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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)77
The number (and %) of the onco-proteins22 (28.57 %)
The number (and %) of the tumor suppressors10 (12.99 %)
Total number of binary PPIs (saturation %)282 (9.64 %)
The number (and %) of affected PPIs75 (26.60 %)
The number of possible different fusions14
PPI diameter5
PPI radius3
The average degree of PPI6.416
Assortativity coefficient-0.3234
The network average Clustering coefficient0.447
The number (and %) of a zero Clustering coefficients12 (15.58 %)
The number (and %) of a zero Betweenness Centrality21 (27.27 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MCU,KAT7 All fusions
Proteins found in more fusions SAT1 (see 6 fusions); APP (see 5 fusions); ORC2 (see 2 fusions); ABCC1 (see 1 fusions); CEP70 (see 1 fusions); MCM2 (see 1 fusions); ATN1 (see 1 fusions); EZH2 (see 1 fusions); DVL3 (see 1 fusions); VIM (see 1 fusions); KATNBL1 (see 1 fusions); MYC (see 2 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MCUparental protein160.142703.720MCU (PF04678, IPR006769): Mitochondrial calcium uniporter
2 KAT7parental protein590.0723139.774MOZ_SAS (PF01853, IPR002717): MOZ/SAS family
zf-C2HC (PF01530, IPR002515, SM00343): Zinc finger, C2HC type
zf-met (PF12874): Zinc-finger of C2H2 type
EFTUD2 (PF16004, IPR031950): 116 kDa U5 small nuclear ribonucleoprotein component N-terminus
3 ABCC1oncoprotein200ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
ABC_ATPase (PF09818, IPR019195): Predicted ATPase of the ABC class
DUF2304 (PF10066, IPR019277): Uncharacterized conserved protein (DUF2304)
DUF4131 (PF13567, IPR025405): Domain of unknown function (DUF4131)
4 APPprotein found in more fusions190.150412.473APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 ARoncoprotein100.33324.174Androgen_recep (PF02166, IPR001103): Androgen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
6 ATN1protein found in more fusions31.0000Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
7 BARD1suppressor120.327105.521BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
zf-RING_6 (PF14835): zf-RING of BARD1-type protein
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
8 CAAP1interactor30.33311.229Ribosomal_L32p (PF01783, IPR002677): Ribosomal L32p protein family
CAAP1 (PF15335): Caspase activity and apoptosis inhibitor 1
9 CALCOCO2interactor41.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
zf-C2H2_4 (PF13894): C2H2-type zinc finger
10 CBX8interactor60.5006.856Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
RBR (PF17208): RNA binding Region
CBX7_C (PF17218): CBX family C-terminal motif
11 CDC6oncoprotein60.66723.056Cdc6_C (PF09079, IPR015163, SM01074): CDC6, C terminal winged helix domain
AAA_22 (PF13401, IPR003593): AAA domain
ORC5_C (PF14630, IPR020796): Origin recognition complex (ORC) subunit 5 C-terminus
12 CDK11Boncoprotein200DDHD (PF02862, IPR004177, SM01127): DDHD domain
DivIC (PF04977, IPR007060): Septum formation initiator
Pkinase (PF00069, IPR000719): Protein kinase domain
DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748)
13 CDT1oncoprotein80.50017.569CDT1 (PF08839, IPR014939, SM01075): DNA replication factor CDT1 like
CDT1_C (PF16679, IPR032054): DNA replication factor Cdt1 C-terminal domain
14 CEP70protein found in more fusions40.6670.667IncA (PF04156, IPR007285): IncA protein
Mog1 (PF04603, IPR007681): Ran-interacting Mog1 protein
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
Colicin-DNase (PF12639, IPR024622): DNase/tRNase domain of colicin-like bacteriocin
15 COLEC10interactor100Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
16 CSNK1Einteractor80.52432.449APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
17 DAXXoncoprotein60.5004.198Daxx (PF03344, IPR005012): Daxx N-terminal Rassf1C-interacting domain
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Nop14 (PF04147, IPR007276): Nop14-like family
RF-1 (PF00472, IPR000352): RF-1 domain
Vpu (PF00558, IPR008187): Vpu protein
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
18 DDB2suppressor70.33318.804WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
19 DDX11interactor100DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
DEAD_2 (PF06733, IPR010614): DEAD_2
HBB (PF06777, IPR010643): Helical and beta-bridge domain
Helicase_C_2 (PF13307, IPR006555): Helicase C-terminal domain
20 DVL3protein found in more fusions50.8330.400DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
Dishevelled (PF02377, IPR003351): Dishevelled specific domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DIX (PF00778, IPR001158, SM00021): DIX domain
Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
21 DYNC1I1interactor100CDC45 (PF02724, IPR003874): CDC45-like protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Dynein_IC2 (PF11540, IPR025956): Cytoplasmic dynein 1 intermediate chain 2
AviRa (PF11599, IPR024268): RRNA methyltransferase AviRa
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
22 ELAVL1oncoprotein200.140699.102RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
23 ERLIN2interactor60.5339.826Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4346 (PF14251, IPR025595): Domain of unknown function (DUF4346)
24 EZH2suppressor80.28644.890CDC45 (PF02724, IPR003874): CDC45-like protein
TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain
SET (PF00856, IPR001214, SM00317): SET domain
EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
25 GMNNinteractor21.0000Geminin (PF07412, IPR022786): Geminin
26 GNAI2oncoprotein2014.362G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
27 GOLT1Binteractor60.6674.602Got1 (PF04178, IPR007305): Got1/Sft2-like family
28 HAP1interactor110.28928.943HAP1_N (PF04849, IPR006933): HAP1 N-terminal conserved region
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
29 HIST1H2BGoncoprotein70.33318.580Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
30 HIST1H3Ainteractor90.42917.222Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
31 HIST1H4Ainteractor50.7003.833CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
32 HIST2H2ACinteractor80.46422.965Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
33 HOOK2interactor31.0000HOOK (PF05622, IPR008636): HOOK protein
34 IFI16suppressor40.6671.561HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
35 ING3suppressor60.46726.317PHD (PF00628, IPR019787, SM00249): PHD-finger
Rifin_STEVOR (PF02009, IPR002858): Rifin/stevor family
ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding
36 ING4suppressor90.32131.438PHD (PF00628, IPR019787, SM00249): PHD-finger
SOGA (PF11365, IPR027881): Protein SOGA
ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding
zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
37 ING5suppressor100.35627.428ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding
38 JADE1interactor50.6003.000C1_2 (PF03107, IPR004146): C1 domain
Glyco_hydro_57 (PF03065, IPR004300): Glycosyl hydrolase family 57
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
eIF-5_eIF-2B (PF01873, IPR002735, SM00653): Domain found in IF2B/IF5
PHD_2 (PF13831): PHD-finger
zf-HC5HC2H_2 (PF13832): PHD-zinc-finger like domain
39 JADE2interactor60.5335.000PRA-PH (PF01503, IPR021130): Phosphoribosyl-ATP pyrophosphohydrolase
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
PHD_2 (PF13831): PHD-finger
zf-HC5HC2H_2 (PF13832): PHD-zinc-finger like domain
zf-RRPl_C4 (PF17026, IPR031502): Putative ribonucleoprotein zinc-finger pf C4 type
40 JADE3interactor70.33330.510Enterotoxin_ST (PF02048, IPR001489): Heat-stable enterotoxin ST
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
PHD_2 (PF13831): PHD-finger
zf-HC5HC2H_2 (PF13832): PHD-zinc-finger like domain
41 JUNoncoprotein50.5009.487bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
42 KATNBL1protein found in more fusions40.33321.121Nucleo_P87 (PF07267, IPR009893): Nucleopolyhedrovirus capsid protein P87
Katanin_con80 (PF13925, IPR028021): con80 domain of Katanin
43 KCTD13interactor200BTB_2 (PF02214, IPR003131): BTB/POZ domain
44 LRIF1interactor80.4767.733LRIF1 (PF15741, IPR026191): Ligand-dependent nuclear receptor-interacting factor 1
45 MCM2oncoprotein170.250306.339AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
46 MEAF6interactor70.52440.164ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
NuA4 (PF09340, IPR015418): Histone acetyltransferase subunit NuA4
47 MRPL58interactor50.40028.847RF-1 (PF00472, IPR000352): RF-1 domain
48 MYConcoprotein140.141321.874HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
49 NDUFA4interactor60.40050.128B12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
50 NDUFA9interactor70.42937.174Epimerase (PF01370, IPR001509): NAD dependent epimerase/dehydratase family
51 NINLinteractor30.6670.500PD40 (PF07676, IPR011659): WD40-like Beta Propeller Repeat
TBCA (PF02970, IPR004226): Tubulin binding cofactor A
DUF2389 (PF09493, IPR012663): Tryptophan-rich protein (DUF2389)
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
FAM184 (PF15665): Family with sequence similarity 184, A and B
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
52 NYXinteractor100LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
53 ORC1interactor51.0000AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
BAH (PF01426, IPR001025, SM00439): BAH domain
Cdc6_C (PF09079, IPR015163, SM01074): CDC6, C terminal winged helix domain
54 ORC2protein found in more fusions61.0000ORC2 (PF04084, IPR007220): Origin recognition complex subunit 2
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
55 PACSIN1interactor40.33310.329FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain
DUF2605 (PF10792, IPR019728): Protein of unknown function (DUF2605)
DUF4446 (PF14584, IPR027981): Protein of unknown function (DUF4446)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
NPF (PF16601): Rabosyn-5 repeating NPF sequence-motif
56 POLBinteractor21.0000DNA_pol_lambd_f (PF10391, IPR018944): Fingers domain of DNA polymerase lambda
HHH_2 (PF12826): Helix-hairpin-helix motif
HHH_8 (PF14716, IPR010996): Helix-hairpin-helix domain
DNA_pol_B_thumb (PF14791, IPR029398): DNA polymerase beta thumb
DNA_pol_B_palm (PF14792, IPR028207): DNA polymerase beta palm
57 POU5F1oncoprotein50.50025.355Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
58 PPIDinteractor40.5004.059Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
59 RAB7Asuppressor31.0000Ras (PF00071, IPR001806, SM00173): Ras family
60 RGL2interactor100RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif
61 RNF2interactor160.238345.320zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
62 RPS10interactor80.46416.075S10_plectin (PF03501, IPR005326): Plectin/S10 domain
63 S100A4interactor21.0000S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
64 SAT1protein found in more fusions40.6670.618Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
65 SEPT5oncoprotein31.0000Septin (PF00735, IPR000038): Septin
66 SLC1A5interactor2031.405SDF (PF00375, IPR001991): Sodium:dicarboxylate symporter family
67 SLC38A2oncoprotein40.50020.559Aa_trans (PF01490, IPR004758): Transmembrane amino acid transporter protein
68 SNAPINinteractor21.0000Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
69 TMPOinteractor30.33311.329LEM (PF03020, IPR003887, SM00540): LEM domain
Thymopoietin (PF08198, IPR013146): Thymopoietin protein
LAP2alpha (PF11560, IPR021623): Lamina-associated polypeptide 2 alpha
70 TP53suppressor190.196249.233DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
71 VAPAinteractor60.40095.457DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
72 VIMsuppressor110.40043.330Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
73 WDR33interactor40.83310.397Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
74 XPO1interactor130.282133.879CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
75 ZBTB8Ainteractor40.6670.821BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
76 ZNF165interactor100SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
77 ZNF526interactor100Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger

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