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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)19
The number (and %) of the onco-proteins6 (31.58 %)
The number (and %) of the tumor suppressors3 (15.79 %)
Total number of binary PPIs (saturation %)36 (21.05 %)
The number (and %) of affected PPIs18 (50.00 %)
The number of possible different fusions3
PPI diameter5
PPI radius3
The average degree of PPI2.737
Assortativity coefficient-0.3046
The network average Clustering coefficient0.219
The number (and %) of a zero Clustering coefficients11 (57.89 %)
The number (and %) of a zero Betweenness Centrality10 (52.63 %)


List of the fusions

PPI for parental proteins: RNGTT,ASMTL All fusions
Proteins found in more fusions APP (see 4 fusions); MYC (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 RNGTTparental protein90.167115.467DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
mRNA_cap_C (PF03919, IPR013846): mRNA capping enzyme, C-terminal domain
mRNA_cap_enzyme (PF01331, IPR001339): mRNA capping enzyme, catalytic domain
2 ASMTLparental protein90178.167Maf (PF02545, IPR003697): Maf-like protein
Methyltransf_2 (PF00891, IPR001077): O-methyltransferase
Dimerisation2 (PF16864, IPR031725): Dimerisation domain
3 APPprotein found in more fusions4098.933APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 BARD1suppressor40.33345.733BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
zf-RING_6 (PF14835): zf-RING of BARD1-type protein
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
5 BRCA1suppressor50.50011.433BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
6 CRKoncoprotein100SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
7 HERC2interactor31.0000ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
MIB_HERC2 (PF06701, IPR010606): Mib_herc2
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
8 HLA-DRB4interactor100DUF202 (PF02656, IPR003807): Domain of unknown function (DUF202)
MHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
9 IRF3suppressor200IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
10 KRT31interactor100Filament (PF00038, IPR001664): Intermediate filament protein
11 KRT40interactor2043.900Filament (PF00038, IPR001664): Intermediate filament protein
UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
12 MYConcoprotein50.33349.533HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
13 NTRK1oncoprotein50.5009.267I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
14 NUP50interactor30.33335.567NUP50 (PF08911, IPR015007): NUP50 (Nucleoporin 50 kDa)
Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain
15 PNMA1oncoprotein100PNMA (PF14893, IPR026523): PNMA
16 RNMTinteractor21.0000Pox_MCEL (PF03291, IPR004971): mRNA capping enzyme
SH3BGR (PF04908, IPR006993): SH3-binding, glutamic acid-rich protein
17 SOX2oncoprotein200HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOXp (PF12336, IPR022097): SOX transcription factor
18 TDO2interactor200Trp_dioxygenase (PF03301, IPR004981): Tryptophan 2,3-dioxygenase
19 WDR4interactor100WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat

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