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Fusion ID: Protein names:	8660 4539
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Visualization interactions

Cytoscape Web for: parental proteins MT-ND4L, IRS2

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Statistics and Network structure information

Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	43
The number (and %) of the onco-proteins	18 (41.86 %)
The number (and %) of the tumor suppressors	9 (20.93 %)
Total number of binary PPIs (saturation %)	244 (27.02 %)
The number (and %) of affected PPIs	41 (16.80 %)
The number of possible different fusions	15
PPI diameter	4
PPI radius	2
The average degree of PPI	10.326
Assortativity coefficient	-0.1749
The network average Clustering coefficient	0.562
The number (and %) of a zero Clustering coefficients	3 (6.98 %)
The number (and %) of a zero Betweenness Centrality	5 (11.63 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: MT-ND4L,IRS2	All fusions
Proteins found in more fusions	SFN (see 1 fusions); JAK1 (see 1 fusions); PTPN11 (see 1 fusions); SRPK2 (see 1 fusions); GRB2 (see 1 fusions); YWHAG (see 1 fusions); RPTOR (see 3 fusions); YWHAZ (see 5 fusions); EGFR (see 2 fusions); PIK3R1 (see 1 fusions); STAT1 (see 1 fusions); NEDD4 (see 1 fusions); MYC (see 2 fusions); YWHAH (see 2 fusions);

List of the fusions

PPI for parental proteins: MT-ND4L,IRS2

All fusions

Proteins found in more fusions

SFN (see 1 fusions); JAK1 (see 1 fusions); PTPN11 (see 1 fusions); SRPK2 (see 1 fusions); GRB2 (see 1 fusions); YWHAG (see 1 fusions); RPTOR (see 3 fusions); YWHAZ (see 5 fusions); EGFR (see 2 fusions); PIK3R1 (see 1 fusions); STAT1 (see 1 fusions); NEDD4 (see 1 fusions); MYC (see 2 fusions); YWHAH (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	MT-ND4L	parental protein	1	0	0	Oxidored_q2 (PF00420, IPR001133): NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
2	IRS2	parental protein	40	0.224	622.369	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein PRIMA1 (PF16101): Proline-rich membrane anchor 1
3	BCL2	oncoprotein	4	0.667	0.333	Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
4	COPS2	suppressor	1	0	0	YozE_SAM_like (PF06855, IPR023089): YozE SAM-like fold TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat DUF2087 (PF09860, IPR018656): Uncharacterized protein conserved in bacteria (DUF2087) PCI (PF01399, IPR000717, SM00088): PCI domain TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
5	DVL2	interactor	8	0.619	2.883	DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Dishevelled (PF02377, IPR003351): Dishevelled specific domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) DIX (PF00778, IPR001158, SM00021): DIX domain Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
6	EGFR	oncoprotein	22	0.376	88.421	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
7	ELAVL1	oncoprotein	16	0.381	39.310	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
8	EPN1	interactor	6	0.800	1.086	ENTH (PF01417, IPR001026, SM00273): ENTH domain UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
9	EPOR	oncoprotein	6	0.667	1.708	EpoR_lig-bind (PF09067, IPR015152): Erythropoietin receptor, ligand binding fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
10	ESR1	suppressor	13	0.424	18.786	Oest_recep (PF02159, IPR001292): Oestrogen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
11	FBXW11	interactor	7	0.867	0.450	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain F-box-like (PF12937, IPR001810): F-box-like
12	GRB10	oncoprotein	9	0.500	6.502	BPS (PF08947, IPR015042): BPS (Between PH and SH2) PH (PF00169, IPR001849, SM00233): PH domain RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain SH2 (PF00017, IPR000980, SM00252): SH2 domain Argos (PF11581, IPR021633): Antagonist of EGFR signalling, Argos
13	GRB2	oncoprotein	22	0.433	65.665	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
14	INSR	interactor	10	0.644	5.573	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain
15	IRS1	interactor	24	0.279	122.885	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain
16	JAK1	oncoprotein	14	0.538	33.595	FERM_M (PF00373, IPR019748): FERM central domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain
17	MRPL1	interactor	1	0	0	CUB_2 (PF02408, IPR003366): CUB-like domain Ribosomal_L1 (PF00687, IPR028364): Ribosomal protein L1p/L10e family
18	MYC	oncoprotein	11	0.533	11.985	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain Myc_N (PF01056, IPR012682): Myc amino-terminal region
19	NEDD4	suppressor	6	0.800	0.375	Rota_NS26 (PF01525, IPR002512): Rotavirus NS26 WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
20	NETO2	interactor	2	1.000	0	CUB (PF00431, IPR000859, SM00042): CUB domain Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
21	NISCH	interactor	3	1.000	0	PX (PF00787, IPR001683, SM00312): PX domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_9 (PF14580): Leucine-rich repeat DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
22	NTRK1	oncoprotein	27	0.317	155.243	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
23	PIK3CA	oncoprotein	10	0.533	20.649	PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2 PI3K_p85B (PF02192, IPR003113, SM00143): PI3-kinase family, p85-binding domain PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF2321 (PF10083, IPR016891): Uncharacterized protein conserved in bacteria (DUF2321) PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
24	PIK3R1	oncoprotein	15	0.462	24.395	RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
25	PIK3R3	interactor	5	0.900	0.250	SH2 (PF00017, IPR000980, SM00252): SH2 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
26	PLCG1	oncoprotein	7	0.762	2.305	C2 (PF00168, IPR000008, SM00239): C2 domain PH (PF00169, IPR001849, SM00233): PH domain SH2 (PF00017, IPR000980, SM00252): SH2 domain PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain PH_12 (PF16457, IPR001849): Pleckstrin homology domain
27	PTPN11	suppressor	13	0.667	7.984	SH2 (PF00017, IPR000980, SM00252): SH2 domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
28	RPTOR	protein found in more fusions	7	0.533	1.894	HEAT (PF02985, IPR000357): HEAT repeat WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain HEAT_2 (PF13646): HEAT repeats Raptor_N (PF14538, IPR029347): Raptor N-terminal CASPase like domain
29	SFN	suppressor	9	0.714	2.119	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
30	SIRT1	suppressor	10	0.472	8.091	DUF592 (PF04574, IPR007654): Protein of unknown function (DUF592) SIR2 (PF02146, IPR003000): Sir2 family TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
31	SOCS1	suppressor	9	0.750	4.902	SH2 (PF00017, IPR000980, SM00252): SH2 domain SOCS_box (PF07525, IPR001496): SOCS box
32	SOCS3	suppressor	9	0.556	6.170	SH2 (PF00017, IPR000980, SM00252): SH2 domain SOCS_box (PF07525, IPR001496): SOCS box
33	SRPK2	oncoprotein	5	0.667	0.533	DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387) Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator Pkinase (PF00069, IPR000719): Protein kinase domain S-antigen (PF05756, IPR008825): S-antigen protein DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
34	STAT1	suppressor	8	0.333	86.717	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
35	TYK2	interactor	5	0.667	4.930	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
36	UBTF	interactor	5	0.800	0.325	Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein HMG_box_2 (PF09011, IPR009071): HMG-box domain HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box DUF4473 (PF14747, IPR027913): Domain of unknown function (DUF4473) HMG_box_5 (PF14887, IPR029215): HMG (high mobility group) box 5
37	XPO1	interactor	15	0.419	45.718	CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
38	YWHAB	interactor	14	0.604	15.538	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein Virulence_fact (PF13769, IPR025989): Virulence factor
39	YWHAE	oncoprotein	13	0.628	10.896	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
40	YWHAG	protein found in more fusions	14	0.654	10.186	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
41	YWHAH	protein found in more fusions	13	0.712	5.741	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
42	YWHAQ	interactor	14	0.549	16.712	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
43	YWHAZ	protein found in more fusions	13	0.727	6.777	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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