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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins TRPS1, MVB12B (from a repository: Fri Jan 13 04:03:42 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)29
The number (and %) of the onco-proteins6 (20.69 %)
The number (and %) of the tumor suppressors4 (13.79 %)
Total number of binary PPIs (saturation %)64 (15.76 %)
The number (and %) of affected PPIs27 (42.19 %)
The number of possible different fusions3
PPI diameter5
PPI radius3
The average degree of PPI3.586
Assortativity coefficient-0.4024
The network average Clustering coefficient0.475
The number (and %) of a zero Clustering coefficients10 (34.48 %)
The number (and %) of a zero Betweenness Centrality17 (58.62 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MVB12B,TRPS1 All fusions
Proteins found in more fusions CTBP1 (see 2 fusions); NLK (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MVB12Bparental protein100.178234.728CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
DUF2464 (PF10240, IPR018798): Protein of unknown function (DUF2464)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
2 TRPS1parental protein170.103390.873Rubredoxin (PF00301, IPR024935): Rubredoxin
zf-BED (PF02892, IPR003656, SM00614): BED zinc finger
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
zf-C2H2_7 (PF15269): Zinc-finger
3 CDK18oncoprotein100APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
4 CDK2AP1suppressor21.0000CDK2AP (PF09806, IPR019187): Cyclin-dependent kinase 2-associated protein
5 CEP170P1interactor200NA
6 CTBP1protein found in more fusions50.50071.7592-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
7 DYNLL1interactor31.0000Dynein_light (PF01221, IPR001372): Dynein light chain type 1
8 FEM1Binteractor100Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
9 FOXJ2interactor100SARAF (PF06682, IPR009567): SOCE-associated regulatory factor of calcium homoeostasis
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
Spt20 (PF12090, IPR021950): Spt20 family
Pro-rich (PF15240, IPR026086): Proline-rich
10 HDAC1suppressor60.60012.727FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
11 ITM2Cinteractor100BRICHOS (PF04089, IPR007084, SM01039): BRICHOS domain
12 LNX1interactor3053.759PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
13 MAPK3oncoprotein31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
14 MCM6interactor31.0000MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
YmgB (PF10798, IPR024753): Biofilm development protein YmgB/AriR
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
15 METTL15interactor100Methyltransf_5 (PF01795, IPR002903): MraW methylase family
16 MVB12Ainteractor50.80011.636DUF2464 (PF10240, IPR018798): Protein of unknown function (DUF2464)
17 NFATC1oncoprotein40.6677.767RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
18 NLKprotein found in more fusions200Pkinase (PF00069, IPR000719): Protein kinase domain
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
19 PLCG1oncoprotein100C2 (PF00168, IPR000008, SM00239): C2 domain
PH (PF00169, IPR001849, SM00233): PH domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
PH_12 (PF16457, IPR001849): Pleckstrin homology domain
20 RNF4interactor41.0000Sgf11 (PF08209, IPR013246): Sgf11 (transcriptional regulation protein)
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-UDP (PF14569, IPR027934): Zinc-binding RING-finger
21 SEC16Ainteractor2069.231APC_r (PF05923): APC repeat
Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16
Sec16 (PF12932, IPR024340): Vesicle coat trafficking protein Sec16 mid-region
22 SLC25A41interactor31.0000Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
23 SUMO1interactor41.0000Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
24 TEAD2interactor21.0000TEA (PF01285, IPR000818, SM00426): TEA/ATTS domain family
25 TP53BP1suppressor50.40023.30053-BP1_Tudor (PF09038, IPR015125): Tumour suppressor p53-binding protein-1 Tudor
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
DUF4772 (PF15997, IPR031940): Domain of unknown function (DUF4772)
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
26 TSG101suppressor70.400272.241APG6 (PF04111, IPR007243): Autophagy protein Apg6
Laminin_II (PF06009, IPR010307): Laminin Domain II
UEV (PF05743, IPR008883): UEV domain
Vps23_core (PF09454, IPR017916): Vps23 core domain
27 UBE2Iinteractor90.321212.343UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
28 VPS28interactor50.80011.636VPS28 (PF03997, IPR007143): VPS28 protein
29 VPS37Ainteractor41.0000Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
UEV (PF05743, IPR008883): UEV domain

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