136 UBE2Iinteractor260.230486.234UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
137 UQCRHinteractor30.3332.026Herpes_pp85 (PF04637, IPR006731): Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25)
138 USP18interactor70.7142.432TAFII55_N (PF04658, IPR006751): TAFII55 protein conserved region
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
139 VAPAinteractor210.343190.475DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
140 VDAC1interactor270.419366.663Porin_3 (PF01459, IPR027246): Eukaryotic porin
141 VDAC2interactor300.393269.491Porin_3 (PF01459, IPR027246): Eukaryotic porin
142 VDAC3protein found in more fusions230.486122.052Porin_3 (PF01459, IPR027246): Eukaryotic porin
143 VIMsuppressor130.409137.398Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
144 WDR34interactor50.8000.476GTF2I (PF02946, IPR004212): GTF2I-like repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
145 XIAPinteractor120.50971.789BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
146 XPO1interactor370.192863.323CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
147 YBX3interactor40.3336.841CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain
Herpes_LMP1 (PF05297, IPR007961): Herpesvirus latent membrane protein 1 (LMP1)
148 YWHAZprotein found in more fusions170.433127.66614-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
149 ZBTB16suppressor140.449177.530BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger

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