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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins TM9SF2, PSTPIP2 (from a repository: Sun Aug 18 19:07:29 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)13
The number (and %) of the onco-proteins2 (15.38 %)
The number (and %) of the tumor suppressors1 (7.69 %)
Total number of binary PPIs (saturation %)21 (26.92 %)
The number (and %) of affected PPIs11 (52.38 %)
The number of possible different fusions4
PPI diameter5
PPI radius3
The average degree of PPI2.615
Assortativity coefficient-0.5855
The network average Clustering coefficient0.483
The number (and %) of a zero Clustering coefficients4 (30.77 %)
The number (and %) of a zero Betweenness Centrality7 (53.85 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PSTPIP2,TM9SF2 All fusions
Proteins found in more fusions SMAD4 (see 3 fusions); GRB2 (see 1 fusions); SHC1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PSTPIP2parental protein30.66710.000FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain
DUF2393 (PF09624, IPR013417): Protein of unknown function (DUF2393)
2 TM9SF2parental protein80.107103.000FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
EMP70 (PF02990, IPR004240): Endomembrane protein 70
3 ATP1B3interactor100Na_K-ATPase (PF00287, IPR000402): Sodium / potassium ATPase beta chain
4 CDC5Linteractor40.33354.000OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
5 GRB2oncoprotein31.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
6 MMGT1interactor21.0000MMgT (PF10270, IPR018937): Membrane magnesium transporter
7 RPN2interactor21.0000Ribophorin_II (PF05817, IPR008814): Oligosaccharyltransferase subunit Ribophorin II
8 SHC1oncoprotein40.66710.000PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
9 SLC25A3interactor100Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
10 SMAD4suppressor200MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
11 SRSF7interactor2064.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TP2 (PF01254, IPR000678): Nuclear transition protein 2
zf-CCHC (PF00098, IPR001878): Zinc knuckle
12 TCTN3interactor40.5003.000DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
13 UNC93B1interactor21.0000UNC-93 (PF05978, IPR010291): Ion channel regulatory protein UNC-93
Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup
DUF4131 (PF13567, IPR025405): Domain of unknown function (DUF4131)

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