1 |
MT-ND4L | parental protein | 1 | 0 | 0 | Oxidored_q2 (PF00420, IPR001133): NADH-ubiquinone/plastoquinone oxidoreductase chain 4L |
2 |
IRS2 | parental protein | 40 | 0.224 | 622.369 | CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein PRIMA1 (PF16101): Proline-rich membrane anchor 1 |
3 |
BCL2 | oncoprotein | 4 | 0.667 | 0.333 | Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4 |
4 |
COPS2 | suppressor | 1 | 0 | 0 | YozE_SAM_like (PF06855, IPR023089): YozE SAM-like fold TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat DUF2087 (PF09860, IPR018656): Uncharacterized protein conserved in bacteria (DUF2087) PCI (PF01399, IPR000717, SM00088): PCI domain TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat |
5 |
DVL2 | interactor | 8 | 0.619 | 2.883 | DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Dishevelled (PF02377, IPR003351): Dishevelled specific domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) DIX (PF00778, IPR001158, SM00021): DIX domain Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal |
6 |
EGFR | oncoprotein | 22 | 0.376 | 88.421 | Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV |
7 |
ELAVL1 | oncoprotein | 16 | 0.381 | 39.310 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
8 |
EPN1 | interactor | 6 | 0.800 | 1.086 | ENTH (PF01417, IPR001026, SM00273): ENTH domain UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif |
9 |
EPOR | oncoprotein | 6 | 0.667 | 1.708 | EpoR_lig-bind (PF09067, IPR015152): Erythropoietin receptor, ligand binding fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain |
10 |
ESR1 | suppressor | 13 | 0.424 | 18.786 | Oest_recep (PF02159, IPR001292): Oestrogen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal |
11 |
FBXW11 | interactor | 7 | 0.867 | 0.450 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain F-box-like (PF12937, IPR001810): F-box-like |
12 |
GRB10 | oncoprotein | 9 | 0.500 | 6.502 | BPS (PF08947, IPR015042): BPS (Between PH and SH2) PH (PF00169, IPR001849, SM00233): PH domain RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain SH2 (PF00017, IPR000980, SM00252): SH2 domain Argos (PF11581, IPR021633): Antagonist of EGFR signalling, Argos |
13 |
GRB2 | oncoprotein | 22 | 0.433 | 65.665 | SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093) |
14 |
INSR | interactor | 10 | 0.644 | 5.573 | fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain |
15 |
IRS1 | interactor | 24 | 0.279 | 122.885 | CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain |
16 |
JAK1 | oncoprotein | 14 | 0.538 | 33.595 | FERM_M (PF00373, IPR019748): FERM central domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain |
17 |
MRPL1 | interactor | 1 | 0 | 0 | CUB_2 (PF02408, IPR003366): CUB-like domain Ribosomal_L1 (PF00687, IPR028364): Ribosomal protein L1p/L10e family |
18 |
MYC | oncoprotein | 11 | 0.533 | 11.985 | HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain Myc_N (PF01056, IPR012682): Myc amino-terminal region |
19 |
NEDD4 | suppressor | 6 | 0.800 | 0.375 | Rota_NS26 (PF01525, IPR002512): Rotavirus NS26 WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) |
20 |
NETO2 | interactor | 2 | 1.000 | 0 | CUB (PF00431, IPR000859, SM00042): CUB domain Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A |
21 |
NISCH | interactor | 3 | 1.000 | 0 | PX (PF00787, IPR001683, SM00312): PX domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_9 (PF14580): Leucine-rich repeat DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611) |
22 |
NTRK1 | oncoprotein | 27 | 0.317 | 155.243 | I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain |
23 |
PIK3CA | oncoprotein | 10 | 0.533 | 20.649 | PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2 PI3K_p85B (PF02192, IPR003113, SM00143): PI3-kinase family, p85-binding domain PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF2321 (PF10083, IPR016891): Uncharacterized protein conserved in bacteria (DUF2321) PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase |
24 |
PIK3R1 | oncoprotein | 15 | 0.462 | 24.395 | RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain |
25 |
PIK3R3 | interactor | 5 | 0.900 | 0.250 | SH2 (PF00017, IPR000980, SM00252): SH2 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain |
26 |
PLCG1 | oncoprotein | 7 | 0.762 | 2.305 | C2 (PF00168, IPR000008, SM00239): C2 domain PH (PF00169, IPR001849, SM00233): PH domain SH2 (PF00017, IPR000980, SM00252): SH2 domain PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain PH_12 (PF16457, IPR001849): Pleckstrin homology domain |
27 |
PTPN11 | suppressor | 13 | 0.667 | 7.984 | SH2 (PF00017, IPR000980, SM00252): SH2 domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase |
28 |
RPTOR | protein found in more fusions | 7 | 0.533 | 1.894 | HEAT (PF02985, IPR000357): HEAT repeat WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain HEAT_2 (PF13646): HEAT repeats Raptor_N (PF14538, IPR029347): Raptor N-terminal CASPase like domain |
29 |
SFN | suppressor | 9 | 0.714 | 2.119 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
30 |
SIRT1 | suppressor | 10 | 0.472 | 8.091 | DUF592 (PF04574, IPR007654): Protein of unknown function (DUF592) SIR2 (PF02146, IPR003000): Sir2 family TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain |
31 |
SOCS1 | suppressor | 9 | 0.750 | 4.902 | SH2 (PF00017, IPR000980, SM00252): SH2 domain SOCS_box (PF07525, IPR001496): SOCS box |
32 |
SOCS3 | suppressor | 9 | 0.556 | 6.170 | SH2 (PF00017, IPR000980, SM00252): SH2 domain SOCS_box (PF07525, IPR001496): SOCS box |
33 |
SRPK2 | oncoprotein | 5 | 0.667 | 0.533 | DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387) Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator Pkinase (PF00069, IPR000719): Protein kinase domain S-antigen (PF05756, IPR008825): S-antigen protein DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) |
34 |
STAT1 | suppressor | 8 | 0.333 | 86.717 | SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain |
35 |
TYK2 | interactor | 5 | 0.667 | 4.930 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase |
36 |
UBTF | interactor | 5 | 0.800 | 0.325 | Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein HMG_box_2 (PF09011, IPR009071): HMG-box domain HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box DUF4473 (PF14747, IPR027913): Domain of unknown function (DUF4473) HMG_box_5 (PF14887, IPR029215): HMG (high mobility group) box 5 |
37 |
XPO1 | interactor | 15 | 0.419 | 45.718 | CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region |
38 |
YWHAB | interactor | 14 | 0.604 | 15.538 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein Virulence_fact (PF13769, IPR025989): Virulence factor |
39 |
YWHAE | oncoprotein | 13 | 0.628 | 10.896 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
40 |
YWHAG | protein found in more fusions | 14 | 0.654 | 10.186 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
41 |
YWHAH | protein found in more fusions | 13 | 0.712 | 5.741 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
42 |
YWHAQ | interactor | 14 | 0.549 | 16.712 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
43 |
YWHAZ | protein found in more fusions | 13 | 0.727 | 6.777 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |