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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins EXTL3, LMLN (from a repository: Mon Dec 30 00:34:38 2019)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)15
The number (and %) of the onco-proteins3 (20.00 %)
The number (and %) of the tumor suppressors1 (6.67 %)
Total number of binary PPIs (saturation %)19 (18.10 %)
The number (and %) of affected PPIs13 (68.42 %)
The number of possible different fusions2
PPI diameter5
PPI radius3
The average degree of PPI2.133
Assortativity coefficient-0.5551
The network average Clustering coefficient0.246
The number (and %) of a zero Clustering coefficients9 (60.00 %)
The number (and %) of a zero Betweenness Centrality11 (73.33 %)


List of the fusions

PPI for parental proteins: EXTL3,LMLN All fusions
Proteins found in more fusions PLEKHA5 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 EXTL3parental protein100.022160.000Exostosin (PF03016, IPR004263): Exostosin family
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Glyco_transf_64 (PF09258, IPR015338): Glycosyl transferase family 64 domain
2 LMLNparental protein30.33326.000Peptidase_M8 (PF01457, IPR001577): Leishmanolysin
3 GLRA2interactor100Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
4 KRASoncoprotein40.33366.000Ras (PF00071, IPR001806, SM00173): Ras family
5 LPAR1oncoprotein2080.0007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
6 NRG1interactor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Neuregulin (PF02158, IPR002154): Neuregulin family
7 PLEKHA5protein found in more fusions200PH (PF00169, IPR001849, SM00233): PH domain
WW (PF00397, IPR001202, SM00456): WW domain
MKLP1_Arf_bdg (PF16540, IPR032384): Arf6-interacting domain of mitotic kinesin-like protein 1
8 PON2interactor21.0000Arylesterase (PF01731, IPR002640): Arylesterase
9 SCARA3interactor21.0000Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
Filament (PF00038, IPR001664): Intermediate filament protein
Flagellin_C (PF00700, IPR001029): Bacterial flagellin C-terminal helical region
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
zf-C2H2_10 (PF16588, IPR001878): C2H2 zinc-finger
10 SLC39A4suppressor100Zip (PF02535, IPR003689): ZIP Zinc transporter
Class_IIIsignal (PF04021, IPR007166): Class III signal peptide
11 SYNE4interactor100KASH (PF10541, IPR012315): Nuclear envelope localisation domain
12 TMEM25interactor100C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
DUF4674 (PF15719, IPR029779): Domain of unknown function (DUF4674)
13 WBP1interactor100WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
14 XIAPinteractor31.0000BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
15 ZACNinteractor100Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region

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