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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ZFYVE9, ASMTL (from a repository: Wed Mar 15 08:37:18 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)49
The number (and %) of the onco-proteins15 (30.61 %)
The number (and %) of the tumor suppressors9 (18.37 %)
Total number of binary PPIs (saturation %)127 (10.80 %)
The number (and %) of affected PPIs48 (37.80 %)
The number of possible different fusions8
PPI diameter5
PPI radius3
The average degree of PPI4.490
Assortativity coefficient-0.3505
The network average Clustering coefficient0.364
The number (and %) of a zero Clustering coefficients20 (40.82 %)
The number (and %) of a zero Betweenness Centrality24 (48.98 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ZFYVE9,ASMTL All fusions
Proteins found in more fusions PML (see 4 fusions); ERBIN (see 4 fusions); APP (see 4 fusions); RNF11 (see 1 fusions); DAZAP2 (see 2 fusions); UBC (see 1 fusions); SMAD3 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ZFYVE9parental protein390.0731565.969FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
SARA (PF11409, IPR024608): Smad anchor for receptor activation (SARA)
DUF3480 (PF11979, IPR022557): Domain of unknown function (DUF3480)
2 ASMTLparental protein90466.321Maf (PF02545, IPR003697): Maf-like protein
Methyltransf_2 (PF00891, IPR001077): O-methyltransferase
Dimerisation2 (PF16864, IPR031725): Dimerisation domain
3 ANKLE2interactor21.0000Cauli_VI (PF01693, IPR011320): Caulimovirus viroplasmin
LEM (PF03020, IPR003887, SM00540): LEM domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Telomere_Sde2_2 (PF13297): Telomere stability C-terminal
4 APPprotein found in more fusions90.179395.912APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 BAG6interactor40.6673.200DUF1179 (PF06678, IPR009564): Protein of unknown function (DUF1179)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939)
DUF3538 (PF12057, IPR021925): Domain of unknown function (DUF3538)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
6 BMP4suppressor100TGFb_propeptide (PF00688, IPR001111): TGF-beta propeptide
TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
7 CHD6interactor100CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
BORG_CEP (PF14957, IPR029273): Cdc42 effector
8 CLTConcoprotein70.42913.460Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
Clathrin_H_link (PF13838): Clathrin-H-link
9 CTNNB1oncoprotein110.41895.960Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
10 DAZAP2protein found in more fusions50.6671.400DAZAP2 (PF11029, IPR022730): DAZ associated protein 2 (DAZAP2)
11 EIF4G1oncoprotein21.0000DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
MA3 (PF02847, IPR003891, SM00544): MA3 domain
MIF4G (PF02854, IPR003890, SM00543): MIF4G domain
Neisseria_TspB (PF05616, IPR008708): Neisseria meningitidis TspB protein
W2 (PF02020, IPR003307, SM00515): eIF4-gamma/eIF5/eIF2-epsilon
12 ERBINoncoprotein90.50018.867LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
13 ETS2suppressor100Ets (PF00178, IPR000418, SM00413): Ets-domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
14 FAM46Ainteractor21.0000NTP_transf_7 (PF07984, IPR012937, SM01153): Nucleotidyltransferase
15 FHL2oncoprotein80.52443.497LIM (PF00412, IPR001781, SM00132): LIM domain
zf-ribbon_3 (PF13248): zinc-ribbon domain
16 HERC2interactor50.5003.850ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
MIB_HERC2 (PF06701, IPR010606): Mib_herc2
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
17 HLA-DRB4interactor100DUF202 (PF02656, IPR003807): Domain of unknown function (DUF202)
MHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
18 IRF3suppressor3049.606IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
19 JUPsuppressor31.0000Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
20 KRT31interactor2057.469Filament (PF00038, IPR001664): Intermediate filament protein
21 KRT40interactor100Filament (PF00038, IPR001664): Intermediate filament protein
UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
22 NIT1interactor200CN_hydrolase (PF00795, IPR003010): Carbon-nitrogen hydrolase
23 NUP155interactor100Nucleoporin_C (PF03177, IPR007187): Non-repetitive/WGA-negative nucleoporin C-terminal
Nucleoporin_N (PF08801, IPR014908): Nup133 N terminal like
24 PMLsuppressor61.0000zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
25 PNMA1oncoprotein100PNMA (PF14893, IPR026523): PNMA
26 PPARGsuppressor80.61938.164zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
PPARgamma_N (PF12577, IPR022590): PPAR gamma N-terminal region
