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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CHMP2A, ADAM23 (from a repository: Sun Dec 16 17:27:02 2018)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)35
The number (and %) of the onco-proteins12 (34.29 %)
The number (and %) of the tumor suppressors3 (8.57 %)
Total number of binary PPIs (saturation %)96 (16.13 %)
The number (and %) of affected PPIs34 (35.42 %)
The number of possible different fusions4
PPI diameter4
PPI radius2
The average degree of PPI4.800
Assortativity coefficient-0.3149
The network average Clustering coefficient0.474
The number (and %) of a zero Clustering coefficients8 (22.86 %)
The number (and %) of a zero Betweenness Centrality13 (37.14 %)


List of the fusions

PPI for parental proteins: ADAM23,CHMP2A All fusions
Proteins found in more fusions CHMP2B (see 1 fusions); VPS4A (see 1 fusions); CHMP3 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 ADAM23parental protein100EGF_2 (PF07974, IPR013111): EGF-like domain
Pep_M12B_propep (PF01562, IPR002870): Reprolysin family propeptide
Reprolysin (PF01421, IPR001590): Reprolysin (M12B) family zinc metalloprotease
ADAM_CR (PF08516, IPR006586, SM00608): ADAM cysteine-rich
Disintegrin (PF00200, IPR001762, SM00050): Disintegrin
2 CHMP2Aparental protein330.089809.568Snf7 (PF03357, IPR005024): Snf7
3 ATP6AP2interactor50.6671.400Phosphodiest (PF01663, IPR002591): Type I phosphodiesterase / nucleotide pyrophosphatase
Renin_r (PF07850, IPR012493): Renin receptor-like protein
4 CDV3interactor30.3339.081TraT (PF05818, IPR008874): Enterobacterial TraT complement resistance protein
CDV3 (PF15359, IPR026806): Carnitine deficiency-associated protein 3
5 CHMP2Bprotein found in more fusions100.36121.222Involucrin (PF00904, IPR000354): Involucrin repeat
Snf7 (PF03357, IPR005024): Snf7
6 CHMP3protein found in more fusions80.5248.475Snf7 (PF03357, IPR005024): Snf7
7 CHMP4Binteractor110.42221.208Snf7 (PF03357, IPR005024): Snf7
8 CSTF2interactor30.6671.030RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
CSTF_C (PF14304, IPR026896): Transcription termination and cleavage factor C-terminal
CSTF2_hinge (PF14327, IPR025742): Hinge domain of cleavage stimulation factor subunit 2
9 DOCK8interactor200DHR-2 (PF06920, IPR010703): Dock homology region 2
DUF3398 (PF11878, IPR021816): Domain of unknown function (DUF3398)
DOCK-C2 (PF14429, IPR027007): C2 domain in Dock180 and Zizimin proteins
DOCK_N (PF16172, IPR032376): DOCK N-terminus
10 E2F4suppressor21.0000E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain
Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
SPX (PF03105, IPR004331): SPX domain
DUF3584 (PF12128, IPR021979): Protein of unknown function (DUF3584)
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
11 EIF2B5interactor21.0000Hexapep (PF00132, IPR001451): Bacterial transferase hexapeptide (six repeats)
W2 (PF02020, IPR003307, SM00515): eIF4-gamma/eIF5/eIF2-epsilon
12 EIF4EBP1oncoprotein100eIF_4EBP (PF05456, IPR008606): Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
13 ELAVL1oncoprotein90.03685.667RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
14 ERLIN1interactor21.0000Ribosomal_L33 (PF00471, IPR001705): Ribosomal protein L33
Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4346 (PF14251, IPR025595): Domain of unknown function (DUF4346)
15 HNRNPA3oncoprotein30.6670.500IATP (PF04568, IPR007648): Mitochondrial ATPase inhibitor, IATP
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
16 ITGA4interactor70.4676.333FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
17 MITD1interactor50.6002.667MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain
MIT_C (PF16565, IPR032341): Phospholipase D-like domain at C-terminus of MIT
18 NOL4interactor100NOA36 (PF06524, IPR010531): NOA36 protein
zf-H2C2 (PF09337, IPR015416): His(2)-Cys(2) zinc finger
BEN (PF10523, IPR018379, SM01025): BEN domain
19 PARVAoncoprotein205.081CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
20 PPP1CAsuppressor40.6671.697Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
21 RAB2Aoncoprotein31.0000Ras (PF00071, IPR001806, SM00173): Ras family
22 RAB5Concoprotein70.5716.400Ras (PF00071, IPR001806, SM00173): Ras family
23 RAB7Asuppressor90.33347.200Ras (PF00071, IPR001806, SM00173): Ras family
24 RANBP2oncoprotein200Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
DUF2693 (PF10902, IPR024401): Protein of unknown function (DUF2693)
IR1-M (PF12185, IPR022011): Nup358/RanBP2 E3 ligase domain
Dmrt1 (PF12374, IPR022114): Double-sex mab3 related transcription factor 1
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
25 RRBP1interactor21.0000Fez1 (PF06818): Fez1
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
IncA (PF04156, IPR007285): IncA protein
Pentapeptide_2 (PF01469, IPR002989): Pentapeptide repeats (8 copies)
Rib_recp_KP_reg (PF05104, IPR007794): Ribosome receptor lysine/proline rich region
RTBV_P46 (PF06216, IPR009347): Rice tungro bacilliform virus P46 protein
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449
UPF0767 (PF15990, IPR031933): UPF0767 family
26 STAMBPinteractor31.0000USP8_dimer (PF08969, IPR015063): USP8 dimerisation domain
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
DUF3526 (PF12040, IPR021913): Domain of unknown function (DUF3526)
27 TFGoncoprotein70.4677.000ARS2 (PF04959, IPR007042): Arsenite-resistance protein 2
MucBP (PF06458, IPR009459): MucBP domain
PB1 (PF00564, IPR000270, SM00666): PB1 domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
28 TGFB3oncoprotein205.081TGFb_propeptide (PF00688, IPR001111): TGF-beta propeptide
TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
29 UFD1Linteractor100UFD1 (PF03152, IPR004854): Ubiquitin fusion degradation protein UFD1
30 USP54interactor21.0000UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
31 USP8interactor40.6671.000DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
USP8_dimer (PF08969, IPR015063): USP8 dimerisation domain
SET (PF00856, IPR001214, SM00317): SET domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
NAM-associated (PF14303, IPR029466): No apical meristem-associated C-terminal domain
32 VPS4Aprotein found in more fusions60.7002.333AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain
TIP49 (PF06068, IPR010339): TIP49 C-terminus
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
YCII (PF03795, IPR005545): YCII-related domain
33 VPS4Binteractor50.50013.081AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_2 (PF07724, IPR013093): AAA domain (Cdc48 subfamily)
MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain
MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
TIP49 (PF06068, IPR010339): TIP49 C-terminus
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
34 VTA1interactor50.60012.556Vta1 (PF04652): Vta1 like
35 XPO1interactor80.25041.419CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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