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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ARHGAP44, CCNF (from a repository: Wed Aug 21 23:19:27 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)19
The number (and %) of the onco-proteins8 (42.11 %)
The number (and %) of the tumor suppressors2 (10.53 %)
Total number of binary PPIs (saturation %)36 (21.05 %)
The number (and %) of affected PPIs17 (47.22 %)
The number of possible different fusions4
PPI diameter2
PPI radiusinf
The average degree of PPI3.053
Assortativity coefficient-0.2202
The network average Clustering coefficient0.472
The number (and %) of a zero Clustering coefficients7 (36.84 %)
The number (and %) of a zero Betweenness Centrality12 (63.16 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ARHGAP44,CCNF All fusions
Proteins found in more fusions CUL1 (see 3 fusions); MYBL2 (see 4 fusions); RAC1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ARHGAP44parental protein50.10018.000BAR (PF03114, IPR004148, SM00721): BAR domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
2 CCNFparental protein120.167100.333Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
Sel1 (PF08238, IPR006597, SM00671): Sel1 repeat
F-box (PF00646, IPR001810, SM00256): F-box domain
3 CCNB1oncoprotein40.8330.667Adeno_E1A (PF02703, IPR003853): Early E1A protein
Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
4 CCP110interactor21.0000DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349)
IFT20 (PF14931, IPR028172): Intraflagellar transport complex B, subunit 20
CSRNP_N (PF16019, IPR031972): Cysteine/serine-rich nuclear protein N-terminus
CALM_bind (PF16025): Calcium-dependent calmodulin binding
5 CDC42oncoprotein31.0000Ras (PF00071, IPR001806, SM00173): Ras family
6 CDC6oncoprotein31.0000Cdc6_C (PF09079, IPR015163, SM01074): CDC6, C terminal winged helix domain
AAA_22 (PF13401, IPR003593): AAA domain
ORC5_C (PF14630, IPR020796): Origin recognition complex (ORC) subunit 5 C-terminus
7 CDK1oncoprotein60.6003.667Pkinase (PF00069, IPR000719): Protein kinase domain
8 CUL1suppressor50.8330.667Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
9 JPT1interactor100JUPITER (PF17054): Microtubule-Associated protein Jupiter
10 MYBL2oncoprotein200Cmyb_C (PF09316, IPR015395): C-myb, C-terminal
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
11 NUSAP1interactor100GREB1 (PF15782, IPR028422): Gene regulated by oestrogen in breast cancer
NUSAP (PF16006, IPR026756): Nucleolar and spindle-associated protein
12 PSMA6interactor50.6004.000Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
13 RAC1oncoprotein200Ras (PF00071, IPR001806, SM00173): Ras family
14 RBX1oncoprotein50.8330.667zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
15 RRM2interactor100Ribonuc_red_sm (PF00268, IPR000358): Ribonucleotide reductase, small chain
16 SCYL1suppressor100HEAT (PF02985, IPR000357): HEAT repeat
Pkinase (PF00069, IPR000719): Protein kinase domain
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
17 SKP1oncoprotein31.0000Skp1 (PF01466, IPR016072, SM00512): Skp1 family, dimerisation domain
Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
18 TIPRLinteractor100TIP41 (PF04176, IPR007303): TIP41-like family
19 TRIP10interactor31.0000Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Lzipper-MIP1 (PF14389, IPR025757): Leucine-zipper of ternary complex factor MIP1

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