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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PAPSS2, CTGF (from a repository: Sat Dec 1 08:54:15 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)18
The number (and %) of the onco-proteins7 (38.89 %)
The number (and %) of the tumor suppressors3 (16.67 %)
Total number of binary PPIs (saturation %)43 (28.10 %)
The number (and %) of affected PPIs16 (37.21 %)
The number of possible different fusions9
PPI diameter4
PPI radius2
The average degree of PPI3.778
Assortativity coefficient-0.4818
The network average Clustering coefficient0.400
The number (and %) of a zero Clustering coefficients4 (22.22 %)
The number (and %) of a zero Betweenness Centrality4 (22.22 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions APP (see 4 fusions); EGFR (see 2 fusions); ARIH2 (see 2 fusions); VHL (see 1 fusions); FBLN1 (see 3 fusions); ACTB (see 5 fusions); VEGFA (see 1 fusions); CTH (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CTGFparental protein50.20024.305Cys_knot (PF00007, IPR006208): Cystine-knot domain
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
IGFBP (PF00219, IPR000867, SM00121): Insulin-like growth factor binding protein
TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
2 PAPSS2parental protein110.145117.264APS_kinase (PF01583, IPR002891): Adenylylsulphate kinase
ATP-sulfurylase (PF01747, IPR024951): ATP-sulfurylase
DUF258 (PF03193, IPR004881): Protein of unknown function, DUF258
YscJ_FliF (PF01514, IPR006182): Secretory protein of YscJ/FliF family
PUA_2 (PF14306, IPR025980): PUA-like domain
3 ACTBoncoprotein40.6671.682Actin (PF00022, IPR004000, SM00268): Actin
4 APEX1interactor50.40011.912Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
5 APPprotein found in more fusions70.20042.984APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
6 ARIH2protein found in more fusions31.0000IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zinc_ribbon_12 (PF11331, IPR021480): Probable zinc-ribbon domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
PRAS (PF15798, IPR026682): Proline-rich AKT1 substrate 1
7 CTHprotein found in more fusions305.301Cys_Met_Meta_PP (PF01053, IPR000277): Cys/Met metabolism PLP-dependent enzyme
8 EGFRoncoprotein4015.231Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
9 ELAVL1oncoprotein80.19046.004RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
10 FBLN1suppressor304.483ANATO (PF01821, IPR000020, SM00104): Anaphylotoxin-like domain
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
11 GSPT2interactor21.0000GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
12 GTF3C4interactor100TFIIIC_delta (PF12657, IPR024761): Transcription factor IIIC subunit delta N-term
zf-TFIIIC (PF12660, IPR024764): Putative zinc-finger of transcription factor IIIC complex
13 HNRNPA2B1oncoprotein30.6675.301RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
14 RIC8Ainteractor30.6671.000PUL (PF08324, IPR013535): PUL domain
Ric8 (PF10165, IPR019318): Guanine nucleotide exchange factor synembryn
15 TUBB2Ainteractor30.3339.348Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
16 TXNRD1interactor30.33312.349Glutaredoxin (PF00462, IPR002109): Glutaredoxin
Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
Pyr_redox_dim (PF02852, IPR004099): Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
17 VEGFAsuppressor31.0000PDGF (PF00341, IPR000072, SM00141): PDGF/VEGF domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
VEGF_C (PF14554, IPR027928): VEGF heparin-binding domain
18 VHLsuppressor60.40026.835Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): VHL beta domain
VHL_C (PF17211): VHL box domain

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