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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PAPSS2, BRD8 (from a repository: Wed Dec 5 13:54:51 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)38
The number (and %) of the onco-proteins9 (23.68 %)
The number (and %) of the tumor suppressors8 (21.05 %)
Total number of binary PPIs (saturation %)168 (23.90 %)
The number (and %) of affected PPIs36 (21.43 %)
The number of possible different fusions10
PPI diameter5
PPI radius3
The average degree of PPI8.000
Assortativity coefficient-0.1615
The network average Clustering coefficient0.578
The number (and %) of a zero Clustering coefficients3 (7.89 %)
The number (and %) of a zero Betweenness Centrality9 (23.68 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions KAT5 (see 3 fusions); RXRA (see 2 fusions); CTH (see 3 fusions); EWSR1 (see 2 fusions); APP (see 4 fusions); ARIH2 (see 2 fusions); VHL (see 1 fusions); MYC (see 2 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BRD8parental protein250.290405.158Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
2 PAPSS2parental protein110.145136.628APS_kinase (PF01583, IPR002891): Adenylylsulphate kinase
ATP-sulfurylase (PF01747, IPR024951): ATP-sulfurylase
DUF258 (PF03193, IPR004881): Protein of unknown function, DUF258
YscJ_FliF (PF01514, IPR006182): Secretory protein of YscJ/FliF family
PUA_2 (PF14306, IPR025980): PUA-like domain
3 APEX1interactor60.40021.422Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
4 APPprotein found in more fusions100.33399.473APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 ARIH2protein found in more fusions50.50012.311IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zinc_ribbon_12 (PF11331, IPR021480): Probable zinc-ribbon domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
PRAS (PF15798, IPR026682): Proline-rich AKT1 substrate 1
6 CDC5Linteractor40.33312.733OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
7 CTHprotein found in more fusions200Cys_Met_Meta_PP (PF01053, IPR000277): Cys/Met metabolism PLP-dependent enzyme
8 DMAP1interactor150.68620.218DMAP1 (PF05499, IPR008468): DNA methyltransferase 1-associated protein 1 (DMAP1)
SANT_DAMP1_like (PF16282, IPR032563): SANT/Myb-like domain of DAMP1
9 EWSR1oncoprotein31.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
10 FOXR1interactor110.8363.429Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
11 FOXR2interactor110.8363.429Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
12 FSD2interactor100Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
REJ (PF02010, IPR002859): REJ domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
IZUMO (PF15005, IPR029389): Izumo sperm-egg fusion, Ig domain-associated
Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
13 GSPT2interactor21.0000GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
14 GTF3C4interactor30.3339.158TFIIIC_delta (PF12657, IPR024761): Transcription factor IIIC subunit delta N-term
zf-TFIIIC (PF12660, IPR024764): Putative zinc-finger of transcription factor IIIC complex
15 HIST1H2BAinteractor100.84412.433Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
16 HIST1H2BGoncoprotein41.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
17 HNRNPA2B1oncoprotein40.33318.044RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
18 ING3suppressor120.78817.382PHD (PF00628, IPR019787, SM00249): PHD-finger
Rifin_STEVOR (PF02009, IPR002858): Rifin/stevor family
ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding
19 KAT5suppressor200.497123.311MOZ_SAS (PF01853, IPR002717): MOZ/SAS family
Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
20 MAXsuppressor90.9640.182ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
SlyX (PF04102, IPR007236): SlyX
21 MIS18Ainteractor100Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor
Yippee-Mis18 (PF03226, IPR004910): Yippee zinc-binding/DNA-binding /Mis18, centromere assembly
DUF2868 (PF11067, IPR021296): Protein of unknown function (DUF2868)
22 MORF4L1interactor160.61058.517MRG (PF05712, IPR026541): MRG
Fmp27_WPPW (PF10359, IPR019449): RNA pol II promoter Fmp27 protein domain
Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
23 MORF4L2interactor120.71223.198MRG (PF05712, IPR026541): MRG
24 MRGBPinteractor140.69230.061Eaf7 (PF07904, IPR012423): Chromatin modification-related protein EAF7
25 MYConcoprotein140.48777.318HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
26 PLAC1interactor81.0000Paired_CXXCH_1 (PF09699, IPR010177): Doubled CXXCH motif (Paired_CXXCH_1)
27 RIC8Ainteractor30.6671.448PUL (PF08324, IPR013535): PUL domain
Ric8 (PF10165, IPR019318): Guanine nucleotide exchange factor synembryn
28 RXRAoncoprotein31.0000zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
Nuc_recep-AF1 (PF11825, IPR021780): Nuclear/hormone receptor activator site AF-1
29 SOX2oncoprotein50.3337.506HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOXp (PF12336, IPR022097): SOX transcription factor
30 THRBsuppressor40.6677.333zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
31 TP53suppressor160.181235.607DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
32 TP63suppressor31.0000Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
33 TP73suppressor60.7005.329P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
34 TRRAPinteractor150.70523.811BALF1 (PF06861, IPR010677): BALF1 protein
BP28CT (PF08146, IPR012954, SM01036): BP28CT (NUC211) domain
DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
CLASP_N (PF12348, IPR024395): CLASP N terminal
Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal
HEAT_EZ (PF13513): HEAT-like repeat
TRC8_N (PF13705, IPR025754): TRC8 N-terminal domain
ACDC (PF14733, IPR028078): AP2-coincident C-terminal
35 TUBB2Ainteractor70.19088.017Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
36 TXNRD1interactor30.6674.196Glutaredoxin (PF00462, IPR002109): Glutaredoxin
Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
Pyr_redox_dim (PF02852, IPR004099): Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
37 VHLsuppressor70.53323.687Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): VHL beta domain
VHL_C (PF17211): VHL box domain
38 YEATS4interactor150.70516.661YEATS (PF03366, IPR005033): YEATS family
SOGA (PF11365, IPR027881): Protein SOGA

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