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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MSRB3, MPZL1 (from a repository: Sun Jul 21 03:33:31 2019)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)33
The number (and %) of the onco-proteins5 (15.15 %)
The number (and %) of the tumor suppressors6 (18.18 %)
Total number of binary PPIs (saturation %)72 (13.64 %)
The number (and %) of affected PPIs31 (43.06 %)
The number of possible different fusions5
PPI diameter5
PPI radius3
The average degree of PPI3.515
Assortativity coefficient-0.3728
The network average Clustering coefficient0.278
The number (and %) of a zero Clustering coefficients15 (45.45 %)
The number (and %) of a zero Betweenness Centrality17 (51.52 %)


List of the fusions

PPI for parental proteins: MPZL1,MSRB3 All fusions
Proteins found in more fusions STAT3 (see 2 fusions); LGALS3 (see 2 fusions); PTPN11 (see 1 fusions); GAPDH (see 5 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 MPZL1parental protein210.076588.410Adeno_E3_CR2 (PF02439, IPR003470): Adenovirus E3 region protein CR2
FTR1 (PF03239, IPR004923): Iron permease FTR1 family
Trp_oprn_chp (PF09534, IPR019051): Tryptophan-associated transmembrane protein (Trp_oprn_chp)
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
2 MSRB3parental protein100.044241.538SelR (PF01641, IPR002579): SelR domain
3 AZIN1interactor2040.086Orn_Arg_deC_N (PF02784, IPR022644): Pyridoxal-dependent decarboxylase, pyridoxal binding domain
Orn_DAP_Arg_deC (PF00278, IPR022643): Pyridoxal-dependent decarboxylase, C-terminal sheet domain
4 BAIAP2interactor200IMD (PF08397, IPR013606): IRSp53/MIM homology domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
5 CCDC8interactor70.33366.986Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
6 CRKLoncoprotein50.30069.924SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
7 DOK7interactor100Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
PH (PF00169, IPR001849, SM00233): PH domain
8 ELAVL1oncoprotein100.278100.771RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
9 EXOSC4interactor200RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
10 FHL3interactor3022.686LIM (PF00412, IPR001781, SM00132): LIM domain
Med27 (PF11571, IPR021627): Mediator complex subunit 27
11 GAPDHoncoprotein3032.619Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
OstA (PF03968, IPR005653): OstA-like protein
12 GOLGA2interactor2030.867ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
13 HCCSinteractor21.0000Cyto_heme_lyase (PF01265, IPR000511): Cytochrome c/c1 heme lyase
14 KIF7suppressor21.0000ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
MMR_HSR1_C (PF08438, IPR013646): GTPase of unknown function C-terminal
Nbs1_C (PF08599, IPR013908): DNA damage repair protein Nbs1
XhlA (PF10779, IPR019715): Haemolysin XhlA
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
YlqD (PF11068, IPR021297): YlqD protein
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
15 LGALS3oncoprotein50.50054.067Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
16 LGALS9interactor31.0000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
Peptidase_C62 (PF12380, IPR024348): Gill-associated viral 3C-like peptidase
17 LIPFinteractor100Abhydro_lipase (PF04083, IPR006693): Partial alpha/beta-hydrolase lipase region
Abhydrolase_1 (PF00561, IPR000073): alpha/beta hydrolase fold
18 LNX2interactor31.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DZR (PF12773, IPR025874): Double zinc ribbon
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
19 MAPK8IP2interactor200BUD22 (PF09073, IPR015158): BUD22
CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
SH3_9 (PF14604, IPR001452): Variant SH3 domain
20 MOV10interactor40.16733.338AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
21 MYO5Cinteractor31.0000DIL (PF01843, IPR018444, SM01132): DIL domain
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Pilus_CpaD (PF09476, IPR019027): Pilus biogenesis CpaD protein (pilus_cpaD)
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
YtxH (PF12732, IPR024623): YtxH-like protein
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
22 NOXRED1interactor100F420_oxidored (PF03807, IPR028939): NADP oxidoreductase coenzyme F420-dependent
23 NXF1interactor50.16762.767NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
24 PAPD5interactor21.0000NTP_transf_2 (PF01909, IPR002934): Nucleotidyltransferase domain
PAP_assoc (PF03828, IPR002058): Cid1 family poly A polymerase
Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
Secretin_N_2 (PF07655, IPR011514): Secretin N-terminal domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
25 PRDM4suppressor200zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Ecl1 (PF12855, IPR024368): Life-span regulatory factor
zf-met (PF12874): Zinc-finger of C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
26 PTPN11suppressor70.53314.133SH2 (PF00017, IPR000980, SM00252): SH2 domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
27 SLC39A4suppressor100Zip (PF02535, IPR003689): ZIP Zinc transporter
Class_IIIsignal (PF04021, IPR007166): Class III signal peptide
28 SPACA1interactor100DUF912 (PF06024, IPR009261): Nucleopolyhedrovirus protein of unknown function (DUF912)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
29 SRConcoprotein50.33329.962Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
30 STAT3suppressor70.26777.395SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
31 TCF4suppressor100CDC45 (PF02724, IPR003874): CDC45-like protein
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
32 TMEM17interactor100Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
33 TRIP6interactor40.16744.452DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
LIM (PF00412, IPR001781, SM00132): LIM domain

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