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Fusion ID: Protein names:	89782 2137
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Visualization interactions

Cytoscape Web for: parental proteins EXTL3, LMLN (from a repository: Mon Dec 30 00:34:38 2019)

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Statistics and Network structure information

Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	15
The number (and %) of the onco-proteins	3 (20.00 %)
The number (and %) of the tumor suppressors	1 (6.67 %)
Total number of binary PPIs (saturation %)	19 (18.10 %)
The number (and %) of affected PPIs	13 (68.42 %)
The number of possible different fusions	2
PPI diameter	5
PPI radius	3
The average degree of PPI	2.133
Assortativity coefficient	-0.5551
The network average Clustering coefficient	0.246
The number (and %) of a zero Clustering coefficients	9 (60.00 %)
The number (and %) of a zero Betweenness Centrality	11 (73.33 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: EXTL3,LMLN	All fusions
Proteins found in more fusions	PLEKHA5 (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	EXTL3	parental protein	10	0.022	160.000	Exostosin (PF03016, IPR004263): Exostosin family TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein Glyco_transf_64 (PF09258, IPR015338): Glycosyl transferase family 64 domain
2	LMLN	parental protein	3	0.333	26.000	Peptidase_M8 (PF01457, IPR001577): Leishmanolysin
3	GLRA2	interactor	1	0	0	Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
4	KRAS	oncoprotein	4	0.333	66.000	Ras (PF00071, IPR001806, SM00173): Ras family
5	LPAR1	oncoprotein	2	0	80.000	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
6	NRG1	interactor	1	0	0	EGF (PF00008, IPR000742, SM00181): EGF-like domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain Neuregulin (PF02158, IPR002154): Neuregulin family
7	PLEKHA5	protein found in more fusions	2	0	0	PH (PF00169, IPR001849, SM00233): PH domain WW (PF00397, IPR001202, SM00456): WW domain MKLP1_Arf_bdg (PF16540, IPR032384): Arf6-interacting domain of mitotic kinesin-like protein 1
8	PON2	interactor	2	1.000	0	Arylesterase (PF01731, IPR002640): Arylesterase
9	SCARA3	interactor	2	1.000	0	Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies) Filament (PF00038, IPR001664): Intermediate filament protein Flagellin_C (PF00700, IPR001029): Bacterial flagellin C-terminal helical region Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding zf-C2H2_10 (PF16588, IPR001878): C2H2 zinc-finger
10	SLC39A4	suppressor	1	0	0	Zip (PF02535, IPR003689): ZIP Zinc transporter Class_IIIsignal (PF04021, IPR007166): Class III signal peptide
11	SYNE4	interactor	1	0	0	KASH (PF10541, IPR012315): Nuclear envelope localisation domain
12	TMEM25	interactor	1	0	0	C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain DUF4674 (PF15719, IPR029779): Domain of unknown function (DUF4674)
13	WBP1	interactor	1	0	0	WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
14	XIAP	interactor	3	1.000	0	BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
15	ZACN	interactor	1	0	0	Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region

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