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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins LHX4, ATP8A2 (from a repository: Wed Dec 20 19:50:15 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)34
The number (and %) of the onco-proteins7 (20.59 %)
The number (and %) of the tumor suppressors5 (14.71 %)
Total number of binary PPIs (saturation %)59 (10.52 %)
The number (and %) of affected PPIs32 (54.24 %)
The number of possible different fusions4
PPI diameter2
PPI radiusinf
The average degree of PPI3.059
Assortativity coefficient-0.4651
The network average Clustering coefficient0.367
The number (and %) of a zero Clustering coefficients19 (55.88 %)
The number (and %) of a zero Betweenness Centrality26 (76.47 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ATP8A2,LHX4 All fusions
Proteins found in more fusions THAP12 (see 1 fusions); CHMP1A (see 2 fusions); SMAD4 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ATP8A2parental protein202.000E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase (PF00702, IPR023214): haloacid dehalogenase-like hydrolase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
PhoLip_ATPase_N (PF16209, IPR032631): Phospholipid-translocating ATPase N-terminal
PhoLip_ATPase_C (PF16212, IPR032630): Phospholipid-translocating P-type ATPase C-terminal
2 LHX4parental protein300.046818.500LIM (PF00412, IPR001781, SM00132): LIM domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
3 ABI1oncoprotein50.7002.000Abi_HHR (PF07815, IPR012849): Abl-interactor HHR
Cytochrom_B558a (PF05038, IPR007732): Cytochrome Cytochrome b558 alpha-subunit
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF4124 (PF13511, IPR025392): Domain of unknown function (DUF4124)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
ATP-synt_ab_Xtn (PF16886, IPR031686): ATPsynthase alpha/beta subunit N-term extension
4 ABI2suppressor41.0000Abi_HHR (PF07815, IPR012849): Abl-interactor HHR
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
SH3_9 (PF14604, IPR001452): Variant SH3 domain
TMEM171 (PF15471, IPR029173): Transmembrane protein family 171
ATP-synt_ab_Xtn (PF16886, IPR031686): ATPsynthase alpha/beta subunit N-term extension
5 ARID2suppressor100ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain
RFX_DNA_binding (PF02257, IPR003150): RFX DNA-binding domain
BAF250_C (PF12031, IPR021906): SWI/SNF-like complex subunit BAF250/Osa
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
6 C1orf52interactor100MRI (PF15325, IPR028278): Modulator of retrovirus infection
DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
DUF4660 (PF15559, IPR029089): Domain of unknown function (DUF4660)
7 CEP97interactor100IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
LRR_8 (PF13855, IPR001611): Leucine rich repeat
LRR_9 (PF14580): Leucine-rich repeat
8 CHCHD2interactor200CHCH (PF06747, IPR010625): CHCH domain
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
9 CHMP1Aprotein found in more fusions200Snf7 (PF03357, IPR005024): Snf7
10 CYFIP1interactor31.0000DUF1394 (PF07159, IPR009828): Protein of unknown function (DUF1394)
FragX_IP (PF05994, IPR008081): Cytoplasmic Fragile-X interacting family
11 CYFIP2interactor40.6672.000DUF1394 (PF07159, IPR009828): Protein of unknown function (DUF1394)
FragX_IP (PF05994, IPR008081): Cytoplasmic Fragile-X interacting family
zf-CW (PF07496, IPR011124): CW-type Zinc Finger
12 DCAF5interactor100WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
DUF2634 (PF10934, IPR020288): Protein of unknown function (DUF2634)
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
13 FDX1Linteractor100Fer2 (PF00111, IPR001041): 2Fe-2S iron-sulfur cluster binding domain
14 IFT172interactor100Coatomer_WDAD (PF04053, IPR006692): Coatomer WD associated region
Mad3_BUB1_I (PF08311, IPR013212, SM00777): Mad3/BUB1 homology region 1
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
RPN7 (PF10602, IPR019585): 26S proteasome subunit RPN7
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
15 ISL1interactor60.9000.500LIM (PF00412, IPR001781, SM00132): LIM domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
16 ISL2interactor41.0000LIM (PF00412, IPR001781, SM00132): LIM domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
17 LDB1oncoprotein31.0000LIM_bind (PF01803): LIM-domain binding protein
18 LDB2interactor41.0000LIM_bind (PF01803): LIM-domain binding protein
19 LONRF1interactor31.0000LON_substr_bdg (PF02190, IPR003111, SM00464): ATP-dependent protease La (LON) substrate-binding domain
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
DZR (PF12773, IPR025874): Double zinc ribbon
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
TPR_19 (PF14559): Tetratricopeptide repeat
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
20 ORC6interactor100ORC6 (PF05460, IPR008721): Origin recognition complex subunit 6 (ORC6)
21 SH2D1Ainteractor100SH2 (PF00017, IPR000980, SM00252): SH2 domain
22 SMAD4suppressor31.0000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
23 SNRNP25interactor100ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
24 SSBP2suppressor60.7332.500SSDP (PF04503): Single-stranded DNA binding protein, SSDP
25 SSBP4oncoprotein60.7332.500SSDP (PF04503): Single-stranded DNA binding protein, SSDP
26 SSX1oncoprotein100KRAB (PF01352, IPR001909, SM00349): KRAB box
SSXRD (PF09514, IPR019041): SSXRD motif
27 TCAPinteractor100Telethonin (PF09470, IPR015667): Telethonin protein
28 THAP12protein found in more fusions200FGF-BP1 (PF06473, IPR010510): FGF binding protein 1 (FGF-BP1)
Dimer_Tnp_hAT (PF05699, IPR008906): hAT family C-terminal dimerisation region
THAP (PF05485, IPR006612, SM00980): THAP domain
DUF4371 (PF14291, IPR025398): Domain of unknown function (DUF4371)
29 TXNDC5interactor100Thioredoxin (PF00085, IPR013766): Thioredoxin
30 UIMC1suppressor100Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
31 USP2interactor21.0000UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
32 WASF2oncoprotein50.7002.000RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
WH2 (PF02205, IPR003124, SM00246): WH2 motif
WASH_WAHD (PF11945, IPR021854): WAHD domain of WASH complex
33 ZBTB8OSinteractor100Archease (PF01951, IPR023572): Archease protein family (MTH1598/TM1083)
34 ZNF574interactor100Zn-ribbon_8 (PF09723, IPR013429, SM00834): Zinc ribbon domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-CSL (PF05207, IPR007872): CSL zinc finger
zf-HIT (PF04438, IPR007529): HIT zinc finger
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
zinc_ribbon_12 (PF11331, IPR021480): Probable zinc-ribbon domain
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain
zf-met (PF12874): Zinc-finger of C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
zf-C2H2_11 (PF16622, IPR007087): zinc-finger C2H2-type

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