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Visible interactions: all affected independent (normal) nothing (blank)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)65
The number (and %) of the onco-proteins18 (27.69 %)
The number (and %) of the tumor suppressors5 (7.69 %)
Total number of binary PPIs (saturation %)226 (10.87 %)
The number (and %) of affected PPIs63 (27.88 %)
The number of possible different fusions14
PPI diameter5
PPI radius3
The average degree of PPI6.000
Assortativity coefficient-0.3186
The network average Clustering coefficient0.446
The number (and %) of a zero Clustering coefficients21 (32.31 %)
The number (and %) of a zero Betweenness Centrality27 (41.54 %)


List of the fusions

PPI for parental proteins: TAX1BP1,CHI3L1 All fusions
Proteins found in more fusions GABARAP (see 2 fusions); OPTN (see 1 fusions); TSG101 (see 2 fusions); HNRNPD (see 1 fusions); TRAF6 (see 1 fusions); EMILIN1 (see 2 fusions); RNF11 (see 1 fusions); DAZAP2 (see 2 fusions); UBC (see 7 fusions); VCP (see 4 fusions); RIPK1 (see 1 fusions); MYO6 (see 3 fusions); PARK2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 TAX1BP1parental protein600.0732967.788CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
PolyA_pol (PF01743, IPR002646): Poly A polymerase head domain
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
zf-C2H2_4 (PF13894): C2H2-type zinc finger
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
2 CHI3L1parental protein30250.000Glyco_hydro_18 (PF00704, IPR001223): Glycosyl hydrolases family 18
3 AGO1interactor21.0000ArgoL1 (PF08699, IPR014811, SM01163): Argonaute linker 1 domain
PAZ (PF02170, IPR003100, SM00949): PAZ domain
Piwi (PF02171, IPR003165, SM00950): Piwi domain
ArgoN (PF16486, IPR032474): N-terminal domain of argonaute
ArgoMid (PF16487, IPR032473): Mid domain of argonaute
ArgoL2 (PF16488, IPR032472): Argonaute linker 2 domain
4 BREoncoprotein30.333366.000BRE (PF06113, IPR010358): Brain and reproductive organ-expressed protein (BRE)
5 CALCOCO2interactor220.219138.917bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
zf-C2H2_4 (PF13894): C2H2-type zinc finger
6 CD55oncoprotein200Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
HYLS1_C (PF15311, IPR027918): Hydrolethalus syndrome protein 1 C-terminus
7 COG7interactor31.0000COG7 (PF10191, IPR019335): Golgi complex component 7 (COG7)
8 CWF19L2interactor30.6670.333CwfJ_C_1 (PF04677, IPR006768): Protein similar to CwfJ C-terminus 1
CwfJ_C_2 (PF04676, IPR006767): Protein similar to CwfJ C-terminus 2
DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
Pap_E4 (PF02711, IPR003861): E4 protein
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
DUF4519 (PF15012, IPR027960): Domain of unknown function (DUF4519)
MRI (PF15325, IPR028278): Modulator of retrovirus infection
9 CXXC1interactor100ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
PHD (PF00628, IPR019787, SM00249): PHD-finger
PLATZ (PF04640, IPR006734): PLATZ transcription factor
zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain
DUF2116 (PF09889, IPR019216): Uncharacterized protein containing a Zn-ribbon (DUF2116)
Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
DUF3347 (PF11827, IPR021782): Protein of unknown function (DUF3347)
zf-CpG_bind_C (PF12269, IPR022056): CpG binding protein zinc finger C terminal domain
10 DAZAP2protein found in more fusions70.6005.440DAZAP2 (PF11029, IPR022730): DAZ associated protein 2 (DAZAP2)
11 DSTNinteractor21.0000Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
12 EMILIN1protein found in more fusions200C1q (PF00386, IPR001073, SM00110): C1q domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
EMI (PF07546, IPR011489): EMI domain
IncA (PF04156, IPR007285): IncA protein
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Unstab_antitox (PF09720, IPR013406): Putative addiction module component
DUF2802 (PF10975, IPR021244): Protein of unknown function (DUF2802)
DUF3720 (PF12517, IPR022195): Protein of unknown function (DUF3720)
MscS_porin (PF12795, IPR024393): Mechanosensitive ion channel porin domain