27 PPP1CAsuppressor60.7333.300Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
28 PPP1CBinteractor50.6004.467Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
29 PPP1CConcoprotein60.53372.090Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
30 PPP1R3Ainteractor40.8330.500CBM_21 (PF03370, IPR005036): Carbohydrate/starch-binding module (family 21)
31 PPP2R1Aoncoprotein60.40011.598TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
HEAT (PF02985, IPR000357): HEAT repeat
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
32 RBBP6oncoprotein100DUF936 (PF06075, IPR010341): Plant protein of unknown function (DUF936)
DWNN (PF08783, IPR014891): DWNN domain
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
U-box (PF04564, IPR003613, SM00504): U-box domain
SBF2 (PF12335, IPR022096): Myotubularin protein
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
zf-CCHC_2 (PF13696, IPR025829): Zinc knuckle
AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term
CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106
PRIMA1 (PF16101): Proline-rich membrane anchor 1
33 RHOT2interactor100EF_assoc_1 (PF08355, IPR013566): EF hand associated
EF_assoc_2 (PF08356, IPR013567): EF hand associated
Ras (PF00071, IPR001806, SM00173): Ras family
SPARC_Ca_bdg (PF10591, IPR019577): Secreted protein acidic and rich in cysteine Ca binding region
AAA_16 (PF13191): AAA ATPase domain
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
34 RNF11protein found in more fusions50.50039.251zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-ANAPC11 (PF12861, IPR024991): Anaphase-promoting complex subunit 11 RING-H2 finger
35 RNPEPinteractor100Leuk-A4-hydro_C (PF09127, IPR015211): Leukotriene A4 hydrolase, C-terminal
Peptidase_M1 (PF01433, IPR014782): Peptidase family M1
36 SCYL2interactor21.0000CENP-B_N (PF04218, IPR007889): CENP-B N-terminal DNA-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
37 SMAD2suppressor100.500116.106MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
38 SMAD3oncoprotein110.48973.351MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
39 SPG20interactor40.33340.077MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain
Senescence (PF06911, IPR009686): Senescence-associated protein
40 STAM2interactor50.7003.321GAT (PF03127, IPR004152): GAT domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
41 SUMF2interactor100FGE-sulfatase (PF03781, IPR005532): Sulfatase-modifying factor enzyme 1
42 SUPT5Hinteractor100KOW (PF00467, IPR005824, SM00739): KOW motif
Ribonuc_P_40 (PF08584, IPR013893): Ribonuclease P 40kDa (Rpp40) subunit
Spt5-NGN (PF03439, IPR005100): Early transcription elongation factor of RNA pol II, NGN section
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
DUF3912 (PF13051, IPR025023): Protein of unknown function (DUF3912)
43 SVEP1interactor21.0000EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
HYR (PF02494, IPR003410): HYR domain
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
Pentaxin (PF00354, IPR001759, SM00159): Pentaxin family
VERL (PF11386, IPR021526): Vitelline envelope receptor for lysin
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
44 TDO2interactor200Trp_dioxygenase (PF03301, IPR004981): Tryptophan 2,3-dioxygenase
45 TSG101suppressor60.400117.815APG6 (PF04111, IPR007243): Autophagy protein Apg6
Laminin_II (PF06009, IPR010307): Laminin Domain II
UEV (PF05743, IPR008883): UEV domain
Vps23_core (PF09454, IPR017916): Vps23 core domain
46 UBCprotein found in more fusions120.23642.449ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
47 UBXN11interactor100DivIC (PF04977, IPR007060): Septum formation initiator
SEP (PF08059, IPR012989, SM00553): SEP domain
UBX (PF00789, IPR001012, SM00166): UBX domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
TRPM_tetra (PF16519, IPR032415): Tetramerisation domain of TRPM
48 WDR4interactor100WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
49 ZMYND8oncoprotein100DUF1640 (PF07798, IPR024461): Protein of unknown function (DUF1640)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
PHD (PF00628, IPR019787, SM00249): PHD-finger
PWWP (PF00855, IPR000313, SM00293): PWWP domain
RNA_pol_Rbc25 (PF08292, IPR013238): RNA polymerase III subunit Rpc25
TCP (PF03634, IPR005333): TCP family transcription factor
zf-MYND (PF01753, IPR002893): MYND finger
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
DUF3544 (PF12064, IPR021931): Domain of unknown function (DUF3544)
CAML (PF14963, IPR016719): Calcium signal-modulating cyclophilin ligand

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