Find Fusion Network

Fusion ID:
Protein names:

Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PINK1, LACRT (from a repository: Wed Dec 7 20:23:12 2016)

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Force Directed
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)81
The number (and %) of the onco-proteins26 (32.10 %)
The number (and %) of the tumor suppressors8 (9.88 %)
Total number of binary PPIs (saturation %)333 (10.28 %)
The number (and %) of affected PPIs81 (24.32 %)
The number of possible different fusions21
PPI diameter4
PPI radius2
The average degree of PPI7.383
Assortativity coefficient-0.2541
The network average Clustering coefficient0.494
The number (and %) of a zero Clustering coefficients16 (19.75 %)
The number (and %) of a zero Betweenness Centrality27 (33.33 %)


List of the fusions

PPI for parental proteins: PINK1,LACRT All fusions
Proteins found in more fusions STAT3 (see 2 fusions); TRAF6 (see 1 fusions); APP (see 4 fusions); MCL1 (see 2 fusions); KIF11 (see 1 fusions); PRKDC (see 3 fusions); BCL2L1 (see 1 fusions); SNCAIP (see 1 fusions); IMMT (see 4 fusions); HSP90AA1 (see 2 fusions); NID1 (see 1 fusions); MAP3K7 (see 7 fusions); HSP90AB1 (see 1 fusions); UBC (see 1 fusions); MARK2 (see 2 fusions); CDC37 (see 2 fusions); TGM2 (see 4 fusions); PINK1 (see 3 fusions); SMAD3 (see 3 fusions); BAG2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 PINK1parental protein610.0982804.693Pkinase (PF00069, IPR000719): Protein kinase domain
2 LACRTparental protein200.0531233.560NA
3 AKT1oncoprotein190.320187.110PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
4 ALDH3B1interactor2012.219Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
5 APPprotein found in more fusions240.1661068.647APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
6 APPL2interactor100PH (PF00169, IPR001849, SM00233): PH domain
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
BAR_3 (PF16746): BAR domain of APPL family
7 BAG2protein found in more fusions90.60710.213IncA (PF04156, IPR007285): IncA protein
Mnd1 (PF03962, IPR005647): Mnd1 family
ParD_antitoxin (PF03693, IPR022789): Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH
8 BCL2L1oncoprotein70.5334.038Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
9 BCL2L2oncoprotein21.0000Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
ABATE (PF07336, IPR010852): Putative stress-induced transcription regulator
10 C22orf31interactor100DUF4662 (PF15578, IPR028970): Domain of unknown function (DUF4662)
11 CCDC148interactor100DMA (PF03474, IPR005173): DMRTA motif
Endonuc_Holl (PF10107, IPR019287): Endonuclease related to archaeal Holliday junction resolvase
FKS1_dom1 (PF14288, IPR026899): 1,3-beta-glucan synthase subunit FKS1, domain-1
12 CDC37protein found in more fusions110.55643.578CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain
CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
Rho_Binding (PF08912, IPR015008): Rho Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
13 COPS8interactor40.6670.667CSN8_PSD8_EIF3K (PF10075): CSN8/PSMD8/EIF3K family
14 CRLS1interactor100CDP-OH_P_transf (PF01066, IPR000462): CDP-alcohol phosphatidyltransferase
DUF2162 (PF09930, IPR017199): Predicted transporter (DUF2162)
15 DNM1Linteractor31.0000Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
AAA_16 (PF13191): AAA ATPase domain
16 FBXO7interactor31.0000Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
PI31_Prot_N (PF11566, IPR021625): PI31 proteasome regulator N-terminal
F-box-like (PF12937, IPR001810): F-box-like
17 FN1oncoprotein150.162306.340fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
18 FN3KRPinteractor21.0000Fructosamin_kin (PF03881, IPR016477): Fructosamine kinase
19 HECW2interactor200C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
20 HSD17B10interactor110.273209.435adh_short (PF00106, IPR002198): short chain dehydrogenase
21 HSH2Dinteractor100SH2 (PF00017, IPR000980, SM00252): SH2 domain
22 HSP90AA1oncoprotein240.336200.125HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
23 HSP90AB1oncoprotein150.54926.301HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
24 HSPA1Ainteractor130.41063.772HSP70 (PF00012, IPR013126): Hsp70 protein
25 HSPA1Binteractor50.6003.771HSP70 (PF00012, IPR013126): Hsp70 protein
26 HSPA4interactor180.346185.026Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
27 HTRA2suppressor70.6673.973Peptidase_S32 (PF05579, IPR008760): Equine arteritis virus serine endopeptidase S32
PDZ_2 (PF13180, IPR001478): PDZ domain
Trypsin_2 (PF13365): Trypsin-like peptidase domain
28 IMMTprotein found in more fusions50.6671.333Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
29 IRAK1interactor160.314174.793Death (PF00531, IPR000488, SM00005): Death domain
Pkinase (PF00069, IPR000719): Protein kinase domain
30 IRS4interactor50.8000.802CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
PH_11 (PF15413): Pleckstrin homology domain
31 KCNIP4interactor21.0000EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
32 KIF11protein found in more fusions200Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2
DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
Gag_p17 (PF00540, IPR000071): gag gene protein p17 (matrix protein)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF3510 (PF12022, IPR024603): Domain of unknown function (DUF3510)
Microtub_bind (PF13931, IPR025901): Kinesin-associated microtubule-binding
33 KRASoncoprotein80.47631.143Ras (PF00071, IPR001806, SM00173): Ras family
34 MAP1Binteractor40.8330.667DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
MAP1B_neuraxin (PF00414, IPR000102): Neuraxin and MAP1B repeat
Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup
Striatin (PF08232, IPR013258): Striatin family
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
35 MAP1LC3Ainteractor80.50039.283Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
36 MAP3K7oncoprotein80.57118.992Mnd1 (PF03962, IPR005647): Mnd1 family
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
37 MAPKAP1interactor31.0000SIN1 (PF05422, IPR008828): Stress-activated map kinase interacting protein 1 (SIN1)
CRIM (PF16978, IPR031567): SAPK-interacting protein 1 (Sin1), middle CRIM domain
SIN1_PH (PF16979, IPR031313): SAPK-interacting protein 1 (Sin1), Pleckstrin-homology
38 MARK2protein found in more fusions31.0000DUF702 (PF05142, IPR007818): Domain of unknown function (DUF702)
KA1 (PF02149, IPR001772): Kinase associated domain 1
Pkinase (PF00069, IPR000719): Protein kinase domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
39 MCL1oncoprotein70.6003.083Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
40 NAE1interactor40.8335.890ThiF (PF00899, IPR000594): ThiF family
41 NEUROD1interactor100HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
YL1 (PF05764, IPR008895): YL1 nuclear protein
Neuro_bHLH (PF12533, IPR022575): Neuronal helix-loop-helix transcription factor
42 NID1protein found in more fusions200EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
G2F (PF07474, IPR006605, SM00682): G2F domain
NIDO (PF06119, IPR003886, SM00539): Nidogen-like
Ldl_recept_b (PF00058, IPR000033, SM00135): Low-density lipoprotein receptor repeat class B
Thyroglobulin_1 (PF00086, IPR000716, SM00211): Thyroglobulin type-1 repeat
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EGF_3 (PF12947, IPR024731): EGF domain
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
43 PARK2suppressor320.189546.204IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
44 PARK7suppressor90.5009.196DJ-1_PfpI (PF01965, IPR002818): DJ-1/PfpI family
45 PARLinteractor100Rhomboid (PF01694, IPR022764): Rhomboid family
46 PGAM5interactor50.5009.533His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1)
47 POLLinteractor21.0000HHH (PF00633, IPR000445): Helix-hairpin-helix motif
DNA_pol_lambd_f (PF10391, IPR018944): Fingers domain of DNA polymerase lambda
HHH_5 (PF14520): Helix-hairpin-helix domain
HHH_8 (PF14716, IPR010996): Helix-hairpin-helix domain
DNA_pol_B_thumb (PF14791, IPR029398): DNA polymerase beta thumb
DNA_pol_B_palm (PF14792, IPR028207): DNA polymerase beta palm
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
48 PPP1R3Cinteractor21.0000CBM_21 (PF03370, IPR005036): Carbohydrate/starch-binding module (family 21)
49 PRAP1interactor1003HBOH (PF10605, IPR016582): 3HB-oligomer hydrolase (3HBOH)
PRAP (PF15314, IPR027922): Proline-rich acidic protein 1, pregnancy-specific uterine
50 PRKDCprotein found in more fusions60.8002.688FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
NUC194 (PF08163, IPR012582): NUC194 domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
51 PSMC6interactor70.66712.951AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_2 (PF07724, IPR013093): AAA domain (Cdc48 subfamily)
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
52 PSMD1interactor90.6117.256PA26 (PF04636, IPR006730): PA26 p53-induced protein (sestrin)
PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
HEAT_2 (PF13646): HEAT repeats
53 PSMD2oncoprotein41.0000PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
THAP (PF05485, IPR006612, SM00980): THAP domain
HEAT_2 (PF13646): HEAT repeats
54 PTENsuppressor110.45575.204DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
55 RB1CC1suppressor21.0000Arc_PepC_II (PF06847, IPR009655): Archaeal Peptidase A24 C-terminus Type II
