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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MICAL1, TNFRSF14 (from a repository: Sat Mar 25 23:51:51 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)48
The number (and %) of the onco-proteins14 (29.17 %)
The number (and %) of the tumor suppressors5 (10.42 %)
Total number of binary PPIs (saturation %)129 (11.44 %)
The number (and %) of affected PPIs47 (36.43 %)
The number of possible different fusions7
PPI diameter4
PPI radius2
The average degree of PPI4.375
Assortativity coefficient-0.4377
The network average Clustering coefficient0.297
The number (and %) of a zero Clustering coefficients19 (39.58 %)
The number (and %) of a zero Betweenness Centrality16 (33.33 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MICAL1,TNFRSF14 All fusions
Proteins found in more fusions CHD3 (see 1 fusions); APP (see 4 fusions); A2M (see 2 fusions); NEDD9 (see 1 fusions); GRB2 (see 1 fusions); GSK3B (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MICAL1parental protein170.154426.889CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DAO (PF01266, IPR006076): FAD dependent oxidoreductase
FAD_binding_3 (PF01494, IPR002938): FAD binding domain
LIM (PF00412, IPR001781, SM00132): LIM domain
DUF3585 (PF12130, IPR022735): Protein of unknown function (DUF3585)
NAD_binding_7 (PF13241, IPR006367): Putative NAD(P)-binding
2 TNFRSF14parental protein300.0371249.295Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Hum_adeno_E3A (PF05393, IPR008652): Human adenovirus early E3A glycoprotein
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
3 A2Mprotein found in more fusions40.33319.356A2M (PF00207, IPR001599): Alpha-2-macroglobulin family
A2M_comp (PF07678, IPR011626): A-macroglobulin complement component
A2M_N (PF01835, IPR002890): MG2 domain
A2M_N_2 (PF07703, IPR011625): Alpha-2-macroglobulin family N-terminal region
A2M_recep (PF07677, IPR009048): A-macroglobulin receptor
MP (PF01107, IPR028919): Viral movement protein (MP)
SVA (PF05326, IPR007990): Seminal vesicle autoantigen (SVA)
Thiol-ester_cl (PF10569, IPR019565): Alpha-macro-globulin thiol-ester bond-forming region
4 ABL1oncoprotein70.73310.100Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
5 APPprotein found in more fusions110.133184.839APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
6 BTLAinteractor100V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
7 CD160interactor100Ig_3 (PF13927): Immunoglobulin domain
8 CEP126interactor2020.190Nop25 (PF09805, IPR019186): Nucleolar protein 12 (25kDa)
K1377 (PF15352, IPR028257): Susceptibility to monomelic amyotrophy
9 CHD3oncoprotein60.40032.595CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain
CHDNT (PF08073, IPR012958): CHDNT (NUC034) domain
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
DUF1086 (PF06461, IPR009462, SM01146): Domain of Unknown Function (DUF1086)
DUF1087 (PF06465, IPR009463, SM01147): Domain of Unknown Function (DUF1087)
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
PHD (PF00628, IPR019787, SM00249): PHD-finger
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF2956 (PF11169, IPR021339): Protein of unknown function (DUF2956)
FAM176 (PF14851): FAM176 family
10 CRKoncoprotein60.7335.433SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
11 DGKDinteractor200CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
PH (PF00169, IPR001849, SM00233): PH domain
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
DAGK_acc (PF00609, IPR000756, SM00045): Diacylglycerol kinase accessory domain
DAGK_cat (PF00781, IPR001206, SM00046): Diacylglycerol kinase catalytic domain
SBE2 (PF17076, IPR031403): SBE2, cell-qall formation
12 DRAP1interactor40.33323.156CBFD_NFYB_HMF (PF00808, IPR003958): Histone-like transcription factor (CBF/NF-Y) and archaeal histone
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
13 DYNLL1interactor306.162Dynein_light (PF01221, IPR001372): Dynein light chain type 1
14 EHD1interactor31.0000Gp-FAR-1 (PF05823, IPR008632): Nematode fatty acid retinoid binding protein (Gp-FAR-1)
Gtr1_RagA (PF04670, IPR006762): Gtr1/RagA G protein conserved region
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EHD_N (PF16880, IPR031692): N-terminal EH-domain containing protein
15 GADD45Asuppressor40.6675.769Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
16 GCN1interactor209.869Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
CLASP_N (PF12348, IPR024395): CLASP N terminal
