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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)33
The number (and %) of the onco-proteins11 (33.33 %)
The number (and %) of the tumor suppressors3 (9.09 %)
Total number of binary PPIs (saturation %)60 (11.36 %)
The number (and %) of affected PPIs31 (51.67 %)
The number of possible different fusions5
PPI diameter5
PPI radius3
The average degree of PPI2.970
Assortativity coefficient-0.3458
The network average Clustering coefficient0.427
The number (and %) of a zero Clustering coefficients12 (36.36 %)
The number (and %) of a zero Betweenness Centrality20 (60.61 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions HNRNPD (see 1 fusions); CTBP1 (see 2 fusions); TNF (see 1 fusions); VEGFA (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CEP68parental protein70.143237.462Spectrin (PF00435, IPR002017): Spectrin repeat
2 NRP1parental protein240.040806.757CUB (PF00431, IPR000859, SM00042): CUB domain
MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu
F5_F8_type_C (PF00754, IPR000421, SM00231): F5/8 type C domain
DUF3481 (PF11980, IPR022579): C-terminal domain of neuropilin glycoprotein
3 AGERoncoprotein100C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
4 BTRConcoprotein50.167201.590WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
5 CCDC8interactor30136.076Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
6 CDK5RAP2interactor30.6679.371APG6 (PF04111, IPR007243): Autophagy protein Apg6
bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
DUF1993 (PF09351, IPR018531): Domain of unknown function (DUF1993)
IncA (PF04156, IPR007285): IncA protein
LPP (PF04728, IPR006817): Lipoprotein leucine-zipper
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
Tup_N (PF08581, IPR013890): Tup N-terminal
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
Cyclin_C_2 (PF16899, IPR031658): Cyclin C-terminal domain
7 CSNK2A2interactor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
8 CTBP1protein found in more fusions2002-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
9 EVA1Cinteractor100Gal_Lectin (PF02140, IPR000922): Galactose binding lectin domain
FAM176 (PF14851): FAM176 family
10 GINM1interactor100NA
11 GPR183interactor21.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
12 HNRNPDoncoprotein50.50068.376CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Keratin_2_head (PF16208, IPR032444): Keratin type II head
13 ICAM2interactor100ICAM_N (PF03921, IPR013768): Intercellular adhesion molecule (ICAM), N-terminal domain
SecE (PF00584, IPR001901): SecE/Sec61-gamma subunits of protein translocation complex
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
14 KDRoncoprotein40.33381.376Ehrlichia_rpt (PF09528, IPR019048): Ehrlichia tandem repeat (Ehrlichia_rpt)
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
15 L1CAMoncoprotein100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
EVC2_like (PF12297, IPR022076): Ellis van Creveld protein 2 like protein
Bravo_FIGEY (PF13882, IPR026966): Bravo-like intracellular region
Ig_3 (PF13927): Immunoglobulin domain
16 PCNTinteractor30.333103.576Caldesmon (PF02029, IPR006018): Caldesmon
CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF1640 (PF07798, IPR024461): Protein of unknown function (DUF1640)
DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
SlyX (PF04102, IPR007236): SlyX
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
PACT_coil_coil (PF10495, IPR019528): Pericentrin-AKAP-450 domain of centrosomal targeting protein
zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein
PP2C_C (PF07830, IPR012911, SM00332): Protein serine/threonine phosphatase 2C, C-terminal domain
Tho2 (PF11262, IPR021418): Transcription factor/nuclear export subunit protein 2
Colicin-DNase (PF12639, IPR024622): DNase/tRNase domain of colicin-like bacteriocin
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
DUF4239 (PF14023, IPR025333): Protein of unknown function (DUF4239)
WD40_alt (PF14077, IPR026987): Alternative WD40 repeat motif
FlxA (PF14282, IPR025577): FlxA-like protein
FAM184 (PF15665): Family with sequence similarity 184, A and B
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
17 PDGFBoncoprotein200PDGF (PF00341, IPR000072, SM00141): PDGF/VEGF domain
PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region
18 PGFoncoprotein31.0000PDGF (PF00341, IPR000072, SM00141): PDGF/VEGF domain
19 PIP5K1Aoncoprotein21.0000PIP5K (PF01504, IPR002498): Phosphatidylinositol-4-phosphate 5-Kinase
20 PLVAPinteractor100PV-1 (PF06637, IPR009538): PV-1 protein (PLVAP)
21 PLXNA1interactor31.0000Plexin_cytopl (PF08337, IPR013548): Plexin cytoplasmic RasGAP domain
PSI (PF01437, IPR002165, SM00423): Plexin repeat
Sema (PF01403, IPR001627, SM00630): Sema domain
TIG (PF01833, IPR002909): IPT/TIG domain
22 PRKAR2Binteractor30.6671.000RIIa (PF02197, IPR003117, SM00394): Regulatory subunit of type II PKA R-subunit
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
23 RPL27interactor100Ribosomal_L27e (PF01777, IPR001141): Ribosomal L27e protein family
24 SRRM1interactor21.0000DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
ETRAMP (PF09716, IPR006389): Malarial early transcribed membrane protein (ETRAMP)
Hepatitis_core (PF00906, IPR002006): Hepatitis core antigen
MAP65_ASE1 (PF03999, IPR007145): Microtubule associated protein (MAP65/ASE1 family)
PWI (PF01480, IPR002483, SM00311): PWI domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
25 TGFBR1oncoprotein21.0000Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase (PF00069, IPR000719): Protein kinase domain
TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
26 TGFBR2suppressor30.6671.000ecTbetaR2 (PF08917, IPR015013): Transforming growth factor beta receptor 2 ectodomain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
27 TGFBR3suppressor40.5003.000Delta_lysin (PF05372, IPR008034): Delta lysin family
Zona_pellucida (PF00100, IPR001507, SM00241): Zona pellucida-like domain
28 TMEM30Ainteractor100CDC50 (PF03381, IPR005045): LEM3 (ligand-effect modulator 3) family / CDC50 family
29 TNFoncoprotein40.66756.671TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
30 USHBP1interactor200DASH_Dam1 (PF08653, IPR013962): DASH complex subunit Dam1
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
SlyX (PF04102, IPR007236): SlyX
MCC-bdg_PDZ (PF10506, IPR019536): PDZ domain of MCC-2 bdg protein for Usher syndrome
YlqD (PF11068, IPR021297): YlqD protein
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
CAGE1 (PF15066, IPR029381): Cancer-associated gene protein 1 family
TEX13 (PF15186, IPR028193): Testis-expressed sequence 13 protein family
31 USO1interactor31.0000Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
Uso1_p115_head (PF04869, IPR006953): Uso1 / p115 like vesicle tethering protein, head region
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
MutS_III (PF05192, IPR007696, SM00533): MutS domain III
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
MG1 (PF11974, IPR021868): Alpha-2-macroglobulin MG1 domain
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
32 VEGFAsuppressor60.40013.743PDGF (PF00341, IPR000072, SM00141): PDGF/VEGF domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
VEGF_C (PF14554, IPR027928): VEGF heparin-binding domain
33 VEGFBinteractor21.0000PDGF (PF00341, IPR000072, SM00141): PDGF/VEGF domain

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