Nup54 (PF13874, IPR025712): Nucleoporin complex subunit 54
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
13 FAM168Ainteractor50.6670.600TCRP1 (PF14944, IPR029247): Tongue Cancer Chemotherapy Resistant Protein 1
14 FAM189A2interactor40.5000.887CD20 (PF04103, IPR007237): CD20-like family
15 FAM58Ainteractor100Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
16 FHL5interactor200LIM (PF00412, IPR001781, SM00132): LIM domain
zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain
17 FOXC2oncoprotein200Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
18 GABARAPsuppressor80.8101.240Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
19 GABARAPL1interactor70.6672.921Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
VitD-bind_III (PF09164, IPR015247): Vitamin D binding protein, domain III
20 GABARAPL2interactor80.7502.506Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
21 GABRR1interactor200Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
22 HNRNPDoncoprotein50.6671.400CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Keratin_2_head (PF16208, IPR032444): Keratin type II head
23 HSD17B3interactor100adh_short (PF00106, IPR002198): short chain dehydrogenase
24 IKBKEinteractor110.6896.460IncA (PF04156, IPR007285): IncA protein
Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
zf-RING_9 (PF13901, IPR025258): Putative zinc-RING and/or ribbon
25 IKBKGinteractor130.62110.546CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
26 ITCHinteractor80.4768.733C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
27 KIF5Binteractor30.6670.667ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Sec2p (PF06428, IPR009449): GDP/GTP exchange factor Sec2p
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF3584 (PF12128, IPR021979): Protein of unknown function (DUF3584)
HAUS-augmin3 (PF14932, IPR032733): HAUS augmin-like complex subunit 3
DUF4226 (PF10774, IPR019710): Domain of unknown function (DUF4226)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
28 LDLRAD4interactor30.6670.333Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
DUF2615 (PF11027, IPR020309): Protein of unknown function (DUF2615)
29 LGALS8interactor21.0000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
30 LMO3oncoprotein100LIM (PF00412, IPR001781, SM00132): LIM domain
31 MAP1LC3Binteractor80.6434.487Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
32 MAP1LC3Cinteractor50.9000.154Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
33 MED4interactor30.6670.667Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
34 MRPL11interactor100Ribosomal_L11 (PF00298, IPR020783): Ribosomal protein L11, RNA binding domain
Ribosomal_L11_N (PF03946, IPR020784): Ribosomal protein L11, N-terminal domain
35 MRPL53interactor100MRP_L53 (PF10780, IPR019716): 39S ribosomal protein L53/MRP-L53
36 MTRF1Linteractor100PCRF (PF03462, IPR005139, SM00937): PCRF domain
RF-1 (PF00472, IPR000352): RF-1 domain
37 MYO6protein found in more fusions90.6075.121BUD22 (PF09073, IPR015158): BUD22
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Rad9 (PF04139, IPR007268): Rad9
Sec62 (PF03839, IPR004728): Translocation protein Sec62
XhlA (PF10779, IPR019715): Haemolysin XhlA
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
DUF4887 (PF16228, IPR032615): Domain of unknown function (DUF4887)
Myosin-VI_CBD (PF16521, IPR032412): Myosin VI cargo binding domain
38 NMRK1interactor100AAA_18 (PF13238): AAA domain
39 NTRK1oncoprotein120.30939.856I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
40 OPTNprotein found in more fusions190.294265.341ARD (PF03079, IPR004313): ARD/ARD' family
bZIP_1 (PF00170, IPR004827): bZIP transcription factor
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
41 ORC5interactor31.0000AAA_16 (PF13191): AAA ATPase domain
ORC5_C (PF14630, IPR020796): Origin recognition complex (ORC) subunit 5 C-terminus
42 PARK2suppressor90.53610.871IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
43 PLEKHN1interactor100PH (PF00169, IPR001849, SM00233): PH domain