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
TFCD_C (PF12612, IPR022577): Tubulin folding cofactor D C terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
17 GRB2oncoprotein100.41761.441SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
18 GSK3Bsuppressor70.20055.003Pkinase (PF00069, IPR000719): Protein kinase domain
19 IMPA2interactor200Inositol_P (PF00459, IPR000760): Inositol monophosphatase family
20 ITFG1interactor100FG-GAP (PF01839, IPR013517): FG-GAP repeat
K1 (PF02960, IPR004121): K1 glycoprotein
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
21 MBTPS1interactor100Peptidase_S8 (PF00082, IPR000209): Subtilase family
DUF4350 (PF14258, IPR025646): Domain of unknown function (DUF4350)
22 NDUFS2interactor30.33311.760Complex1_49kDa (PF00346, IPR001135): Respiratory-chain NADH dehydrogenase, 49 Kd subunit
NiFeSe_Hases (PF00374, IPR001501): Nickel-dependent hydrogenase
23 NEDD9protein found in more fusions50.50014.747Serine_rich (PF08824, IPR014928): Serine rich protein interaction domain
DUF3513 (PF12026, IPR021901): Domain of unknown function (DUF3513)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
24 NTRK1oncoprotein130.152210.484I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
25 P4HBinteractor40.6679.869Glycos_trans_3N (PF02885, IPR017459): Glycosyl transferase family, helical bundle domain
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
26 PDIA6interactor30.6679.869FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
27 PIK3R3interactor60.40050.474SH2 (PF00017, IPR000980, SM00252): SH2 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
28 RAB10oncoprotein202.973Ras (PF00071, IPR001806, SM00173): Ras family
29 RAB1Aoncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
30 RAD21oncoprotein30.33311.852Rad21_Rec8 (PF04824, IPR006909): Conserved region of Rad21 / Rec8 like protein
Rad21_Rec8_N (PF04825, IPR006910): N terminus of Rad21 / Rec8 like protein
FAM176 (PF14851): FAM176 family
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
31 RPS6KA6suppressor202.973Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
32 SEC11Ainteractor100Peptidase_S24 (PF00717, IPR019759): Peptidase S24-like
33 SERPINA4interactor2015.968Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
34 SLC25A41interactor21.0000Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
35 SRConcoprotein100.389113.927Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
36 TAB1interactor40.16741.149PP2C (PF00481, IPR001932): Protein phosphatase 2C
37 TAS2R7interactor100TAS2R (PF05296, IPR007960): Taste receptor protein (TAS2R)
38 TNFSF13interactor200DUF1049 (PF06305, IPR010445): Protein of unknown function (DUF1049)
TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
39 TNFSF14interactor40.6674.915TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
40 TRAF1oncoprotein50.66729.167HypA (PF01155, IPR000688): Hydrogenase/urease nickel incorporation, metallochaperone, hypA
SlyX (PF04102, IPR007236): SlyX
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
41 TRAF2interactor90.28663.809MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
42 TRAF3oncoprotein70.53350.460ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
S-AdoMet_synt_M (PF02772, IPR022629): S-adenosylmethionine synthetase, central domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
MPS2 (PF17060, IPR031433): Monopolar spindle protein 2
Spc29 (PF17082, IPR031392): Spindle Pole Component 29
43 TRAF5interactor41.0000Sina (PF03145, IPR018121): Seven in absentia protein family
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
HMMR_N (PF15905, IPR031787): Hyaluronan mediated motility receptor N-terminal
Spc29 (PF17082, IPR031392): Spindle Pole Component 29
44 UBQLN4interactor31.0000CRF (PF00473, IPR000187, SM00039): Corticotropin-releasing factor family
DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
Arm_2 (PF04826, IPR006911): Armadillo-like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
partial_CstF (PF15861, IPR031721): Partial cleavage stimulation factor domain
45 UGGT1interactor209.869Glyco_transf_8 (PF01501, IPR002495): Glycosyl transferase family 8
UDP-g_GGTase (PF06427, IPR009448): UDP-glucose:Glycoprotein Glucosyltransferase
46 VIMsuppressor90.357173.639Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
47 WDR73interactor100WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
48 ZBTB48suppressor200BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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