DHC (PF09626, IPR018588): Dihaem cytochrome c
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
ATG11 (PF10377, IPR019460): Autophagy-related protein 11
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Jag_N (PF14804, IPR032782): Jag N-terminus
NPBW (PF15180, IPR013297): Neuropeptides B and W
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
Goodbye (PF17109, IPR031350): fungal STAND N-terminal Goodbye domain
56 RHOT1interactor30.6670.619EF_assoc_1 (PF08355, IPR013566): EF hand associated
EF_assoc_2 (PF08356, IPR013567): EF hand associated
Ras (PF00071, IPR001806, SM00173): Ras family
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
57 RHOT2interactor21.0000EF_assoc_1 (PF08355, IPR013566): EF hand associated
EF_assoc_2 (PF08356, IPR013567): EF hand associated
Ras (PF00071, IPR001806, SM00173): Ras family
SPARC_Ca_bdg (PF10591, IPR019577): Secreted protein acidic and rich in cysteine Ca binding region
AAA_16 (PF13191): AAA ATPase domain
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
58 RICTORinteractor50.6003.021RasGEF_N_2 (PF14663, IPR029453): Rapamycin-insensitive companion of mTOR RasGEF_N domain
RICTOR_N (PF14664, IPR028267): Rapamycin-insensitive companion of mTOR, N-term
RICTOR_phospho (PF14665, IPR029259): Rapamycin-insensitive companion of mTOR, phosphorylation-site
RICTOR_M (PF14666, IPR029451): Rapamycin-insensitive companion of mTOR, middle domain
RICTOR_V (PF14668, IPR029452): Rapamycin-insensitive companion of mTOR, domain 5
59 RSPO1oncoprotein100TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
Furin-like_2 (PF15913, IPR006212): Furin-like repeat, cysteine-rich
60 SARM1interactor40.8331.000Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Carb_kinase (PF01256, IPR000631): Carbohydrate kinase
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
HEAT_2 (PF13646): HEAT repeats
TIR_2 (PF13676, IPR000157): TIR domain
61 SDC1oncoprotein30.33328.063Herpes_TAF50 (PF03326, IPR004998): Herpesvirus transcription activation factor (transactivator)
Syndecan (PF01034, IPR027789): Syndecan domain
DUF3592 (PF12158, IPR021994): Protein of unknown function (DUF3592)
AJAP1_PANP_C (PF15298, IPR029198): AJAP1/PANP C-terminus
62 SLC25A10interactor2043.089Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
63 SMAD3oncoprotein70.40068.387MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
64 SNCAinteractor150.48465.418Synuclein (PF01387, IPR001058): Synuclein
65 SNCAIPprotein found in more fusions41.0000Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
SNCAIP_SNCA_bd (PF16700, IPR032027): Synphilin-1 alpha-Synuclein-binding domain
66 SOCS4interactor100SH2 (PF00017, IPR000980, SM00252): SH2 domain
SOCS (PF12610, IPR001496, SM00253): Suppressor of cytokine signalling
SOCS_box (PF07525, IPR001496): SOCS box
67 STAT3suppressor60.9000.200SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
68 TGM2protein found in more fusions80.381282.129Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain
Transglut_N (PF00868, IPR001102): Transglutaminase family
Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily
69 TOLLIPinteractor60.7002.967C2 (PF00168, IPR000008, SM00239): C2 domain
CUE (PF02845, IPR003892, SM00546): CUE domain
70 TOMM20interactor80.57110.380RSN1_7TM (PF02714, IPR003864): Calcium-dependent channel, 7TM region, putative phosphate
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
71 TOMM22interactor60.8671.200Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Tom22 (PF04281, IPR005683): Mitochondrial import receptor subunit Tom22
72 TOMM40interactor100.53317.432Porin_3 (PF01459, IPR027246): Eukaryotic porin
73 TOMM70interactor80.6077.152PBP_GOBP (PF01395, IPR006170, SM00708): PBP/GOBP family
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
NRBF2_MIT (PF17169): MIT domain of nuclear receptor-binding factor 2
74 TRAF6protein found in more fusions190.275172.495SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
75 TUBA1Aoncoprotein110.54515.888Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
76 TUBBinteractor150.52449.993Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
77 UBCprotein found in more fusions160.32481.704ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
78 UBE2Minteractor70.46714.126UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
79 VIMsuppressor80.33338.090Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
80 VTNinteractor21.0000Hemopexin (PF00045, IPR018487, SM00120): Hemopexin
Somatomedin_B (PF01033, IPR001212, SM00201): Somatomedin B domain
81 WWOXsuppressor4038.160adh_short (PF00106, IPR002198): short chain dehydrogenase
WW (PF00397, IPR001202, SM00456): WW domain

B a c k    t o    T o p ⇑