44 RAB18oncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
45 RAD18interactor50.8330.667PhoU_div (PF01865, IPR018445): Protein of unknown function DUF47
SAP (PF02037, IPR003034, SM00513): SAP domain
zf-CpG_bind_C (PF12269, IPR022056): CpG binding protein zinc finger C terminal domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
46 RAD54L2interactor100SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
FAM176 (PF14851): FAM176 family
ERCC3_RAD25_C (PF16203, IPR032438): ERCC3/RAD25/XPB C-terminal helicase
47 REEP4interactor100TB2_DP1_HVA22 (PF03134, IPR004345): TB2/DP1, HVA22 family
48 RIPK1protein found in more fusions90.6793.736Death (PF00531, IPR000488, SM00005): Death domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RHIM (PF12721, IPR025735): RIP homotypic interaction motif
49 RNF11protein found in more fusions130.62110.731zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-ANAPC11 (PF12861, IPR024991): Anaphase-promoting complex subunit 11 RING-H2 finger
50 RNF126interactor60.8000.900Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zinc_ribbon_9 (PF14369): zinc-ribbon
51 SSX2oncoprotein100KRAB (PF01352, IPR001909, SM00349): KRAB box
52 STARD13suppressor100RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
START (PF01852, IPR002913, SM00234): START domain
53 TBC1D17interactor40.8330.286RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
DUF3548 (PF12068, IPR021935): Domain of unknown function (DUF3548)
54 TBK1interactor130.50023.075DUF713 (PF05218, IPR007883): Protein of unknown function (DUF713)
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
Pkinase (PF00069, IPR000719): Protein kinase domain
55 TCEA2interactor21.0000Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain
TFIIS_C (PF01096, IPR001222): Transcription factor S-II (TFIIS)
TFIIS_M (PF07500, IPR003618): Transcription factor S-II (TFIIS), central domain
DUF4423 (PF14394, IPR025537): Domain of unknown function (DUF4423)
56 TNFAIP3suppressor110.6676.641OTU (PF02338, IPR003323): OTU-like cysteine protease
zf-A20 (PF01754, IPR002653, SM00259): A20-like zinc finger
Thioredoxin_3 (PF13192, IPR012336): Thioredoxin domain
57 TNIP1interactor160.41048.796ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
Filament (PF00038, IPR001664): Intermediate filament protein
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
DUF4201 (PF13870, IPR025254): Domain of unknown function (DUF4201)
FlxA (PF14282, IPR025577): FlxA-like protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
58 TNIP3interactor50.8001.067ZapB (PF06005, IPR009252): Cell division protein ZapB
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
HAUS-augmin3 (PF14932, IPR032733): HAUS augmin-like complex subunit 3
CK2S (PF15011, IPR029159): Casein Kinase 2 substrate
zf-C2H2_9 (PF16293, IPR032553): C2H2 type zinc-finger (1 copy)
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
59 TRAF3oncoprotein80.7621.536ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
S-AdoMet_synt_M (PF02772, IPR022629): S-adenosylmethionine synthetase, central domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
MPS2 (PF17060, IPR031433): Monopolar spindle protein 2
Spc29 (PF17082, IPR031392): Spindle Pole Component 29
60 TRAF6protein found in more fusions90.5715.386SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
61 TSG101suppressor70.7332.400APG6 (PF04111, IPR007243): Autophagy protein Apg6
Laminin_II (PF06009, IPR010307): Laminin Domain II
UEV (PF05743, IPR008883): UEV domain
Vps23_core (PF09454, IPR017916): Vps23 core domain
62 TSHZ3interactor100LMP (PF04778, IPR006864): LMP repeated region
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
zf-met (PF12874): Zinc-finger of C2H2 type
zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
63 UBCprotein found in more fusions240.285387.747ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
64 UBE2Ainteractor41.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
65 VCPprotein found in more fusions100.47215.767AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)

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