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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)29
The number (and %) of the onco-proteins8 (27.59 %)
The number (and %) of the tumor suppressors7 (24.14 %)
Total number of binary PPIs (saturation %)90 (22.17 %)
The number (and %) of affected PPIs27 (30.00 %)
The number of possible different fusions10
PPI diameter5
PPI radius3
The average degree of PPI5.379
Assortativity coefficient-0.4226
The network average Clustering coefficient0.436
The number (and %) of a zero Clustering coefficients3 (10.34 %)
The number (and %) of a zero Betweenness Centrality6 (20.69 %)


List of the fusions

PPI for parental proteins: SMYD2,PAPSS2 All fusions
Proteins found in more fusions HSP90AA1 (see 5 fusions); CTH (see 3 fusions); APP (see 4 fusions); ARIH2 (see 2 fusions); VHL (see 1 fusions); TP53 (see 3 fusions); GSK3B (see 1 fusions); SNX1 (see 1 fusions); CDC37 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 SMYD2parental protein160.200191.086Complex1_LYR (PF05347, IPR008011): Complex 1 protein (LYR family)
SET (PF00856, IPR001214, SM00317): SET domain
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
2 PAPSS2parental protein110.145117.308APS_kinase (PF01583, IPR002891): Adenylylsulphate kinase
ATP-sulfurylase (PF01747, IPR024951): ATP-sulfurylase
DUF258 (PF03193, IPR004881): Protein of unknown function, DUF258
YscJ_FliF (PF01514, IPR006182): Secretory protein of YscJ/FliF family
PUA_2 (PF14306, IPR025980): PUA-like domain
3 AKAP11interactor21.0000E_raikovi_mat (PF06360, IPR009064): Euplotes raikovi mating pheromone
RNA_lig_T4_1 (PF09511, IPR019039): RNA ligase
4 APEX1interactor70.28644.060Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
5 APPprotein found in more fusions100.22273.990APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
6 ARIH2protein found in more fusions40.6673.018IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zinc_ribbon_12 (PF11331, IPR021480): Probable zinc-ribbon domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
PRAS (PF15798, IPR026682): Proline-rich AKT1 substrate 1
7 AXIN1suppressor41.0000Axin_b-cat_bind (PF08833, IPR014936): Axin beta-catenin binding domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
DIX (PF00778, IPR001158, SM00021): DIX domain
AXIN1_TNKS_BD (PF16646, IPR032101): Axin-1 tankyrase binding domain
8 CDC37protein found in more fusions60.5004.410CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain
CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
Rho_Binding (PF08912, IPR015008): Rho Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
9 CLASP2interactor40.5001.400HEAT (PF02985, IPR000357): HEAT repeat
TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair
CLASP_N (PF12348, IPR024395): CLASP N terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal
HEAT_EZ (PF13513): HEAT-like repeat
10 CTHprotein found in more fusions200Cys_Met_Meta_PP (PF01053, IPR000277): Cys/Met metabolism PLP-dependent enzyme
11 EPB41L3suppressor21.00004_1_CTD (PF05902, IPR008379): 4.1 protein C-terminal domain (CTD)
FA (PF08736, IPR014847): FERM adjacent (FA)
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
SAB (PF04382, IPR007477): SAB domain
12 ESR1suppressor60.50010.194Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
13 GOLGA4interactor30.3334.087ACCA (PF03255, IPR001095): Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit
ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DivIC (PF04977, IPR007060): Septum formation initiator
DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
Fez1 (PF06818): Fez1
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
GRIP (PF01465, IPR000237, SM00755): GRIP domain
Mnd1 (PF03962, IPR005647): Mnd1 family
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
SlyX (PF04102, IPR007236): SlyX
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
XhlA (PF10779, IPR019715): Haemolysin XhlA
YlqD (PF11068, IPR021297): YlqD protein
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
RecQ_Zn_bind (PF16124, IPR032284): RecQ zinc-binding
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
TetR_C_13 (PF16925, IPR011075): Bacterial transcriptional repressor C-terminal
14 GSK3Bsuppressor100.30659.738Pkinase (PF00069, IPR000719): Protein kinase domain
15 GSPT2interactor30.6674.940GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
16 GTF3C4interactor203.018TFIIIC_delta (PF12657, IPR024761): Transcription factor IIIC subunit delta N-term
zf-TFIIIC (PF12660, IPR024764): Putative zinc-finger of transcription factor IIIC complex
17 HIST2H3Cinteractor100Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
18 HNRNPA2B1oncoprotein50.30014.520RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
19 HSP90AA1oncoprotein90.42919.343HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
20 IGF2BP1oncoprotein50.6002.336RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
KH_1 (PF00013, IPR004088, SM00322): KH domain
KH_4 (PF13083): KH domain
MOEP19 (PF16005, IPR031952): KH-like RNA-binding domain
21 MOV10interactor60.40012.812AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
22 NXF1interactor90.21438.594NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
23 RB1suppressor21.0000RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
Rb_C (PF08934, IPR015030): Rb C-terminal domain
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
DUF4592 (PF15262, IPR028030): Domain of unknown function (DUF4592)
24 RIC8Ainteractor30.6670.917PUL (PF08324, IPR013535): PUL domain
Ric8 (PF10165, IPR019318): Guanine nucleotide exchange factor synembryn
25 SNX1protein found in more fusions60.30021.372PX (PF00787, IPR001683, SM00312): PX domain
Sorting_nexin (PF03700, IPR005329): Sorting nexin, N-terminal domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
26 TP53suppressor160.171203.355DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
27 TUBB2Ainteractor30.33311.394Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
28 TXNRD1interactor40.5007.739Glutaredoxin (PF00462, IPR002109): Glutaredoxin
Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
Pyr_redox_dim (PF02852, IPR004099): Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
29 VHLsuppressor70.40018.369Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): VHL beta domain
VHL_C (PF17211): VHL box domain

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